UniProtKB/Swiss-Prot protein knowledgebase release 2018_01 statistics





1.  INTRODUCTION



Release 2018_01 of 31-Jan-18 of UniProtKB/Swiss-Prot contains 556568 sequence entries,

comprising 199530821 amino acids abstracted from 257937 references. 



182 sequences have been added since release 2017_12, the sequence data of

76 existing entries has been updated and the annotations of

84685 entries have been revised.



Number of fragments: 9126

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 39809





Protein existence (PE):           entries     %



1: Evidence at protein level        97904   17.6%

2: Evidence at transcript level     57073   10.3%

3: Inferred from homology          386055   69.4%

4: Predicted                        13673    2.5%

5: Uncertain                         1863    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13577



   The first twenty species represent 119973 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5641

                            2x: 1936

                            3x: 1047

                            4x:  689

                            5x:  506

                            6x:  406

                            7x:  292

                            8x:  247

                            9x:  231

                           10x:  135

                       11- 20x:  734

                       21- 50x:  446

                       51-100x:  218

                         >100x: 1049





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20258  Homo sapiens (Human)

       2      16958  Mus musculus (Mouse)

       3      15621  Arabidopsis thaliana (Mouse-ear cress)

       4       8022  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       5999  Bos taurus (Bovine)

       7       5141  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4443  Escherichia coli (strain K12)

       9       4185  Bacillus subtilis (strain 168)

      10       4136  Dictyostelium discoideum (Slime mold)

      11       3995  Caenorhabditis elegans

      12       3922  Oryza sativa subsp. japonica (Rice)

      13       3496  Drosophila melanogaster (Fruit fly)

      14       3425  Xenopus laevis (African clawed frog)

      15       3043  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2288  Gallus gallus (Chicken)

      17       2219  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2168  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2035  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1795  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      24       1705  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1683  Shigella flexneri

      27       1422  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1324  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1172  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1063  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1031  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35       1005  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        975  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        930  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      38        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      39        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      40        926  Staphylococcus aureus (strain N315)

      41        914  Kluyveromyces lactis   

      42        909  Acanthamoeba polyphaga mimivirus (APMV)

      43        899  Staphylococcus aureus (strain COL)

      44        895  Staphylococcus aureus (strain MW2)

      45        893  Oryctolagus cuniculus (Rabbit)

      46        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      47        889  Staphylococcus aureus (strain MSSA476)

      48        888  Staphylococcus aureus (strain MRSA252)

      49        882  Salmonella choleraesuis (strain SC-B67)

      50        881  Emericella nidulans  

      51        881  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      52        879  Shigella sonnei (strain Ss046)

      53        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      54        862  Candida glabrata   

      55        854  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      58        829  Shigella boydii serotype 4 (strain Sb227)

      59        825  Escherichia coli (strain UTI89 / UPEC)

      60        822  Shigella dysenteriae serotype 1 (strain Sd197)

      61        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      62        817  Canis lupus familiaris (Dog) (Canis familiaris)

      63        815  Oryza sativa subsp. indica (Rice)

      64        803  Zea mays (Maize)

      65        796  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      66        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      67        791  Escherichia coli (strain SMS-3-5 / SECEC)

      68        784  Aquifex aeolicus (strain VF5)

      69        776  Pasteurella multocida (strain Pm70)

      70        774  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      71        771  Escherichia coli (strain K12 / DH10B)

      72        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      73        770  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      74        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      75        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      76        762  Escherichia coli (strain 55989 / EAEC)

      77        761  Escherichia coli O8 (strain IAI1)

      78        760  Shigella flexneri serotype 5b (strain 8401)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        759  Staphylococcus epidermidis (strain ATCC 12228)

      81        758  Staphylococcus aureus (strain NCTC 8325)

      82        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      86        746  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      87        741  Bacillus anthracis

      88        741  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      97        715  Enterobacter sp. (strain 638)

      98        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      99        714  Escherichia coli O1:K1 / APEC

