UniProtKB/Swiss-Prot protein knowledgebase release 2021_03 statistics
1. INTRODUCTION
Release 2021_03 of 02-Jun-21 of UniProtKB/Swiss-Prot contains 565254 sequence entries,
comprising 203850821 amino acids abstracted from 279685 references.
633 sequences have been added since release 2021_02, the sequence data of
26 existing entries has been updated and the annotations of
279556 entries have been revised.
Number of fragments: 9261
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40563
Protein existence (PE): entries %
1: Evidence at protein level 106971 18.9%
2: Evidence at transcript level 56260 10%
3: Inferred from homology 386903 68.4%
4: Predicted 13273 2.3%
5: Uncertain 1847 0.3%
The growth of the database is summarized below.
2. TAXONOMIC ORIGIN
Total number of species represented in this release of UniProtKB/Swiss-Prot: 14085
The first twenty species represent 121862 sequences: 21.6 % of the total
number of entries.
2.1 Table of the frequency of occurrence of species
Species represented 1x: 5758
2x: 2035
3x: 1090
4x: 728
5x: 513
6x: 430
7x: 319
8x: 256
9x: 234
10x: 144
11- 20x: 824
21- 50x: 475
51-100x: 224
>100x: 1055
2.2 Table of the most represented species
------ --------- --------------------------------------------
Number Frequency Species
------ --------- --------------------------------------------
1 20386 Homo sapiens (Human)
2 17082 Mus musculus (Mouse)
3 16111 Arabidopsis thaliana (Mouse-ear cress)
4 8135 Rattus norvegicus (Rat)
5 6721 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
6 6014 Bos taurus (Bovine)
7 5137 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
8 4519 Escherichia coli (strain K12)
9 4265 Caenorhabditis elegans
10 4191 Bacillus subtilis (strain 168)
11 4150 Dictyostelium discoideum (Slime mold)
12 4119 Oryza sativa subsp. japonica (Rice)
13 3641 Drosophila melanogaster (Fruit fly)
14 3471 Xenopus laevis (African clawed frog)
15 3204 Danio rerio (Zebrafish) (Brachydanio rerio)
16 2297 Gallus gallus (Chicken)
17 2258 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
18 2218 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
19 2045 Escherichia coli O157:H7
20 1898 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
21 1806 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
22 1787 Methanocaldococcus jannaschii
23 1707 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
24 1705 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
25 1702 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
26 1688 Shigella flexneri
27 1438 Sus scrofa (Pig)
28 1403 Pseudomonas aeruginosa
29 1347 Salmonella typhi
30 1244 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
31 1174 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
32 1085 Synechocystis sp. (strain PCC 6803 / Kazusa)
33 1036 Archaeoglobus fulgidus
34 1027 Yersinia pestis
35 1014 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
36 988 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
37 978 Emericella nidulans
38 941 Staphylococcus aureus (strain Mu50 / ATCC 700699)
39 930 Salmonella paratyphi A (strain ATCC 9150 / SARB42)
40 929 Staphylococcus aureus (strain N315)
41 928 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
42 919 Kluyveromyces lactis
43 909 Acanthamoeba polyphaga mimivirus (APMV)
44 903 Staphylococcus aureus (strain COL)
45 896 Staphylococcus aureus (strain MW2)
46 894 Oryctolagus cuniculus (Rabbit)
47 894 Escherichia coli O6:K15:H31 (strain 536 / UPEC)
48 890 Staphylococcus aureus (strain MSSA476)
49 888 Staphylococcus aureus (strain MRSA252)
50 887 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
51 882 Salmonella choleraesuis (strain SC-B67)
52 879 Shigella sonnei (strain Ss046)
53 878 Candida glabrata
54 875 Neurospora crassa
55 863 Yersinia pseudotuberculosis serotype I (strain IP32953)
56 852 Oryza sativa subsp. indica (Rice)
57 847 Escherichia coli O9:H4 (strain HS)
