Home  |  Contact



         UniProtKB/Swiss-Prot protein knowledgebase release 2019_07 statistics





1.  INTRODUCTION



Release 2019_07 of 31-Jul-19 of UniProtKB/Swiss-Prot contains 560537 sequence entries,

comprising 201466755 amino acids abstracted from 267799 references. 



78 sequences have been added since release 2019_06, the sequence data of

18 existing entries has been updated and the annotations of

112753 entries have been revised.



Number of fragments: 9172

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40097





Protein existence (PE):           entries     %



1: Evidence at protein level       101247   18.1%

2: Evidence at transcript level     57201   10.2%

3: Inferred from homology          386802     69%

4: Predicted                        13464    2.4%

5: Uncertain                         1823    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13790



   The first twenty species represent 121001 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5687

                            2x: 1974

                            3x: 1072

                            4x:  700

                            5x:  518

                            6x:  410

                            7x:  303

                            8x:  253

                            9x:  229

                           10x:  142

                       11- 20x:  765

                       21- 50x:  462

                       51-100x:  224

                         >100x: 1051





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20431  Homo sapiens (Human)

       2      17019  Mus musculus (Mouse)

       3      15879  Arabidopsis thaliana (Mouse-ear cress)

       4       8071  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6008  Bos taurus (Bovine)

       7       5140  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4519  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4147  Dictyostelium discoideum (Slime mold)

      11       4068  Caenorhabditis elegans

      12       4051  Oryza sativa subsp. japonica (Rice)

      13       3573  Drosophila melanogaster (Fruit fly)

      14       3445  Xenopus laevis (African clawed frog)

      15       3113  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2291  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2181  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2040  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1797  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1685  Shigella flexneri

      27       1431  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1332  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1174  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1066  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1035  Archaeoglobus fulgidus 

      34       1024  Yersinia pestis

      35       1010  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        977  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        940  Emericella nidulans  

      38        940  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      40        929  Staphylococcus aureus (strain N315)

      41        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      42        919  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        902  Staphylococcus aureus (strain COL)

      45        896  Staphylococcus aureus (strain MW2)

      46        894  Oryctolagus cuniculus (Rabbit)

      47        894  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      48        889  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        883  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      51        882  Salmonella choleraesuis (strain SC-B67)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        856  Neurospora crassa 

      56        844  Oryza sativa subsp. indica (Rice)

      57        841  Escherichia coli O9:H4 (strain HS)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        829  Shigella boydii serotype 4 (strain Sb227)

      60        827  Canis lupus familiaris (Dog) (Canis familiaris)

      61        826  Zea mays (Maize)

      62        825  Escherichia coli (strain UTI89 / UPEC)

      63        822  Shigella dysenteriae serotype 1 (strain Sd197)

      64        821  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      65        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      66        803  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      67        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      68        792  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      69        791  Escherichia coli (strain SMS-3-5 / SECEC)

      70        789  Staphylococcus aureus (strain NCTC 8325)

      71        786  Aquifex aeolicus (strain VF5)

      72        776  Pasteurella multocida (strain Pm70)

      73        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        771  Escherichia coli (strain K12 / DH10B)

      75        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      76        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Shigella flexneri serotype 5b (strain 8401)

      80        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      81        759  Staphylococcus epidermidis (strain ATCC 12228)

      82        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        751  Bacillus anthracis

      86        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      87        746  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      88        742  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        721  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      97        715  Enterobacter sp. (strain 638)

      98        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      99        714  Escherichia coli O1:K1 / APEC

     100        714  Salmonella paratyphi A (strain AKU_12601)

     101        713  Salmonella newport (strain SL254)

     102        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     103        713  Salmonella agona (strain SL483)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        675  Staphylococcus aureus (strain USA300)

     118        674  Escherichia coli

     119        672  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        668  Bacillus cereus 

     122        667  Yersinia pestis (strain Pestoides F)

     123        664  Bradyrhizobium diazoefficiens 

     124        664  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     125        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        650  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        650  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        640  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        622  Treponema pallidum (strain Nichols)

     135        620  Methanothermobacter thermautotrophicus  

     136        615  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     137        614  Staphylococcus haemolyticus (strain JCSC1435)

     138        614  Xanthomonas campestris pv. campestris 

     139        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     140        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     141        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     142        602  Photobacterium profundum (strain SS9)

