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Cellosaurus DUT (CVCL_ZI16)

[Text version]
Cell line name DUT
Accession CVCL_ZI16
Resource Identification Initiative To cite this cell line use: DUT (RRID:CVCL_ZI16)
Comments Population: African; Kenyan.
Selected for resistance to: ChEBI; CHEBI:472805; Ouabain.
Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; 914; B2M; Simple; p.Met1Ile (c.3G>C); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ala5_Ala80del (c.14_241del228); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0008 (Daudi)
Children:
CVCL_6217 (DUTKO-1)
Sex of cell Male
Age at sampling 16Y
Category Cancer cell line
Publications

PubMed=6278187; DOI=10.1093/jnci/68.2.179
Zeuthen J., Klein G., Ber R., Masucci G., Bisballe S., Povey S., Terasaki P.I., Ralph P.
Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. I Isolation, characterization, cell surface markers, and B-cell markers.
J. Natl. Cancer Inst. 68:179-195(1982)

PubMed=6278188; DOI=10.1093/jnci/68.2.197
Klein G., Zeuthen J., Ber R., Ernberg I.
Human lymphoma-lymphoma hybrids and lymphoma-leukemia hybrids. II Epstein-Barr virus induction patterns.
J. Natl. Cancer Inst. 68:197-202(1982)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZI16
Encyclopedic resources Wikidata; Q98125927
Entry history
Entry creation02-Jul-2020
Last entry update05-Oct-2023
Version number8