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         UniProtKB/Swiss-Prot protein knowledgebase release 2020_01 statistics





1.  INTRODUCTION



Release 2020_01 of 26-Feb-20 of UniProtKB/Swiss-Prot contains 561911 sequence entries,

comprising 202173710 amino acids abstracted from 270528 references. 



348 sequences have been added since release 2019_11, the sequence data of

21 existing entries has been updated and the annotations of

481746 entries have been revised.



Number of fragments: 9207

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40255





Protein existence (PE):           entries     %



1: Evidence at protein level       102492   18.2%

2: Evidence at transcript level     57229   10.2%

3: Inferred from homology          386968   68.9%

4: Predicted                        13385    2.4%

5: Uncertain                         1837    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13875



   The first twenty species represent 121183 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5706

                            2x: 1993

                            3x: 1079

                            4x:  706

                            5x:  516

                            6x:  408

                            7x:  312

                            8x:  253

                            9x:  230

                           10x:  144

                       11- 20x:  788

                       21- 50x:  465

                       51-100x:  222

                         >100x: 1053





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20365  Homo sapiens (Human)

       2      17033  Mus musculus (Mouse)

       3      15940  Arabidopsis thaliana (Mouse-ear cress)

       4       8091  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6011  Bos taurus (Bovine)

       7       5140  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4518  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4149  Dictyostelium discoideum (Slime mold)

      11       4114  Caenorhabditis elegans

      12       4070  Oryza sativa subsp. japonica (Rice)

      13       3602  Drosophila melanogaster (Fruit fly)

      14       3448  Xenopus laevis (African clawed frog)

      15       3147  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2292  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2198  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2040  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1800  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1706  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      25       1697  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1685  Shigella flexneri

      27       1433  Sus scrofa (Pig)

      28       1364  Pseudomonas aeruginosa 

      29       1347  Salmonella typhi

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1175  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1066  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1035  Archaeoglobus fulgidus 

      34       1025  Yersinia pestis

      35       1011  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        986  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        941  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      38        941  Emericella nidulans  

      39        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      40        929  Staphylococcus aureus (strain N315)

      41        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      42        919  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        903  Staphylococcus aureus (strain COL)

      45        896  Staphylococcus aureus (strain MW2)

      46        894  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      47        894  Oryctolagus cuniculus (Rabbit)

      48        890  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        883  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      51        882  Salmonella choleraesuis (strain SC-B67)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        864  Neurospora crassa 

      55        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      56        845  Oryza sativa subsp. indica (Rice)

      57        841  Escherichia coli O9:H4 (strain HS)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        831  Zea mays (Maize)

      60        829  Shigella boydii serotype 4 (strain Sb227)

      61        827  Canis lupus familiaris (Dog) (Canis familiaris)

      62        825  Escherichia coli (strain UTI89 / UPEC)

      63        824  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      64        822  Shigella dysenteriae serotype 1 (strain Sd197)

      65        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      66        803  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      67        802  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      68        797  Staphylococcus aureus (strain NCTC 8325)

      69        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      70        791  Escherichia coli (strain SMS-3-5 / SECEC)

      71        786  Aquifex aeolicus (strain VF5)

      72        771  Escherichia coli (strain K12 / DH10B)

      73        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        770  Pasteurella multocida (strain Pm70)

      75        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      76        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Staphylococcus epidermidis (strain ATCC 12228)

      80        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      81        760  Shigella flexneri serotype 5b (strain 8401)

      82        756  Escherichia coli (strain SE11)

      83        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        751  Bacillus anthracis

      86        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      87        748  Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      88        742  Bacillus halodurans 

      89        739  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        725  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      93        722  Salmonella enteritidis PT4 (strain P125109)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      97        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      98        715  Enterobacter sp. (strain 638)

      99        714  Escherichia coli O1:K1 / APEC

     100        714  Salmonella paratyphi A (strain AKU_12601)

     101        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     102        713  Salmonella agona (strain SL483)

