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         UniProtKB/Swiss-Prot protein knowledgebase release 2018_11 statistics





1.  INTRODUCTION



Release 2018_11 of 05-Dec-18 of UniProtKB/Swiss-Prot contains 558898 sequence entries,

comprising 200750628 amino acids abstracted from 263453 references. 



219 sequences have been added since release 2018_10, the sequence data of

28 existing entries has been updated and the annotations of

337657 entries have been revised.



Number of fragments: 9154

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40004





Protein existence (PE):           entries     %



1: Evidence at protein level        99780   17.9%

2: Evidence at transcript level     57193   10.2%

3: Inferred from homology          386593   69.2%

4: Predicted                        13493    2.4%

5: Uncertain                         1839    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13696



   The first twenty species represent 120727 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5664

                            2x: 1957

                            3x: 1066

                            4x:  695

                            5x:  515

                            6x:  407

                            7x:  298

                            8x:  248

                            9x:  230

                           10x:  140

                       11- 20x:  751

                       21- 50x:  457

                       51-100x:  218

                         >100x: 1050





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20412  Homo sapiens (Human)

       2      17001  Mus musculus (Mouse)

       3      15823  Arabidopsis thaliana (Mouse-ear cress)

       4       8054  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6003  Bos taurus (Bovine)

       7       5141  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4477  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4146  Dictyostelium discoideum (Slime mold)

      11       4036  Caenorhabditis elegans

      12       4029  Oryza sativa subsp. japonica (Rice)

      13       3549  Drosophila melanogaster (Fruit fly)

      14       3444  Xenopus laevis (African clawed frog)

      15       3086  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2291  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2173  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2037  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1796  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      24       1706  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1683  Shigella flexneri

      27       1427  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1326  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1173  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1064  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1034  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35       1009  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        975  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        930  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      38        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      39        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      40        926  Staphylococcus aureus (strain N315)

      41        924  Emericella nidulans  

      42        918  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        899  Staphylococcus aureus (strain COL)

      45        895  Staphylococcus aureus (strain MW2)

      46        893  Oryctolagus cuniculus (Rabbit)

      47        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      48        889  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        882  Salmonella choleraesuis (strain SC-B67)

      51        882  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        855  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        834  Oryza sativa subsp. indica (Rice)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        829  Shigella boydii serotype 4 (strain Sb227)

      60        825  Escherichia coli (strain UTI89 / UPEC)

      61        822  Canis lupus familiaris (Dog) (Canis familiaris)

      62        822  Shigella dysenteriae serotype 1 (strain Sd197)

      63        821  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      64        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      65        810  Zea mays (Maize)

      66        796  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      67        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      68        792  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      69        791  Escherichia coli (strain SMS-3-5 / SECEC)

      70        784  Aquifex aeolicus (strain VF5)

      71        776  Pasteurella multocida (strain Pm70)

      72        771  Escherichia coli (strain K12 / DH10B)

      73        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        766  Staphylococcus aureus (strain NCTC 8325)

      75        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      76        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        760  Shigella flexneri serotype 5b (strain 8401)

      81        759  Staphylococcus epidermidis (strain ATCC 12228)

      82        756  Escherichia coli (strain SE11)

      83        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        751  Bacillus anthracis

      86        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      87        746  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      88        741  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Vibrio vulnificus (strain YJ016)

      94        718  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      97        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      98        715  Enterobacter sp. (strain 638)

      99        714  Salmonella paratyphi A (strain AKU_12601)

     100        714  Escherichia coli O1:K1 / APEC

     101        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     102        713  Salmonella agona (strain SL483)

     103        713  Salmonella newport (strain SL254)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        673  Escherichia coli

     118        673  Staphylococcus aureus (strain USA300)

     119        670  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        664  Bradyrhizobium diazoefficiens 

     124        664  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     125        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        646  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        645  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        622  Treponema pallidum (strain Nichols)

     135        620  Methanothermobacter thermautotrophicus  

     136        615  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     137        614  Staphylococcus haemolyticus (strain JCSC1435)

     138        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     139        610  Xanthomonas campestris pv. campestris 

     140        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     141        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     142        602  Staphylococcus saprophyticus subsp. saprophyticus 

     143        602  Photobacterium profundum (strain SS9)

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        594  Pseudomonas aeruginosa (strain UCBPP-PA14)

     147        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     148        594  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        580  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        559  Clostridium acetobutylicum 