     100        714  Salmonella paratyphi A (strain AKU_12601)

     101        713  Salmonella agona (strain SL483)

     102        713  Salmonella newport (strain SL254)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        673  Staphylococcus aureus (strain USA300)

     118        671  Escherichia coli

     119        670  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        662  Bradyrhizobium diazoefficiens 

     124        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     125        653  Debaryomyces hansenii   

     126        650  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     127        646  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        645  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        620  Methanothermobacter thermautotrophicus  

     135        620  Treponema pallidum (strain Nichols)

     136        613  Staphylococcus haemolyticus (strain JCSC1435)

     137        610  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)

     138        610  Xanthomonas campestris pv. campestris 

     139        607  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     140        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     141        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     142        602  Staphylococcus saprophyticus subsp. saprophyticus 

     143        602  Photobacterium profundum (strain SS9)

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        594  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     147        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     148        593  Pseudomonas aeruginosa (strain UCBPP-PA14)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        579  Brucella suis biovar 1 (strain 1330)

     153        578  Caenorhabditis briggsae

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Vibrio fischeri (strain ATCC 700601 / ES114)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter crescentus (strain ATCC 19089 / CB15)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        559  Clostridium acetobutylicum 

     165        557  Xanthomonas axonopodis pv. citri (strain 306)

     166        554  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     167        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     168        553  Oceanobacillus iheyensis 

     169        552  Pseudomonas fluorescens (strain Pf0-1)

     170        550  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     171        549  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        537  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Sodalis glossinidius (strain morsitans)

     176        529  Listeria monocytogenes serotype 4b (strain F2365)

     177        528  Corynebacterium glutamicum 

     178        527  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        522  Xylella fastidiosa (strain 9a5c)

     180        518  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     181        517  Chromobacterium violaceum 

     182        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        513  Deinococcus radiodurans 

     185        513  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     186        512  Pseudomonas aeruginosa (strain PA7)

     187        511  Staphylococcus aureus (strain Newman)

     188        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     189        510  Geobacillus kaustophilus (strain HTA426)

     190        508  Streptomyces avermitilis 

     191        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     192        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     193        502  Pseudomonas entomophila (strain L48)

     194        501  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     195        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     196        499  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     199        497  Haemophilus influenzae (strain 86-028NP)

     200        496  Bacillus clausii (strain KSM-K16)

     201        496  Burkholderia pseudomallei (strain K96243)

     202        494  Proteus mirabilis (strain HI4320)

     203        493  Xanthomonas campestris pv. campestris (strain 8004)

     204        493  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        487  Shewanella sp. (strain MR-7)

     209        487  Methanosarcina mazei  

     210        486  Mannheimia succiniciproducens (strain MBEL55E)

     211        485  Thermosynechococcus elongatus (strain BP-1)

     212        484  Pseudomonas aeruginosa (strain LESB58)

     213        484  Pyrococcus horikoshii 

     214        484  Shewanella sp. (strain MR-4)

     215        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     216        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     217        483  Brucella abortus (strain 2308)

     218        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     219        479  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     220        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     221        477  Pyrococcus abyssi (strain GE5 / Orsay)

     222        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     223        475  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     224        474  Burkholderia lata 

     225        473  Nicotiana tabacum (Common tobacco)

     226        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     227        472  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     228        468  Clostridium perfringens (strain 13 / Type A)

     229        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     231        466  Shewanella sp. (strain ANA-3)

     232        466  Shewanella frigidimarina (strain NCIMB 400)

     233        466  Pseudomonas putida (strain GB-1)

     234        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     235        464  Aeromonas hydrophila subsp. hydrophila 

     236        463  Enterococcus faecalis (strain ATCC 700802 / V583)

     237        462  Burkholderia mallei (strain ATCC 23344)

     238        462  Campylobacter jejuni subsp. jejuni serotype O:2 

     239        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     241        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     242        457  Ovis aries (Sheep)

     243        455  Staphylococcus aureus (strain JH1)

