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Cellosaurus SW620/AD300 (CVCL_ZZ39)

[Text version]
Cell line name SW620/AD300
Synonyms SW620/AD-300; SW620/Ad300; SW620 Ad300; Ad300
Accession CVCL_ZZ39
Resource Identification Initiative To cite this cell line use: SW620/AD300 (RRID:CVCL_ZZ39)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0547 (SW620)
Children:
CVCL_B6Y0 (SW620/Ad300-ABCB1ko)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=14871996; DOI=10.1158/1078-0432.CCR-1044-3
Hu Y.-P., Krishan A., Nie W.-J., Sridhar K.S., Mayer L.D., Bally M.
Synergistic cytotoxicity of pyrazoloacridine with doxorubicin, etoposide, and topotecan in drug-resistant tumor cells.
Clin. Cancer Res. 10:1160-1169(2004)

PubMed=34977876; DOI=10.1002/mco2.106
Lei Z.-N., Teng Q.-X., Wu Z.-X., Ping F.-F., Song P., Wurpel J.N.D., Chen Z.-S.
Overcoming multidrug resistance by knockout of ABCB1 gene using CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells.
MedComm 2:765-777(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_ZZ39
Chemistry resources ChEMBL-Cells; CHEMBL4630768
ChEMBL-Targets; CHEMBL4630776
PubChem_Cell_line; CVCL_ZZ39
Encyclopedic resources Wikidata; Q102114957
Entry history
Entry creation29-Oct-2020
Last entry update05-Oct-2023
Version number9