     103        713  Salmonella newport (strain SL254)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        686  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        677  Staphylococcus aureus (strain USA300)

     118        676  Escherichia coli

     119        672  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        668  Bacillus cereus 

     122        667  Yersinia pestis (strain Pestoides F)

     123        664  Bradyrhizobium diazoefficiens 

     124        664  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     125        657  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        650  Shewanella oneidensis (strain MR-1)

     128        650  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        640  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Methanothermobacter thermautotrophicus  

     134        622  Treponema pallidum (strain Nichols)

     135        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     136        618  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     137        615  Xanthomonas campestris pv. campestris 

     138        614  Staphylococcus haemolyticus (strain JCSC1435)

     139        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     140        608  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     141        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     142        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     143        602  Staphylococcus saprophyticus subsp. saprophyticus 

     144        602  Photobacterium profundum (strain SS9)

     145        601  Salmonella paratyphi C (strain RKS4594)

     146        600  Yersinia pestis bv. Antiqua (strain Angola)

     147        598  Pseudomonas aeruginosa (strain UCBPP-PA14)

     148        595  Bacillus cereus (strain ATCC 10987 / NRS 248)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        584  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        580  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        572  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        560  Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 

     165        559  Clostridium acetobutylicum 

     166        557  Xanthomonas axonopodis pv. citri (strain 306)

     167        556  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     168        555  Pseudomonas fluorescens (strain Pf0-1)

     169        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     170        553  Oceanobacillus iheyensis 

     171        551  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        540  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        530  Corynebacterium glutamicum 

     176        529  Listeria monocytogenes serotype 4b (strain F2365)

     177        529  Sodalis glossinidius (strain morsitans)

     178        528  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        524  Staphylococcus aureus (strain Newman)

     180        522  Xylella fastidiosa (strain 9a5c)

     181        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     182        517  Chromobacterium violaceum 

     183        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     184        516  Deinococcus radiodurans 

     185        515  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     186        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     187        513  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     188        512  Pseudomonas aeruginosa (strain PA7)

     189        511  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     190        511  Streptomyces avermitilis 

     191        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     192        510  Geobacillus kaustophilus (strain HTA426)

     193        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     194        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     195        502  Pseudomonas entomophila (strain L48)

     196        501  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     199        497  Haemophilus influenzae (strain 86-028NP)

     200        496  Bacillus clausii (strain KSM-K16)

     201        496  Burkholderia pseudomallei (strain K96243)

     202        496  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     203        494  Proteus mirabilis (strain HI4320)

     204        493  Pyrococcus horikoshii 

     205        493  Xanthomonas campestris pv. campestris (strain 8004)

     206        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     207        491  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     209        488  Methanosarcina mazei  

     210        487  Shewanella sp. (strain MR-7)

     211        486  Brucella abortus (strain 2308)

     212        486  Mannheimia succiniciproducens (strain MBEL55E)

     213        485  Thermosynechococcus elongatus (strain BP-1)

     214        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     215        484  Shewanella sp. (strain MR-4)

     216        484  Pseudomonas aeruginosa (strain LESB58)

     217        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     218        482  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     219        482  Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 

     220        480  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     221        480  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     222        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     223        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     224        477  Nicotiana tabacum (Common tobacco)

     225        477  Pyrococcus abyssi (strain GE5 / Orsay)

     226        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     227        474  Burkholderia lata 

     228        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     229        469  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        468  Pseudomonas putida (strain GB-1)

     231        468  Clostridium perfringens (strain 13 / Type A)

     232        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     233        467  Shewanella frigidimarina (strain NCIMB 400)

     234        467  Enterococcus faecalis (strain ATCC 700802 / V583)

     235        467  Aeromonas hydrophila subsp. hydrophila 

     236        466  Shewanella sp. (strain ANA-3)

     237        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     238        465  Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)

     239        463  Burkholderia mallei (strain ATCC 23344)

     240        459  Ovis aries (Sheep)