     165        557  Xanthomonas axonopodis pv. citri (strain 306)

     166        555  Pseudomonas fluorescens (strain Pf0-1)

     167        555  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     168        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     169        553  Oceanobacillus iheyensis 

     170        551  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     171        550  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        537  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Corynebacterium glutamicum 

     176        529  Sodalis glossinidius (strain morsitans)

     177        529  Listeria monocytogenes serotype 4b (strain F2365)

     178        527  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        522  Xylella fastidiosa (strain 9a5c)

     180        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     181        517  Chromobacterium violaceum 

     182        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        514  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     185        513  Staphylococcus aureus (strain Newman)

     186        513  Deinococcus radiodurans 

     187        512  Pseudomonas aeruginosa (strain PA7)

     188        511  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     189        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     190        510  Geobacillus kaustophilus (strain HTA426)

     191        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     192        508  Streptomyces avermitilis 

     193        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     194        502  Pseudomonas entomophila (strain L48)

     195        501  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     196        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     199        497  Haemophilus influenzae (strain 86-028NP)

     200        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     201        496  Bacillus clausii (strain KSM-K16)

     202        496  Burkholderia pseudomallei (strain K96243)

     203        494  Proteus mirabilis (strain HI4320)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        488  Methanosarcina mazei  

     209        487  Shewanella sp. (strain MR-7)

     210        487  Pyrococcus horikoshii 

     211        486  Mannheimia succiniciproducens (strain MBEL55E)

     212        485  Thermosynechococcus elongatus (strain BP-1)

     213        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     214        484  Pseudomonas aeruginosa (strain LESB58)

     215        484  Shewanella sp. (strain MR-4)

     216        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     217        483  Brucella abortus (strain 2308)

     218        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     219        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        478  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     221        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     222        477  Pyrococcus abyssi (strain GE5 / Orsay)

     223        475  Nicotiana tabacum (Common tobacco)

     224        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     225        475  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     226        474  Burkholderia lata 

     227        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     228        468  Clostridium perfringens (strain 13 / Type A)

     229        467  Shewanella frigidimarina (strain NCIMB 400)

     230        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     231        466  Shewanella sp. (strain ANA-3)

     232        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     233        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     234        466  Pseudomonas putida (strain GB-1)

     235        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     236        464  Aeromonas hydrophila subsp. hydrophila 

     237        463  Enterococcus faecalis (strain ATCC 700802 / V583)

     238        462  Burkholderia mallei (strain ATCC 23344)

     239        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     241        458  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     242        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     243        457  Ovis aries (Sheep)

     244        455  Staphylococcus aureus (strain JH1)

     245        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     246        453  Pseudomonas putida (strain W619)

     247        452  Aeromonas salmonicida (strain A449)

     248        452  Shewanella baltica (strain OS185)

     249        452  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     250        450  Caldanaerobacter subterraneus subsp. tengcongensis  





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19544 (  3%)

    Bacteria         333732 ( 60%)

    Eukaryota        188781 ( 34%)

    Viruses           16841 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20413 ( 11%)           (  4%)

     Other Mammalia         46690 ( 25%)           (  8%)

     Other Vertebrata       18347 ( 10%)           (  3%)

     Viridiplantae          39754 ( 21%)           (  7%)

     Fungi                  33823 ( 18%)           (  6%)

     Insecta                 9221 (  5%)           (  2%)

     Nematoda                4941 (  3%)           (  1%)

     Other                  15592 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9581             1001-1100     3990

                 51- 100   42549             1101-1200     2801

                101- 150   59007             1201-1300     2141

                151- 200   58891             1301-1400     2005

                201- 250   57734             1401-1500     1623

                251- 300   51461             1501-1600      791

                301- 350   51827             1601-1700      616

                351- 400   44973             1701-1800      557

                401- 450   36957             1801-1900      474

                451- 500   29796             1901-2000      377

                501- 550   21507             2001-2100      248

                551- 600   15350             2101-2200      338

                601- 650   12824             2201-2300      314

                651- 700    9221             2301-2400      212

                701- 750    7653             2401-2500      161

                751- 800    5530             >2500         1283

                801- 850    4771

                851- 900    5208

                901- 950    4049

                951-1000    2924



   





   The average sequence length in UniProtKB/Swiss-Prot is 359 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2759