58 839 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
59 834 Escherichia coli O139:H28 (strain E24377A / ETEC)
60 833 Zea mays (Maize)
61 833 Canis lupus familiaris (Dog) (Canis familiaris)
62 829 Shigella boydii serotype 4 (strain Sb227)
63 825 Escherichia coli (strain UTI89 / UPEC)
64 822 Shigella dysenteriae serotype 1 (strain Sd197)
65 819 Escherichia coli
66 808 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
67 803 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
68 800 Staphylococcus aureus (strain NCTC 8325 / PS 47)
69 793 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
70 791 Escherichia coli (strain SMS-3-5 / SECEC)
71 787 Aquifex aeolicus (strain VF5)
72 775 Escherichia coli O127:H6 (strain E2348/69 / EPEC)
73 771 Escherichia coli (strain K12 / DH10B)
74 770 Pasteurella multocida (strain Pm70)
75 765 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
76 765 Escherichia coli (strain K12 / MC4100 / BW2952)
77 762 Escherichia coli (strain 55989 / EAEC)
78 761 Escherichia coli O8 (strain IAI1)
79 760 Shigella flexneri serotype 5b (strain 8401)
80 760 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
81 760 Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
82 758 Escherichia coli O45:K1 (strain S88 / ExPEC)
83 756 Escherichia coli (strain SE11)
84 756 Bacillus anthracis
85 753 Escherichia coli O7:K1 (strain IAI39 / ExPEC)
86 748 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
87 748 Escherichia coli O157:H7 (strain EC4115 / EHEC)
88 742 Bacillus halodurans
89 739 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
90 733 Vibrio vulnificus (strain CMCP6)
91 731 Escherichia coli O81 (strain ED1a)
92 726 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
93 722 Salmonella enteritidis PT4 (strain P125109)
94 718 Vibrio vulnificus (strain YJ016)
95 716 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
96 715 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
97 715 Enterobacter sp. (strain 638)
98 715 Yersinia pestis bv. Antiqua (strain Nepal516)
99 714 Salmonella paratyphi A (strain AKU_12601)
100 714 Escherichia coli O1:K1 / APEC
101 713 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
102 713 Salmonella newport (strain SL254)
103 713 Salmonella agona (strain SL483)
104 712 Salmonella schwarzengrund (strain CVM19633)
105 711 Yersinia pestis bv. Antiqua (strain Antiqua)
106 710 Salmonella heidelberg (strain SL476)
107 702 Salmonella dublin (strain CT_02021853)
108 699 Klebsiella pneumoniae (strain 342)
109 698 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
110 697 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
111 695 Escherichia fergusonii
112 692 Pan troglodytes (Chimpanzee)
113 687 Escherichia coli
114 686 Mycoplasma pneumoniae (strain ATCC 29342 / M129)
115 684 Salmonella gallinarum (strain 287/91 / NCTC 13346)
116 680 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
117 678 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
118 678 Staphylococcus aureus (strain USA300)
119 672 Serratia proteamaculans (strain 568)
120 669 Mycobacterium leprae (strain TN)
121 668 Bacillus cereus
122 667 Yersinia pestis (strain Pestoides F)
123 665 Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
124 664 Bradyrhizobium diazoefficiens
125 658 Sinorhizobium fredii (strain NBRC 101917 / NGR234)
126 653 Shewanella oneidensis (strain MR-1)
127 653 Debaryomyces hansenii
128 651 Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
129 643 Staphylococcus aureus (strain bovine RF122 / ET3-1)
130 642 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
131 641 Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
132 634 Yersinia pseudotuberculosis serotype IB (strain PB1/+)
133 622 Methanothermobacter thermautotrophicus
134 622 Treponema pallidum (strain Nichols)
135 622 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
136 621 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
