UniProtKB/Swiss-Prot protein knowledgebase release 2018_03 statistics





1.  INTRODUCTION



Release 2018_03 of 28-Mar-18 of UniProtKB/Swiss-Prot contains 557012 sequence entries,

comprising 199714119 amino acids abstracted from 258792 references. 



199 sequences have been added since release 2018_02, the sequence data of

184 existing entries has been updated and the annotations of

146788 entries have been revised.



Number of fragments: 9152

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 39832





Protein existence (PE):           entries     %



1: Evidence at protein level        98403   17.7%

2: Evidence at transcript level     57025   10.2%

3: Inferred from homology          386093   69.3%

4: Predicted                        13627    2.4%

5: Uncertain                         1864    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13602



   The first twenty species represent 120143 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5646

                            2x: 1938

                            3x: 1051

                            4x:  689

                            5x:  509

                            6x:  405

                            7x:  294

                            8x:  247

                            9x:  232

                           10x:  135

                       11- 20x:  740

                       21- 50x:  449

                       51-100x:  218

                         >100x: 1049





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20316  Homo sapiens (Human)

       2      16968  Mus musculus (Mouse)

       3      15686  Arabidopsis thaliana (Mouse-ear cress)

       4       8022  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6002  Bos taurus (Bovine)

       7       5141  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4443  Escherichia coli (strain K12)

       9       4185  Bacillus subtilis (strain 168)

      10       4136  Dictyostelium discoideum (Slime mold)

      11       4009  Caenorhabditis elegans

      12       3923  Oryza sativa subsp. japonica (Rice)

      13       3509  Drosophila melanogaster (Fruit fly)

      14       3426  Xenopus laevis (African clawed frog)

      15       3046  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2290  Gallus gallus (Chicken)

      17       2219  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2168  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2035  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1795  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      24       1705  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1683  Shigella flexneri

      27       1423  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1324  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1172  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1063  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1031  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35       1006  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        975  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      38        930  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      40        926  Staphylococcus aureus (strain N315)

      41        914  Kluyveromyces lactis   

      42        909  Acanthamoeba polyphaga mimivirus (APMV)

      43        899  Staphylococcus aureus (strain COL)

      44        895  Staphylococcus aureus (strain MW2)

      45        893  Oryctolagus cuniculus (Rabbit)

      46        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      47        889  Staphylococcus aureus (strain MSSA476)

      48        888  Staphylococcus aureus (strain MRSA252)

      49        887  Emericella nidulans  

      50        882  Salmonella choleraesuis (strain SC-B67)

      51        881  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      52        879  Shigella sonnei (strain Ss046)

      53        871  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        854  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      58        829  Shigella boydii serotype 4 (strain Sb227)

      59        825  Escherichia coli (strain UTI89 / UPEC)

      60        822  Shigella dysenteriae serotype 1 (strain Sd197)

      61        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      62        817  Canis lupus familiaris (Dog) (Canis familiaris)

      63        816  Oryza sativa subsp. indica (Rice)

      64        803  Zea mays (Maize)

      65        796  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      66        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      67        791  Escherichia coli (strain SMS-3-5 / SECEC)

      68        784  Aquifex aeolicus (strain VF5)

      69        776  Pasteurella multocida (strain Pm70)

      70        774  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      71        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      72        771  Escherichia coli (strain K12 / DH10B)

      73        770  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      74        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      75        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      76        762  Escherichia coli (strain 55989 / EAEC)

      77        761  Escherichia coli O8 (strain IAI1)

      78        760  Shigella flexneri serotype 5b (strain 8401)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        759  Staphylococcus epidermidis (strain ATCC 12228)

      81        758  Staphylococcus aureus (strain NCTC 8325)

      82        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      86        746  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      87        741  Bacillus anthracis

      88        741  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Vibrio vulnificus (strain YJ016)

      94        718  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Enterobacter sp. (strain 638)

      97        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      98        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      99        714  Escherichia coli O1:K1 / APEC

