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Cellosaurus publication CLPUB00431

Publication number CLPUB00431
Authors Inufusa H.
Title Characterization and metastatic study in nude mouse of human lung adenocarcinoma cell line KUM.LK-2.
Citation Kinki Daigaku Igaku Zasshi 12:631-641(1987)
Web pages https://ci.nii.ac.jp/naid/110000060156/en
Abstract Characterization and metastatic study were performed in new established human lung adenocarcinoma cell line, KUM.LK-2 which produced spontaneous lung metastasis in nude mice by subcutaneous implantation. The KUM.LK-2 cell line was established from the 2nd generation of nude mouse to which human lung adenocarcinoma was serially transplanted. The KUM.LK-2 produced spontaneous lung metastasis when the cells were subcutaneously implanted into nude mice. Metastasis was not found in the cases of intra-muscle implantation and intravenous injection. The KUM.LK-2 cell produced carcinoembryonic antigen and carbohydrated antigen 19-9 in vitro, but these tumor markers were not detected in the serum of KUM.LK-2 transplanted nude mice. From this study the model of spontaneous lung metastasis of human cancer was established. It is suggested that metastasis of human cancer in the nude mouse is not dominated only by blood supply and new vascular genesis. And it may be concluded that the usefulness of nude mice as an amplifier of tumor marker is bounded by tumor line.
Cell lines CVCL_W526; KUM.LK-2