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         UniProtKB/Swiss-Prot protein knowledgebase release 2019_03 statistics





1.  INTRODUCTION



Release 2019_03 of 10-Apr-19 of UniProtKB/Swiss-Prot contains 559634 sequence entries,

comprising 201129965 amino acids abstracted from 265241 references. 



411 sequences have been added since release 2019_02, the sequence data of

63 existing entries has been updated and the annotations of

145277 entries have been revised.



Number of fragments: 9168

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40033





Protein existence (PE):           entries     %



1: Evidence at protein level       100377   17.9%

2: Evidence at transcript level     57168   10.2%

3: Inferred from homology          386786   69.1%

4: Predicted                        13478    2.4%

5: Uncertain                         1825    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13741



   The first twenty species represent 120805 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5673

                            2x: 1970

                            3x: 1067

                            4x:  698

                            5x:  513

                            6x:  412

                            7x:  299

                            8x:  248

                            9x:  228

                           10x:  142

                       11- 20x:  759

                       21- 50x:  461

                       51-100x:  220

                         >100x: 1051





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20415  Homo sapiens (Human)

       2      17013  Mus musculus (Mouse)

       3      15834  Arabidopsis thaliana (Mouse-ear cress)

       4       8061  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6006  Bos taurus (Bovine)

       7       5140  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4481  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4146  Dictyostelium discoideum (Slime mold)

      11       4043  Caenorhabditis elegans

      12       4035  Oryza sativa subsp. japonica (Rice)

      13       3558  Drosophila melanogaster (Fruit fly)

      14       3445  Xenopus laevis (African clawed frog)

      15       3100  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2291  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2173  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2039  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1797  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1683  Shigella flexneri

      27       1428  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1328  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1174  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1064  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1034  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35       1010  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        977  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        940  Emericella nidulans  

      38        931  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      40        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      41        927  Staphylococcus aureus (strain N315)

      42        919  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        900  Staphylococcus aureus (strain COL)

      45        896  Staphylococcus aureus (strain MW2)

      46        894  Oryctolagus cuniculus (Rabbit)

      47        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      48        889  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        883  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      51        882  Salmonella choleraesuis (strain SC-B67)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        856  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        839  Oryza sativa subsp. indica (Rice)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        829  Shigella boydii serotype 4 (strain Sb227)

      60        825  Canis lupus familiaris (Dog) (Canis familiaris)

      61        825  Escherichia coli (strain UTI89 / UPEC)

      62        822  Shigella dysenteriae serotype 1 (strain Sd197)

      63        821  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      64        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      65        814  Zea mays (Maize)

      66        803  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      67        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      68        792  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      69        791  Escherichia coli (strain SMS-3-5 / SECEC)

      70        784  Aquifex aeolicus (strain VF5)

      71        776  Pasteurella multocida (strain Pm70)

      72        771  Escherichia coli (strain K12 / DH10B)

      73        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        766  Staphylococcus aureus (strain NCTC 8325)

      75        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      76        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        760  Shigella flexneri serotype 5b (strain 8401)

      81        759  Staphylococcus epidermidis (strain ATCC 12228)

      82        756  Escherichia coli (strain SE11)

      83        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        751  Bacillus anthracis

      86        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      87        746  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      88        741  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Enterobacter sp. (strain 638)

      97        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      98        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      99        714  Salmonella paratyphi A (strain AKU_12601)

     100        714  Escherichia coli O1:K1 / APEC

     101        713  Salmonella agona (strain SL483)

     102        713  Salmonella newport (strain SL254)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     109        698  Klebsiella pneumoniae (strain 342)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        674  Escherichia coli

     118        673  Staphylococcus aureus (strain USA300)

     119        672  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        664  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     124        664  Bradyrhizobium diazoefficiens 

     125        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        650  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        645  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Treponema pallidum (strain Nichols)

     134        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     135        620  Methanothermobacter thermautotrophicus  

     136        615  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     137        614  Staphylococcus haemolyticus (strain JCSC1435)

     138        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     139        610  Xanthomonas campestris pv. campestris 

     140        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     141        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     142        602  Staphylococcus saprophyticus subsp. saprophyticus 

     143        602  Photobacterium profundum (strain SS9)

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        595  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     147        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     148        594  Pseudomonas aeruginosa (strain UCBPP-PA14)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        580  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        559  Clostridium acetobutylicum 