     100        714  Salmonella paratyphi A (strain AKU_12601)

     101        713  Salmonella newport (strain SL254)

     102        713  Salmonella agona (strain SL483)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     109        698  Klebsiella pneumoniae (strain 342)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        673  Escherichia coli

     118        673  Staphylococcus aureus (strain USA300)

     119        670  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        662  Bradyrhizobium diazoefficiens 

     124        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     125        653  Debaryomyces hansenii   

     126        650  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     127        646  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        645  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        622  Treponema pallidum (strain Nichols)

     135        620  Methanothermobacter thermautotrophicus  

     136        613  Staphylococcus haemolyticus (strain JCSC1435)

     137        610  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)

     138        610  Xanthomonas campestris pv. campestris 

     139        607  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     140        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     141        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     142        602  Staphylococcus saprophyticus subsp. saprophyticus 

     143        602  Photobacterium profundum (strain SS9)

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        594  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     147        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     148        593  Pseudomonas aeruginosa (strain UCBPP-PA14)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        579  Brucella suis biovar 1 (strain 1330)

     153        578  Caenorhabditis briggsae

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Vibrio fischeri (strain ATCC 700601 / ES114)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     163        562  Bacillus cereus (strain ZK / E33L)

     164        559  Clostridium acetobutylicum 

     165        557  Xanthomonas axonopodis pv. citri (strain 306)

     166        555  Pseudomonas fluorescens (strain Pf0-1)

     167        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     168        554  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     169        553  Oceanobacillus iheyensis 

     170        550  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     171        549  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        537  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Listeria monocytogenes serotype 4b (strain F2365)

     176        529  Sodalis glossinidius (strain morsitans)

     177        528  Corynebacterium glutamicum 

     178        527  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        522  Xylella fastidiosa (strain 9a5c)

     180        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     181        517  Chromobacterium violaceum 

     182        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        513  Deinococcus radiodurans 

     185        513  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     186        512  Pseudomonas aeruginosa (strain PA7)

     187        511  Staphylococcus aureus (strain Newman)

     188        510  Geobacillus kaustophilus (strain HTA426)

     189        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     190        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     191        508  Streptomyces avermitilis 

     192        507  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     193        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     194        502  Pseudomonas entomophila (strain L48)

     195        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     196        499  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        497  Haemophilus influenzae (strain 86-028NP)

     199        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     200        496  Bacillus clausii (strain KSM-K16)

     201        496  Burkholderia pseudomallei (strain K96243)

     202        494  Proteus mirabilis (strain HI4320)

     203        493  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        487  Methanosarcina mazei  

     209        487  Shewanella sp. (strain MR-7)

     210        486  Mannheimia succiniciproducens (strain MBEL55E)

     211        485  Thermosynechococcus elongatus (strain BP-1)

     212        485  Pyrococcus horikoshii 

     213        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     214        484  Shewanella sp. (strain MR-4)

     215        484  Pseudomonas aeruginosa (strain LESB58)

     216        483  Brucella abortus (strain 2308)

     217        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     218        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     219        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     221        477  Pyrococcus abyssi (strain GE5 / Orsay)

     222        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     223        475  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     224        474  Burkholderia lata 

     225        473  Nicotiana tabacum (Common tobacco)

     226        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     227        472  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     228        468  Clostridium perfringens (strain 13 / Type A)

     229        466  Shewanella sp. (strain ANA-3)

     230        466  Shewanella frigidimarina (strain NCIMB 400)

     231        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     232        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     233        466  Pseudomonas putida (strain GB-1)

     234        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     235        464  Aeromonas hydrophila subsp. hydrophila 

     236        463  Campylobacter jejuni subsp. jejuni serotype O:2 

     237        463  Enterococcus faecalis (strain ATCC 700802 / V583)

     238        462  Burkholderia mallei (strain ATCC 23344)

     239        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     241        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     242        457  Ovis aries (Sheep)

