Home  |  Contact

Cellosaurus publication CLPUB00447

Publication number CLPUB00447
Authors Mulivor R.A., Suchy S.F.
Title 1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
Citation (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992)
Web pages http://hdl.handle.net/2027/mdp.39015026044019
Abstract This edition of the catalog is dedicated to Dr. Arthur E. Green who retired from the Coriell Institute for Medical Research on May 1, 1992 after 39 years of dedicated service. Since its inception in 1972, Dr. Greene served as either the Director or Assistant Director of the National Institute of General Medical Sciences (NIGMS) Human Genetic Mutant Cell Repository. Dr. Greene helped to develop many of the basic techniques of culture which have become standard around the world. He coauthored more than 170 publications covering a wide range of topics, including polio virus cultivation, insect cell line cultivation and identification, and the cryogenic storage of cell lines. His easy-going manner and his encyclopedic knowledge of the collections will be greatly missed. Nineteen ninety-two marked the twentieth anniversary of the NIGMS Human Genetic Mutant Cell Repository. During the 1950's and 1960's, scientific research had turned increasingly toward working with cultured cells. However serious problems with interspecies and intraspecies contamination and misidentification were discovered that invalidated research findings. Dr. DeWitt Stetten, Director of the NIGMS, realized that the solution would be to establish a national collection which would house well documented, highly characterized, contamination-free cell cultures which would be available to all qualified scientists. Following a national competition, the Coriell Institute was awarded its first contract in 1972. As science advanced, so have the services offered by the CCR. Somatic cell hybrid mapping panels, regional mapping panels, extended family pedigrees and cultures from vanishing populations are now part of collection. DNA is also being provided for many of the cultures in the collection. The next decade will probably witness additional changes in the scope of the NIGMS Repository's activities. Since 1972, the CCR have processed more than 13,000 submitted cell cultures, solid tissue biopsies, and peripheral blood specimens and provided more than 60,000 cell cultures and 2,500 DNA samples to investigators. These activities have resulted in a worldwide reputation for excellent, well characterized, thoroughly documented and contamination free cell cultures and high quality DNA samples. This edition of the catalog lists a total of 5,270 cell cultures and 275 DNA samples. The format of the catalog has been revised and three sections have been added or updated: Specially Characterized Lymphoblast Cultures, Extended Families - Lymphoblast Cultures, and Human Diversity Collection - Lymphoblast Cultures. The first section contains cultures characterized by HLA typing, the second contains cultures from the Amish, Utah, and Venezuelan pedigrees as well as a listing of pedigrees found elsewhere in the catalog that should prove useful for gene linkage studies, and the third section lists cultures from a variety of diverse human populations such as Amerindians, Melanesians, Pygmies, Japanese, Cambodians, and Chinese. Many of the cultures found in this section are part of the Yale- Stanford collection and are a representative sample of the larger collection that is available from the contributor, Dr. Kenneth Kidd (Yale University). Appendix D, which presents the diagrammatic representation of chromosomally aberrant cell cultures has been revised and updated for the 16th edition and a new series of diagrams showing the human chromosomes or of human chromosomes present in the collection of human/rodent somatic cell hybrids has been added to the catalog section containing the to this collection. Investigators are encouraged to contact the Repository to submit specimens from individuals with well documented genetic diseases or somatic cell hybrids retaining human chromosomes not currently in the collection.
Cell lines View cell lines