ID   143B rho-0 EtBr
AC   CVCL_ZL52
DR   cancercelllines; CVCL_ZL52
DR   PRIDE; PXD002425
DR   Wikidata; Q98125110
RX   PubMed=20188060;
RX   PubMed=26852163;
CC   Population: Caucasian.
CC   Characteristics: Cell line devoid of mitochondrial DNA (rho0). Obtained by growth of parental cell line with ethidium bromide.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala59Thr (c.175G>A); ClinVar=VCV000012581; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
DI   NCIt; C9145; Osteosarcoma
DI   ORDO; Orphanet_668; Osteosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2270 ! 143B
SX   Female
AG   13Y
CA   Cancer cell line
DT   Created: 02-07-20; Last updated: 05-10-23; Version: 8
//
RX   PubMed=20188060; DOI=10.1016/j.bbabio.2010.02.021;
RA   Wittig I., Meyer B., Heide H., Steger M., Bleier L., Wumaier Z.,
RA   Karas M., Schagger H.;
RT   "Assembly and oligomerization of human ATP synthase lacking
RT   mitochondrial subunits a and A6L.";
RL   Biochim. Biophys. Acta 1797:1004-1011(2010).
//
RX   PubMed=26852163; DOI=10.1074/mcp.M115.053181;
RA   Aretz I., Hardt C., Wittig I., Meierhofer D.;
RT   "An impaired respiratory electron chain triggers down-regulation of
RT   the energy metabolism and de-ubiquitination of solute carrier amino
RT   acid transporters.";
RL   Mol. Cell. Proteomics 15:1526-1538(2016).
//