     243        455  Staphylococcus aureus (strain JH1)

     244        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        453  Pseudomonas putida (strain W619)

     246        452  Aeromonas salmonicida (strain A449)

     247        452  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     248        452  Shewanella baltica (strain OS185)

     249        450  Dechloromonas aromatica (strain RCB)

     250        450  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19494 (  3%)

    Bacteria         333480 ( 60%)

    Eukaryota        187246 ( 34%)

    Viruses           16792 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20317 ( 11%)           (  4%)

     Other Mammalia         46603 ( 25%)           (  8%)

     Other Vertebrata       18239 ( 10%)           (  3%)

     Viridiplantae          39411 ( 21%)           (  7%)

     Fungi                  33161 ( 18%)           (  6%)

     Insecta                 9140 (  5%)           (  2%)

     Nematoda                4909 (  3%)           (  1%)

     Other                  15466 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9483             1001-1100     3974

                 51- 100   42419             1101-1200     2783

                101- 150   58865             1201-1300     2130

                151- 200   58789             1301-1400     1982

                201- 250   57627             1401-1500     1598

                251- 300   51307             1501-1600      781

                301- 350   51689             1601-1700      611

                351- 400   44854             1701-1800      541

                401- 450   36858             1801-1900      465

                451- 500   29677             1901-2000      376

                501- 550   21374             2001-2100      245

                551- 600   15271             2101-2200      320

                601- 650   12742             2201-2300      311

                651- 700    9192             2301-2400      207

                701- 750    7626             2401-2500      155

                751- 800    5498             >2500         1244

                801- 850    4749

                851- 900    5187

                901- 950    4028

                951-1000    2902



   





   The average sequence length in UniProtKB/Swiss-Prot is 358 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2716





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  857

                       2x:  381

                       3x:  171

                       4x:  133

                       5x:  108

                       6x:   94

                       7x:   66

                       8x:   48

                       9x:   46

                      10x:   30

                  11- 20x:  214

                  21- 50x:  223

                  51-100x:  118

                    >100x:  227





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24194   Journal of Biological Chemistry

    2        11143   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6540   Journal of Bacteriology