     143        602  Staphylococcus saprophyticus subsp. saprophyticus 

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        598  Pseudomonas aeruginosa (strain UCBPP-PA14)

     147        595  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     148        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        580  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     163        562  Bacillus cereus (strain ZK / E33L)

     164        559  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     165        559  Clostridium acetobutylicum 

     166        557  Xanthomonas axonopodis pv. citri (strain 306)

     167        555  Pseudomonas fluorescens (strain Pf0-1)

     168        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     169        553  Oceanobacillus iheyensis 

     170        551  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     171        550  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        540  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Listeria monocytogenes serotype 4b (strain F2365)

     176        529  Sodalis glossinidius (strain morsitans)

     177        529  Corynebacterium glutamicum 

     178        528  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        524  Staphylococcus aureus (strain Newman)

     180        522  Xylella fastidiosa (strain 9a5c)

     181        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     182        517  Chromobacterium violaceum 

     183        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     184        515  Deinococcus radiodurans 

     185        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     186        514  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     187        513  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     188        512  Pseudomonas aeruginosa (strain PA7)

     189        511  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     190        510  Geobacillus kaustophilus (strain HTA426)

     191        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     192        508  Streptomyces avermitilis 

     193        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     194        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     195        502  Pseudomonas entomophila (strain L48)

     196        501  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     199        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     200        497  Haemophilus influenzae (strain 86-028NP)

     201        496  Bacillus clausii (strain KSM-K16)

     202        496  Burkholderia pseudomallei (strain K96243)

     203        494  Proteus mirabilis (strain HI4320)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        491  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        488  Methanosarcina mazei  

     209        488  Pyrococcus horikoshii 

     210        487  Shewanella sp. (strain MR-7)

     211        486  Mannheimia succiniciproducens (strain MBEL55E)

     212        486  Brucella abortus (strain 2308)

     213        485  Thermosynechococcus elongatus (strain BP-1)

     214        484  Pseudomonas aeruginosa (strain LESB58)

     215        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     216        484  Shewanella sp. (strain MR-4)

     217        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     218        481  Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 

     219        481  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     221        479  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     222        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     223        477  Pyrococcus abyssi (strain GE5 / Orsay)

     224        476  Nicotiana tabacum (Common tobacco)

     225        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     226        474  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     227        474  Burkholderia lata 

     228        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     229        469  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        468  Clostridium perfringens (strain 13 / Type A)

     231        468  Pseudomonas putida (strain GB-1)

     232        467  Shewanella frigidimarina (strain NCIMB 400)

     233        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     234        466  Shewanella sp. (strain ANA-3)

     235        466  Aeromonas hydrophila subsp. hydrophila 

     236        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     237        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     238        465  Enterococcus faecalis (strain ATCC 700802 / V583)

     239        463  Burkholderia mallei (strain ATCC 23344)

     240        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     241        458  Ovis aries (Sheep)

     242        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     243        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     244        455  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        455  Staphylococcus aureus (strain JH1)

     246        455  Shewanella baltica (strain OS185)

     247        453  Pseudomonas putida (strain W619)

     248        453  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     249        452  Aeromonas salmonicida (strain A449)

     250        450  Caldanaerobacter subterraneus subsp. tengcongensis  





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19561 (  3%)

    Bacteria         334117 ( 60%)

    Eukaryota        189998 ( 34%)

    Viruses           16861 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20432 ( 11%)           (  4%)

     Other Mammalia         46753 ( 25%)           (  8%)

     Other Vertebrata       18395 ( 10%)           (  3%)

     Viridiplantae          40050 ( 21%)           (  7%)

     Fungi                  34106 ( 18%)           (  6%)

     Insecta                 9319 (  5%)           (  2%)

     Nematoda                4977 (  3%)           (  1%)

     Other                  15966 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9668             1001-1100     4005

                 51- 100   42705             1101-1200     2808

                101- 150   59182             1201-1300     2148

                151- 200   58999             1301-1400     2013

                201- 250   57860             1401-1500     1627

                251- 300   51565             1501-1600      800

                301- 350   51961             1601-1700      621

                351- 400   45108             1701-1800      561

                401- 450   37074             1801-1900      478

                451- 500   29907             1901-2000      378

                501- 550   21614             2001-2100      250

                551- 600   15400             2101-2200      344

                601- 650   12853             2201-2300      318

                651- 700    9238             2301-2400      214

                701- 750    7667             2401-2500      163

                751- 800    5546             >2500         1314

                801- 850    4786

                851- 900    5210

                901- 950    4052

                951-1000    2928



   