     165        557  Xanthomonas axonopodis pv. citri (strain 306)

     166        555  Pseudomonas fluorescens (strain Pf0-1)

     167        555  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     168        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     169        553  Oceanobacillus iheyensis 

     170        551  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     171        550  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        537  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Listeria monocytogenes serotype 4b (strain F2365)

     176        529  Corynebacterium glutamicum 

     177        529  Sodalis glossinidius (strain morsitans)

     178        527  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        522  Xylella fastidiosa (strain 9a5c)

     180        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     181        517  Chromobacterium violaceum 

     182        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        514  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     185        513  Staphylococcus aureus (strain Newman)

     186        513  Deinococcus radiodurans 

     187        513  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     188        512  Pseudomonas aeruginosa (strain PA7)

     189        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     190        510  Geobacillus kaustophilus (strain HTA426)

     191        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     192        508  Streptomyces avermitilis 

     193        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     194        502  Pseudomonas entomophila (strain L48)

     195        501  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     196        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     199        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     200        497  Haemophilus influenzae (strain 86-028NP)

     201        496  Burkholderia pseudomallei (strain K96243)

     202        496  Bacillus clausii (strain KSM-K16)

     203        494  Proteus mirabilis (strain HI4320)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        488  Methanosarcina mazei  

     209        487  Pyrococcus horikoshii 

     210        487  Shewanella sp. (strain MR-7)

     211        486  Mannheimia succiniciproducens (strain MBEL55E)

     212        485  Thermosynechococcus elongatus (strain BP-1)

     213        485  Brucella abortus (strain 2308)

     214        484  Pseudomonas aeruginosa (strain LESB58)

     215        484  Shewanella sp. (strain MR-4)

     216        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     217        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     218        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     219        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        479  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     221        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     222        477  Pyrococcus abyssi (strain GE5 / Orsay)

     223        477  Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 

     224        476  Nicotiana tabacum (Common tobacco)

     225        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     226        474  Burkholderia lata 

     227        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     228        468  Clostridium perfringens (strain 13 / Type A)

     229        468  Pseudomonas putida (strain GB-1)

     230        467  Shewanella frigidimarina (strain NCIMB 400)

     231        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     232        466  Shewanella sp. (strain ANA-3)

     233        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     234        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     235        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     236        465  Enterococcus faecalis (strain ATCC 700802 / V583)

     237        464  Aeromonas hydrophila subsp. hydrophila 

     238        463  Burkholderia mallei (strain ATCC 23344)

     239        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        459  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     241        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     242        457  Ovis aries (Sheep)

     243        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     244        455  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        455  Staphylococcus aureus (strain JH1)

     246        453  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     247        453  Pseudomonas putida (strain W619)

     248        452  Aeromonas salmonicida (strain A449)

     249        452  Shewanella baltica (strain OS185)

     250        450  Caldanaerobacter subterraneus subsp. tengcongensis  





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19553 (  3%)

    Bacteria         333879 ( 60%)

    Eukaryota        189358 ( 34%)

    Viruses           16844 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20416 ( 11%)           (  4%)

     Other Mammalia         46721 ( 25%)           (  8%)

     Other Vertebrata       18371 ( 10%)           (  3%)

     Viridiplantae          39840 ( 21%)           (  7%)

     Fungi                  34064 ( 18%)           (  6%)

     Insecta                 9236 (  5%)           (  2%)

     Nematoda                4949 (  3%)           (  1%)

     Other                  15761 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9590             1001-1100     3999

                 51- 100   42641             1101-1200     2802

                101- 150   59080             1201-1300     2145

                151- 200   58916             1301-1400     2004

                201- 250   57774             1401-1500     1625

                251- 300   51502             1501-1600      794

                301- 350   51896             1601-1700      619

                351- 400   45036             1701-1800      560

                401- 450   37012             1801-1900      475

                451- 500   29857             1901-2000      378

                501- 550   21574             2001-2100      250

                551- 600   15377             2101-2200      341

                601- 650   12839             2201-2300      315

                651- 700    9226             2301-2400      214

                701- 750    7654             2401-2500      163

                751- 800    5540             >2500         1306

                801- 850    4777

                851- 900    5208

                901- 950    4051

                951-1000    2926



   





   The average sequence length in UniProtKB/Swiss-Prot is 359 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2781