     244        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        453  Pseudomonas putida (strain W619)

     246        452  Shewanella baltica (strain OS185)

     247        452  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     248        452  Aeromonas salmonicida (strain A449)

     249        450  Caldanaerobacter subterraneus subsp. tengcongensis  

     250        450  Dechloromonas aromatica (strain RCB)





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19487 (  4%)

    Bacteria         333413 ( 60%)

    Eukaryota        186882 ( 34%)

    Viruses           16786 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20259 ( 11%)           (  4%)

     Other Mammalia         46586 ( 25%)           (  8%)

     Other Vertebrata       18216 ( 10%)           (  3%)

     Viridiplantae          39330 ( 21%)           (  7%)

     Fungi                  33025 ( 18%)           (  6%)

     Insecta                 9118 (  5%)           (  2%)

     Nematoda                4894 (  3%)           (  1%)

     Other                  15454 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9410             1001-1100     3970

                 51- 100   42401             1101-1200     2782

                101- 150   58804             1201-1300     2129

                151- 200   58764             1301-1400     1979

                201- 250   57616             1401-1500     1595

                251- 300   51286             1501-1600      777

                301- 350   51667             1601-1700      609

                351- 400   44822             1701-1800      537

                401- 450   36843             1801-1900      463

                451- 500   29657             1901-2000      374

                501- 550   21360             2001-2100      244

                551- 600   15256             2101-2200      319

                601- 650   12734             2201-2300      311

                651- 700    9183             2301-2400      203

                701- 750    7617             2401-2500      157

                751- 800    5482             >2500         1240

                801- 850    4746

                851- 900    5189

                901- 950    4022

                951-1000    2894



   





   The average sequence length in UniProtKB/Swiss-Prot is 358 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2707





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  852

                       2x:  381

                       3x:  174

                       4x:  128

                       5x:  106

                       6x:   94

                       7x:   69

                       8x:   48

                       9x:   46

                      10x:   28

                  11- 20x:  216

                  21- 50x:  220

                  51-100x:  118

                    >100x:  227





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24123   Journal of Biological Chemistry

    2        11118   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6524   Journal of Bacteriology