   The average sequence length in UniProtKB/Swiss-Prot is 359 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2814





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  893

                       2x:  407

                       3x:  162

                       4x:  129

                       5x:  111

                       6x:  101

                       7x:   73

                       8x:   57

                       9x:   34

                      10x:   36

                  11- 20x:  222

                  21- 50x:  234

                  51-100x:  121

                    >100x:  234





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24866   Journal of Biological Chemistry

    2        11565   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6652   Journal of Bacteriology

    4         5677   Biochemical and Biophysical Research Communications

    5         5387   Biochemistry

    6         5020   Nucleic Acids Research

    7         4853   FEBS Letters

    8         4817   Gene

    9         4711   The EMBO Journal

   10         4600   Nature

   11         4364   Molecular and Cellular Biology

   12         4297   Journal of Molecular Biology

   13         3678   Biochimica et Biophysica Acta

   14         3600   Cell

   15         3406   European Journal of Biochemistry

   16         3278   Journal of Virology

   17         3050   Science

   18         2880   Biochemical Journal

   19         2589   Plant Physiology

   20         2553   Molecular Microbiology

   21         2536   Genomics

   22         2211   Journal of Cell Biology

   23         2183   The American Journal of Human Genetics

   24         2023   The Plant Cell

   25         1976   PLoS ONE

   26         1871   Plant Molecular Biology

   27         1867   The Plant Journal

   28         1842   Genes and Development

   29         1837   Human Molecular Genetics

   30         1813   Virology

   31         1764   Nature Genetics

   32         1681   Molecular Biology of the Cell

   33         1679   Development

   34         1578   Human Mutation

   35         1560   Molecular Cell

   36         1543   Oncogene

   37         1496   Journal of Immunology

   38         1395   Molecular and General Genetics

   39         1361   Structure

   40         1347   Journal of Biochemistry

   41         1318   Genetics

   42         1270   Journal of Cell Science

   43         1167   Blood

   44         1149   Journal of General Virology

   45         1134   Infection and Immunity

   46         1073   Microbiology

   47         1060   Current Biology

   48         1058   Archives of Biochemistry and Biophysics

   49         1055   Developmental Biology

   50          918   Journal of Neuroscience

   51          908   Applied and Environmental Microbiology

   52          895   Acta Crystallographica, Section D

   53          887   Cancer Research

   54          844   FEMS Microbiology Letters

   55          838   Yeast

   56          781   Protein Science

   57          780   Toxicon

   58          765   Neuron

   59          745   Journal of Clinical Investigation

   60          697   Human Genetics

   61          694   American Journal of Physiology

   62          692   Plant and Cell Physiology

   63          661   PLoS Genetics

   64          658   The Journal of Experimental Medicine

   65          649   Mechanisms of Development

   66          646   Nature Structural Biology

   67          631   Proteins

   68          620   Journal of Medical Genetics

   69          581   Nature Cell Biology

   70          574   Current Genetics

   71          554   Bioscience, Biotechnology, and Biochemistry

   72          546   Nature Structural and Molecular Biology

   73          539   Journal of Neurochemistry

   74          539   Molecular Endocrinology

   75          524   The FEBS Journal

   76          521   The Journal of Clinical Endocrinology and Metabolism

   77          519   Developmental Cell

   78          506   Endocrinology

   79          491   Nature Communications

   80          489   Mammalian Genome

   81          477   Antimicrobial Agents and Chemotherapy

   82          475   Immunogenetics

   83          461   Experimental Cell Research

   84          450   Molecular and Biochemical Parasitology

   85          433   Planta

   86          432   Eukaryotic Cell

   87          419   RNA

   88          417   Peptides

   89          409   Scientific Reports

   90          407   Journal of Molecular Evolution

   91          398   Molecular Biology and Evolution

   92          396   PLoS Pathogens

   93          392   Journal of Experimental Botany

   94          389   Journal of the American Chemical Society

   95          388   DNA and Cell Biology

   96          382   Molecular Pharmacology

   97          375   DNA Sequence

   98          370   Neurology

   99          370   The FASEB Journal

  100          369   EMBO Reports

  101          366   Journal of Investigative Dermatology

  102          361   American Journal of Medical Genetics. Part A

  103          358   Acta Crystallographica, Section F

  104          355   Molecular Plant-Microbe Interactions

  105          352   Comparative Biochemistry and Physiology

  106          349   Biology of Reproduction

  107          345   European Journal of Human Genetics

  108          342   Immunity

  109          340   Brain Research. Molecular Brain Research

  110          328   Tissue Antigens

  111          326   Virus Research

  112          325   Genes to Cells

  113          321   The New England Journal of Medicine

  114          321   Biochimie

  115          314   Developmental Dynamics