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  879

                       2x:  396

                       3x:  164

                       4x:  136

                       5x:  108

                       6x:   99

                       7x:   72

                       8x:   54

                       9x:   34

                      10x:   39

                  11- 20x:  217

                  21- 50x:  231

                  51-100x:  121

                    >100x:  231





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24633   Journal of Biological Chemistry

    2        11446   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6625   Journal of Bacteriology

    4         5647   Biochemical and Biophysical Research Communications

    5         5350   Biochemistry

    6         5005   Nucleic Acids Research

    7         4830   FEBS Letters

    8         4808   Gene

    9         4695   The EMBO Journal

   10         4543   Nature

   11         4346   Molecular and Cellular Biology

   12         4271   Journal of Molecular Biology

   13         3640   Biochimica et Biophysica Acta

   14         3580   Cell

   15         3400   European Journal of Biochemistry

   16         3262   Journal of Virology

   17         3019   Science

   18         2864   Biochemical Journal

   19         2562   Plant Physiology

   20         2537   Molecular Microbiology

   21         2535   Genomics

   22         2203   Journal of Cell Biology

   23         2155   The American Journal of Human Genetics

   24         1999   The Plant Cell

   25         1921   PLoS ONE

   26         1863   Plant Molecular Biology

   27         1840   The Plant Journal

   28         1837   Genes and Development

   29         1814   Human Molecular Genetics

   30         1803   Virology

   31         1757   Nature Genetics

   32         1673   Development

   33         1667   Molecular Biology of the Cell

   34         1576   Human Mutation

   35         1547   Molecular Cell

   36         1541   Oncogene

   37         1469   Journal of Immunology

   38         1395   Molecular and General Genetics

   39         1348   Structure

   40         1340   Journal of Biochemistry

   41         1314   Genetics

   42         1258   Journal of Cell Science

   43         1159   Blood

   44         1146   Journal of General Virology

   45         1118   Infection and Immunity

   46         1060   Microbiology

   47         1051   Current Biology

   48         1049   Developmental Biology

   49         1047   Archives of Biochemistry and Biophysics

   50          906   Journal of Neuroscience

   51          904   Applied and Environmental Microbiology

   52          884   Acta Crystallographica, Section D

   53          884   Cancer Research

   54          838   Yeast

   55          837   FEMS Microbiology Letters

   56          775   Protein Science

   57          772   Toxicon

   58          751   Neuron

   59          732   Journal of Clinical Investigation

   60          692   Human Genetics

   61          677   American Journal of Physiology

   62          676   Plant and Cell Physiology

   63          649   Mechanisms of Development

   64          647   The Journal of Experimental Medicine

   65          646   Nature Structural Biology

   66          643   PLoS Genetics

   67          621   Proteins

   68          608   Journal of Medical Genetics

   69          576   Nature Cell Biology

   70          574   Current Genetics

   71          551   Bioscience, Biotechnology, and Biochemistry

   72          539   Nature Structural and Molecular Biology

   73          536   Journal of Neurochemistry

   74          533   Molecular Endocrinology

   75          520   The Journal of Clinical Endocrinology and Metabolism

   76          518   Developmental Cell

   77          511   The FEBS Journal

   78          503   Endocrinology

   79          489   Mammalian Genome

   80          473   Immunogenetics

   81          467   Antimicrobial Agents and Chemotherapy

   82          459   Experimental Cell Research

   83          448   Molecular and Biochemical Parasitology

   84          444   Nature Communications

   85          431   Eukaryotic Cell

   86          429   Planta

   87          417   RNA

   88          412   Peptides

   89          407   Journal of Molecular Evolution

   90          398   Molecular Biology and Evolution

   91          388   Journal of Experimental Botany

   92          388   DNA and Cell Biology

   93          384   Journal of the American Chemical Society

   94          378   Molecular Pharmacology

   95          374   DNA Sequence

   96          373   PLoS Pathogens

   97          370   Scientific Reports

   98          369   Neurology

   99          366   EMBO Reports

  100          362   Journal of Investigative Dermatology

  101          358   The FASEB Journal

  102          350   Comparative Biochemistry and Physiology

  103          350   Acta Crystallographica, Section F

  104          348   Biology of Reproduction

  105          344   American Journal of Medical Genetics. Part A

  106          342   Molecular Plant-Microbe Interactions

  107          339   European Journal of Human Genetics

  108          339   Brain Research. Molecular Brain Research

  109          336   Immunity

  110          326   Tissue Antigens

  111          324   Virus Research

  112          320   The New England Journal of Medicine

  113          319   Genes to Cells

  114          319   Biochimie

  115          314   Developmental Dynamics

  116          299   Clinical Genetics

  117          298   Genome Research

