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Cellosaurus BT474-J4 (CVCL_ZL46)

[Text version]

Cell line name BT474-J4
Synonyms BT-474-J4
Accession CVCL_ZL46
Resource Identification Initiative To cite this cell line use: BT474-J4 (RRID:CVCL_ZL46)
Comments Selected for resistance to: ChEBI; CHEBI:49603; Lapatinib (Tykerb; Tyverb).
Omics: Transcriptome analysis.
Sequence variations Heterozygous for MAPK1 p.His61Gln (c.183C>G) (from parent cell line).
Heterozygous for PIK3CA p.Lys111Asn (c.333G>C) (ClinVar=VCV000376483) (PubMed=19671800).
Homozygous for TP53 p.Glu285Lys (c.853G>A) (ClinVar=VCV000420133) (PubMed=19671800).
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0179 (BT-474)
Sex of cell Female
Age at sampling 60Y
Category Cancer cell line

PubMed=19671800; DOI=10.1158/0008-5472.CAN-08-4490
Liu L., Greger J., Shi H., Liu Y., Greshock J., Annan R., Halsey W., Sathe G.M., Martin A.-M., Gilmer T.M.
Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL.
Cancer Res. 69:6871-6878(2009)

Gene expression databases GEO; GSM799174
GEO; GSM799175
GEO; GSM799176
GEO; GSM799177
GEO; GSM799178
GEO; GSM799179
GEO; GSM799180
GEO; GSM799181
GEO; GSM799182
GEO; GSM799183
GEO; GSM799184
GEO; GSM799185
Entry history
Entry creation02-Jul-2020
Last entry update02-Jul-2020
Version number1