  116          306   Clinical Genetics

  117          299   Genome Research

  118          297   Biological Chemistry Hoppe-Seyler

  119          296   Annals of Neurology

  120          284   European Journal of Immunology

  121          282   Cytogenetics and Cell Genetics

  122          279   BMC Genomics

  123          277   Nature Immunology

  124          271   Investigative Ophthalmology and Visual Science

  125          271   Journal of General Microbiology

  126          263   Journal of Lipid Research

  127          261   Applied Microbiology and Biotechnology

  128          259   Journal of Medicinal Chemistry

  129          259   Journal of Human Genetics

  130          256   PLoS Biology

  131          245   Archives of Microbiology

  132          239   Glycobiology

  133          233   Journal of Cellular Biochemistry

  134          232   Traffic

  135          232   Molecular Immunology

  136          231   DNA Research

  137          230   Cell Reports

  138          225   Molecular Genetics and Metabolism

  139          221   Cell Cycle

  140          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  141          217   Circulation Research

  142          214   Diabetes

  143          213   Archives of Virology

  144          210   Nature Medicine

  145          208   Molecular and Cellular Endocrinology

  146          207   Phytochemistry

  147          205   Protein Expression and Purification

  148          205   Fungal Genetics and Biology

  149          196   Molecular Genetics and Genomics

  150          190   Molecular and Cellular Neuroscience





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1230038                 2.19                                         

   Journal                           1053709     457730      1.88       1                                 

   Submitted to EMBL/GenBank/DDBJ     165433     149764      0.30       2                                 

   Submitted to other databases         7412       6845      0.01       3                                 

   Book citation                        1810       1787     <0.01       4                                 

   Plant Gene Register                   612        599     <0.01       5                                 

   Thesis                                434        431     <0.01       6                                 

   Unpublished observations              413        409     <0.01       7                                 

   Patent                                209        203     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 415210



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2558216                 4.56                                         

   ACTIVITY REGULATION                 15179      15178      0.03      16                                 

   ALLERGEN                              853        853     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25311      25311      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8586       8586      0.02      20                                 

   BIOTECHNOLOGY                        1031       1016     <0.01      25                                 

   CATALYTIC ACTIVITY                 291054     239675      0.52       4                                 

   CAUTION                             13154      12889      0.02      18                                 

   COFACTOR                           126236     114888      0.23       7                                 

   DEVELOPMENTAL STAGE                 12334      12333      0.02      19                                 

   DISEASE                              7165       4815      0.01      21                                 

   DISRUPTION PHENOTYPE                14927      14924      0.03      17                                 

   DOMAIN                              49857      42755      0.09       9                                 

   FUNCTION                           468952     447904      0.84       2                                 

   INDUCTION                           21531      21519      0.04      14                                 

   INTERACTION                         19336      19336      0.03      15                                 

   MASS SPECTROMETRY                    7032       5299      0.01      22                                 

   MISCELLANEOUS                       38899      35771      0.07      12                                 

   PATHWAY                            138964     125958      0.25       6                                 

   PHARMACEUTICAL                        117        113     <0.01      29                                 

   POLYMORPHISM                         1331       1274     <0.01      24                                 

   PTM                                 57715      42359      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44160      44160      0.08      11                                 

   SIMILARITY                         509363     505197      0.91       1                                 

   SUBCELLULAR LOCATION               350585     343068      0.63       3                                 

   SUBUNIT                            279810     278900      0.50       5                                 

   TISSUE SPECIFICITY                  46518      46517      0.08      10                                 

   TOXIC DOSE                            675        616     <0.01      27                                 

   WEB RESOURCE                         6914       5748      0.01      23                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4548756                 8.11                                         