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  872

                       2x:  389

                       3x:  165

                       4x:  133

                       5x:  110

                       6x:   99

                       7x:   67

                       8x:   57

                       9x:   38

                      10x:   32

                  11- 20x:  220

                  21- 50x:  226

                  51-100x:  120

                    >100x:  231





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24497   Journal of Biological Chemistry

    2        11358   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6610   Journal of Bacteriology

    4         5625   Biochemical and Biophysical Research Communications

    5         5319   Biochemistry

    6         4986   Nucleic Acids Research

    7         4819   FEBS Letters

    8         4805   Gene

    9         4685   The EMBO Journal

   10         4509   Nature

   11         4336   Molecular and Cellular Biology

   12         4256   Journal of Molecular Biology

   13         3619   Biochimica et Biophysica Acta

   14         3560   Cell

   15         3393   European Journal of Biochemistry

   16         3234   Journal of Virology

   17         2997   Science

   18         2848   Biochemical Journal

   19         2554   Plant Physiology

   20         2534   Genomics

   21         2524   Molecular Microbiology

   22         2191   Journal of Cell Biology

   23         2138   The American Journal of Human Genetics

   24         1989   The Plant Cell

   25         1882   PLoS ONE

   26         1855   Plant Molecular Biology

   27         1833   Genes and Development

   28         1827   The Plant Journal

   29         1800   Human Molecular Genetics

   30         1795   Virology

   31         1746   Nature Genetics

   32         1666   Development

   33         1659   Molecular Biology of the Cell

   34         1570   Human Mutation

   35         1540   Oncogene

   36         1533   Molecular Cell

   37         1424   Journal of Immunology

   38         1394   Molecular and General Genetics

   39         1338   Journal of Biochemistry

   40         1332   Structure

   41         1311   Genetics

   42         1247   Journal of Cell Science

   43         1154   Blood

   44         1144   Journal of General Virology

   45         1109   Infection and Immunity

   46         1053   Microbiology

   47         1047   Current Biology

   48         1045   Developmental Biology

   49         1042   Archives of Biochemistry and Biophysics

   50          900   Applied and Environmental Microbiology

   51          893   Journal of Neuroscience

   52          882   Cancer Research

   53          875   Acta Crystallographica, Section D

   54          838   Yeast

   55          836   FEMS Microbiology Letters

   56          769   Protein Science

   57          767   Toxicon

   58          743   Neuron

   59          723   Journal of Clinical Investigation

   60          688   Human Genetics

   61          675   Plant and Cell Physiology

   62          673   American Journal of Physiology

   63          648   Mechanisms of Development

   64          645   Nature Structural Biology

   65          636   PLoS Genetics

   66          629   The Journal of Experimental Medicine

   67          617   Proteins

   68          600   Journal of Medical Genetics

   69          574   Current Genetics

   70          571   Nature Cell Biology

   71          551   Bioscience, Biotechnology, and Biochemistry

   72          532   Molecular Endocrinology

   73          531   Journal of Neurochemistry

   74          529   Nature Structural and Molecular Biology

   75          518   The Journal of Clinical Endocrinology and Metabolism

   76          509   Developmental Cell

   77          504   The FEBS Journal

   78          503   Endocrinology

   79          488   Mammalian Genome

   80          472   Immunogenetics

   81          466   Antimicrobial Agents and Chemotherapy

   82          457   Experimental Cell Research

   83          448   Molecular and Biochemical Parasitology

   84          431   Eukaryotic Cell

   85          425   Planta

   86          416   RNA

   87          411   Peptides

   88          407   Journal of Molecular Evolution

   89          402   Nature Communications

   90          397   Molecular Biology and Evolution

   91          386   DNA and Cell Biology

   92          383   Journal of Experimental Botany

   93          375   Molecular Pharmacology

   94          375   Journal of the American Chemical Society

   95          374   DNA Sequence

   96          362   EMBO Reports

   97          360   PLoS Pathogens

   98          360   Neurology

   99          359   Journal of Investigative Dermatology

  100          352   The FASEB Journal

  101          349   Comparative Biochemistry and Physiology

  102          347   Biology of Reproduction

  103          347   Acta Crystallographica, Section F

  104          342   Molecular Plant-Microbe Interactions

  105          340   Scientific Reports

  106          339   Brain Research. Molecular Brain Research

  107          336   American Journal of Medical Genetics. Part A

  108          333   European Journal of Human Genetics

  109          328   Immunity

  110          326   Tissue Antigens

  111          321   Virus Research

  112          318   Biochimie

  113          318   The New England Journal of Medicine

  114          317   Genes to Cells

  115          313   Developmental Dynamics

  116          296   Biological Chemistry Hoppe-Seyler