    4         5558   Biochemical and Biophysical Research Communications

    5         5227   Biochemistry

    6         4960   Nucleic Acids Research

    7         4801   Gene

    8         4788   FEBS Letters

    9         4643   The EMBO Journal

   10         4421   Nature

   11         4306   Molecular and Cellular Biology

   12         4198   Journal of Molecular Biology

   13         3585   Biochimica et Biophysica Acta

   14         3517   Cell

   15         3381   European Journal of Biochemistry

   16         3096   Journal of Virology

   17         2954   Science

   18         2817   Biochemical Journal

   19         2532   Genomics

   20         2498   Plant Physiology

   21         2456   Molecular Microbiology

   22         2160   Journal of Cell Biology

   23         2087   The American Journal of Human Genetics

   24         1934   The Plant Cell

   25         1840   Plant Molecular Biology

   26         1810   Genes and Development

   27         1777   Human Molecular Genetics

   28         1777   PLoS ONE

   29         1775   The Plant Journal

   30         1729   Virology

   31         1726   Nature Genetics

   32         1645   Development

   33         1632   Molecular Biology of the Cell

   34         1559   Human Mutation

   35         1532   Oncogene

   36         1492   Molecular Cell

   37         1402   Journal of Immunology

   38         1392   Molecular and General Genetics

   39         1332   Journal of Biochemistry

   40         1301   Structure

   41         1300   Genetics

   42         1219   Journal of Cell Science

   43         1134   Blood

   44         1109   Journal of General Virology

   45         1100   Infection and Immunity

   46         1043   Microbiology

   47         1036   Current Biology

   48         1034   Archives of Biochemistry and Biophysics

   49         1020   Developmental Biology

   50          877   Cancer Research

   51          875   Journal of Neuroscience

   52          872   Applied and Environmental Microbiology

   53          857   Acta Crystallographica, Section D

   54          832   Yeast

   55          828   FEMS Microbiology Letters

   56          761   Protein Science

   57          756   Toxicon

   58          733   Neuron

   59          711   Journal of Clinical Investigation

   60          680   Human Genetics

   61          664   American Journal of Physiology

   62          657   Plant and Cell Physiology

   63          642   Nature Structural Biology

   64          642   Mechanisms of Development

   65          619   The Journal of Experimental Medicine

   66          607   Proteins

   67          590   PLoS Genetics

   68          584   Journal of Medical Genetics

   69          568   Current Genetics

   70          559   Nature Cell Biology

   71          536   Bioscience, Biotechnology, and Biochemistry

   72          532   Molecular Endocrinology

   73          527   Journal of Neurochemistry

   74          514   The Journal of Clinical Endocrinology and Metabolism

   75          509   Nature Structural and Molecular Biology

   76          497   Endocrinology

   77          494   Developmental Cell

   78          488   Mammalian Genome

   79          483   The FEBS Journal

   80          472   Immunogenetics

   81          449   Experimental Cell Research

   82          447   Molecular and Biochemical Parasitology

   83          433   Antimicrobial Agents and Chemotherapy

   84          419   Eukaryotic Cell

   85          416   Planta

   86          409   Peptides

   87          409   RNA

   88          408   Journal of Molecular Evolution

   89          396   Molecular Biology and Evolution

   90          386   DNA and Cell Biology

   91          373   DNA Sequence

   92          369   Molecular Pharmacology

   93          359   Journal of Experimental Botany

   94          357   Journal of the American Chemical Society

   95          355   Journal of Investigative Dermatology

   96          354   Neurology

   97          352   EMBO Reports

   98          346   Comparative Biochemistry and Physiology

   99          343   The FASEB Journal

  100          340   Biology of Reproduction

  101          340   Brain Research. Molecular Brain Research

  102          335   Acta Crystallographica, Section F

  103          332   Nature Communications

  104          326   Tissue Antigens

  105          322   European Journal of Human Genetics

  106          320   Molecular Plant-Microbe Interactions

  107          320   American Journal of Medical Genetics. Part A

  108          319   Immunity

  109          313   Biochimie

  110          311   Genes to Cells

  111          310   The New England Journal of Medicine

  112          308   PLoS Pathogens

  113          307   Developmental Dynamics

  114          300   Virus Research

  115          296   Biological Chemistry Hoppe-Seyler

  116          294   Genome Research

  117          284   Clinical Genetics

  118          282   Cytogenetics and Cell Genetics

  119          278   Annals of Neurology

  120          270   Journal of General Microbiology

  121          266   European Journal of Immunology

  122          263   BMC Genomics

  123          263   Investigative Ophthalmology and Visual Science

  124          261   Nature Immunology

  125          249   Journal of Human Genetics

  126          247   Applied Microbiology and Biotechnology

  127          243   Journal of Medicinal Chemistry

  128          239   Scientific Reports

  129          238   Archives of Microbiology

  130          232   PLoS Biology

  131          229   DNA Research

  132          229   Glycobiology

  133          227   Journal of Cellular Biochemistry

  134          222   Traffic

  135          218   Molecular Genetics and Metabolism

  136          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  137          216   Cell Cycle

  138          213   Journal of Lipid Research

  139          212   Circulation Research

  140          207   Archives of Virology

  141          207   Diabetes

  142          206   Molecular and Cellular Endocrinology

  143          206   Molecular Immunology

  144          202   Protein Expression and Purification

  145          199   Phytochemistry

  146          189   Molecular Genetics and Genomics

  147          187   Nature Medicine

  148          183   Molecular and Cellular Neuroscience

  149          182   Insect Biochemistry and Molecular Biology

  150          179   International Journal of Cancer





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1204461                 2.16                                         