   ACT_SITE                           164539      99896      0.29      10                                 

   BINDING                            408460     108213      0.73       2                                 

   CA_BIND                              4206       1743      0.01      36                                 

   CARBOHYD                           116699      30015      0.21      15                                 

   CHAIN                              568548     553403      1.01       1                                 

   COILED                              22072      15273      0.04      27                                 

   COMPBIAS                            59133      31809      0.11      21                                 

   CONFLICT                           135719      47491      0.24      13                                 

   CROSSLNK                            23686       8506      0.04      26                                 

   DISULFID                           126435      33986      0.23      14                                 

   DNA_BIND                            11848      10600      0.02      32                                 

   DOMAIN                             197791     121280      0.35       9                                 

   HELIX                              264533      24248      0.47       6                                 

   INIT_MET                            17198      17198      0.03      28                                 

   INTRAMEM                             2791       1275     <0.01      37                                 

   LIPID                               13109       8463      0.02      30                                 

   METAL                              392106      95843      0.70       3                                 

   MOD_RES                            249567      72112      0.45       7                                 

   MOTIF                               43675      28474      0.08      23                                 

   MUTAGEN                             73035      15878      0.13      18                                 

   NON_CONS                             2258        789     <0.01      38                                 

   NON_STD                               357        282     <0.01      39                                 

   NON_TER                             12437       9544      0.02      31                                 

   NP_BIND                            158223      85956      0.28      11                                 

   PEPTIDE                             11673       8042      0.02      33                                 

   PROPEP                              14347      12239      0.03      29                                 

   REGION                             201173      94658      0.36       8                                 

   REPEAT                             105727      14799      0.19      16                                 

   SIGNAL                              42240      42239      0.08      24                                 

   SITE                                59689      32435      0.11      20                                 

   STRAND                             274688      22854      0.49       5                                 

   TOPO_DOM                           141118      28879      0.25      12                                 

   TRANSIT                              9152       9036      0.02      34                                 

   TRANSMEM                           372068      77663      0.66       4                                 

   TURN                                63643      19691      0.11      19                                 

   UNSURE                               4469        805      0.01      35                                 

   VAR_SEQ                             52083      22083      0.09      22                                 

   VARIANT                             97654      17143      0.17      17                                 

   ZN_FING                             30607      13437      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18466894                32.95                                                           

   ABCD                                 1376       1376     <0.01     122      Protocols and materials databases            

   Allergome                            1899       1238     <0.01     117      Protein family/group databases               

   ArachnoServer                        1163       1154     <0.01     126      Organism-specific databases                  

   Araport                             15900      15804      0.03      79      Organism-specific databases                  

   Bgee                                56649      56649      0.10      42      Gene expression databases                    

   BindingDB                            5157       5157      0.01      96      Chemistry                                    

   BioCyc                             269996     244420      0.48      22      Enzyme and pathway databases                 

   BioGrid                             52425      51876      0.09      45      Protein-protein interaction databases        

   BioMuta                             20387      20373      0.04      65      Polymorphism and mutation databases          

   BRENDA                              12936      12162      0.02      82      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     127      PTM databases                                

   CAZy                                 9505       8568      0.02      85      Protein family/group databases               

   CCDS                                48312      34266      0.09      49      Sequence databases                           

   CDD                                186506     169460      0.33      26      Family and domain databases                  

   CGD                                  1998       1981     <0.01     116      Organism-specific databases                  

   ChEMBL                               7280       7159      0.01      91      Chemistry                                    

   ChiTaRS                             20491      20479      0.04      64      Other                                        

   CollecTF                              133        133     <0.01     149      Gene expression databases                    

   ComplexPortal                        8972       4691      0.02      86      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     150      2D gel databases                             

   ConoServer                            952        869     <0.01     128      Organism-specific databases                  

   CORUM                                5805       5805      0.01      95      Protein-protein interaction databases        

   CPTAC                                2221       1423     <0.01     113      Proteomic databases                          

   CTD                                 75191      74292      0.13      40      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     146      PTM databases                                

   dictyBase                            4212       4098      0.01     104      Organism-specific databases                  

   DIP                                 17394      17362      0.03      75      Protein-protein interaction databases        

   DisGeNET                            15731      15500      0.03      80      Organism-specific databases                  

   DisProt                               700        700     <0.01     132      Family and domain databases                  

   DMDM                                16274      16272      0.03      78      Polymorphism and mutation databases          

   DNASU                               19010      18944      0.03      70      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     148      2D gel databases                             

   DrugBank                            18747       3637      0.03      71      Chemistry                                    

   EchoBASE                             4159       4159      0.01     106      Organism-specific databases                  