137 615 Xanthomonas campestris pv. campestris
138 614 Staphylococcus haemolyticus (strain JCSC1435)
139 613 Mesorhizobium japonicum (Mesorhizobium loti
140 612 Pseudomonas aeruginosa (strain UCBPP-PA14)
141 608 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
142 604 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
143 603 Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
144 602 Photobacterium profundum (strain SS9)
145 602 Staphylococcus saprophyticus subsp. saprophyticus
146 601 Salmonella paratyphi C (strain RKS4594)
147 600 Yersinia pestis bv. Antiqua (strain Angola)
148 595 Bacillus cereus (strain ATCC 10987 / NRS 248)
149 591 Pectobacterium carotovorum subsp. carotovorum (strain PC1)
150 584 Rickettsia prowazekii (strain Madrid E)
151 583 Neisseria meningitidis serogroup B (strain MC58)
152 581 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
153 579 Caenorhabditis briggsae
154 579 Brucella suis biovar 1 (strain 1330)
155 574 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
156 573 Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
157 573 Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)
158 572 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
159 569 Bacillus thuringiensis subsp. konkukian (strain 97-27)
160 568 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
161 567 Pseudomonas syringae pv. syringae (strain B728a)
162 564 Bacillus licheniformis
163 562 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
164 562 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
165 562 Bacillus cereus (strain ZK / E33L)
166 559 Clostridium acetobutylicum
167 559 Thermotoga maritima
168 557 Xanthomonas axonopodis pv. citri (strain 306)
169 555 Pseudomonas fluorescens (strain Pf0-1)
170 554 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
171 554 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
172 553 Oceanobacillus iheyensis
173 547 Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv. phaseolicola
174 540 Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
175 534 Corynebacterium glutamicum
176 531 Erwinia tasmaniensis
177 529 Sodalis glossinidius (strain morsitans)
178 529 Listeria monocytogenes serotype 4b (strain F2365)
179 528 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
180 524 Staphylococcus aureus (strain Newman)
181 522 Xylella fastidiosa (strain 9a5c)
182 521 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
183 519 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
184 517 Chromobacterium violaceum
185 516 Deinococcus radiodurans
186 516 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
187 515 Xylella fastidiosa (strain Temecula1 / ATCC 700964)
188 514 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
189 512 Pseudomonas aeruginosa (strain PA7)
190 511 Streptomyces avermitilis
191 510 Haemophilus ducreyi (strain 35000HP / ATCC 700724)
192 510 Geobacillus kaustophilus (strain HTA426)
193 508 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
194 507 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
195 502 Pseudomonas entomophila (strain L48)
196 502 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
197 499 Haemophilus influenzae (strain 86-028NP)
198 499 Brucella abortus biovar 1 (strain 9-941)
199 498 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
200 496 Rickettsia conorii (strain ATCC VR-613 / Malish 7)
201 496 Bacillus clausii (strain KSM-K16)
202 496 Burkholderia pseudomallei (strain K96243)
203 494 Xanthomonas campestris pv. campestris (strain 8004)
204 494 Proteus mirabilis (strain HI4320)
205 494 Pyrococcus horikoshii
206 493 Thermosynechococcus elongatus (strain BP-1)
207 492 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42)
208 491 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
209 491 Vibrio campbellii (strain ATCC BAA-1116 / BB120)
210 490 Methanosarcina mazei
211 489 Brucella abortus (strain 2308)