     241        459  Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator 

     242        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     243        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     244        455  Staphylococcus aureus (strain JH1)

     245        455  Shewanella baltica (strain OS185)

     246        455  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     247        453  Pseudomonas putida (strain W619)

     248        453  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     249        452  Aeromonas salmonicida (strain A449)

     250        450  Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19599 (  3%)

    Bacteria         334434 ( 60%)

    Eukaryota        190885 ( 34%)

    Viruses           16993 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20366 ( 11%)           (  4%)

     Other Mammalia         46865 ( 25%)           (  8%)

     Other Vertebrata       18448 ( 10%)           (  3%)

     Viridiplantae          40254 ( 21%)           (  7%)

     Fungi                  34414 ( 18%)           (  6%)

     Insecta                 9358 (  5%)           (  2%)

     Nematoda                5024 (  3%)           (  1%)

     Other                  16156 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9677             1001-1100     4027

                 51- 100   42796             1101-1200     2819

                101- 150   59316             1201-1300     2153

                151- 200   59080             1301-1400     2022

                201- 250   57940             1401-1500     1632

                251- 300   51698             1501-1600      801

                301- 350   52068             1601-1700      621

                351- 400   45164             1701-1800      566

                401- 450   37169             1801-1900      483

                451- 500   30000             1901-2000      382

                501- 550   21718             2001-2100      254

                551- 600   15466             2101-2200      351

                601- 650   12898             2201-2300      323

                651- 700    9263             2301-2400      218

                701- 750    7690             2401-2500      170

                751- 800    5568             >2500         1334

                801- 850    4804

                851- 900    5226

                901- 950    4059

                951-1000    2948



   





   The average sequence length in UniProtKB/Swiss-Prot is 359 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2851





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  912

                       2x:  399

                       3x:  173

                       4x:  130

                       5x:  116

                       6x:   91

                       7x:   77

                       8x:   60

                       9x:   38

                      10x:   37

                  11- 20x:  226

                  21- 50x:  232

                  51-100x:  124

                    >100x:  236





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        25081   Journal of Biological Chemistry

    2        11697   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6730   Journal of Bacteriology