  117          296   Genome Research

  118          294   Clinical Genetics

  119          287   Annals of Neurology

  120          282   Cytogenetics and Cell Genetics

  121          273   European Journal of Immunology

  122          271   Journal of General Microbiology

  123          269   BMC Genomics

  124          268   Nature Immunology

  125          266   Investigative Ophthalmology and Visual Science

  126          260   Applied Microbiology and Biotechnology

  127          254   Journal of Human Genetics

  128          250   Journal of Medicinal Chemistry

  129          245   PLoS Biology

  130          241   Archives of Microbiology

  131          233   Glycobiology

  132          231   DNA Research

  133          229   Journal of Cellular Biochemistry

  134          228   Journal of Lipid Research

  135          224   Traffic

  136          220   Cell Cycle

  137          218   Molecular Genetics and Metabolism

  138          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  139          215   Circulation Research

  140          213   Archives of Virology

  141          213   Molecular Immunology

  142          208   Diabetes

  143          207   Molecular and Cellular Endocrinology

  144          204   Protein Expression and Purification

  145          203   Phytochemistry

  146          202   Fungal Genetics and Biology

  147          198   Nature Medicine

  148          197   Cell Reports

  149          196   Molecular Genetics and Genomics

  150          185   Chemistry and Biology





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1218938                 2.18                                         

   Journal                           1041539     454671      1.86       1                                 

   Submitted to EMBL/GenBank/DDBJ     166597     150958      0.30       2                                 

   Submitted to other databases         7369       6804      0.01       3                                 

   Book citation                        1766       1743     <0.01       4                                 

   Plant Gene Register                   611        598     <0.01       5                                 

   Thesis                                433        430     <0.01       6                                 

   Unpublished observations              408        404     <0.01       7                                 

   Patent                                209        203     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 407031



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2528661                 4.52                                         

   ACTIVITY REGULATION                 14758      14758      0.03      16                                 

   ALLERGEN                              732        732     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25255      25255      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8196       8196      0.01      20                                 

   BIOTECHNOLOGY                         965        951     <0.01      25                                 

   CATALYTIC ACTIVITY                 280857     236553      0.50       4                                 

   CAUTION                             12836      12591      0.02      18                                 

   COFACTOR                           123073     112694      0.22       7                                 

   DEVELOPMENTAL STAGE                 12114      12113      0.02      19                                 

   DISEASE                              6998       4693      0.01      21                                 

   DISRUPTION PHENOTYPE                14241      14240      0.03      17                                 

   DOMAIN                              48790      41994      0.09       9                                 

   FUNCTION                           465638     445143      0.83       2                                 

   INDUCTION                           20930      20918      0.04      14                                 

   INTERACTION                         19158      19158      0.03      15                                 

   MASS SPECTROMETRY                    6928       5219      0.01      22                                 

   MISCELLANEOUS                       38524      35464      0.07      12                                 

   PATHWAY                            138080     125263      0.25       6                                 

   PHARMACEUTICAL                        116        112     <0.01      29                                 

   POLYMORPHISM                         1319       1263     <0.01      24                                 

   PTM                                 56375      41678      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44037      44037      0.08      11                                 

   SIMILARITY                         507792     503644      0.91       1                                 

   SUBCELLULAR LOCATION               348787     341461      0.62       3                                 

   SUBUNIT                            278381     277583      0.50       5                                 

   TISSUE SPECIFICITY                  45732      45731      0.08      10                                 

   TOXIC DOSE                            666        609     <0.01      27                                 

   WEB RESOURCE                         6756       5595      0.01      23                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4485822                 8.03                                         