    4         5547   Biochemical and Biophysical Research Communications

    5         5210   Biochemistry

    6         4955   Nucleic Acids Research

    7         4797   Gene

    8         4780   FEBS Letters

    9         4632   The EMBO Journal

   10         4402   Nature

   11         4302   Molecular and Cellular Biology

   12         4192   Journal of Molecular Biology

   13         3582   Biochimica et Biophysica Acta

   14         3501   Cell

   15         3373   European Journal of Biochemistry

   16         3075   Journal of Virology

   17         2945   Science

   18         2812   Biochemical Journal

   19         2532   Genomics

   20         2487   Plant Physiology

   21         2447   Molecular Microbiology

   22         2154   Journal of Cell Biology

   23         2079   The American Journal of Human Genetics

   24         1927   The Plant Cell

   25         1839   Plant Molecular Biology

   26         1805   Genes and Development

   27         1771   Human Molecular Genetics

   28         1769   The Plant Journal

   29         1746   PLoS ONE

   30         1723   Virology

   31         1721   Nature Genetics

   32         1633   Development

   33         1626   Molecular Biology of the Cell

   34         1556   Human Mutation

   35         1532   Oncogene

   36         1485   Molecular Cell

   37         1398   Journal of Immunology

   38         1392   Molecular and General Genetics

   39         1330   Journal of Biochemistry

   40         1295   Genetics

   41         1295   Structure

   42         1216   Journal of Cell Science

   43         1132   Blood

   44         1105   Journal of General Virology

   45         1096   Infection and Immunity

   46         1039   Microbiology

   47         1029   Current Biology

   48         1028   Archives of Biochemistry and Biophysics

   49         1009   Developmental Biology

   50          876   Cancer Research

   51          873   Journal of Neuroscience

   52          870   Applied and Environmental Microbiology

   53          853   Acta Crystallographica, Section D

   54          832   Yeast

   55          827   FEMS Microbiology Letters

   56          758   Protein Science

   57          754   Toxicon

   58          726   Neuron

   59          708   Journal of Clinical Investigation

   60          680   Human Genetics

   61          662   American Journal of Physiology

   62          657   Plant and Cell Physiology

   63          642   Nature Structural Biology

   64          640   Mechanisms of Development

   65          616   The Journal of Experimental Medicine

   66          606   Proteins

   67          584   Journal of Medical Genetics

   68          580   PLoS Genetics

   69          567   Current Genetics

   70          557   Nature Cell Biology

   71          536   Bioscience, Biotechnology, and Biochemistry

   72          532   Molecular Endocrinology

   73          526   Journal of Neurochemistry

   74          513   The Journal of Clinical Endocrinology and Metabolism

   75          501   Nature Structural and Molecular Biology

   76          496   Endocrinology

   77          488   Mammalian Genome

   78          486   Developmental Cell

   79          477   The FEBS Journal

   80          470   Immunogenetics

   81          449   Experimental Cell Research

   82          447   Molecular and Biochemical Parasitology

   83          432   Antimicrobial Agents and Chemotherapy

   84          418   Eukaryotic Cell

   85          411   Planta

   86          407   Journal of Molecular Evolution

   87          404   RNA

   88          404   Peptides

   89          396   Molecular Biology and Evolution

   90          386   DNA and Cell Biology

   91          373   DNA Sequence

   92          367   Molecular Pharmacology

   93          356   Journal of Experimental Botany

   94          355   Journal of Investigative Dermatology

   95          354   Neurology

   96          352   Journal of the American Chemical Society

   97          348   EMBO Reports

   98          346   Comparative Biochemistry and Physiology

   99          342   The FASEB Journal

  100          340   Brain Research. Molecular Brain Research

  101          339   Biology of Reproduction

  102          332   Acta Crystallographica, Section F

  103          325   Tissue Antigens

  104          323   Nature Communications

  105          321   European Journal of Human Genetics

  106          320   Molecular Plant-Microbe Interactions

  107          320   American Journal of Medical Genetics. Part A

  108          316   Immunity

  109          309   Biochimie

  110          308   Genes to Cells

  111          308   The New England Journal of Medicine

  112          307   Developmental Dynamics

  113          303   PLoS Pathogens

  114          300   Virus Research

  115          296   Biological Chemistry Hoppe-Seyler

  116          292   Genome Research

  117          284   Clinical Genetics

  118          282   Cytogenetics and Cell Genetics

  119          278   Annals of Neurology

  120          270   Journal of General Microbiology

  121          265   European Journal of Immunology

  122          263   Investigative Ophthalmology and Visual Science

  123          261   BMC Genomics

  124          260   Nature Immunology

  125          249   Journal of Human Genetics

  126          245   Applied Microbiology and Biotechnology

  127          242   Journal of Medicinal Chemistry

  128          237   Archives of Microbiology

  129          228   Glycobiology

  130          228   PLoS Biology

  131          228   DNA Research

  132          226   Journal of Cellular Biochemistry

  133          222   Scientific Reports

  134          221   Traffic

  135          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  136          217   Molecular Genetics and Metabolism

  137          213   Cell Cycle

  138          212   Journal of Lipid Research

  139          212   Circulation Research

  140          206   Archives of Virology

  141          206   Diabetes

  142          205   Molecular and Cellular Endocrinology

  143          205   Molecular Immunology

  144          201   Protein Expression and Purification

  145          199   Phytochemistry

  146          188   Molecular Genetics and Genomics

  147          187   Nature Medicine

  148          181   Insect Biochemistry and Molecular Biology

  149          181   Molecular and Cellular Neuroscience

  150          179   International Journal of Cancer





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1201192                 2.16                                         

