Home  |  Contact

Cellosaurus MCF-7 Tx200 (CVCL_ZZ20)

[Text version]
Cell line name MCF-7 Tx200
Accession CVCL_ZZ20
Resource Identification Initiative To cite this cell line use: MCF-7 Tx200 (RRID:CVCL_ZZ20)
Comments Population: Caucasian.
Doubling time: 79.3 hours (PubMed=8562478; PubMed=9815641).
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=8562478
Wosikowski K., Regis J.T., Robey R.W., Alvarez M., Buters J.T.M., Gudas J.M., Bates S.E.
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell Growth Differ. 6:1395-1403(1995)

PubMed=9815641
Wosikowski K., Schuurhuis D., Kops G.J.P.L., Saceda M., Bates S.E.
Altered gene expression in drug-resistant human breast cancer cells.
Clin. Cancer Res. 3:2405-2414(1997)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ20
Encyclopedic resources Wikidata; Q102114502
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number6