Home  |  Contact



         UniProtKB/Swiss-Prot protein knowledgebase release 2019_11 statistics





1.  INTRODUCTION



Release 2019_11 of 11-Dec-19 of UniProtKB/Swiss-Prot contains 561568 sequence entries,

comprising 201997950 amino acids abstracted from 269719 references. 



224 sequences have been added since release 2019_10, the sequence data of

22 existing entries has been updated and the annotations of

561344 entries have been revised.



Number of fragments: 9202

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40216





Protein existence (PE):           entries     %



1: Evidence at protein level       102111   18.2%

2: Evidence at transcript level     57277   10.2%

3: Inferred from homology          386945   68.9%

4: Predicted                        13398    2.4%

5: Uncertain                         1837    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13856



   The first twenty species represent 121123 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5704

                            2x: 1993

                            3x: 1078

                            4x:  704

                            5x:  516

                            6x:  411

                            7x:  307

                            8x:  249

                            9x:  230

                           10x:  144

                       11- 20x:  780

                       21- 50x:  465

                       51-100x:  222

                         >100x: 1053





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20367  Homo sapiens (Human)

       2      17027  Mus musculus (Mouse)

       3      15922  Arabidopsis thaliana (Mouse-ear cress)

       4       8085  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6008  Bos taurus (Bovine)

       7       5140  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4518  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4149  Dictyostelium discoideum (Slime mold)

      11       4105  Caenorhabditis elegans

      12       4070  Oryza sativa subsp. japonica (Rice)

      13       3599  Drosophila melanogaster (Fruit fly)

      14       3448  Xenopus laevis (African clawed frog)

      15       3138  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2291  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2191  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2040  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1799  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1706  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1685  Shigella flexneri

      27       1432  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1339  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1175  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1066  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1035  Archaeoglobus fulgidus 

      34       1025  Yersinia pestis

      35       1011  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        977  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        941  Emericella nidulans  

      38        941  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      40        929  Staphylococcus aureus (strain N315)

      41        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      42        919  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        903  Staphylococcus aureus (strain COL)

      45        896  Staphylococcus aureus (strain MW2)

      46        894  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      47        894  Oryctolagus cuniculus (Rabbit)

      48        889  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        883  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      51        882  Salmonella choleraesuis (strain SC-B67)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        856  Neurospora crassa 

      56        844  Oryza sativa subsp. indica (Rice)

      57        841  Escherichia coli O9:H4 (strain HS)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        831  Zea mays (Maize)

      60        829  Shigella boydii serotype 4 (strain Sb227)

      61        827  Canis lupus familiaris (Dog) (Canis familiaris)

      62        825  Escherichia coli (strain UTI89 / UPEC)

      63        822  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      64        822  Shigella dysenteriae serotype 1 (strain Sd197)

      65        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      66        803  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      67        802  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      68        797  Staphylococcus aureus (strain NCTC 8325)

      69        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      70        791  Escherichia coli (strain SMS-3-5 / SECEC)

      71        786  Aquifex aeolicus (strain VF5)

      72        771  Escherichia coli (strain K12 / DH10B)

      73        770  Pasteurella multocida (strain Pm70)

      74        770  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      75        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      76        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        760  Shigella flexneri serotype 5b (strain 8401)

      81        759  Staphylococcus epidermidis (strain ATCC 12228)

      82        756  Escherichia coli (strain SE11)

      83        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        751  Bacillus anthracis

      86        748  Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      87        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      88        742  Bacillus halodurans 

      89        739  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        724  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      93        722  Salmonella enteritidis PT4 (strain P125109)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      97        715  Enterobacter sp. (strain 638)

      98        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      99        714  Salmonella paratyphi A (strain AKU_12601)

     100        714  Escherichia coli O1:K1 / APEC

     101        713  Salmonella newport (strain SL254)

     102        713  Salmonella agona (strain SL483)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     109        698  Klebsiella pneumoniae (strain 342)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        686  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        677  Staphylococcus aureus (strain USA300)