   ACT_SITE                           163657      99346      0.29      10                                 

   BINDING                            403952     106515      0.72       2                                 

   CA_BIND                              4177       1730      0.01      36                                 

   CARBOHYD                           115834      29778      0.21      15                                 

   CHAIN                              566776     551826      1.01       1                                 

   COILED                              22022      15224      0.04      27                                 

   COMPBIAS                            59023      31760      0.11      20                                 

   CONFLICT                           135211      47345      0.24      13                                 

   CROSSLNK                            23597       8464      0.04      26                                 

   DISULFID                           124995      33668      0.22      14                                 

   DNA_BIND                            11646      10535      0.02      32                                 

   DOMAIN                             194480     119878      0.35       9                                 

   HELIX                              254370      23521      0.46       6                                 

   INIT_MET                            17163      17163      0.03      28                                 

   INTRAMEM                             2656       1199     <0.01      37                                 

   LIPID                               13035       8420      0.02      30                                 

   METAL                              380886      94160      0.68       3                                 

   MOD_RES                            248588      71846      0.44       7                                 

   MOTIF                               43083      28086      0.08      23                                 

   MUTAGEN                             69887      15311      0.13      18                                 

   NON_CONS                             2257        787     <0.01      38                                 

   NON_STD                               357        282     <0.01      39                                 

   NON_TER                             12393       9508      0.02      31                                 

   NP_BIND                            156863      85217      0.28      11                                 

   PEPTIDE                             11578       7968      0.02      33                                 

   PROPEP                              14215      12127      0.03      29                                 

   REGION                             197903      93670      0.35       8                                 

   REPEAT                             105498      14748      0.19      16                                 

   SIGNAL                              41665      41663      0.07      24                                 

   SITE                                57874      31744      0.10      21                                 

   STRAND                             264910      22134      0.47       5                                 

   TOPO_DOM                           140360      28766      0.25      12                                 

   TRANSIT                              9093       8977      0.02      34                                 

   TRANSMEM                           370755      77358      0.66       4                                 

   TURN                                61239      19060      0.11      19                                 

   UNSURE                               4454        796      0.01      35                                 

   VAR_SEQ                             51990      22021      0.09      22                                 

   VARIANT                             96845      17086      0.17      17                                 

   ZN_FING                             30535      13409      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18980779                33.96                                                           

   Allergome                            1770       1157     <0.01     121      Protein family/group databases               

   ArachnoServer                        1145       1136     <0.01     130      Organism-specific databases                  

   Araport                             15844      15748      0.03      83      Organism-specific databases                  

   Bgee                                56478      56478      0.10      45      Gene expression databases                    

   BindingDB                            5000       5000      0.01     104      Chemistry                                    

   BioCyc                             237341     232844      0.42      24      Enzyme and pathway databases                 

   BioGrid                             51009      50508      0.09      50      Protein-protein interaction databases        

   BioMuta                             17236      17227      0.03      79      Polymorphism and mutation databases          

   BRENDA                              12911      12137      0.02      86      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     129      PTM databases                                

   CAZy                                 9490       8555      0.02      89      Protein family/group databases               

   CCDS                                48182      34160      0.09      52      Sequence databases                           

   CDD                                185133     169158      0.33      27      Family and domain databases                  

   CGD                                  1997       1980     <0.01     118      Organism-specific databases                  

   ChEMBL                               6868       6868      0.01      96      Chemistry                                    

   ChiTaRS                             20480      20469      0.04      69      Other                                        

   CleanEx                             30012      29381      0.05      58      Gene expression databases                    

   CollecTF                              133        133     <0.01     152      Gene expression databases                    

   ComplexPortal                        8550       4498      0.02      90      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     153      2D gel databases                             

   ConoServer                            951        868     <0.01     131      Organism-specific databases                  

   CORUM                                5803       5803      0.01     100      Protein-protein interaction databases        

   CTD                                 74980      74083      0.13      43      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     148      PTM databases                                

   dictyBase                            4221       4106      0.01     108      Organism-specific databases                  

   DIP                                 17358      17326      0.03      77      Protein-protein interaction databases        

   DisGeNET                            14839      14605      0.03      84      Organism-specific databases                  

   DisProt                               708        703     <0.01     135      3D structure databases                       

   DMDM                                16276      16276      0.03      82      Polymorphism and mutation databases          

   DNASU                               18993      18926      0.03      73      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     150      2D gel databases                             

   DrugBank                            18747       3637      0.03      74      Chemistry                                    

   EchoBASE                             4159       4159      0.01     109      Organism-specific databases                  

   EcoGene                              4293       4293      0.01     107      Organism-specific databases                  

   eggNOG                             664897     331735      1.19       5      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     120      Protein-protein interaction databases        

   EMBL                               984602     547172      1.76       3      Sequence databases                           

   Ensembl                             90923      50603      0.16      41      Genome annotation databases                  