    4         5713   Biochemical and Biophysical Research Communications

    5         5425   Biochemistry

    6         5053   Nucleic Acids Research

    7         4870   FEBS Letters

    8         4824   Gene

    9         4731   The EMBO Journal

   10         4646   Nature

   11         4392   Molecular and Cellular Biology

   12         4328   Journal of Molecular Biology

   13         3723   Biochimica et Biophysica Acta

   14         3618   Cell

   15         3421   European Journal of Biochemistry

   16         3307   Journal of Virology

   17         3077   Science

   18         2909   Biochemical Journal

   19         2620   Plant Physiology

   20         2593   Molecular Microbiology

   21         2537   Genomics

   22         2222   Journal of Cell Biology

   23         2220   The American Journal of Human Genetics

   24         2054   PLoS ONE

   25         2045   The Plant Cell

   26         1893   The Plant Journal

   27         1878   Plant Molecular Biology

   28         1858   Human Molecular Genetics

   29         1852   Genes and Development

   30         1816   Virology

   31         1778   Nature Genetics

   32         1697   Molecular Biology of the Cell

   33         1689   Development

   34         1583   Human Mutation

   35         1578   Molecular Cell

   36         1543   Oncogene

   37         1512   Journal of Immunology

   38         1396   Molecular and General Genetics

   39         1372   Structure

   40         1359   Journal of Biochemistry

   41         1329   Genetics

   42         1285   Journal of Cell Science

   43         1178   Blood

   44         1155   Infection and Immunity

   45         1151   Journal of General Virology

   46         1085   Microbiology

   47         1073   Current Biology

   48         1067   Archives of Biochemistry and Biophysics

   49         1062   Developmental Biology

   50          933   Applied and Environmental Microbiology

   51          931   Journal of Neuroscience

   52          904   Acta Crystallographica, Section D

   53          889   Cancer Research

   54          847   FEMS Microbiology Letters

   55          839   Yeast

   56          799   Toxicon

   57          789   Protein Science

   58          771   Neuron

   59          754   Journal of Clinical Investigation

   60          709   Plant and Cell Physiology

   61          704   Human Genetics

   62          703   American Journal of Physiology

   63          703   PLoS Genetics

   64          669   The Journal of Experimental Medicine

   65          649   Mechanisms of Development

   66          646   Nature Structural Biology

   67          641   Proteins

   68          630   Journal of Medical Genetics

   69          586   Nature Cell Biology

   70          575   Current Genetics

   71          558   Nature Structural and Molecular Biology

   72          557   Bioscience, Biotechnology, and Biochemistry

   73          553   Nature Communications

   74          543   The FEBS Journal

   75          542   Journal of Neurochemistry

   76          540   Molecular Endocrinology

   77          526   Developmental Cell

   78          523   The Journal of Clinical Endocrinology and Metabolism

   79          509   Endocrinology

   80          494   Antimicrobial Agents and Chemotherapy

   81          488   Mammalian Genome

   82          465   Experimental Cell Research

   83          461   Scientific Reports

   84          451   Molecular and Biochemical Parasitology

   85          435   Planta

   86          434   Eukaryotic Cell

   87          430   Immunogenetics

   88          424   PLoS Pathogens

   89          421   RNA

   90          420   Peptides

   91          407   Journal of Molecular Evolution

   92          403   Journal of the American Chemical Society

   93          400   Molecular Biology and Evolution

   94          399   Journal of Experimental Botany

   95          388   DNA and Cell Biology

   96          385   Molecular Pharmacology

   97          375   EMBO Reports

   98          375   DNA Sequence

   99          374   The FASEB Journal

  100          372   Neurology

  101          372   Acta Crystallographica, Section F

  102          372   American Journal of Medical Genetics. Part A

  103          370   Journal of Investigative Dermatology

  104          366   Molecular Plant-Microbe Interactions

  105          360   European Journal of Human Genetics

  106          351   Biology of Reproduction

  107          351   Comparative Biochemistry and Physiology

  108          348   Immunity

  109          340   Brain Research. Molecular Brain Research

  110          331   Virus Research

  111          329   Genes to Cells

  112          329   Biochimie

  113          322   The New England Journal of Medicine

  114          318   Developmental Dynamics

  115          315   Clinical Genetics

  116          302   Annals of Neurology

  117          299   Genome Research

  118          297   Biological Chemistry Hoppe-Seyler

  119          287   European Journal of Immunology

  120          284   BMC Genomics

  121          282   Cytogenetics and Cell Genetics

  122          281   Nature Immunology

  123          278   Investigative Ophthalmology and Visual Science

  124          272   Journal of General Microbiology

  125          270   Applied Microbiology and Biotechnology

  126          268   Journal of Lipid Research

  127          266   Journal of Human Genetics

  128          263   PLoS Biology

  129          262   Journal of Medicinal Chemistry

  130          256   Cell Reports

  131          249   Archives of Microbiology

  132          247   Glycobiology

  133          238   Molecular Immunology

  134          236   Journal of Cellular Biochemistry

  135          234   Traffic

  136          232   DNA Research

  137          228   Molecular Genetics and Metabolism

  138          225   Cell Cycle

  139          219   Diabetes

  140          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  141          217   Circulation Research

  142          217   Archives of Virology

  143          215   Protein Expression and Purification

  144          214   Phytochemistry

  145          211   Nature Medicine

  146          209   Fungal Genetics and Biology

  147          208   Molecular and Cellular Endocrinology

  148          198   Molecular Genetics and Genomics

  149          192   Chemistry and Biology

  150          192   Tissue Antigens





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1238044                 2.20                                         