     118        676  Escherichia coli

     119        672  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        668  Bacillus cereus 

     122        667  Yersinia pestis (strain Pestoides F)

     123        664  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     124        664  Bradyrhizobium diazoefficiens 

     125        657  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        650  Shewanella oneidensis (strain MR-1)

     128        650  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        640  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Treponema pallidum (strain Nichols)

     134        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     135        620  Methanothermobacter thermautotrophicus  

     136        615  Xanthomonas campestris pv. campestris 

     137        615  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     138        614  Staphylococcus haemolyticus (strain JCSC1435)

     139        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     140        608  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     141        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     142        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     143        602  Photobacterium profundum (strain SS9)

     144        602  Staphylococcus saprophyticus subsp. saprophyticus 

     145        601  Salmonella paratyphi C (strain RKS4594)

     146        600  Yersinia pestis bv. Antiqua (strain Angola)

     147        598  Pseudomonas aeruginosa (strain UCBPP-PA14)

     148        595  Bacillus cereus (strain ATCC 10987 / NRS 248)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        584  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        580  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        572  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        560  Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 

     165        559  Clostridium acetobutylicum 

     166        557  Xanthomonas axonopodis pv. citri (strain 306)

     167        555  Pseudomonas fluorescens (strain Pf0-1)

     168        555  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     169        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     170        553  Oceanobacillus iheyensis 

     171        551  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        540  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        530  Corynebacterium glutamicum 

     176        529  Listeria monocytogenes serotype 4b (strain F2365)

     177        529  Sodalis glossinidius (strain morsitans)

     178        528  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        524  Staphylococcus aureus (strain Newman)

     180        522  Xylella fastidiosa (strain 9a5c)

     181        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     182        517  Chromobacterium violaceum 

     183        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     184        515  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     185        515  Deinococcus radiodurans 

     186        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     187        513  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     188        512  Pseudomonas aeruginosa (strain PA7)

     189        511  Streptomyces avermitilis 

     190        511  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     191        510  Geobacillus kaustophilus (strain HTA426)

     192        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     193        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     194        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     195        502  Pseudomonas entomophila (strain L48)

     196        501  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     199        497  Haemophilus influenzae (strain 86-028NP)

     200        496  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     201        496  Bacillus clausii (strain KSM-K16)

     202        496  Burkholderia pseudomallei (strain K96243)

     203        494  Proteus mirabilis (strain HI4320)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     207        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     208        491  Pyrococcus horikoshii 

     209        488  Methanosarcina mazei  

     210        487  Shewanella sp. (strain MR-7)

     211        486  Mannheimia succiniciproducens (strain MBEL55E)

     212        486  Brucella abortus (strain 2308)

     213        485  Thermosynechococcus elongatus (strain BP-1)

     214        484  Shewanella sp. (strain MR-4)

     215        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     216        484  Pseudomonas aeruginosa (strain LESB58)

     217        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     218        482  Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 

     219        482  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     221        480  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     222        480  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     223        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     224        477  Nicotiana tabacum (Common tobacco)

     225        477  Pyrococcus abyssi (strain GE5 / Orsay)

     226        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     227        474  Burkholderia lata 

     228        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     229        469  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        468  Pseudomonas putida (strain GB-1)

     231        468  Clostridium perfringens (strain 13 / Type A)

     232        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     233        467  Shewanella frigidimarina (strain NCIMB 400)

     234        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     235        466  Shewanella sp. (strain ANA-3)

     236        466  Enterococcus faecalis (strain ATCC 700802 / V583)

     237        466  Aeromonas hydrophila subsp. hydrophila 

     238        465  Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)

     239        463  Burkholderia mallei (strain ATCC 23344)

     240        459  Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator 

     241        458  Ovis aries (Sheep)

     242        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     243        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     244        455  Shewanella baltica (strain OS185)

     245        455  Staphylococcus aureus (strain JH1)