   Journal                           1012113     452686      1.82       1                                 

   Submitted to EMBL/GenBank/DDBJ     181650     158820      0.33       2                                 

   Submitted to other databases         7348       6794      0.01       3                                 

   Book citation                        1703       1680     <0.01       4                                 

   Plant Gene Register                   611        598     <0.01       5                                 

   Thesis                                434        431     <0.01       6                                 

   Unpublished observations              397        393     <0.01       7                                 

   Patent                                199        195     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 399446



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2494692                 4.48                                         

   ALLERGEN                              715        715     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25139      25139      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        7917       7917      0.01      20                                 

   BIOTECHNOLOGY                         854        843     <0.01      25                                 

   CATALYTIC ACTIVITY                 265350     235054      0.48       5                                 

   CAUTION                             12693      12451      0.02      18                                 

   COFACTOR                           122396     112200      0.22       7                                 

   DEVELOPMENTAL STAGE                 11839      11838      0.02      19                                 

   DISEASE                              6817       4554      0.01      22                                 

   DISRUPTION PHENOTYPE                13194      13194      0.02      17                                 

   DOMAIN                              47597      41039      0.09       9                                 

   ENZYME REGULATION                   14289      14287      0.03      16                                 

   FUNCTION                           461808     441717      0.83       2                                 

   INDUCTION                           20113      20101      0.04      15                                 

   INTERACTION                         20618      20618      0.04      14                                 

   MASS SPECTROMETRY                    6675       5048      0.01      23                                 

   MISCELLANEOUS                       38037      35171      0.07      12                                 

   PATHWAY                            137536     124736      0.25       6                                 

   PHARMACEUTICAL                        109        107     <0.01      29                                 

   POLYMORPHISM                         1254       1198     <0.01      24                                 

   PTM                                 54980      40907      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44022      44022      0.08      11                                 

   SIMILARITY                         505306     501160      0.91       1                                 

   SUBCELLULAR LOCATION               346868     339667      0.62       3                                 

   SUBUNIT                            275376     275046      0.49       4                                 

   TISSUE SPECIFICITY                  44975      44974      0.08      10                                 

   TOXIC DOSE                            662        608     <0.01      27                                 

   WEB RESOURCE                         6926       5767      0.01      21                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4425964                 7.95                                         

   ACT_SITE                           162334      98350      0.29      10                                 

   BINDING                            399292     105298      0.72       2                                 

   CA_BIND                              4169       1728      0.01      36                                 

   CARBOHYD                           116013      29650      0.21      15                                 

   CHAIN                              564846     550070      1.01       1                                 

   COILED                              21959      15191      0.04      27                                 

   COMPBIAS                            58841      31638      0.11      20                                 

   CONFLICT                           134644      47132      0.24      13                                 

   CROSSLNK                            23383       8388      0.04      26                                 

   DISULFID                           122570      33154      0.22      14                                 

   DNA_BIND                            11587      10480      0.02      32                                 

   DOMAIN                             192356     118613      0.35       9                                 

   HELIX                              245054      22771      0.44       7                                 

   INIT_MET                            17128      17128      0.03      28                                 

   INTRAMEM                             2623       1179     <0.01      37                                 

   LIPID                               12936       8355      0.02      30                                 

   METAL                              375317      93398      0.67       3                                 

   MOD_RES                            247744      71319      0.44       6                                 

   MOTIF                               42115      27630      0.08      23                                 

   MUTAGEN                             65995      14663      0.12      18                                 

   NON_CONS                             2257        787     <0.01      38                                 

   NON_STD                               358        283     <0.01      39                                 

   NON_TER                             12348       9462      0.02      31                                 

   NP_BIND                            155085      84474      0.28      11                                 

   PEPTIDE                             11383       7839      0.02      33                                 

   PROPEP                              14050      11989      0.03      29                                 

   REGION                             193175      92189      0.35       8                                 

   REPEAT                             104382      14700      0.19      16                                 

   SIGNAL                              41304      41303      0.07      24                                 

   SITE                                56137      31271      0.10      21                                 

   STRAND                             255640      21438      0.46       5                                 

   TOPO_DOM                           139374      28614      0.25      12                                 

   TRANSIT                              9031       8915      0.02      34                                 

   TRANSMEM                           368969      76953      0.66       4                                 

   TURN                                58988      18455      0.11      19                                 

   UNSURE                               4429        788      0.01      35                                 

   VAR_SEQ                             51790      21909      0.09      22                                 

   VARIANT                             95997      17032      0.17      17                                 

   ZN_FING                             30361      13317      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18557484                33.32                                                           