212 489 Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
213 487 Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans R2)
214 487 Shewanella sp. (strain MR-7)
215 486 Mannheimia succiniciproducens (strain MBEL55E)
216 484 Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
217 484 Staphylococcus aureus (strain Mu3 / ATCC 700698)
218 484 Pseudomonas aeruginosa (strain LESB58)
219 484 Shewanella sp. (strain MR-4)
220 483 Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
221 482 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
222 480 Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
223 478 Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)
224 477 Pyrococcus abyssi (strain GE5 / Orsay)
225 477 Nicotiana tabacum (Common tobacco)
226 475 Cupriavidus necator
227 475 Burkholderia lata
228 472 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
229 469 Clostridium perfringens (strain 13 / Type A)
230 469 Rhodobacter sphaeroides
231 468 Pseudomonas putida (strain GB-1)
232 467 Shewanella frigidimarina (strain NCIMB 400)
233 467 Aeromonas hydrophila subsp. hydrophila
234 467 Enterococcus faecalis (strain ATCC 700802 / V583)
235 467 Campylobacter jejuni subsp. jejuni serotype O:2
236 466 Shewanella sp. (strain ANA-3)
237 466 Xanthomonas campestris pv. vesicatoria (strain 85-10)
238 465 Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)
239 463 Burkholderia mallei (strain ATCC 23344)
240 459 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
241 459 Ovis aries (Sheep)
242 458 Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
243 457 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
244 455 Staphylococcus aureus (strain JH1)
245 455 Shewanella baltica (strain OS185)
246 455 Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
247 453 Pseudomonas putida (strain W619)
248 453 Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
249 452 Aeromonas salmonicida (strain A449)
250 451 Caldanaerobacter subterraneus subsp. tengcongensis
2.3 Taxonomic distribution of the sequences
Kingdom sequences (% of the database)
Archaea 19653 ( 3%)
Bacteria 335066 ( 59%)
Eukaryota 193521 ( 34%)
Viruses 17014 ( 3%)
Within Eukaryota:
Category sequences (% of Eukaryota) (% of the complete database)
Human 20387 ( 11%) ( 4%)
Other Mammalia 47033 ( 24%) ( 8%)
Other Vertebrata 18677 ( 10%) ( 3%)
Viridiplantae 40925 ( 21%) ( 7%)
Fungi 35360 ( 18%) ( 6%)
Insecta 9457 ( 5%) ( 2%)
Nematoda 5174 ( 3%) ( 1%)
Other 16508 ( 9%) ( 3%)
3. SEQUENCE SIZE
Repartition of the sequences by size (excluding fragments)
From To Number From To Number
1- 50 9789 1001-1100 4045
51- 100 43089 1101-1200 2850
101- 150 59497 1201-1300 2180
151- 200 59219 1301-1400 2045
201- 250 58118 1401-1500 1653
251- 300 51969 1501-1600 817
301- 350 52393 1601-1700 625
351- 400 45463 1701-1800 573
401- 450 37377 1801-1900 490
451- 500 30246 1901-2000 388
501- 550 21982 2001-2100 260
551- 600 15584 2101-2200 367
601- 650 12976 2201-2300 332
651- 700 9315 2301-2400 226
701- 750 7766 2401-2500 183
751- 800 5634 >2500 1390
801- 850 4849
851- 900 5252
901- 950 4078
951-1000 2973
The average sequence length in UniProtKB/Swiss-Prot is 360 amino acids.
The shortest sequence is GWA_SEPOF (P83570): 2 amino acids.
The longest sequence is TITIN_MOUSE (A2ASS6): 35213 amino acids.
4. JOURNAL CITATIONS
Note: the following citation statistics reflect the number of distinct
journal citations.
Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2942
4.1 Table of the frequency of journal citations
Journals cited 1x: 939
2x: 408
3x: 182
4x: 145
5x: 122
6x: 86
7x: 63
8x: 70
9x: 44
10x: 32
11- 20x: 238
21- 50x: 244
51-100x: 126
>100x: 243
4.2 List of the most cited journals in UniProtKB/Swiss-Prot
Nb Citations Journal name
-- --------- -------------------------------------------------------------
1 25882 Journal of Biological Chemistry
2 12046 Proceedings of the National Academy of Sciences of the U.S.A.
