Cellosaurus publication CLPUB00416

Publication number CLPUB00416
Authors Oberlin L.
Title Treatment of pancreatic carcinoma cell lines in vitro and vivo with a monoclonal antibody against the transferrin receptor.
Citation Thesis VMD (2009), Justus-Liebig-Universitat Giessen, Germany
Web pages http://geb.uni-giessen.de/geb/volltexte/2010/7414/pdf/OberlinLaura_2009_12_08.pdf
Abstract People are getting older. Increased life expectancy puts diseases such as cancer in the foreground. A particularly aggressive and malignant form is pancreatic carcinoma, in which tens of thousands of people die every year in industrialized countries despite the most intensive treatment. Current tumor therapies such as resection, radiation, chemotherapy and combinations thereof do not or only to a very limited extent. The mean survival rate for the first year is 20% and only 1% of the patients survive the 5th year after diagnosis. Without treatment, death occurs on average 3-6 months after diagnosis. Especially the almost inauspicious prognosis and the bad treatability let research oncologists worldwide for new therapies. One approach to this is the 'starvation' of cancer cells. Due to the enormous iron requirement of proliferating cells, it seems reasonable to suppose that by reducing iron uptake into the cell, it can cause it to shrink. Exactly this approach is described in the present work. Both in vitro and in vivo, it was tested whether one can achieve a positive effect by an antibody therapy against the transferrin receptor, which infiltrates iron into the cell.
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