     246        455  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     247        453  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     248        453  Pseudomonas putida (strain W619)

     249        452  Aeromonas salmonicida (strain A449)

     250        450  Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19581 (  3%)

    Bacteria         334357 ( 60%)

    Eukaryota        190642 ( 34%)

    Viruses           16988 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20368 ( 11%)           (  4%)

     Other Mammalia         46839 ( 25%)           (  8%)

     Other Vertebrata       18434 ( 10%)           (  3%)

     Viridiplantae          40216 ( 21%)           (  7%)

     Fungi                  34262 ( 18%)           (  6%)

     Insecta                 9354 (  5%)           (  2%)

     Nematoda                5015 (  3%)           (  1%)

     Other                  16154 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9678             1001-1100     4021

                 51- 100   42770             1101-1200     2816

                101- 150   59297             1201-1300     2153

                151- 200   59067             1301-1400     2020

                201- 250   57926             1401-1500     1629

                251- 300   51664             1501-1600      801

                301- 350   52036             1601-1700      620

                351- 400   45135             1701-1800      566

                401- 450   37136             1801-1900      481

                451- 500   29983             1901-2000      382

                501- 550   21689             2001-2100      253

                551- 600   15449             2101-2200      347

                601- 650   12884             2201-2300      323

                651- 700    9252             2301-2400      218

                701- 750    7686             2401-2500      167

                751- 800    5561             >2500         1329

                801- 850    4797

                851- 900    5225

                901- 950    4058

                951-1000    2947



   





   The average sequence length in UniProtKB/Swiss-Prot is 359 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2846





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  911

                       2x:  400

                       3x:  171

                       4x:  130

                       5x:  115

                       6x:   91

                       7x:   77

                       8x:   61

                       9x:   40

                      10x:   33

                  11- 20x:  225

                  21- 50x:  233

                  51-100x:  124

                    >100x:  235





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        25014   Journal of Biological Chemistry

    2        11658   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6708   Journal of Bacteriology

