Molecular Cytogenetics of Common Epithelial Cancers > Colon Carcinoma cell lines > HCA7

HCA7   [Cellosaurus entry CVCL_0289]

Colon Cancer Cell Line

Description

Microsatellite-unstable line with a large number of rearrangements but little numerical change.

   
Notable Features

Remarkable for multiple reciprocal translocations, and, although microsatellite-unstable, has a highly structurally-rearranged karyotype

   
Representative SKY Karyotype
   
   

43 (42–43), der(X)t(X;4)(p22;q25~26)*, 1x1, der(1)del(1)(q)t(1;16)(p13;p11.2)*, 2x1, der(2)t(2;11)(q14~21;q21)*, 3x0, del(3)(p13p21), der(3)t(1;3)(?p36;q27~29)*, 4x1, der(4)t(X;4)(p22;q25~26)*, 5x2, 6x0, der(6)t(6;7)(q21~22;q31)*, der(6)t(6;18)(q13~15;q11.2)*, 7x1, der(7)t(6;7)(q21~22;q31)*, 8x2, 9x1, der(9)t(9;21)(p12~13;q11.2), 10x2, 11x1, der(11)t(2;11)(q14~21;q21)*, 12x1, dup(12)(q?), 13x1, 14x1, i(14)(q10), 15x1, del(15)(?q12q15), 16x1, der(16)t(1;16)(p13;p11.2)t(1;3)(p36;q27~29)*, 17x2, 18x1, der(18)t(6;18)(q13~15;q11.2)*, 19x2, 20x2, 21x1, 22x2[14]/ 44 (40–45), idem, +2, -der(2)t(2;11)(q14~21;q21), -der(3)t(1;3)(?p36;q27~29), +der(?)t(3;14), +6, -der(6)t(6;7)(q21~22;q31), +7, -der(7)t(6;7)(q21~22;q31), -10, +der(10)t(3;10), +11, -der(11)t(2;11)(q14~21;q21), +14, - i(14)(q10), -der(16)t(1;16)(p13;p11.2)t(1;3)(p36;q27~29), +der(16)t(1;16)(p13;p11.2)* [7]

*reciprocal translocations

   
   


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Colon Cancer Cell Lines