   Allergome                            1739       1136     <0.01     119      Protein family/group databases               

   ArachnoServer                        1149       1140     <0.01     127      Organism-specific databases                  

   Araport                             15706      15611      0.03      82      Organism-specific databases                  

   Bgee                                56225      56224      0.10      45      Gene expression databases                    

   BindingDB                            4902       4902      0.01     102      Chemistry                                    

   BioCyc                             158213     154223      0.28      28      Enzyme and pathway databases                 

   BioGrid                             50473      49984      0.09      50      Protein-protein interaction databases        

   BioMuta                             17244      17239      0.03      77      Polymorphism and mutation databases          

   BRENDA                              12865      12093      0.02      86      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     125      PTM databases                                

   CAZy                                 9450       8524      0.02      89      Protein family/group databases               

   CCDS                                47604      33882      0.09      52      Sequence databases                           

   CDD                                180711     165701      0.32      25      Family and domain databases                  

   CGD                                  1987       1970     <0.01     117      Organism-specific databases                  

   ChEMBL                               6526       6526      0.01      93      Chemistry                                    

   ChiTaRS                             20449      20439      0.04      67      Other                                        

   CleanEx                             30019      29387      0.05      58      Gene expression databases                    

   CollecTF                              133        133     <0.01     146      Gene expression databases                    

   COMPLUYEAST-2DPAGE                     97         97     <0.01     147      2D gel databases                             

   ConoServer                            949        866     <0.01     128      Organism-specific databases                  

   CORUM                                5168       5168      0.01      99      Protein-protein interaction databases        

   CTD                                 74702      73823      0.13      43      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     143      PTM databases                                

   dictyBase                            4212       4097      0.01     105      Organism-specific databases                  

   DIP                                 17336      17304      0.03      76      Protein-protein interaction databases        

   DisGeNET                            14852      14615      0.03      83      Organism-specific databases                  

   DisProt                               708        703     <0.01     132      3D structure databases                       

   DMDM                                16360      16296      0.03      80      Polymorphism and mutation databases          

   DNASU                               18952      18881      0.03      72      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     144      2D gel databases                             

   DrugBank                            18749       3637      0.03      73      Chemistry                                    

   EchoBASE                             4159       4159      0.01     107      Organism-specific databases                  

   EcoGene                              4293       4293      0.01     104      Organism-specific databases                  

   eggNOG                             663444     331024      1.19       5      Phylogenomic databases                       

   ELM                                  1809       1809     <0.01     118      Protein-protein interaction databases        

   EMBL                               987926     545400      1.77       3      Sequence databases                           

   Ensembl                             88586      50151      0.16      41      Genome annotation databases                  

   EnsemblBacteria                    354412     335312      0.64      17      Genome annotation databases                  

   EnsemblFungi                        30460      28734      0.05      57      Genome annotation databases                  

   EnsemblMetazoa                      15867      10338      0.03      81      Genome annotation databases                  

   EnsemblPlants                       28653      21155      0.05      62      Genome annotation databases                  

   EnsemblProtists                      4960       4784      0.01     101      Genome annotation databases                  

   EPD                                 20220      20220      0.04      70      Proteomic databases                          

   ESTHER                               2489       2489     <0.01     114      Protein family/group databases               

   euHCVdb                                55         44     <0.01     149      Organism-specific databases                  

   EuPathDB                            37662      37482      0.07      55      Organism-specific databases                  