    4         5702   Biochemical and Biophysical Research Communications

    5         5414   Biochemistry

    6         5035   Nucleic Acids Research

    7         4863   FEBS Letters

    8         4824   Gene

    9         4720   The EMBO Journal

   10         4643   Nature

   11         4385   Molecular and Cellular Biology

   12         4314   Journal of Molecular Biology

   13         3706   Biochimica et Biophysica Acta

   14         3612   Cell

   15         3414   European Journal of Biochemistry

   16         3300   Journal of Virology

   17         3072   Science

   18         2894   Biochemical Journal

   19         2612   Plant Physiology

   20         2588   Molecular Microbiology

   21         2537   Genomics

   22         2219   Journal of Cell Biology

   23         2206   The American Journal of Human Genetics

   24         2040   The Plant Cell

   25         2035   PLoS ONE

   26         1889   The Plant Journal

   27         1877   Plant Molecular Biology

   28         1854   Human Molecular Genetics

   29         1849   Genes and Development

   30         1814   Virology

   31         1774   Nature Genetics

   32         1695   Molecular Biology of the Cell

   33         1687   Development

   34         1581   Human Mutation

   35         1575   Molecular Cell

   36         1543   Oncogene

   37         1507   Journal of Immunology

   38         1395   Molecular and General Genetics

   39         1370   Structure

   40         1352   Journal of Biochemistry

   41         1328   Genetics

   42         1284   Journal of Cell Science

   43         1178   Blood

   44         1151   Infection and Immunity

   45         1150   Journal of General Virology

   46         1082   Microbiology

   47         1070   Current Biology

   48         1062   Archives of Biochemistry and Biophysics

   49         1062   Developmental Biology

   50          932   Applied and Environmental Microbiology

   51          929   Journal of Neuroscience

   52          901   Acta Crystallographica, Section D

   53          888   Cancer Research

   54          846   FEMS Microbiology Letters

   55          839   Yeast

   56          793   Toxicon

   57          788   Protein Science

   58          770   Neuron

   59          752   Journal of Clinical Investigation

   60          704   Plant and Cell Physiology

   61          703   Human Genetics

   62          700   American Journal of Physiology

   63          693   PLoS Genetics

   64          665   The Journal of Experimental Medicine

   65          649   Mechanisms of Development

   66          646   Nature Structural Biology

   67          637   Proteins

   68          627   Journal of Medical Genetics

   69          584   Nature Cell Biology

   70          574   Current Genetics

   71          556   Bioscience, Biotechnology, and Biochemistry

   72          552   Nature Structural and Molecular Biology

   73          542   Journal of Neurochemistry

   74          539   Molecular Endocrinology

   75          539   The FEBS Journal

   76          537   Nature Communications

   77          525   Developmental Cell

   78          521   The Journal of Clinical Endocrinology and Metabolism

   79          506   Endocrinology

   80          488   Mammalian Genome

   81          483   Antimicrobial Agents and Chemotherapy

   82          464   Experimental Cell Research

   83          450   Molecular and Biochemical Parasitology

   84          445   Scientific Reports

   85          434   Planta

   86          433   Eukaryotic Cell

   87          430   Immunogenetics

   88          421   RNA

   89          418   Peptides

   90          416   PLoS Pathogens

   91          407   Journal of Molecular Evolution

   92          399   Molecular Biology and Evolution

   93          399   Journal of the American Chemical Society

   94          397   Journal of Experimental Botany

   95          388   DNA and Cell Biology

   96          383   Molecular Pharmacology

   97          375   EMBO Reports

   98          375   DNA Sequence

   99          374   The FASEB Journal

  100          371   Neurology

  101          371   Acta Crystallographica, Section F

  102          370   Journal of Investigative Dermatology

  103          369   American Journal of Medical Genetics. Part A

  104          366   Molecular Plant-Microbe Interactions

  105          358   European Journal of Human Genetics

  106          351   Biology of Reproduction

  107          351   Comparative Biochemistry and Physiology

  108          347   Immunity

  109          340   Brain Research. Molecular Brain Research

  110          328   Virus Research

  111          327   Genes to Cells

  112          324   Biochimie

  113          321   The New England Journal of Medicine

  114          318   Developmental Dynamics

  115          314   Clinical Genetics

  116          301   Annals of Neurology

  117          299   Genome Research

  118          297   Biological Chemistry Hoppe-Seyler

  119          287   European Journal of Immunology

  120          284   BMC Genomics

  121          282   Cytogenetics and Cell Genetics

  122          281   Nature Immunology

  123          276   Investigative Ophthalmology and Visual Science

  124          272   Journal of General Microbiology

  125          268   Applied Microbiology and Biotechnology

  126          267   Journal of Lipid Research

  127          266   Journal of Human Genetics

  128          262   PLoS Biology

  129          261   Journal of Medicinal Chemistry

  130          252   Cell Reports

  131          248   Archives of Microbiology

  132          241   Glycobiology

  133          237   Molecular Immunology

  134          235   Journal of Cellular Biochemistry

  135          234   Traffic

  136          232   DNA Research

  137          227   Molecular Genetics and Metabolism

  138          222   Cell Cycle

  139          219   Diabetes

  140          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  141          217   Archives of Virology

  142          217   Circulation Research

  143          213   Protein Expression and Purification

  144          212   Phytochemistry

  145          210   Nature Medicine

  146          208   Molecular and Cellular Endocrinology

  147          207   Fungal Genetics and Biology

  148          197   Molecular Genetics and Genomics

  149          192   Chemistry and Biology

  150          192   Tissue Antigens





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1235631                 2.20                                         

   Journal                           1059599     459060      1.89       1                                 

   Submitted to EMBL/GenBank/DDBJ     165030     149457      0.29       2                                 

   Submitted to other databases         7460       6881      0.01       3                                 

   Book citation                        1834       1811     <0.01       4                                 

   Plant Gene Register                   612        599     <0.01       5                                 

   Unpublished observations              445        441     <0.01       6                                 

   Thesis                                435        432     <0.01       7                                 

   Patent                                210        204     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 419314