  118          296   Biological Chemistry Hoppe-Seyler

  119          291   Annals of Neurology

  120          284   European Journal of Immunology

  121          282   Cytogenetics and Cell Genetics

  122          272   Nature Immunology

  123          271   BMC Genomics

  124          271   Journal of General Microbiology

  125          268   Investigative Ophthalmology and Visual Science

  126          261   Applied Microbiology and Biotechnology

  127          255   Journal of Human Genetics

  128          254   Journal of Medicinal Chemistry

  129          246   PLoS Biology

  130          242   Archives of Microbiology

  131          237   Journal of Lipid Research

  132          235   Glycobiology

  133          231   DNA Research

  134          231   Journal of Cellular Biochemistry

  135          230   Traffic

  136          224   Molecular Genetics and Metabolism

  137          220   Cell Cycle

  138          219   Molecular Immunology

  139          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  140          216   Circulation Research

  141          213   Archives of Virology

  142          212   Cell Reports

  143          212   Diabetes

  144          208   Molecular and Cellular Endocrinology

  145          206   Nature Medicine

  146          205   Phytochemistry

  147          204   Protein Expression and Purification

  148          204   Fungal Genetics and Biology

  149          196   Molecular Genetics and Genomics

  150          187   Chemistry and Biology





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1223354                 2.19                                         

   Journal                           1046418     455995      1.87       1                                 

   Submitted to EMBL/GenBank/DDBJ     166105     150455      0.30       2                                 

   Submitted to other databases         7391       6823      0.01       3                                 

   Book citation                        1772       1749     <0.01       4                                 

   Plant Gene Register                   612        599     <0.01       5                                 

   Thesis                                434        431     <0.01       6                                 

   Unpublished observations              407        403     <0.01       7                                 

   Patent                                209        203     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 410399



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2542077                 4.54                                         

   ACTIVITY REGULATION                 14924      14924      0.03      16                                 

   ALLERGEN                              774        774     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25273      25273      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8348       8348      0.01      20                                 

   BIOTECHNOLOGY                        1005        990     <0.01      25                                 

   CATALYTIC ACTIVITY                 285167     238633      0.51       4                                 

   CAUTION                             13023      12761      0.02      18                                 

   COFACTOR                           124248     113744      0.22       7                                 

   DEVELOPMENTAL STAGE                 12222      12221      0.02      19                                 

   DISEASE                              7060       4741      0.01      21                                 

   DISRUPTION PHENOTYPE                14548      14545      0.03      17                                 

   DOMAIN                              49201      42263      0.09       9                                 

   FUNCTION                           467636     446818      0.84       2                                 

   INDUCTION                           21094      21082      0.04      14                                 

   INTERACTION                         19234      19234      0.03      15                                 

   MASS SPECTROMETRY                    6972       5261      0.01      22                                 

   MISCELLANEOUS                       38672      35586      0.07      12                                 

   PATHWAY                            138514     125660      0.25       6                                 

   PHARMACEUTICAL                        117        113     <0.01      29                                 

   POLYMORPHISM                         1323       1267     <0.01      24                                 

   PTM                                 57212      42070      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44082      44082      0.08      11                                 

   SIMILARITY                         508552     504404      0.91       1                                 

   SUBCELLULAR LOCATION               349710     342280      0.62       3                                 

   SUBUNIT                            278915     278067      0.50       5                                 

   TISSUE SPECIFICITY                  46080      46079      0.08      10                                 

   TOXIC DOSE                            671        613     <0.01      27                                 

   WEB RESOURCE                         6873       5711      0.01      23                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4512213                 8.06                                         