   Journal                           1007296     450519      1.81       1                                 

   Submitted to EMBL/GenBank/DDBJ     183266     160444      0.33       2                                 

   Submitted to other databases         7333       6784      0.01       3                                 

   Book citation                        1652       1629     <0.01       4                                 

   Plant Gene Register                   611        598     <0.01       5                                 

   Thesis                                432        429     <0.01       6                                 

   Unpublished observations              397        393     <0.01       7                                 

   Patent                                199        195     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 398157



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2486847                 4.47                                         

   ALLERGEN                              715        715     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25082      25082      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        7878       7878      0.01      20                                 

   BIOTECHNOLOGY                         835        833     <0.01      25                                 

   CATALYTIC ACTIVITY                 264877     234814      0.48       5                                 

   CAUTION                             12621      12384      0.02      18                                 

   COFACTOR                           121962     111905      0.22       7                                 

   DEVELOPMENTAL STAGE                 11773      11772      0.02      19                                 

   DISEASE                              6800       4543      0.01      22                                 

   DISRUPTION PHENOTYPE                13004      13004      0.02      17                                 

   DOMAIN                              47213      40715      0.08       9                                 

   ENZYME REGULATION                   14212      14210      0.03      16                                 

   FUNCTION                           460619     440759      0.83       2                                 

   INDUCTION                           20003      19995      0.04      14                                 

   INTERACTION                         19095      19095      0.03      15                                 

   MASS SPECTROMETRY                    6635       5017      0.01      23                                 

   MISCELLANEOUS                       37972      35111      0.07      12                                 

   PATHWAY                            137444     124655      0.25       6                                 

   PHARMACEUTICAL                        104        104     <0.01      29                                 

   POLYMORPHISM                         1200       1144     <0.01      24                                 

   PTM                                 54536      40685      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    43953      43953      0.08      11                                 

   SIMILARITY                         504938     500792      0.91       1                                 

   SUBCELLULAR LOCATION               346329     339176      0.62       3                                 

   SUBUNIT                            273998     273714      0.49       4                                 

   TISSUE SPECIFICITY                  44853      44852      0.08      10                                 

   TOXIC DOSE                            655        604     <0.01      27                                 

   WEB RESOURCE                         6914       5755      0.01      21                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4407075                 7.92                                         

   ACT_SITE                           162174      98246      0.29      10                                 

   BINDING                            397867     104486      0.71       2                                 

   CA_BIND                              4165       1726      0.01      36                                 

   CARBOHYD                           115207      29505      0.21      15                                 

   CHAIN                              564375     549725      1.01       1                                 

   COILED                              21957      15176      0.04      27                                 

   COMPBIAS                            58777      31594      0.11      19                                 

   CONFLICT                           134518      47084      0.24      13                                 

   CROSSLNK                            23242       8320      0.04      26                                 

   DISULFID                           122078      32979      0.22      14                                 

   DNA_BIND                            11577      10474      0.02      32                                 

   DOMAIN                             191028     117730      0.34       9                                 

   HELIX                              242217      22551      0.44       7                                 

   INIT_MET                            17067      17067      0.03      28                                 

   INTRAMEM                             2622       1178     <0.01      37                                 

   LIPID                               12918       8337      0.02      30                                 

   METAL                              373719      93245      0.67       3                                 

   MOD_RES                            246985      71154      0.44       6                                 

   MOTIF                               42031      27565      0.08      23                                 

   MUTAGEN                             65474      14542      0.12      18                                 

   NON_CONS                             2248        783     <0.01      38                                 

   NON_STD                               360        285     <0.01      39                                 

   NON_TER                             12275       9390      0.02      31                                 

   NP_BIND                            154800      84368      0.28      11                                 

   PEPTIDE                             11267       7729      0.02      33                                 

   PROPEP                              13888      11900      0.02      29                                 

   REGION                             191577      91393      0.34       8                                 

   REPEAT                             103498      14669      0.19      16                                 

   SIGNAL                              41244      41234      0.07      24                                 

   SITE                                55786      31122      0.10      21                                 

   STRAND                             252718      21241      0.45       5                                 

   TOPO_DOM                           139036      28531      0.25      12                                 

   TRANSIT                              9025       8909      0.02      34                                 

   TRANSMEM                           368573      76865      0.66       4                                 

   TURN                                58302      18278      0.10      20                                 

   UNSURE                               4429        788      0.01      35                                 

   VAR_SEQ                             51772      21885      0.09      22                                 

   VARIANT                             95887      17021      0.17      17                                 

   ZN_FING                             30392      13368      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18382524                33.03                                                           