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2576081                 4.59                                         

   ACTIVITY REGULATION                 15428      15426      0.03      17                                 

   ALLERGEN                              875        875     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25358      25358      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8791       8790      0.02      20                                 

   BIOTECHNOLOGY                        1119       1103     <0.01      25                                 

   CATALYTIC ACTIVITY                 295063     240549      0.53       4                                 

   CAUTION                             13259      12993      0.02      18                                 

   COFACTOR                           126470     115099      0.23       7                                 

   DEVELOPMENTAL STAGE                 12503      12502      0.02      19                                 

   DISEASE                              7286       4897      0.01      21                                 

   DISRUPTION PHENOTYPE                15449      15446      0.03      16                                 

   DOMAIN                              50537      43316      0.09       9                                 

   FUNCTION                           470500     449369      0.84       2                                 

   INDUCTION                           21926      21913      0.04      14                                 

   INTERACTION                         19605      19605      0.03      15                                 

   MASS SPECTROMETRY                    6876       5286      0.01      23                                 

   MISCELLANEOUS                       43789      38485      0.08      12                                 

   PATHWAY                            139436     126350      0.25       6                                 

   PHARMACEUTICAL                        121        117     <0.01      29                                 

   POLYMORPHISM                         1271       1217     <0.01      24                                 

   PTM                                 58308      42637      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44381      44305      0.08      11                                 

   SIMILARITY                         510381     506204      0.91       1                                 

   SUBCELLULAR LOCATION               351612     344031      0.63       3                                 

   SUBUNIT                            280625     279682      0.50       5                                 

   TISSUE SPECIFICITY                  46868      46867      0.08      10                                 

   TOXIC DOSE                            675        616     <0.01      27                                 

   WEB RESOURCE                         6942       5767      0.01      22                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4585387                 8.17                                         

   ACT_SITE                           165494     100194      0.29      10                                 

   BINDING                            409570     108607      0.73       2                                 

   CA_BIND                              4206       1743      0.01      36                                 

   CARBOHYD                           117497      30181      0.21      15                                 

   CHAIN                              569675     554420      1.01       1                                 

   COILED                              22110      15304      0.04      27                                 

   COMPBIAS                            59176      31836      0.11      21                                 

   CONFLICT                           136589      47666      0.24      13                                 

   CROSSLNK                            23812       8518      0.04      26                                 

   DISULFID                           126911      34050      0.23      14                                 

   DNA_BIND                            11890      10632      0.02      32                                 

   DOMAIN                             200406     123083      0.36       9                                 

   HELIX                              269919      24621      0.48       6                                 

   INIT_MET                            17339      17291      0.03      28                                 

   INTRAMEM                             2791       1275     <0.01      37                                 

   LIPID                               13221       8525      0.02      30                                 

   METAL                              396295      96813      0.71       3                                 

   MOD_RES                            254507      72399      0.45       7                                 

   MOTIF                               44288      28949      0.08      23                                 

   MUTAGEN                             74931      16257      0.13      18                                 

   NON_CONS                             2523        820     <0.01      38                                 

   NON_STD                               357        282     <0.01      39                                 

   NON_TER                             12516       9591      0.02      31                                 

   NP_BIND                            158698      86135      0.28      11                                 

   PEPTIDE                             11696       8061      0.02      33                                 

   PROPEP                              14384      12272      0.03      29                                 

   REGION                             202158      95034      0.36       8                                 

   REPEAT                             106330      14854      0.19      16                                 

   SIGNAL                              42533      42532      0.08      24                                 

   SITE                                59753      32439      0.11      20                                 

   STRAND                             280191      23206      0.50       5                                 

   TOPO_DOM                           141328      28916      0.25      12                                 

   TRANSIT                              9180       9064      0.02      34                                 

   TRANSMEM                           372666      77811      0.66       4                                 

   TURN                                65075      20010      0.12      19                                 

   UNSURE                               5577        839      0.01      35                                 

   VAR_SEQ                             52208      22132      0.09      22                                 

   VARIANT                             97568      17120      0.17      17                                 

   ZN_FING                             30019      12800      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18709189                33.32                                                           