   ACT_SITE                           164291      99730      0.29      10                                 

   BINDING                            406856     107749      0.73       2                                 

   CA_BIND                              4177       1730      0.01      36                                 

   CARBOHYD                           116314      29890      0.21      15                                 

   CHAIN                              567612     552545      1.01       1                                 

   COILED                              22039      15232      0.04      27                                 

   COMPBIAS                            59073      31776      0.11      21                                 

   CONFLICT                           135379      47390      0.24      13                                 

   CROSSLNK                            23651       8488      0.04      26                                 

   DISULFID                           125790      33822      0.22      14                                 

   DNA_BIND                            11678      10556      0.02      32                                 

   DOMAIN                             197127     120870      0.35       9                                 

   HELIX                              257934      23793      0.46       6                                 

   INIT_MET                            17173      17173      0.03      28                                 

   INTRAMEM                             2706       1223     <0.01      37                                 

   LIPID                               13067       8439      0.02      30                                 

   METAL                              382309      94663      0.68       3                                 

   MOD_RES                            249151      71952      0.45       7                                 

   MOTIF                               43320      28215      0.08      23                                 

   MUTAGEN                             71238      15534      0.13      18                                 

   NON_CONS                             2258        788     <0.01      38                                 

   NON_STD                               357        282     <0.01      39                                 

   NON_TER                             12410       9526      0.02      31                                 

   NP_BIND                            157851      85795      0.28      11                                 

   PEPTIDE                             11617       7994      0.02      33                                 

   PROPEP                              14275      12171      0.03      29                                 

   REGION                             199883      94187      0.36       8                                 

   REPEAT                             105602      14770      0.19      16                                 

   SIGNAL                              41894      41893      0.07      24                                 

   SITE                                59215      32235      0.11      20                                 

   STRAND                             268686      22399      0.48       5                                 

   TOPO_DOM                           140500      28782      0.25      12                                 

   TRANSIT                              9111       8995      0.02      34                                 

   TRANSMEM                           371283      77505      0.66       4                                 

   TURN                                62193      19298      0.11      19                                 

   UNSURE                               4461        803      0.01      35                                 

   VAR_SEQ                             52030      22040      0.09      22                                 

   VARIANT                             97151      17104      0.17      17                                 

   ZN_FING                             30551      13418      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               19010780                33.97                                                           

   Allergome                            1805       1179     <0.01     121      Protein family/group databases               

   ArachnoServer                        1145       1136     <0.01     130      Organism-specific databases                  

   Araport                             15855      15759      0.03      83      Organism-specific databases                  

   Bgee                                56548      56548      0.10      45      Gene expression databases                    

   BindingDB                            5001       5001      0.01     102      Chemistry                                    

   BioCyc                             269794     244259      0.48      23      Enzyme and pathway databases                 

   BioGrid                             51782      51278      0.09      48      Protein-protein interaction databases        

   BioMuta                             20371      20359      0.04      70      Polymorphism and mutation databases          

   BRENDA                              12919      12145      0.02      86      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     129      PTM databases                                

   CAZy                                 9499       8563      0.02      89      Protein family/group databases               

   CCDS                                48190      34163      0.09      51      Sequence databases                           

   CDD                                185307     169310      0.33      27      Family and domain databases                  

   CGD                                  1998       1981     <0.01     118      Organism-specific databases                  

   ChEMBL                               6869       6869      0.01      96      Chemistry                                    

   ChiTaRS                             20481      20470      0.04      69      Other                                        

   CollecTF                              133        133     <0.01     152      Gene expression databases                    

   ComplexPortal                        8717       4621      0.02      90      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     153      2D gel databases                             

   ConoServer                            952        869     <0.01     131      Organism-specific databases                  

   CORUM                                5802       5802      0.01      99      Protein-protein interaction databases        

   CTD                                 75058      74156      0.13      43      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     149      PTM databases                                

   dictyBase                            4220       4105      0.01     108      Organism-specific databases                  

   DIP                                 17387      17355      0.03      78      Protein-protein interaction databases        

   DisGeNET                            14834      14602      0.03      84      Organism-specific databases                  

   DisProt                               708        703     <0.01     135      3D structure databases                       

   DMDM                                16274      16272      0.03      82      Polymorphism and mutation databases          

   DNASU                               18999      18933      0.03      74      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     151      2D gel databases                             

   DrugBank                            18747       3637      0.03      75      Chemistry                                    

   EchoBASE                             4159       4159      0.01     109      Organism-specific databases                  

   EcoGene                              4293       4293      0.01     107      Organism-specific databases                  

   eggNOG                             665317     331940      1.19       5      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     120      Protein-protein interaction databases        

   EMBL                               985520     547789      1.76       3      Sequence databases                           

   Ensembl                             91577      50673      0.16      41      Genome annotation databases                  