   Allergome                            1732       1130     <0.01     118      Protein family/group databases               

   ArachnoServer                        1149       1140     <0.01     125      Organism-specific databases                  

   Araport                             15641      15547      0.03      82      Organism-specific databases                  

   Bgee                                56079      56078      0.10      44      Gene expression databases                    

   BindingDB                            4901       4901      0.01     102      Chemistry                                    

   BioCyc                              44432      41118      0.08      53      Enzyme and pathway databases                 

   BioGrid                             50180      49701      0.09      49      Protein-protein interaction databases        

   BioMuta                             17242      17237      0.03      76      Polymorphism and mutation databases          

   BRENDA                              12858      12086      0.02      86      Enzyme and pathway databases                 

   CAZy                                 9446       8520      0.02      89      Protein family/group databases               

   CCDS                                47606      33880      0.09      51      Sequence databases                           

   CDD                                178713     164131      0.32      25      Family and domain databases                  

   CGD                                  1978       1961     <0.01     116      Organism-specific databases                  

   ChEMBL                               6523       6523      0.01      93      Chemistry                                    

   ChiTaRS                             16526      16518      0.03      79      Other                                        

   CleanEx                             30023      29393      0.05      59      Gene expression databases                    

   CollecTF                              133        133     <0.01     144      Gene expression databases                    

   COMPLUYEAST-2DPAGE                     97         97     <0.01     145      2D gel databases                             

   ConoServer                            949        866     <0.01     126      Organism-specific databases                  

   CORUM                                5168       5168      0.01      99      Protein-protein interaction databases        

   CTD                                 74635      73758      0.13      42      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     141      PTM databases                                

   dictyBase                            4212       4097      0.01     105      Organism-specific databases                  

   DIP                                 17332      17300      0.03      75      Protein-protein interaction databases        

   DisGeNET                            14856      14619      0.03      83      Organism-specific databases                  

   DisProt                               708        703     <0.01     130      3D structure databases                       

   DMDM                                16364      16300      0.03      80      Polymorphism and mutation databases          

   DNASU                               18949      18878      0.03      71      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     142      2D gel databases                             

   DrugBank                            18749       3637      0.03      72      Chemistry                                    

   EchoBASE                             4159       4159      0.01     107      Organism-specific databases                  

   EcoGene                              4294       4293      0.01     104      Organism-specific databases                  

   eggNOG                             663077     330844      1.19       5      Phylogenomic databases                       

   ELM                                  1807       1807     <0.01     117      Protein-protein interaction databases        

   EMBL                               986940     544995      1.77       3      Sequence databases                           

   Ensembl                             87786      49554      0.16      40      Genome annotation databases                  

   EnsemblBacteria                    355126     336029      0.64      16      Genome annotation databases                  

   EnsemblFungi                        30406      28683      0.05      58      Genome annotation databases                  

   EnsemblMetazoa                      15864      10581      0.03      81      Genome annotation databases                  

   EnsemblPlants                       28046      20785      0.05      62      Genome annotation databases                  

   EnsemblProtists                      4960       4784      0.01     101      Genome annotation databases                  

   EPD                                 20193      20193      0.04      69      Proteomic databases                          

   ESTHER                               2485       2483     <0.01     113      Protein family/group databases               

   euHCVdb                                55         44     <0.01     147      Organism-specific databases                  

   EuPathDB                            37555      37375      0.07      55      Organism-specific databases                  

