ID   SW620/AD300
AC   CVCL_ZZ39
SY   SW620/AD-300; SW620/Ad300; SW620 Ad300; Ad300
DR   cancercelllines; CVCL_ZZ39
DR   ChEMBL-Cells; CHEMBL4630768
DR   ChEMBL-Targets; CHEMBL4630776
DR   PubChem_Cell_line; CVCL_ZZ39
DR   Wikidata; Q102114957
RX   PubMed=14871996;
RX   PubMed=34977876;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0547 ! SW620
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 29-10-20; Last updated: 05-10-23; Version: 9
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RX   PubMed=14871996; DOI=10.1158/1078-0432.CCR-1044-3;
RA   Hu Y.-P., Krishan A., Nie W.-J., Sridhar K.S., Mayer L.D., Bally M.;
RT   "Synergistic cytotoxicity of pyrazoloacridine with doxorubicin,
RT   etoposide, and topotecan in drug-resistant tumor cells.";
RL   Clin. Cancer Res. 10:1160-1169(2004).
//
RX   PubMed=34977876; DOI=10.1002/mco2.106;
RA   Lei Z.-N., Teng Q.-X., Wu Z.-X., Ping F.-F., Song P., Wurpel J.N.D.,
RA   Chen Z.-S.;
RT   "Overcoming multidrug resistance by knockout of ABCB1 gene using
RT   CRISPR/Cas9 system in SW620/Ad300 colorectal cancer cells.";
RL   MedComm 2:765-777(2021).
//