   EnsemblBacteria                    355414     336285      0.64      17      Genome annotation databases                  

   EnsemblFungi                        29304      27806      0.05      60      Genome annotation databases                  

   EnsemblMetazoa                      17355      10154      0.03      78      Genome annotation databases                  

   EnsemblPlants                       27539      20564      0.05      62      Genome annotation databases                  

   EnsemblProtists                      5017       4831      0.01     103      Genome annotation databases                  

   EPD                                 21827      21827      0.04      66      Proteomic databases                          

   ESTHER                               2504       2504     <0.01     116      Protein family/group databases               

   euHCVdb                                55         44     <0.01     154      Organism-specific databases                  

   EuPathDB                            31161      30969      0.06      57      Organism-specific databases                  

   EvolutionaryTrace                   16627      16627      0.03      81      Other                                        

   ExpressionAtlas                     51764      51764      0.09      48      Gene expression databases                    

   FlyBase                              6177       5881      0.01      98      Organism-specific databases                  

   Gene3D                             366895     292791      0.66      16      Family and domain databases                  

   GeneCards                           20364      20193      0.04      71      Organism-specific databases                  

   GeneDB                                575        519     <0.01     139      Genome annotation databases                  

   GeneID                             290368     280087      0.52      23      Genome annotation databases                  

   GeneReviews                          1479       1475     <0.01     122      Organism-specific databases                  

   GeneTree                            59094      59019      0.11      44      Phylogenomic databases                       

   Genevisible                         55240      55240      0.10      46      Gene expression databases                    

   GeneWiki                            10356      10273      0.02      88      Other                                        

   GenomeRNAi                          22107      22107      0.04      65      Other                                        

   GlyConnect                           1439       1353     <0.01     123      PTM databases                                

   GO                                2930845     532701      5.24       1      Ontologies                                   

   Gramene                             27539      20564      0.05      63      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  1957       1957     <0.01     119      Chemistry                                    

   H-InvDB                              5627       4801      0.01     101      Organism-specific databases                  

   HAMAP                              329842     326966      0.59      19      Family and domain databases                  

   HGNC                                20350      20211      0.04      72      Organism-specific databases                  

   HOGENOM                            391734     391734      0.70      15      Phylogenomic databases                       

   HOVERGEN                            76122      76122      0.14      42      Phylogenomic databases                       

   HPA                                 27400      16828      0.05      64      Organism-specific databases                  

   IMGT_GENE-DB                          142        142     <0.01     151      Protein family/group databases               

   InParanoid                         139591     139591      0.25      30      Phylogenomic databases                       

   IntAct                              52784      52784      0.09      47      Protein-protein interaction databases        

   InterPro                          2245755     540571      4.02       2      Family and domain databases                  

   iPTMnet                             51310      51310      0.09      49      PTM databases                                

   KEGG                               502331     474869      0.90       7      Genome annotation databases                  

   KO                                 405035     404594      0.72      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     134      Organism-specific databases                  

   Leproma                               672        669     <0.01     136      Organism-specific databases                  

   MaizeGDB                              510        506     <0.01     140      Organism-specific databases                  

   MalaCards                            4499       4496      0.01     106      Organism-specific databases                  

   MaxQB                               29708      29708      0.05      59      Proteomic databases                          

   MEROPS                              11400      11400      0.02      87      Protein family/group databases               

   MGI                                 16909      16869      0.03      80      Organism-specific databases                  

   MIM                                 21056      15089      0.04      68      Organism-specific databases                  

   MINT                                21795      21795      0.04      67      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     146      Protein family/group databases               

   MoonProt                              279        279     <0.01     147      Protein family/group databases               

   mycoCLAP                              355        352     <0.01     145      Protein family/group databases               

   neXtProt                            20369      20369      0.04      70      Organism-specific databases                  

   OGP                                   373        373     <0.01     144      2D gel databases                             

   OMA                                408686     408686      0.73      13      Phylogenomic databases                       

   OpenTargets                         18383      18224      0.03      75      Organism-specific databases                  

   Orphanet                             7438       3920      0.01      93      Organism-specific databases                  

   OrthoDB                            293639     293639      0.53      21      Phylogenomic databases                       

   PANTHER                            295222     281230      0.53      20      Family and domain databases                  

   PATRIC                              91877      91877      0.16      40      Genome annotation databases                  