   EvolutionaryTrace                   16608      16608      0.03      78      Other                                        

   ExpressionAtlas                     50996      50996      0.09      47      Gene expression databases                    

   FlyBase                              6182       5827      0.01      94      Organism-specific databases                  

   Gene3D                             344331     279292      0.62      17      Family and domain databases                  

   GeneCards                           20206      20037      0.04      67      Organism-specific databases                  

   GeneDB                                571        515     <0.01     134      Genome annotation databases                  

   GeneID                             292496     281812      0.53      21      Genome annotation databases                  

   GeneReviews                          1155       1152     <0.01     124      Organism-specific databases                  

   GeneTree                            58418      58385      0.10      43      Phylogenomic databases                       

   Genevisible                         55211      55211      0.10      45      Gene expression databases                    

   GeneWiki                            10366      10282      0.02      88      Other                                        

   GenomeRNAi                          21980      21978      0.04      65      Other                                        

   GO                                2850015     529941      5.12       1      Ontologies                                   

   Gramene                             28046      20785      0.05      63      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2013       2013     <0.01     115      Chemistry                                    

   H-InvDB                              5588       4767      0.01      98      Organism-specific databases                  

   HAMAP                              328730     326092      0.59      19      Family and domain databases                  

   HGNC                                20191      20049      0.04      70      Organism-specific databases                  

   HOGENOM                            390809     390809      0.70      15      Phylogenomic databases                       

   HOVERGEN                            75910      75910      0.14      41      Phylogenomic databases                       

   HPA                                 27056      16797      0.05      64      Organism-specific databases                  

   IMGT_GENE-DB                          142        142     <0.01     143      Protein family/group databases               

   InParanoid                         136713     136713      0.25      29      Phylogenomic databases                       

   IntAct                              50864      50864      0.09      48      Protein-protein interaction databases        

   InterPro                          2189109     537701      3.93       2      Family and domain databases                  

   iPTMnet                             51222      51222      0.09      46      PTM databases                                

   KEGG                               503424     475053      0.90       8      Genome annotation databases                  

   KO                                 402239     401792      0.72      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     129      Organism-specific databases                  

   Leproma                               672        669     <0.01     132      Organism-specific databases                  

   MaizeGDB                              509        505     <0.01     135      Organism-specific databases                  

   MalaCards                            4165       4163      0.01     106      Organism-specific databases                  

   MaxQB                               29725      29725      0.05      60      Proteomic databases                          

   MEROPS                              11362      11362      0.02      87      Protein family/group databases               

   MGI                                 16862      16822      0.03      77      Organism-specific databases                  

   MIM                                 20701      14923      0.04      66      Organism-specific databases                  

   MINT                                31898      31898      0.06      56      Protein-protein interaction databases        

   MoonProt                               63         63     <0.01     146      Protein family/group databases               

   mycoCLAP                              359        354     <0.01     140      Protein family/group databases               

   neXtProt                            20195      20195      0.04      68      Organism-specific databases                  

   OGP                                   374        374     <0.01     139      2D gel databases                             

   OMA                                403396     403396      0.72      13      Phylogenomic databases                       

   OpenTargets                         18163      18008      0.03      74      Organism-specific databases                  

   Orphanet                             6144       3286      0.01      95      Organism-specific databases                  

   OrthoDB                            292548     292548      0.53      20      Phylogenomic databases                       

   PANTHER                            263290     251174      0.47      23      Family and domain databases                  

   PATRIC                              91713      91713      0.16      39      Genome annotation databases                  

   PaxDb                              124247     124247      0.22      32      Proteomic databases                          

   PDB                                155677      25865      0.28      26      3D structure databases                       

   PDBsum                             155677      25865      0.28      27      3D structure databases                       

   PeptideAtlas                        31886      31886      0.06      57      Proteomic databases                          

   PeroxiBase                            772        756     <0.01     128      Protein family/group databases               

   Pfam                               753933     512915      1.35       4      Family and domain databases                  

