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Cellosaurus LNCAP-AAR (CVCL_ZX07)

[Text version]

Cell line name LNCAP-AAR
Accession CVCL_ZX07
Resource Identification Initiative To cite this cell line use: LNCAP-AAR (RRID:CVCL_ZX07)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:68639; Abiraterone acetate.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Left supraclavicular lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1379 (LNCaP clone FGC)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

CLPUB00570
da Luz Efe F.
Establishment and characterization of abiraterone acetate resistant prostate cancer cell line.
Thesis BSc (2019), Universidade Federal de Santa Catarina, Brazil

Cross-references
Encyclopedic resources Wikidata; Q102114473
Entry history
Entry creation29-Oct-2020
Last entry update23-Jun-2022
Version number4