   PaxDb                              124699     124699      0.22      33      Proteomic databases                          

   PDB                                169808      27053      0.30      29      3D structure databases                       

   PDBsum                             169808      27053      0.30      28      3D structure databases                       

   PeptideAtlas                        32143      32143      0.06      56      Proteomic databases                          

   PeroxiBase                            780        758     <0.01     133      Protein family/group databases               

   Pfam                               760029     517792      1.36       4      Family and domain databases                  

   PharmGKB                            18358      18316      0.03      76      Organism-specific databases                  

   PhosphoSitePlus                     39020      39020      0.07      54      PTM databases                                

   PhylomeDB                           96351      96351      0.17      38      Phylogenomic databases                       

   PIR                                124198     113748      0.22      34      Sequence databases                           

   PIRSF                              108924     107895      0.19      37      Family and domain databases                  

   PMAP-CutDB                           1401       1401     <0.01     124      Other                                        

   PomBase                              5133       5129      0.01     102      Organism-specific databases                  

   PRIDE                              230710     230710      0.41      25      Proteomic databases                          

   PRINTS                             132681     117146      0.24      32      Family and domain databases                  

   PRO                                 95984      95984      0.17      39      Other                                        

   ProDom                              29172      28989      0.05      61      Family and domain databases                  

   ProMEX                                457        457     <0.01     142      Proteomic databases                          

   PROSITE                            467632     298998      0.84      10      Family and domain databases                  

   ProteinModelPortal                 449158     449158      0.80      11      3D structure databases                       

   Proteomes                          479587     455433      0.86       9      Other                                        

   ProteomicsDB                        36380      19829      0.07      55      Proteomic databases                          

   PseudoCAP                            1334       1325     <0.01     126      Organism-specific databases                  

   Reactome                           123242      36345      0.22      35      Enzyme and pathway databases                 

   REBASE                                392        392     <0.01     143      Protein family/group databases               

   RefSeq                             608650     463566      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     127      2D gel databases                             

   RGD                                  7978       7977      0.01      92      Organism-specific databases                  

   SABIO-RK                             4098       4098      0.01     110      Enzyme and pathway databases                 

   SFLD                                 8062       5976      0.01      91      Family and domain databases                  

   SGD                                  6739       6734      0.01      97      Organism-specific databases                  

   SignaLink                            3065       3065      0.01     115      Enzyme and pathway databases                 

   SIGNOR                               4083       4083      0.01     111      Enzyme and pathway databases                 

   SMART                              192382     141901      0.34      26      Family and domain databases                  

   SMR                                444705     444705      0.80      12      3D structure databases                       

   STRING                             332762     332762      0.60      18      Protein-protein interaction databases        

   SUPFAM                             498252     377829      0.89       8      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     128      2D gel databases                             

   SwissLipids                          1360       1273     <0.01     125      Chemistry                                    

   SwissPalm                            7301       7301      0.01      94      PTM databases                                

   TAIR                                14631      14575      0.03      85      Organism-specific databases                  

   TCDB                                 6918       6867      0.01      95      Protein family/group databases               

   TIGRFAMs                           292371     272384      0.52      22      Family and domain databases                  

   TopDownProteomics                    3241       2964      0.01     113      Proteomic databases                          

   TreeFam                             45491      45481      0.08      53      Phylogenomic databases                       

   TubercuList                          2191       2155     <0.01     117      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     141      2D gel databases                             

   UCSC                                49936      45616      0.09      51      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     138      PTM databases                                

   UniGene                            109894      96298      0.20      36      Sequence databases                           

   UniLectin                             238        238     <0.01     149      Protein family/group databases               

   UniPathway                         136320     123530      0.24      31      Enzyme and pathway databases                 

   VectorBase                            597        517     <0.01     137      Genome annotation databases                  

   VGNC                                 3916       3916      0.01     112      Organism-specific databases                  

   WBParaSite                             34         34     <0.01     155      Genome annotation databases                  

   World-2DPAGE                          930        919     <0.01     132      2D gel databases                             

   WormBase                             6024       4595      0.01      99      Organism-specific databases                  

   Xenbase                              4561       4555      0.01     105      Organism-specific databases                  

   ZFIN                                 3066       3061      0.01     114      Organism-specific databases                  



Total number of cross-referenced databases: 155



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.62

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.05   Gly (G) 7.07   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.91

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3883 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79284