3 6906 Journal of Bacteriology
4 5823 Biochemical and Biophysical Research Communications
5 5586 Biochemistry
6 5131 Nucleic Acids Research
7 4960 FEBS Letters
8 4852 Gene
9 4806 The EMBO Journal
10 4780 Nature
11 4466 Molecular and Cellular Biology
12 4406 Journal of Molecular Biology
13 3839 Biochimica et Biophysica Acta
14 3693 Cell
15 3451 European Journal of Biochemistry
16 3398 Journal of Virology
17 3170 Science
18 3012 Biochemical Journal
19 2708 Plant Physiology
20 2698 Molecular Microbiology
21 2539 Genomics
22 2303 The American Journal of Human Genetics
23 2299 PLoS ONE
24 2268 Journal of Cell Biology
25 2103 The Plant Cell
26 1967 The Plant Journal
27 1910 Human Molecular Genetics
28 1894 Plant Molecular Biology
29 1890 Genes and Development
30 1836 Virology
31 1803 Nature Genetics
32 1745 Molecular Biology of the Cell
33 1736 Development
34 1645 Molecular Cell
35 1596 Human Mutation
36 1572 Journal of Immunology
37 1555 Oncogene
38 1415 Structure
39 1406 Molecular and General Genetics
40 1377 Journal of Biochemistry
41 1352 Genetics
42 1316 Journal of Cell Science
43 1204 Blood
44 1197 Infection and Immunity
45 1159 Journal of General Virology
46 1118 Microbiology
47 1106 Developmental Biology
48 1105 Current Biology
49 1099 Archives of Biochemistry and Biophysics
50 964 Journal of Neuroscience
51 957 Applied and Environmental Microbiology
52 944 Acta Crystallographica, Section D
53 910 Cancer Research
54 867 FEMS Microbiology Letters
55 841 Yeast
56 839 Toxicon
57 815 Protein Science
58 796 Journal of Clinical Investigation
59 788 PLoS Genetics
60 784 Neuron
61 753 American Journal of Physiology
62 734 Plant and Cell Physiology
63 734 Nature Communications
64 716 Human Genetics
65 704 The Journal of Experimental Medicine
66 662 Proteins
67 655 Mechanisms of Development
68 652 Journal of Medical Genetics
69 647 Nature Structural Biology
70 615 Scientific Reports
71 605 Nature Cell Biology
72 594 Nature Structural and Molecular Biology
73 594 The FEBS Journal
74 579 Current Genetics
75 578 Bioscience, Biotechnology, and Biochemistry
76 553 Journal of Neurochemistry
77 550 Developmental Cell
78 546 Molecular Endocrinology
79 533 The Journal of Clinical Endocrinology and Metabolism
80 517 Endocrinology
81 511 Antimicrobial Agents and Chemotherapy
82 495 PLoS Pathogens
83 490 Mammalian Genome
84 477 Experimental Cell Research
85 470 Molecular and Biochemical Parasitology
86 452 Eukaryotic Cell
87 445 Journal of the American Chemical Society
88 442 Peptides
89 442 Planta
90 437 RNA
91 430 Immunogenetics
92 425 Journal of Experimental Botany
93 407 Molecular Biology and Evolution
94 406 Journal of Molecular Evolution
95 401 Molecular Pharmacology
96 400 The FASEB Journal
97 396 Acta Crystallographica, Section F
98 395 EMBO Reports
99 392 DNA and Cell Biology
100 390 American Journal of Medical Genetics. Part A
101 383 European Journal of Human Genetics
102 381 Journal of Investigative Dermatology
103 379 Molecular Plant-Microbe Interactions
104 378 Immunity
105 377 DNA Sequence
106 375 Neurology
107 363 Comparative Biochemistry and Physiology
108 359 Biology of Reproduction
109 350 Biochimie
110 341 Brain Research. Molecular Brain Research
111 340 Genes to Cells
112 339 Virus Research
113 338 Clinical Genetics
114 325 Developmental Dynamics
115 323 The New England Journal of Medicine
116 321 Journal of Lipid Research
117 310 Annals of Neurology
118 305 Cell Reports
119 303 Nature Immunology
120 301 Genome Research
121 300 BMC Genomics
122 299 Biological Chemistry Hoppe-Seyler
123 298 European Journal of Immunology
124 287 Investigative Ophthalmology and Visual Science
125 287 Applied Microbiology and Biotechnology
126 286 PLoS Biology
127 284 Journal of Medicinal Chemistry
128 281 Cytogenetics and Cell Genetics
129 273 Journal of Human Genetics
130 273 Journal of General Microbiology
131 263 Glycobiology
132 257 Archives of Microbiology
133 256
134 247 Traffic
135 245 Molecular Immunology
136 242 Molecular Genetics and Metabolism
137 240 Journal of Cellular Biochemistry
138 233 DNA Research
139 232 Phytochemistry
140 230 Protein Expression and Purification
141 230 Nature Medicine
142 229 Cell Cycle
143 225 Circulation Research
144 225 Diabetes
145 222 Archives of Virology
146 218 Fungal Genetics and Biology
147 218 Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
148 217 Nature Chemical Biology
149 210 Molecular and Cellular Endocrinology
150 208 Brain
5. STATISTICS FOR SOME LINE TYPES
The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.
