| Notable Features |
Near-triploid, highly rearranged with 22 structural chromosome abnormalities, involving chromosomes 1, 2, 3, 4, 5, 8, 6, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 22. Half of the rearrangements are whole-arm translocations. Chromosome losses involve chromosomes 3, 6, 8p, 9, 10, 18, 21; gains involve chromosomes 5p, 8q, 19p. Isochromosomes involving 5(p), 8(q) and i(15q). In some cells an extended centromeric region of chromosome 1 was observed and double minutes involving chromosome 11 observed in 3 cells.
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57 (56-60), X, 1x2, der(1;14)(q10?;q10), der(1;15)(q10;q10) a, der(1)del(1), 2x2, 3x1, der(3)t(3;20), 4x2, der(4)del(4)t(1;4), 5x3, i(5p)x2, 6x1, der(6)del(6), 7x3, 8x1, i(8q), 9x2, 10 b x2, der(10)t(1;10)b, 11x2, 12x3, der(13)t(13;15), der(13)t(13;18), der(13)t(1;13), 14x2, 15x2 a, i(15q)a, der(12;15)(q10;q10) a, 16x2, der(16)t(1;16), 17x2, der(17)t(1;17) a, der(17)t(15;17) a, 18x1, der(18)t(10;18) a, 19x3, der(19)t(11;19)dup(11), 20x2, der(20)t(2;20), 21x2, 22x1, der(6;22)(p10;q10), der(22)t(18;22), dmin
a in less than 50% of cells b cells have either 2 copies of 10 or one copy and the translocation
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