   Journal                           1061941     459397      1.89       1                                 

   Submitted to EMBL/GenBank/DDBJ     165086     149506      0.29       2                                 

   Submitted to other databases         7469       6889      0.01       3                                 

   Book citation                        1831       1808     <0.01       4                                 

   Plant Gene Register                   612        599     <0.01       5                                 

   Unpublished observations              452        448     <0.01       6                                 

   Thesis                                437        434     <0.01       7                                 

   Patent                                210        204     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 420626



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2583519                 4.60                                         

   ACTIVITY REGULATION                 15513      15511      0.03      17                                 

   ALLERGEN                              884        884     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25382      25382      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8871       8869      0.02      20                                 

   BIOTECHNOLOGY                        1169       1152     <0.01      25                                 

   CATALYTIC ACTIVITY                 296161     241050      0.53       4                                 

   CAUTION                             13280      13013      0.02      18                                 

   COFACTOR                           126965     115412      0.23       7                                 

   DEVELOPMENTAL STAGE                 12541      12539      0.02      19                                 

   DISEASE                              7318       4922      0.01      21                                 

   DISRUPTION PHENOTYPE                15649      15645      0.03      16                                 

   DOMAIN                              50840      43554      0.09       9                                 

   FUNCTION                           471003     449818      0.84       2                                 

   INDUCTION                           22003      21986      0.04      14                                 

   INTERACTION                         19609      19609      0.03      15                                 

   MASS SPECTROMETRY                    6884       5293      0.01      23                                 

   MISCELLANEOUS                       43815      38512      0.08      12                                 

   PATHWAY                            139855     126752      0.25       6                                 

   PHARMACEUTICAL                        126        121     <0.01      29                                 

   POLYMORPHISM                         1275       1220     <0.01      24                                 

   PTM                                 58321      42691      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44394      44319      0.08      11                                 

   SIMILARITY                         510786     506609      0.91       1                                 

   SUBCELLULAR LOCATION               351934     344310      0.63       3                                 

   SUBUNIT                            283725     280520      0.50       5                                 

   TISSUE SPECIFICITY                  46968      46960      0.08      10                                 

   TOXIC DOSE                            677        618     <0.01      27                                 

   WEB RESOURCE                         6944       5768      0.01      22                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4596622                 8.18                                         

   ACT_SITE                           165728     100393      0.29      10                                 

   BINDING                            410136     108899      0.73       2                                 

   CA_BIND                              4206       1743      0.01      36                                 

   CARBOHYD                           117719      30242      0.21      15                                 

   CHAIN                              570050     554752      1.01       1                                 

   COILED                              22118      15311      0.04      27                                 

   COMPBIAS                            59195      31844      0.11      21                                 

   CONFLICT                           136698      47695      0.24      13                                 

   CROSSLNK                            23855       8561      0.04      26                                 

   DISULFID                           127062      34093      0.23      14                                 

   DNA_BIND                            11901      10643      0.02      32                                 

   DOMAIN                             200711     123304      0.36       9                                 

   HELIX                              270019      24645      0.48       6                                 

   INIT_MET                            17347      17299      0.03      28                                 

   INTRAMEM                             2793       1277     <0.01      37                                 

   LIPID                               13228       8531      0.02      30                                 

   METAL                              399881      96946      0.71       3                                 

   MOD_RES                            254747      72442      0.45       7                                 

   MOTIF                               44347      28979      0.08      23                                 

   MUTAGEN                             75598      16365      0.13      18                                 

   NON_CONS                             2523        820     <0.01      38                                 

   NON_STD                               357        282     <0.01      39                                 

   NON_TER                             12521       9596      0.02      31                                 

   NP_BIND                            158820      86189      0.28      11                                 

   PEPTIDE                             11715       8073      0.02      33                                 

   PROPEP                              14394      12278      0.03      29                                 

   REGION                             202941      95278      0.36       8                                 

   REPEAT                             106369      14861      0.19      16                                 

   SIGNAL                              42577      42576      0.08      24                                 

   SITE                                60160      32526      0.11      20                                 

   STRAND                             280293      23229      0.50       5                                 

   TOPO_DOM                           143488      29267      0.26      12                                 

   TRANSIT                              9176       9060      0.02      34                                 

   TRANSMEM                           373201      78004      0.66       4                                 

   TURN                                65106      20029      0.12      19                                 

   UNSURE                               5577        839      0.01      35                                 

   VAR_SEQ                             52251      22156      0.09      22                                 

   VARIANT                             97748      17130      0.17      17                                 

   ZN_FING                             30066      12847      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18788385                33.44                                                           