   EvolutionaryTrace                   16614      16614      0.03      79      Other                                        

   ExpressionAtlas                     51074      51074      0.09      49      Gene expression databases                    

   FlyBase                              6137       5840      0.01      95      Organism-specific databases                  

   Gene3D                             358753     286966      0.64      16      Family and domain databases                  

   GeneCards                           20264      20095      0.04      68      Organism-specific databases                  

   GeneDB                                571        515     <0.01     135      Genome annotation databases                  

   GeneID                             289866     278931      0.52      22      Genome annotation databases                  

   GeneReviews                          1155       1152     <0.01     126      Organism-specific databases                  

   GeneTree                            59024      59004      0.11      44      Phylogenomic databases                       

   Genevisible                         55220      55220      0.10      46      Gene expression databases                    

   GeneWiki                            10366      10282      0.02      88      Other                                        

   GenomeRNAi                          22005      22002      0.04      64      Other                                        

   GO                                2846623     530529      5.11       1      Ontologies                                   

   Gramene                             28653      21155      0.05      61      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2015       2015     <0.01     116      Chemistry                                    

   H-InvDB                              5588       4768      0.01      98      Organism-specific databases                  

   HAMAP                              328983     326345      0.59      19      Family and domain databases                  

   HGNC                                20252      20110      0.04      69      Organism-specific databases                  

   HOGENOM                            390904     390904      0.70      15      Phylogenomic databases                       

   HOVERGEN                            75921      75921      0.14      42      Phylogenomic databases                       

   HPA                                 27055      16795      0.05      63      Organism-specific databases                  

   IMGT_GENE-DB                          142        142     <0.01     145      Protein family/group databases               

   InParanoid                         136766     136766      0.25      30      Phylogenomic databases                       

   IntAct                              52466      52466      0.09      47      Protein-protein interaction databases        

   InterPro                          2212207     537770      3.97       2      Family and domain databases                  

   iPTMnet                             51222      51222      0.09      48      PTM databases                                

   KEGG                               504509     476023      0.91       7      Genome annotation databases                  

   KO                                 403037     402589      0.72      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     131      Organism-specific databases                  

   Leproma                               672        669     <0.01     133      Organism-specific databases                  

   MaizeGDB                              509        505     <0.01     137      Organism-specific databases                  

   MalaCards                            4164       4162      0.01     106      Organism-specific databases                  

   MaxQB                               29726      29726      0.05      59      Proteomic databases                          

   MEROPS                              11381      11381      0.02      87      Protein family/group databases               

   MGI                                 16872      16832      0.03      78      Organism-specific databases                  

   MIM                                 20756      14965      0.04      66      Organism-specific databases                  

   MINT                                21762      21762      0.04      65      Protein-protein interaction databases        

   MoonProt                               63         63     <0.01     148      Protein family/group databases               

   mycoCLAP                              359        354     <0.01     142      Protein family/group databases               

   neXtProt                            20185      20182      0.04      71      Organism-specific databases                  

   OGP                                   374        374     <0.01     141      2D gel databases                             

   OMA                                416058     416058      0.75      13      Phylogenomic databases                       

   OpenTargets                         18288      18133      0.03      75      Organism-specific databases                  

   Orphanet                             6144       3286      0.01      94      Organism-specific databases                  

   OrthoDB                            292799     292799      0.53      20      Phylogenomic databases                       

   PANTHER                            265863     253563      0.48      23      Family and domain databases                  

   PATRIC                              91733      91733      0.16      40      Genome annotation databases                  

   PaxDb                              124289     124289      0.22      33      Proteomic databases                          

   PDB                                158637      26179      0.28      26      3D structure databases                       

   PDBsum                             158637      26179      0.28      27      3D structure databases                       

   PeptideAtlas                        32068      32068      0.06      56      Proteomic databases                          

   PeroxiBase                            773        755     <0.01     130      Protein family/group databases               