Total Number of Average
Line type / subtype number entries per entry
------------------------------------ -------- --------- ---------
References (RL) 1261529 2.23
Journal 1084809 463023 1.92 1
Submitted to EMBL/GenBank/DDBJ 165505 149820 0.29 2
Submitted to other databases 7603 6993 0.01 3
Book citation 1855 1832 <0.01 4
Plant Gene Register 612 599 <0.01 5
Unpublished observations 487 483 <0.01 6
Thesis 439 436 <0.01 7
Patent 213 206 <0.01 8
Worm Breeder's Gazette 6 6 <0.01 9
Total number of distinct authors cited in UniProtKB/Swiss-Prot: 436524
Total Number of Average
Line type / subtype number entries per entry Rank
------------------------------------ -------- --------- --------- ----
Comments (CC) 2639637 4.67
ACTIVITY REGULATION 16392 16338 0.03 17
ALLERGEN 925 925 <0.01 26
ALTERNATIVE PRODUCTS 25581 25581 0.05 13
BIOPHYSICOCHEMICAL PROPERTIES 9721 9708 0.02 20
BIOTECHNOLOGY 1450 1424 <0.01 24
CATALYTIC ACTIVITY 313402 245464 0.55 4
CAUTION 13686 13400 0.02 18
COFACTOR 128701 117417 0.23 7
DEVELOPMENTAL STAGE 13203 13159 0.02 19
DISEASE 7582 5101 0.01 21
DISRUPTION PHENOTYPE 17467 17455 0.03 16
DOMAIN 53085 45359 0.09 9
FUNCTION 477496 454890 0.84 2
INDUCTION 23016 22961 0.04 15
INTERACTION 23697 23697 0.04 14
MASS SPECTROMETRY 7151 5507 0.01 22
MISCELLANEOUS 44539 39134 0.08 12
PATHWAY 141604 128166 0.25 6
PHARMACEUTICAL 162 154 <0.01 29
POLYMORPHISM 1316 1261 <0.01 25
PTM 60516 43762 0.11 8
RNA EDITING 628 628 <0.01 28
SEQUENCE CAUTION 44695 44624 0.08 11
SIMILARITY 513929 509709 0.91 1
SUBCELLULAR LOCATION 355384 347435 0.63 3
SUBUNIT 288376 284208 0.51 5
TISSUE SPECIFICITY 48526 48298 0.09 10
TOXIC DOSE 815 653 <0.01 27
WEB RESOURCE 6592 5528 0.01 23
Total number of comment topics: 29
Total Number of Average
Line type / subtype number entries per entry Rank
------------------------------------ -------- --------- --------- ----
Features (FT) 5038477 8.91
ACT_SITE 168907 102056 0.30 11
BINDING 422229 112358 0.75 2
CA_BIND 4241 1764 0.01 36
CARBOHYD 120361 30829 0.21 16
CHAIN 573499 557903 1.01 1
COILED 22214 15380 0.04 27
COMPBIAS 171724 73061 0.30 10
CONFLICT 137437 47989 0.24 14
CROSSLNK 24266 8720 0.04 26
DISULFID 129956 34745 0.23 15
DNA_BIND 11979 10731 0.02 33
DOMAIN 208105 127634 0.37 9
HELIX 291530 26160 0.52 7
INIT_MET 17440 17392 0.03 28
INTRAMEM 2889 1334 0.01 37
LIPID 13411 8651 0.02 30
METAL 413401 99071 0.73 3
MOD_RES 257281 73058 0.46 8
MOTIF 45433 29671 0.08 23
MUTAGEN 82213 17592 0.15 19
NON_CONS 2532 825 <0.01 38
NON_STD 358 283 <0.01 39
NON_TER 12595 9663 0.02 31
NP_BIND 161524 87129 0.29 12
PEPTIDE 12060 8278 0.02 32
PROPEP 14761 12595 0.03 29
REGION 411724 193929 0.73 4
REPEAT 107503 14987 0.19 17
SIGNAL 43238 43237 0.08 24