   ABCD                                 1609       1609     <0.01     122      Protocols and materials databases            

   Allergome                            1949       1265     <0.01     120      Protein family/group databases               

   ArachnoServer                        1163       1154     <0.01     129      Organism-specific databases                  

   Araport                             15960      15864      0.03      82      Organism-specific databases                  

   Bgee                                56822      56822      0.10      41      Gene expression databases                    

   BindingDB                            5190       5190      0.01      99      Chemistry                                    

   BioCyc                             270236     244641      0.48      22      Enzyme and pathway databases                 

   BioGrid                             54724      53034      0.10      45      Protein-protein interaction databases        

   BioMuta                             20314      20299      0.04      68      Polymorphism and mutation databases          

   BRENDA                              12963      12181      0.02      85      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     131      PTM databases                                

   CAZy                                 9521       8582      0.02      89      Protein family/group databases               

   CCDS                                48836      34349      0.09      49      Sequence databases                           

   CDD                                184452     167372      0.33      28      Family and domain databases                  

   CGD                                  1999       1982     <0.01     119      Organism-specific databases                  

   ChEMBL                               7270       7149      0.01      95      Chemistry                                    

   ChiTaRS                             29618      29581      0.05      55      Other                                        

   CollecTF                              135        135     <0.01     152      Gene expression databases                    

   ComplexPortal                        9521       5127      0.02      88      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     153      2D gel databases                             

   ConoServer                            954        870     <0.01     132      Organism-specific databases                  

   CORUM                                5805       5805      0.01      98      Protein-protein interaction databases        

   CPTAC                                2221       1423     <0.01     116      Proteomic databases                          

   CTD                                 75252      74359      0.13      40      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     150      PTM databases                                

   dictyBase                            4214       4100      0.01     107      Organism-specific databases                  

   DIP                                 17416      17384      0.03      78      Protein-protein interaction databases        

   DisGeNET                            15647      15416      0.03      83      Organism-specific databases                  

   DisProt                              1377       1365     <0.01     125      Family and domain databases                  

   DMDM                                16197      16195      0.03      81      Polymorphism and mutation databases          

   DNASU                               19042      18976      0.03      73      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     151      2D gel databases                             

   DrugBank                            27238       4518      0.05      61      Chemistry                                    

   DrugCentral                          2532       2532     <0.01     114      Chemistry                                    

   EchoBASE                             4159       4159      0.01     108      Organism-specific databases                  

   eggNOG                             666755     332642      1.19       5      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     121      Protein-protein interaction databases        

   EMBL                               986505     549843      1.76       3      Sequence databases                           

   Ensembl                             97220      51075      0.17      36      Genome annotation databases                  

   EnsemblBacteria                    356093     336904      0.63      16      Genome annotation databases                  

   EnsemblFungi                        29602      28045      0.05      56      Genome annotation databases                  

   EnsemblMetazoa                      17763      10373      0.03      76      Genome annotation databases                  

   EnsemblPlants                       28151      21072      0.05      58      Genome annotation databases                  

   EnsemblProtists                      5009       4830      0.01     102      Genome annotation databases                  

   EPD                                 22051      22051      0.04      65      Proteomic databases                          

   ESTHER                               2547       2546     <0.01     113      Protein family/group databases               

   euHCVdb                                55         44     <0.01     155      Organism-specific databases                  

   EuPathDB                            19720      19708      0.04      72      Organism-specific databases                  