   ABCD                                 1609       1609     <0.01     122      Protocols and materials databases            

   Allergome                            1936       1258     <0.01     120      Protein family/group databases               

   ArachnoServer                        1163       1154     <0.01     129      Organism-specific databases                  

   Araport                             15942      15846      0.03      82      Organism-specific databases                  

   Bgee                                56775      56774      0.10      41      Gene expression databases                    

   BindingDB                            5193       5193      0.01      99      Chemistry                                    

   BioCyc                             270162     244570      0.48      22      Enzyme and pathway databases                 

   BioGrid                             54588      52899      0.10      45      Protein-protein interaction databases        

   BioMuta                             20316      20301      0.04      69      Polymorphism and mutation databases          

   BRENDA                              12959      12177      0.02      85      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     130      PTM databases                                

   CAZy                                 9511       8572      0.02      88      Protein family/group databases               

   CCDS                                48308      34253      0.09      49      Sequence databases                           

   CDD                                184396     167326      0.33      28      Family and domain databases                  

   CGD                                  1999       1982     <0.01     119      Organism-specific databases                  

   ChEMBL                               7266       7145      0.01      94      Chemistry                                    

   ChiTaRS                             29613      29576      0.05      56      Other                                        

   CollecTF                              135        135     <0.01     152      Gene expression databases                    

   ComplexPortal                        9441       5083      0.02      89      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     153      2D gel databases                             

   ConoServer                            954        870     <0.01     131      Organism-specific databases                  

   CORUM                                5805       5805      0.01      98      Protein-protein interaction databases        

   CPTAC                                2221       1423     <0.01     116      Proteomic databases                          

   CTD                                 75211      74320      0.13      40      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     150      PTM databases                                

   dictyBase                            4214       4100      0.01     107      Organism-specific databases                  

   DIP                                 17410      17378      0.03      78      Protein-protein interaction databases        

   DisGeNET                            15648      15417      0.03      83      Organism-specific databases                  

   DisProt                              1377       1365     <0.01     125      Family and domain databases                  

   DMDM                                16197      16195      0.03      81      Polymorphism and mutation databases          

   DNASU                               19023      18957      0.03      73      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     151      2D gel databases                             

   DrugBank                            27238       4518      0.05      62      Chemistry                                    

   DrugCentral                          2531       2531     <0.01     114      Chemistry                                    

   EchoBASE                             4159       4159      0.01     108      Organism-specific databases                  

   eggNOG                             666526     332529      1.19       5      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     121      Protein-protein interaction databases        

   EMBL                               985973     549507      1.76       3      Sequence databases                           

   Ensembl                             97178      51052      0.17      36      Genome annotation databases                  

   EnsemblBacteria                    356006     336822      0.63      16      Genome annotation databases                  

   EnsemblFungi                        29566      28009      0.05      58      Genome annotation databases                  

   EnsemblMetazoa                      17746      10362      0.03      76      Genome annotation databases                  

   EnsemblPlants                       28122      21053      0.05      60      Genome annotation databases                  

   EnsemblProtists                      5009       4830      0.01     102      Genome annotation databases                  

   EPD                                 22046      22046      0.04      66      Proteomic databases                          

   ESTHER                               2539       2538     <0.01     113      Protein family/group databases               

   euHCVdb                                55         44     <0.01     155      Organism-specific databases                  

   EuPathDB                            39041      38847      0.07      54      Organism-specific databases                  

   EvolutionaryTrace                   16631      16631      0.03      80      Other                                        