   EnsemblBacteria                    355532     336401      0.64      17      Genome annotation databases                  

   EnsemblFungi                        29481      27926      0.05      59      Genome annotation databases                  

   EnsemblMetazoa                      17380      10162      0.03      79      Genome annotation databases                  

   EnsemblPlants                       28020      20940      0.05      62      Genome annotation databases                  

   EnsemblProtists                      4997       4812      0.01     103      Genome annotation databases                  

   EPD                                 21830      21830      0.04      67      Proteomic databases                          

   ESTHER                               2518       2518     <0.01     116      Protein family/group databases               

   euHCVdb                                55         44     <0.01     155      Organism-specific databases                  

   EuPathDB                            38827      38634      0.07      55      Organism-specific databases                  

   EvolutionaryTrace                   16632      16632      0.03      81      Other                                        

   ExpressionAtlas                     41010      41010      0.07      53      Gene expression databases                    

   FlyBase                              4863       4737      0.01     104      Organism-specific databases                  

   Gene3D                             368325     293931      0.66      16      Family and domain databases                  

   GeneCards                           20369      20198      0.04      71      Organism-specific databases                  

   GeneDB                                575        519     <0.01     139      Genome annotation databases                  

   GeneID                             290244     280259      0.52      22      Genome annotation databases                  

   GeneReviews                          1479       1475     <0.01     122      Organism-specific databases                  

   GeneTree                            59087      59045      0.11      44      Phylogenomic databases                       

   Genevisible                         55239      55239      0.10      46      Gene expression databases                    

   GeneWiki                            10355      10272      0.02      88      Other                                        

   GenomeRNAi                          22116      22116      0.04      66      Other                                        

   GlyConnect                           1435       1367     <0.01     123      PTM databases                                

   GO                                2946731     533574      5.27       1      Ontologies                                   

   Gramene                             28020      20940      0.05      61      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  1957       1957     <0.01     119      Chemistry                                    

   H-InvDB                              5626       4800      0.01     100      Organism-specific databases                  

   HAMAP                              329890     327004      0.59      18      Family and domain databases                  

   HGNC                                20355      20216      0.04      73      Organism-specific databases                  

   HOGENOM                            391885     391885      0.70      15      Phylogenomic databases                       

   HOVERGEN                            76141      76141      0.14      42      Phylogenomic databases                       

   HPA                                 27387      16821      0.05      63      Organism-specific databases                  

   IMGT_GENE-DB                          253        253     <0.01     148      Protein family/group databases               

   InParanoid                         139651     139651      0.25      30      Phylogenomic databases                       

   IntAct                              53396      53396      0.10      47      Protein-protein interaction databases        

   InterPro                          2252569     541240      4.03       2      Family and domain databases                  

   iPTMnet                             51309      51309      0.09      49      PTM databases                                

   jPOST                               26831      26831      0.05      64      Proteomic databases                          

   KEGG                               502314     475047      0.90       7      Genome annotation databases                  

   KO                                 405342     404902      0.72      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     134      Organism-specific databases                  

   Leproma                               672        669     <0.01     136      Organism-specific databases                  

   MaizeGDB                              510        506     <0.01     140      Organism-specific databases                  

   MalaCards                            4499       4496      0.01     106      Organism-specific databases                  

   MaxQB                               29634      29634      0.05      58      Proteomic databases                          

   MEROPS                              11409      11409      0.02      87      Protein family/group databases               

   MGI                                 16923      16883      0.03      80      Organism-specific databases                  

   MIM                                 21149      15129      0.04      68      Organism-specific databases                  

   MINT                                22414      22414      0.04      65      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     146      Protein family/group databases               

   MoonProt                              280        280     <0.01     147      Protein family/group databases               

   mycoCLAP                              355        352     <0.01     145      Protein family/group databases               

   neXtProt                            20358      20358      0.04      72      Organism-specific databases                  

   OGP                                   373        373     <0.01     144      2D gel databases                             

   OMA                                408955     408955      0.73      13      Phylogenomic databases                       

   OpenTargets                         18388      18229      0.03      76      Organism-specific databases                  

   Orphanet                             7478       3953      0.01      94      Organism-specific databases                  

   OrthoDB                            256669     256669      0.46      24      Phylogenomic databases                       

   PANTHER                            295623     281644      0.53      20      Family and domain databases                  

   PATRIC                              91950      91950      0.16      40      Genome annotation databases                  