   EvolutionaryTrace                   16635      16635      0.03      80      Other                                        

   ExpressionAtlas                     50585      50585      0.09      47      Gene expression databases                    

   FlyBase                              4907       4781      0.01     103      Organism-specific databases                  

   Gene3D                             403258     315002      0.72      15      Family and domain databases                  

   GeneCards                           20342      20164      0.04      67      Organism-specific databases                  

   GeneDB                                582        526     <0.01     139      Genome annotation databases                  

   GeneID                             290782     281145      0.52      20      Genome annotation databases                  

   GeneReviews                          1479       1475     <0.01     123      Organism-specific databases                  

   GeneTree                            56127      56087      0.10      42      Phylogenomic databases                       

   Genevisible                         55238      55238      0.10      43      Gene expression databases                    

   GeneWiki                            10350      10267      0.02      87      Other                                        

   GenomeRNAi                          22154      22154      0.04      64      Other                                        

   GlyConnect                           2250       2109     <0.01     115      PTM databases                                

   GO                                3051756     536848      5.43       1      Ontologies                                   

   Gramene                             28151      21072      0.05      59      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2019       2019     <0.01     118      Chemistry                                    

   HAMAP                              330210     327290      0.59      17      Family and domain databases                  

   HGNC                                20310      20171      0.04      69      Organism-specific databases                  

   HOGENOM                            422973     422973      0.75      12      Phylogenomic databases                       

   HPA                                 27767      16842      0.05      60      Organism-specific databases                  

   IMGT_GENE-DB                          266        266     <0.01     149      Protein family/group databases               

   InParanoid                         139944     139944      0.25      29      Phylogenomic databases                       

   IntAct                              54811      54811      0.10      44      Protein-protein interaction databases        

   InterPro                          2294446     543080      4.08       2      Family and domain databases                  

   iPTMnet                             52606      52606      0.09      46      PTM databases                                

   jPOST                               26777      26777      0.05      62      Proteomic databases                          

   KEGG                               505051     476107      0.90       8      Genome annotation databases                  

   KO                                 408677     408229      0.73      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     135      Organism-specific databases                  

   Leproma                               672        669     <0.01     136      Organism-specific databases                  

   MaizeGDB                              520        516     <0.01     141      Organism-specific databases                  

   MalaCards                            4666       4662      0.01     104      Organism-specific databases                  

   MassIVE                             17476      17476      0.03      77      Proteomic databases                          

   MaxQB                               29591      29591      0.05      57      Proteomic databases                          

   MEROPS                              11461      11459      0.02      86      Protein family/group databases               

   MGI                                 16943      16903      0.03      79      Organism-specific databases                  

   MIM                                 21465      15210      0.04      66      Organism-specific databases                  

   MINT                                22789      22789      0.04      63      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     146      Protein family/group databases               

   MoonProt                              280        280     <0.01     147      Protein family/group databases               

   mycoCLAP                              355        352     <0.01     145      Protein family/group databases               

   neXtProt                            20262      20262      0.04      70      Organism-specific databases                  

   NIAGADS                                68         68     <0.01     154      Organism-specific databases                  

   OGP                                   373        373     <0.01     144      2D gel databases                             

   OMA                                411947     411947      0.73      13      Phylogenomic databases                       

   OpenTargets                         18430      18277      0.03      74      Organism-specific databases                  

   Orphanet                             7598       4044      0.01      93      Organism-specific databases                  

   OrthoDB                            257404     257404      0.46      23      Phylogenomic databases                       

   PANTHER                            281985     270380      0.50      21      Family and domain databases                  

   PATRIC                              92257      92257      0.16      39      Genome annotation databases                  

   PaxDb                              125298     125298      0.22      33      Proteomic databases                          

   PDB                                187425      28468      0.33      26      3D structure databases                       

   PDBsum                             187425      28468      0.33      27      3D structure databases                       

   PeptideAtlas                        32511      32511      0.06      54      Proteomic databases                          

