Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > SK-BR-3
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Breast Carcinoma Cell Line |
| Description | A highly rearranged, near triploid cell line, derived by Fogh and Trempe (1975), obtained from Dr Mike O'Hare. |
| Notable Features | Translocations involve all chromosomes, except 11 and 18. Five markers have been duplicated. Deletions were detected on chromosomes 1, 3, 5, 10 (duplicated), 15 and 18, and an isochromsome 1 is present. |
| Representative SKY Karyotype |  |
| 79(68-79).1x1, i(1)(q), der(1?)t(1;4), der(1)t(1;5), der(1)t(1;10), der(1)t(1;5), del(1)?, 2x2, der(?)t(2;6;4), der(2)t(2;6)x2, 3x2, del(3), 4x1, der(?)t(4;14), 5x2, der(?)t(5;19;4;8), del(5), 6x2, 7x7, 8x1, der(8?)t(13;3;8;3;8;13)x2, der(?)t(8;14), der(8)t(8;21), der(?)t(X;8)x2, der(?)t(20;3;8;17;19;8;3;13), 9x2, 10x1, del(10), der(10?)t(6;4;6;10), 11x4, 12x2, der(12)t(3;12)(?;q23)x2, 13x1, der(13)t(13;20), der(14)t(5;14), der(?)t(9;14), 15x2, del(15), der(15)t(15;17), 16x2, der(16)t(7;16)x2, 17x1, der(?)t(20;19;8;17), 18x2, del(18), 19x1, der(?)t(19;22), 20x3, 21x3, 22x2, Xx2 cp[10] | |
| CGH results | |
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