   EcoGene                              4293       4293      0.01     102      Organism-specific databases                  

   eggNOG                             665883     332214      1.19       5      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     118      Protein-protein interaction databases        

   EMBL                               984958     548626      1.76       3      Sequence databases                           

   Ensembl                             91453      50528      0.16      39      Genome annotation databases                  

   EnsemblBacteria                    355757     336589      0.63      16      Genome annotation databases                  

   EnsemblFungi                        29516      27961      0.05      55      Genome annotation databases                  

   EnsemblMetazoa                      17460      10208      0.03      74      Genome annotation databases                  

   EnsemblPlants                       27943      20923      0.05      57      Genome annotation databases                  

   EnsemblProtists                      5089       4903      0.01      98      Genome annotation databases                  

   EPD                                 22055      22055      0.04      62      Proteomic databases                          

   ESTHER                               2537       2536     <0.01     111      Protein family/group databases               

   euHCVdb                                55         44     <0.01     152      Organism-specific databases                  

   EuPathDB                            19677      19665      0.04      69      Organism-specific databases                  

   EvolutionaryTrace                   16640      16640      0.03      77      Other                                        

   ExpressionAtlas                     49453      49453      0.09      48      Gene expression databases                    

   FlyBase                              4878       4752      0.01      99      Organism-specific databases                  

   Gene3D                             391107     305419      0.70      15      Family and domain databases                  

   GeneCards                           20385      20214      0.04      66      Organism-specific databases                  

   GeneDB                                578        522     <0.01     135      Genome annotation databases                  

   GeneID                             291224     280589      0.52      20      Genome annotation databases                  

   GeneReviews                          1479       1475     <0.01     119      Organism-specific databases                  

   GeneTree                            59311      59271      0.11      41      Phylogenomic databases                       

   Genevisible                         55241      55241      0.10      43      Gene expression databases                    

   GeneWiki                            10355      10272      0.02      84      Other                                        

   GenomeRNAi                          22131      22131      0.04      61      Other                                        

   GlyConnect                           2250       2162     <0.01     112      PTM databases                                

   GO                                2970815     535119      5.30       1      Ontologies                                   

   Gramene                             27943      20923      0.05      56      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  1998       1998     <0.01     115      Chemistry                                    

   HAMAP                              330023     327120      0.59      17      Family and domain databases                  

   HGNC                                20372      20233      0.04      67      Organism-specific databases                  

   HOGENOM                            392093     392093      0.70      14      Phylogenomic databases                       

   HPA                                 27385      16820      0.05      58      Organism-specific databases                  

   IMGT_GENE-DB                          266        266     <0.01     145      Protein family/group databases               

   InParanoid                         139779     139779      0.25      29      Phylogenomic databases                       

   IntAct                              53654      53654      0.10      44      Protein-protein interaction databases        

   InterPro                          2289155     541896      4.08       2      Family and domain databases                  

   iPTMnet                             51311      51311      0.09      46      PTM databases                                

   jPOST                               26849      26849      0.05      59      Proteomic databases                          

   KEGG                               504477     475578      0.90       7      Genome annotation databases                  

   KO                                 406894     406448      0.73      13      Phylogenomic databases                       

   LegioList                             765        763     <0.01     131      Organism-specific databases                  

   Leproma                               672        669     <0.01     133      Organism-specific databases                  

   MaizeGDB                              520        516     <0.01     137      Organism-specific databases                  

   MalaCards                            4499       4496      0.01     101      Organism-specific databases                  

   MaxQB                               29641      29641      0.05      54      Proteomic databases                          

   MEROPS                              11427      11426      0.02      83      Protein family/group databases               

   MGI                                 16929      16889      0.03      76      Organism-specific databases                  

   MIM                                 21301      15179      0.04      63      Organism-specific databases                  

   MINT                                22632      22632      0.04      60      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     143      Protein family/group databases               

   MoonProt                              280        280     <0.01     144      Protein family/group databases               

   mycoCLAP                              355        352     <0.01     142      Protein family/group databases               

   neXtProt                            20352      20352      0.04      68      Organism-specific databases                  

   NIAGADS                                72         72     <0.01     151      Organism-specific databases                  

   OGP                                   373        373     <0.01     141      2D gel databases                             

   OMA                                409717     409717      0.73      12      Phylogenomic databases                       

   OpenTargets                         18427      18269      0.03      72      Organism-specific databases                  

   Orphanet                             7539       3992      0.01      90      Organism-specific databases                  