   ExpressionAtlas                     49505      49505      0.09      48      Gene expression databases                    

   FlyBase                              4904       4778      0.01     103      Organism-specific databases                  

   Gene3D                             402991     314805      0.72      14      Family and domain databases                  

   GeneCards                           20345      20172      0.04      68      Organism-specific databases                  

   GeneDB                                582        526     <0.01     139      Genome annotation databases                  

   GeneID                             290949     281313      0.52      20      Genome annotation databases                  

   GeneReviews                          1479       1475     <0.01     123      Organism-specific databases                  

   GeneTree                            56092      56052      0.10      42      Phylogenomic databases                       

   Genevisible                         55235      55235      0.10      43      Gene expression databases                    

   GeneWiki                            10350      10267      0.02      87      Other                                        

   GenomeRNAi                          22151      22151      0.04      65      Other                                        

   GlyConnect                           2250       2109     <0.01     115      PTM databases                                

   GO                                3035358     536441      5.41       1      Ontologies                                   

   Gramene                             28122      21053      0.05      59      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2013       2013     <0.01     118      Chemistry                                    

   HAMAP                              330185     327265      0.59      17      Family and domain databases                  

   HGNC                                20312      20173      0.04      70      Organism-specific databases                  

   HOGENOM                            392321     392321      0.70      15      Phylogenomic databases                       

   HPA                                 27767      16842      0.05      61      Organism-specific databases                  

   IMGT_GENE-DB                          266        266     <0.01     149      Protein family/group databases               

   InParanoid                         139902     139902      0.25      29      Phylogenomic databases                       

   IntAct                              54793      54793      0.10      44      Protein-protein interaction databases        

   InterPro                          2293226     542767      4.08       2      Family and domain databases                  

   iPTMnet                             52598      52598      0.09      46      PTM databases                                

   jPOST                               26775      26775      0.05      63      Proteomic databases                          

   KEGG                               504894     475950      0.90       7      Genome annotation databases                  

   KO                                 408369     407921      0.73      13      Phylogenomic databases                       

   LegioList                             765        763     <0.01     135      Organism-specific databases                  

   Leproma                               672        669     <0.01     136      Organism-specific databases                  

   MaizeGDB                              520        516     <0.01     141      Organism-specific databases                  

   MalaCards                            4591       4587      0.01     104      Organism-specific databases                  

   MassIVE                             17476      17476      0.03      77      Proteomic databases                          

   MaxQB                               29587      29587      0.05      57      Proteomic databases                          

   MEROPS                              11459      11457      0.02      86      Protein family/group databases               

   MGI                                 16937      16897      0.03      79      Organism-specific databases                  

   MIM                                 21397      15175      0.04      67      Organism-specific databases                  

   MINT                                22786      22786      0.04      64      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     146      Protein family/group databases               

   MoonProt                              280        280     <0.01     147      Protein family/group databases               

   mycoCLAP                              355        352     <0.01     145      Protein family/group databases               

   neXtProt                            20264      20264      0.04      71      Organism-specific databases                  

   NIAGADS                                68         68     <0.01     154      Organism-specific databases                  

   OGP                                   373        373     <0.01     144      2D gel databases                             

   OMA                                411804     411804      0.73      12      Phylogenomic databases                       

   OpenTargets                         18425      18272      0.03      74      Organism-specific databases                  

   Orphanet                             7589       4034      0.01      93      Organism-specific databases                  

   OrthoDB                            257314     257314      0.46      23      Phylogenomic databases                       

   PANTHER                            281924     270319      0.50      21      Family and domain databases                  

   PATRIC                              92190      92190      0.16      39      Genome annotation databases                  

   PaxDb                              125239     125239      0.22      33      Proteomic databases                          

   PDB                                185407      28253      0.33      27      3D structure databases                       

   PDBsum                             185407      28253      0.33      26      3D structure databases                       

   PeptideAtlas                        32498      32498      0.06      55      Proteomic databases                          