   Pfam                               754791     513645      1.36       4      Family and domain databases                  

   PharmGKB                            18371      18329      0.03      74      Organism-specific databases                  

   PhosphoSitePlus                     39001      39001      0.07      54      PTM databases                                

   PhylomeDB                           95531      95531      0.17      38      Phylogenomic databases                       

   PIR                                124032     113593      0.22      34      Sequence databases                           

   PIRSF                              108670     107641      0.20      37      Family and domain databases                  

   PMAP-CutDB                           1462       1462     <0.01     120      Other                                        

   PomBase                              5133       5129      0.01     100      Organism-specific databases                  

   PRIDE                              141706     141706      0.25      29      Proteomic databases                          

   PRINTS                             132679     117218      0.24      32      Family and domain databases                  

   PRO                                 95146      95146      0.17      39      Other                                        

   ProDom                              29125      28942      0.05      60      Family and domain databases                  

   ProMEX                                453        453     <0.01     139      Proteomic databases                          

   PROSITE                            465324     297659      0.84      10      Family and domain databases                  

   ProteinModelPortal                 447822     447822      0.80      11      3D structure databases                       

   Proteomes                          477041     454462      0.86       9      Other                                        

   PseudoCAP                            1332       1323     <0.01     121      Organism-specific databases                  

   Reactome                           123002      36463      0.22      35      Enzyme and pathway databases                 

   REBASE                                397        397     <0.01     140      Protein family/group databases               

   RefSeq                             606520     462080      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     123      2D gel databases                             

   RGD                                  7946       7945      0.01      90      Organism-specific databases                  

   SABIO-RK                             3846       3846      0.01     109      Enzyme and pathway databases                 

   SFLD                                14121       6500      0.03      85      Family and domain databases                  

   SGD                                  6739       6734      0.01      91      Organism-specific databases                  

   SignaLink                            3026       3026      0.01     112      Enzyme and pathway databases                 

   SIGNOR                               4063       4063      0.01     108      Enzyme and pathway databases                 

   SMART                              191570     141407      0.34      24      Family and domain databases                  

   SMR                                439468     439468      0.79      12      3D structure databases                       

   STRING                             332036     332036      0.60      18      Protein-protein interaction databases        

   SUPFAM                             493791     374926      0.89       8      Family and domain databases                  

   SWISS-2DPAGE                         1178       1178     <0.01     124      2D gel databases                             

   SwissLipids                          1314       1228     <0.01     122      Chemistry                                    

   SwissPalm                            5947       5947      0.01      97      PTM databases                                

   TAIR                                14507      14452      0.03      84      Organism-specific databases                  

   TCDB                                 6621       6584      0.01      92      Protein family/group databases               

   TIGRFAMs                           292532     272523      0.53      21      Family and domain databases                  

   TopDownProteomics                    3247       2967      0.01     111      Proteomic databases                          

   TreeFam                             45249      45241      0.08      53      Phylogenomic databases                       

   TubercuList                          2186       2150     <0.01     115      Organism-specific databases                  

   UCD-2DPAGE                            497        497     <0.01     138      2D gel databases                             

   UCSC                                49794      45516      0.09      51      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     134      PTM databases                                

   UniGene                            109412      96095      0.20      36      Sequence databases                           

   UniPathway                         136220     123434      0.24      31      Enzyme and pathway databases                 

   VectorBase                            526        474     <0.01     136      Genome annotation databases                  

   VGNC                                 3514       3514      0.01     110      Organism-specific databases                  

   WBParaSite                             34         34     <0.01     150      Genome annotation databases                  

   World-2DPAGE                          929        918     <0.01     129      2D gel databases                             

   WormBase                             5971       4566      0.01      96      Organism-specific databases                  

   Xenbase                              4529       4523      0.01     103      Organism-specific databases                  

   ZFIN                                 3005       3005      0.01     113      Organism-specific databases                  



Total number of cross-referenced databases: 150



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.61

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.82   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.72   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3870 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79023