   PharmGKB                            18373      18331      0.03      73      Organism-specific databases                  

   PhosphoSitePlus                     39007      39007      0.07      54      PTM databases                                

   PhylomeDB                           95515      95515      0.17      37      Phylogenomic databases                       

   PIR                                123963     113528      0.22      33      Sequence databases                           

   PIRSF                              108639     107611      0.20      36      Family and domain databases                  

   PMAP-CutDB                           1461       1461     <0.01     119      Other                                        

   PomBase                              5133       5129      0.01     100      Organism-specific databases                  

   PRIDE                              141698     141698      0.25      28      Proteomic databases                          

   PRINTS                             132779     117313      0.24      31      Family and domain databases                  

   PRO                                 95149      95149      0.17      38      Other                                        

   ProDom                              29117      28934      0.05      61      Family and domain databases                  

   ProMEX                                453        453     <0.01     137      Proteomic databases                          

   PROSITE                            462480     296274      0.83      10      Family and domain databases                  

   ProteinModelPortal                 447682     447682      0.80      11      3D structure databases                       

   Proteomes                          476131     453949      0.86       9      Other                                        

   PseudoCAP                            1332       1323     <0.01     120      Organism-specific databases                  

   Reactome                           117085      35011      0.21      34      Enzyme and pathway databases                 

   REBASE                                403        403     <0.01     138      Protein family/group databases               

   RefSeq                             610417     465833      1.10       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     122      2D gel databases                             

   RGD                                  7946       7945      0.01      90      Organism-specific databases                  

   SABIO-RK                             3649       3649      0.01     109      Enzyme and pathway databases                 

   SFLD                                14105       6486      0.03      85      Family and domain databases                  

   SGD                                  6739       6734      0.01      91      Organism-specific databases                  

   SignaLink                            3026       3026      0.01     111      Enzyme and pathway databases                 

   SIGNOR                               4025       4025      0.01     108      Enzyme and pathway databases                 

   SMART                              191391     141265      0.34      24      Family and domain databases                  

   SMR                                438230     438230      0.79      12      3D structure databases                       

   STRING                             331879     331879      0.60      18      Protein-protein interaction databases        

   SUPFAM                             503616     378767      0.90       7      Family and domain databases                  

   SWISS-2DPAGE                         1178       1178     <0.01     123      2D gel databases                             

   SwissLipids                          1292       1207     <0.01     121      Chemistry                                    

   SwissPalm                            5947       5947      0.01      97      PTM databases                                

   TAIR                                14445      14390      0.03      84      Organism-specific databases                  

   TCDB                                 6574       6539      0.01      92      Protein family/group databases               

   TIGRFAMs                           292424     272418      0.53      22      Family and domain databases                  

   TopDownProteomics                    3248       2968      0.01     110      Proteomic databases                          

   TreeFam                             45228      45220      0.08      52      Phylogenomic databases                       

   TubercuList                          2186       2150     <0.01     114      Organism-specific databases                  

   UCD-2DPAGE                            497        497     <0.01     136      2D gel databases                             

   UCSC                                49684      45433      0.09      50      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     133      PTM databases                                

   UniGene                            109259      95996      0.20      35      Sequence databases                           

   UniPathway                         136183     123408      0.24      30      Enzyme and pathway databases                 

   VectorBase                            674        587     <0.01     131      Genome annotation databases                  

   WBParaSite                             34         34     <0.01     148      Genome annotation databases                  

   World-2DPAGE                          929        918     <0.01     127      2D gel databases                             

   WormBase                             5958       4551      0.01      96      Organism-specific databases                  

   Xenbase                              4515       4509      0.01     103      Organism-specific databases                  

   ZFIN                                 2998       2998      0.01     112      Organism-specific databases                  



Total number of cross-referenced databases: 148



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.61

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.82   Thr (T) 5.35

   Asn (N) 4.05   Gly (G) 7.08   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.37   Ile (I) 5.92   Pro (P) 4.72   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3867 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 78934