|| Yokoi T., Hirata S., Nishimura F., Miyakawa A., Odajima T., Kohama G.-I., Mochizuki Y.|
||Some properties of a newly established human cell line from a oral squamous carcinoma.|
|| Tumor Res. 25:93-103(1990)|
||A human squamous carcinoma cell line was established from a metastatic
oral squamous carcinoma. The cell line, designated as OSC-20, grew in
cobblestone pattern demonstrating their epithelial origin. Electron
microscopy revealed a presence of tonofilaments and desmosomes. OSC-20
cells were unable to form colonies in an anchorage-independent semisolid
support system of soft agar. Immunofluorescence study indicated that the
cells contained cytokeratins and vimentin. When transplanted into athymic
nude mice, OSC-20 cells produced tumors which on histopathological
examination were shown to be moderately differentiated squamous carcinoma.
OSC-20 cells secreted GST-pi into the culture medium. This cell line may
provide a useful model for the study of human oral cancer.
|| CVCL_3087; OSC-20|