   PeroxiBase                            782        760     <0.01     134      Protein family/group databases               

   Pfam                               780967     522456      1.39       4      Family and domain databases                  

   PharmGKB                            18317      18299      0.03      75      Organism-specific databases                  

   Pharos                              20115      20115      0.04      72      Other                                        

   PhosphoSitePlus                     39063      39063      0.07      53      PTM databases                                

   PhylomeDB                           96854      96854      0.17      38      Phylogenomic databases                       

   PIR                                124204     113945      0.22      34      Sequence databases                           

   PIRSF                              109036     108007      0.19      35      Family and domain databases                  

   PlantReactome                         941        671     <0.01     132      Enzyme and pathway databases                 

   PomBase                              5132       5128      0.01     100      Organism-specific databases                  

   PRIDE                              234554     234554      0.42      24      Proteomic databases                          

   PRINTS                             130484     115770      0.23      31      Family and domain databases                  

   PRO                                 96901      96901      0.17      37      Other                                        

   ProMEX                                464        464     <0.01     143      Proteomic databases                          

   PROSITE                            474058     301613      0.84      10      Family and domain databases                  

   Proteomes                          485417     460429      0.86       9      Other                                        

   ProteomicsDB                        40928      19823      0.07      52      Proteomic databases                          

   PseudoCAP                            1347       1338     <0.01     126      Organism-specific databases                  

   Reactome                           128874      36599      0.23      32      Enzyme and pathway databases                 

   REBASE                                618        378     <0.01     137      Protein family/group databases               

   RefSeq                             612079     466171      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     127      2D gel databases                             

   RGD                                  8009       8007      0.01      92      Organism-specific databases                  

   RNAct                               43016      43016      0.08      51      Other                                        

   SABIO-RK                             4376       4376      0.01     105      Enzyme and pathway databases                 

   SFLD                                 8110       6020      0.01      91      Family and domain databases                  

   SGD                                  6740       6735      0.01      96      Organism-specific databases                  

   SignaLink                            3098       3098      0.01     112      Enzyme and pathway databases                 

   SIGNOR                               4277       4277      0.01     106      Enzyme and pathway databases                 

   SMART                              193215     142455      0.34      25      Family and domain databases                  

   SMR                                445955     445955      0.79      11      3D structure databases                       

   STRING                             328771     328771      0.59      18      Protein-protein interaction databases        

   SUPFAM                             503351     381275      0.90       8      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     128      2D gel databases                             

   SwissLipids                          1397       1310     <0.01     124      Chemistry                                    

   SwissPalm                            8605       8605      0.02      90      PTM databases                                

   TAIR                                14724      14668      0.03      84      Organism-specific databases                  

   TCDB                                 7248       7197      0.01      95      Protein family/group databases               

   TIGRFAMs                           292614     272607      0.52      19      Family and domain databases                  

   TopDownProteomics                    3259       2973      0.01     110      Proteomic databases                          

   TreeFam                             45623      45618      0.08      50      Phylogenomic databases                       

   TubercuList                          2209       2173     <0.01     117      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     142      2D gel databases                             

   UCSC                                50160      45784      0.09      47      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     138      PTM databases                                

   UniLectin                             275        275     <0.01     148      Protein family/group databases               

   UniPathway                         137070     124122      0.24      30      Enzyme and pathway databases                 

   VectorBase                            581        502     <0.01     140      Genome annotation databases                  

   VGNC                                 3938       3938      0.01     109      Organism-specific databases                  

   WBParaSite                             31         31     <0.01     156      Genome annotation databases                  

   World-2DPAGE                          931        920     <0.01     133      2D gel databases                             

   WormBase                             6232       4704      0.01      97      Organism-specific databases                  

   Xenbase                              5011       4980      0.01     101      Organism-specific databases                  

   ZFIN                                 3116       3111      0.01     111      Organism-specific databases                  



Total number of cross-referenced databases: 156



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.63

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3920 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79716