SITE 62312 33468 0.11 21
STRAND 300683 24669 0.53 6
TOPO_DOM 146221 29728 0.26 13
TRANSIT 9300 9181 0.02 34
TRANSMEM 376849 78855 0.67 5
TURN 70510 21306 0.12 20
UNSURE 5597 850 0.01 35
VAR_SEQ 52571 22349 0.09 22
VARIANT 99345 17230 0.18 18
ZN_FING 30278 12948 0.05 25
Total number of feature keys: 39
Total Number of Average
Line type / subtype number entries per entry Rank Category
------------------------------------ -------- --------- --------- ---- -------------------------------------------
Cross-references (DR) 18302460 32.38
ABCD 2717 2717 <0.01 118 Protocols and materials databases
Allergome 2010 1295 <0.01 125 Protein family/group databases
Antibodypedia 32137 32026 0.06 57 Protocols and materials databases
ArachnoServer 1164 1154 <0.01 135 Organism-specific databases
Araport 16131 16035 0.03 86 Organism-specific databases
Bgee 57476 57476 0.10 43 Gene expression databases
BindingDB 6061 6061 0.01 102 Chemistry databases
BioCyc 202443 198389 0.36 24 Enzyme and pathway databases
BioGRID 59325 57494 0.10 41 Protein-protein interaction databases
BioGRID-ORCS 39044 38509 0.07 55 Miscellaneous databases
BioMuta 20307 20289 0.04 72 Genetic variation databases
BMRB 6913 6913 0.01 99 3D structure databases
BRENDA 19017 17442 0.03 75 Enzyme and pathway databases
CarbonylDB 1157 1157 <0.01 136 PTM databases
CAZy 9565 8621 0.02 92 Protein family/group databases
CCDS 48745 34294 0.09 48 Sequence databases
CDD 196781 176326 0.35 25 Family and domain databases
CGD 2001 1984 <0.01 126 Organism-specific databases
ChEMBL 8425 8246 0.01 95 Chemistry databases
ChiTaRS 29663 29626 0.05 61 Miscellaneous databases
CLAE 359 356 <0.01 151 Protein family/group databases
CollecTF 135 135 <0.01 159 Gene expression databases
ComplexPortal 11502 6454 0.02 89 Protein-protein interaction databases
COMPLUYEAST-2DPAGE 97 97 <0.01 161 2D gel databases
ConoServer 968 880 <0.01 139 Organism-specific databases
CORUM 5809 5809 0.01 103 Protein-protein interaction databases
CPTAC 2525 1632 <0.01 121 Proteomic databases
CPTC 303 303 <0.01 153 Protocols and materials databases
CTD 75495 74593 0.13 40 Organism-specific databases
DEPOD 254 254 <0.01 157 PTM databases
dictyBase 4215 4101 0.01 112 Organism-specific databases
DIP 17473 17433 0.03 81 Protein-protein interaction databases
DisGeNET 17033 16808 0.03 82 Organism-specific databases
DisProt 1539 1527 <0.01 128 Family and domain databases
DMDM 16191 16189 0.03 85 Genetic variation databases
DNASU 48110 48033 0.09 50 Protocols and materials databases
DOSAC-COBS-2DPAGE 145 145 <0.01 158 2D gel databases
DrugBank 29424 4706 0.05 63 Chemistry databases
DrugCentral 2564 2564 <0.01 120 Chemistry databases
EchoBASE 4158 4158 0.01 113 Organism-specific databases
