| Publication number |
CLPUB00515 |
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| Authors |
Liu W.-T., Chen S.-C., Lee N., Tan S.-K., Liu S.-F., Dunn P., Chang K.S.-S. |
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| Title |
Establishment and characterization of a cell line of monocytic origin, HL-CZ, from human leukemia. |
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| Citation |
J. Biomed. Lab. Sci. 4:284-292(1989) |
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| Web pages |
http://readopac3.ncl.edu.tw/nclserialFront/search/detail.jsp?sysId=0005305277&dtdId=000040&search_type=detail&la=ch |
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| Abstract |
A cell line of monocytic origin named HL-CZ has been established in long-
term culture from a 50-year-old Chinese male with adult T-cell leukemia.
The cell size in this culture is mostly 16 mum (with a range of 12-30 mum)
in diameter. The doubling time of the cell is 22-26 hrs. The light
microscopy and electron microscopy of the cells show that these monocytic
cells are phagocytic, with single, double or multiple nuclei. Abundant
basophilic cytoplasm is one of the characteristics of the cells. Since
more than 90% of the cells possess CD 15 marker and show early
differentiation in hematopoiesis, it is designated as a population of
promonocyte, The chromosome number of each cell varies from 41 to 75 with
fragment aberration in 91% and the other with isochromatin break and gap.
Some detailed analysis of the cell markers and complicated chromosome
pictures remain for further studies.
|
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| Cell lines |
CVCL_WU73; HL-CZ |
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