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Cellosaurus LanthaScreen ERK2 A375 (CVCL_ZJ05)

[Text version]
Cell line name LanthaScreen ERK2 A375
Accession CVCL_ZJ05
Resource Identification Initiative To cite this cell line use: LanthaScreen ERK2 A375 (RRID:CVCL_ZJ05)
Comments Population: Caucasian.
Characteristics: Transfected with an emGFP-MAPK1/ERK2 construct whose expression is under the control of a CMV promoter.
Transfected with: HGNC; 6871; MAPK1.
Transfected with: UniProtKB; P42212; GFP (with p.Ser65Thr, p.Ser72Ala, p.Asn149Lys, p.Met153Thr, p.Ile167Thr and p.His231Leu = EmGFP).
Transfected with: UniProtKB; P33967; B.cereus Bsr.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Web pages https://www.thermofisher.com/order/catalog/product/K1798
Cross-references
Cell line databases/resources cancercelllines; CVCL_ZJ05
Encyclopedic resources Wikidata; Q98126851
Entry history
Entry creation02-Jul-2020
Last entry update05-Oct-2023
Version number8