   PeroxiBase                            782        760     <0.01     134      Protein family/group databases               

   Pfam                               781339     522662      1.39       4      Family and domain databases                  

   PharmGKB                            18319      18301      0.03      75      Organism-specific databases                  

   Pharos                              20113      20113      0.04      71      Other                                        

   PhosphoSitePlus                     39067      39067      0.07      53      PTM databases                                

   PhylomeDB                           96874      96874      0.17      38      Phylogenomic databases                       

   PIR                                124265     114006      0.22      34      Sequence databases                           

   PIRSF                              109035     108006      0.19      35      Family and domain databases                  

   PlantReactome                        1159        713     <0.01     130      Enzyme and pathway databases                 

   PomBase                              5132       5128      0.01     100      Organism-specific databases                  

   PRIDE                              234597     234597      0.42      24      Proteomic databases                          

   PRINTS                             130594     115840      0.23      31      Family and domain databases                  

   PRO                                 96901      96901      0.17      37      Other                                        

   ProMEX                                466        466     <0.01     143      Proteomic databases                          

   PROSITE                            474504     301853      0.84      10      Family and domain databases                  

   Proteomes                          521667     461267      0.93       7      Other                                        

   ProteomicsDB                        40932      19821      0.07      52      Proteomic databases                          

   PseudoCAP                            1371       1362     <0.01     126      Organism-specific databases                  

   Reactome                           128887      36607      0.23      32      Enzyme and pathway databases                 

   REBASE                                618        378     <0.01     137      Protein family/group databases               

   RefSeq                             613481     467463      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     127      2D gel databases                             

   RGD                                  8015       8013      0.01      92      Organism-specific databases                  

   RNAct                               43012      43012      0.08      51      Other                                        

   SABIO-RK                             4378       4378      0.01     105      Enzyme and pathway databases                 

   SFLD                                 8113       6023      0.01      91      Family and domain databases                  

   SGD                                  6740       6735      0.01      96      Organism-specific databases                  

   SignaLink                            3100       3100      0.01     112      Enzyme and pathway databases                 

   SIGNOR                               4281       4281      0.01     106      Enzyme and pathway databases                 

   SMART                              193333     142528      0.34      25      Family and domain databases                  

   SMR                                447679     447679      0.80      11      3D structure databases                       

   STRING                             328867     328867      0.59      18      Protein-protein interaction databases        

   SUPFAM                             503657     381488      0.90       9      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     128      2D gel databases                             

   SwissLipids                          1411       1324     <0.01     124      Chemistry                                    

   SwissPalm                            8609       8609      0.02      90      PTM databases                                

   TAIR                                14741      14685      0.03      84      Organism-specific databases                  

   TCDB                                 7275       7223      0.01      94      Protein family/group databases               

   TIGRFAMs                           292670     272648      0.52      19      Family and domain databases                  

   TopDownProteomics                    3236       2959      0.01     110      Proteomic databases                          

   TreeFam                             45639      45634      0.08      50      Phylogenomic databases                       

   TubercuList                          2216       2180     <0.01     117      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     142      2D gel databases                             

   UCSC                                50184      45805      0.09      48      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     138      PTM databases                                

   UniLectin                             276        276     <0.01     148      Protein family/group databases               

   UniPathway                         137428     124467      0.24      30      Enzyme and pathway databases                 

   VectorBase                            581        502     <0.01     140      Genome annotation databases                  

   VGNC                                 3965       3954      0.01     109      Organism-specific databases                  

   WBParaSite                              4          4     <0.01     156      Genome annotation databases                  

   World-2DPAGE                          931        920     <0.01     133      2D gel databases                             

   WormBase                             6268       4713      0.01      97      Organism-specific databases                  

   Xenbase                              5011       4980      0.01     101      Organism-specific databases                  

   ZFIN                                 3123       3118      0.01     111      Organism-specific databases                  



Total number of cross-referenced databases: 156



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.63

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3920 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79757