   OrthoDB                            256957     256957      0.46      23      Phylogenomic databases                       

   PANTHER                            281050     269475      0.50      21      Family and domain databases                  

   PATRIC                              92063      92063      0.16      38      Genome annotation databases                  

   PaxDb                              124827     124827      0.22      32      Proteomic databases                          

   PDB                                180810      27867      0.32      27      3D structure databases                       

   PDBsum                             180810      27867      0.32      28      3D structure databases                       

   PeptideAtlas                        32534      32534      0.06      53      Proteomic databases                          

   PeroxiBase                            781        759     <0.01     130      Protein family/group databases               

   Pfam                               780239     521770      1.39       4      Family and domain databases                  

   PharmGKB                            18355      18312      0.03      73      Organism-specific databases                  

   PhosphoSitePlus                     39022      39022      0.07      52      PTM databases                                

   PhylomeDB                           96419      96419      0.17      36      Phylogenomic databases                       

   PIR                                124308     113845      0.22      33      Sequence databases                           

   PIRSF                              108960     107931      0.19      35      Family and domain databases                  

   PMAP-CutDB                           1401       1401     <0.01     120      Other                                        

   PomBase                              5132       5128      0.01      97      Organism-specific databases                  

   PRIDE                              234480     234480      0.42      24      Proteomic databases                          

   PRINTS                             131712     117042      0.23      31      Family and domain databases                  

   PRO                                 95975      95975      0.17      37      Other                                        

   ProMEX                                462        462     <0.01     139      Proteomic databases                          

   PROSITE                            471615     300044      0.84      10      Family and domain databases                  

   Proteomes                          484086     459714      0.86       9      Other                                        

   ProteomicsDB                        40948      19909      0.07      51      Proteomic databases                          

   PseudoCAP                            1340       1331     <0.01     123      Organism-specific databases                  

   Reactome                           118721      36302      0.21      34      Enzyme and pathway databases                 

   REBASE                                406        406     <0.01     140      Protein family/group databases               

   RefSeq                             612046     466455      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     124      2D gel databases                             

   RGD                                  7994       7993      0.01      89      Organism-specific databases                  

   SABIO-RK                             4263       4263      0.01     103      Enzyme and pathway databases                 

   SFLD                                 8096       6008      0.01      88      Family and domain databases                  

   SGD                                  6740       6735      0.01      93      Organism-specific databases                  

   SignaLink                            3069       3069      0.01     110      Enzyme and pathway databases                 

   SIGNOR                               4199       4199      0.01     105      Enzyme and pathway databases                 

   SMART                              192903     142273      0.34      25      Family and domain databases                  

   SMR                                445437     445437      0.79      11      3D structure databases                       

   STRING                             328460     328460      0.59      18      Protein-protein interaction databases        

   SUPFAM                             499387     378684      0.89       8      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     125      2D gel databases                             

   SwissLipids                          1386       1299     <0.01     121      Chemistry                                    

   SwissPalm                            8602       8602      0.02      87      PTM databases                                

   TAIR                                14686      14630      0.03      81      Organism-specific databases                  

   TCDB                                 7118       7069      0.01      92      Protein family/group databases               

   TIGRFAMs                           292546     272546      0.52      19      Family and domain databases                  

   TopDownProteomics                    3240       2963      0.01     108      Proteomic databases                          

   TreeFam                             45577      45567      0.08      50      Phylogenomic databases                       

   TubercuList                          2199       2163     <0.01     114      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     138      2D gel databases                             

   UCSC                                50050      45713      0.09      47      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     134      PTM databases                                

   UniLectin                             239        239     <0.01     147      Protein family/group databases               

   UniPathway                         136861     123926      0.24      30      Enzyme and pathway databases                 

   VectorBase                            573        497     <0.01     136      Genome annotation databases                  

   VGNC                                 3951       3951      0.01     107      Organism-specific databases                  

   WBParaSite                             32         32     <0.01     153      Genome annotation databases                  

   World-2DPAGE                          931        920     <0.01     129      2D gel databases                             

   WormBase                             6123       4667      0.01      94      Organism-specific databases                  

   Xenbase                              4664       4609      0.01     100      Organism-specific databases                  

   ZFIN                                 3092       3087      0.01     109      Organism-specific databases                  



Total number of cross-referenced databases: 153



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.62

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.05   Gly (G) 7.07   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3914 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79494