   PaxDb                              124745     124745      0.22      33      Proteomic databases                          

   PDB                                173839      27359      0.31      29      3D structure databases                       

   PDBsum                             173839      27359      0.31      28      3D structure databases                       

   PeptideAtlas                        32157      32157      0.06      57      Proteomic databases                          

   PeroxiBase                            780        758     <0.01     133      Protein family/group databases               

   Pfam                               764654     519673      1.37       4      Family and domain databases                  

   PharmGKB                            18356      18314      0.03      77      Organism-specific databases                  

   PhosphoSitePlus                     39020      39020      0.07      54      PTM databases                                

   PhylomeDB                           96379      96379      0.17      38      Phylogenomic databases                       

   PIR                                124224     113771      0.22      34      Sequence databases                           

   PIRSF                              108967     107938      0.19      37      Family and domain databases                  

   PMAP-CutDB                           1401       1401     <0.01     124      Other                                        

   PomBase                              5132       5128      0.01     101      Organism-specific databases                  

   PRIDE                              230739     230739      0.41      25      Proteomic databases                          

   PRINTS                             132836     117258      0.24      32      Family and domain databases                  

   PRO                                 95975      95975      0.17      39      Other                                        

   ProDom                              29155      28972      0.05      60      Family and domain databases                  

   ProMEX                                457        457     <0.01     142      Proteomic databases                          

   PROSITE                            470252     299488      0.84      10      Family and domain databases                  

   ProteinModelPortal                 449322     449322      0.80      11      3D structure databases                       

   Proteomes                          482085     457797      0.86       9      Other                                        

   ProteomicsDB                        36364      19821      0.06      56      Proteomic databases                          

   PseudoCAP                            1336       1327     <0.01     126      Organism-specific databases                  

   Reactome                           114798      36411      0.21      35      Enzyme and pathway databases                 

   REBASE                                407        407     <0.01     143      Protein family/group databases               

   RefSeq                             608531     463264      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     127      2D gel databases                             

   RGD                                  7985       7984      0.01      92      Organism-specific databases                  

   SABIO-RK                             4099       4099      0.01     110      Enzyme and pathway databases                 

   SFLD                                 8078       5989      0.01      91      Family and domain databases                  

   SGD                                  6740       6735      0.01      97      Organism-specific databases                  

   SignaLink                            3065       3065      0.01     115      Enzyme and pathway databases                 

   SIGNOR                               4083       4083      0.01     111      Enzyme and pathway databases                 

   SMART                              192599     142044      0.34      26      Family and domain databases                  

   SMR                                445310     445310      0.80      12      3D structure databases                       

   STRING                             328201     328201      0.59      19      Protein-protein interaction databases        

   SUPFAM                             498790     378239      0.89       8      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     128      2D gel databases                             

   SwissLipids                          1367       1279     <0.01     125      Chemistry                                    

   SwissPalm                            7683       7683      0.01      93      PTM databases                                

   TAIR                                14642      14586      0.03      85      Organism-specific databases                  

   TCDB                                 6977       6924      0.01      95      Protein family/group databases               

   TIGRFAMs                           292468     272476      0.52      21      Family and domain databases                  

   TopDownProteomics                    3241       2964      0.01     113      Proteomic databases                          

   TreeFam                             45532      45522      0.08      52      Phylogenomic databases                       

   TubercuList                          2191       2155     <0.01     117      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     141      2D gel databases                             

   UCSC                                49972      45646      0.09      50      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     138      PTM databases                                

   UniGene                            109966      96369      0.20      36      Sequence databases                           

   UniLectin                             238        238     <0.01     150      Protein family/group databases               

   UniPathway                         136487     123677      0.24      31      Enzyme and pathway databases                 

   VectorBase                            597        517     <0.01     137      Genome annotation databases                  

   VGNC                                 3924       3924      0.01     112      Organism-specific databases                  

   WBParaSite                             57         56     <0.01     154      Genome annotation databases                  

   World-2DPAGE                          931        920     <0.01     132      2D gel databases                             

   WormBase                             6075       4642      0.01      98      Organism-specific databases                  

   Xenbase                              4649       4603      0.01     105      Organism-specific databases                  

   ZFIN                                 3079       3074      0.01     114      Organism-specific databases                  



Total number of cross-referenced databases: 155



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.62

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.05   Gly (G) 7.07   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3897 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79347