eggNOG 337209 331338 0.60 14 Phylogenomic databases
ELM 1812 1812 <0.01 127 Protein-protein interaction databases
EMBL 992352 552947 1.76 3 Sequence databases
Ensembl 98303 50798 0.17 35 Genome annotation databases
EnsemblBacteria 309234 297798 0.55 17 Genome annotation databases
EnsemblFungi 30189 28569 0.05 60 Genome annotation databases
EnsemblMetazoa 18483 10824 0.03 78 Genome annotation databases
EnsemblPlants 30512 21620 0.05 58 Genome annotation databases
EnsemblProtists 5060 4879 0.01 106 Genome annotation databases
EPD 21225 21225 0.04 68 Proteomic databases
ESTHER 2588 2587 <0.01 119 Protein family/group databases
euHCVdb 55 44 <0.01 163 Organism-specific databases
EvolutionaryTrace 16679 16679 0.03 84 Miscellaneous databases
ExpressionAtlas 48601 48601 0.09 49 Gene expression databases
FlyBase 4970 4845 0.01 107 Organism-specific databases
Gene3D 416796 323247 0.74 13 Family and domain databases
GeneCards 20348 20183 0.04 70 Organism-specific databases
GeneDB 625 569 <0.01 145 Genome annotation databases
GeneID 308666 283065 0.55 18 Genome annotation databases
GeneReviews 1493 1490 <0.01 129 Organism-specific databases
GeneTree 59065 59019 0.10 42 Phylogenomic databases
Genevisible 55258 55258 0.10 45 Gene expression databases
GeneWiki 10350 10267 0.02 91 Miscellaneous databases
GenomeRNAi 22184 22183 0.04 66 Miscellaneous databases
GlyConnect 2330 2200 <0.01 122 PTM databases
GlyGen 11179 11179 0.02 90 PTM databases
GO 3097265 540846 5.48 1 Ontologies
Gramene 30512 21620 0.05 59 Genome annotation databases
GuidetoPHARMACOLOGY 2052 2052 <0.01 124 Chemistry databases
HAMAP 330628 327703 0.58 15 Family and domain databases
HGNC 20328 20195 0.04 71 Organism-specific databases
HOGENOM 424467 424467 0.75 11 Phylogenomic databases
HPA 18983 18847 0.03 76 Organism-specific databases
IDEAL 986 986 <0.01 138 Family and domain databases
IMGT_GENE-DB 267 267 <0.01 156 Protein family/group databases
InParanoid 140406 140406 0.25 28 Phylogenomic databases
IntAct 56920 56920 0.10 44 Protein-protein interaction databases
InterPro 2334204 546292 4.13 2 Family and domain databases
iPTMnet 52683 52683 0.09 46 PTM databases
jPOST 26397 26397 0.05 64 Proteomic databases
KEGG 502923 477412 0.89 8 Genome annotation databases
LegioList 765 763 <0.01 143 Organism-specific databases
Leproma 672 669 <0.01 144 Organism-specific databases
MaizeGDB 521 517 <0.01 146 Organism-specific databases
MalaCards 4823 4819 0.01 109 Organism-specific databases
MassIVE 18529 18529 0.03 77 Proteomic databases
MaxQB 29621 29621 0.05 62 Proteomic databases
MEROPS 13681 13681 0.02 88 Protein family/group databases
MetOSite 3106 3106 0.01 116 PTM databases
MGI 16992 16952 0.03 83 Organism-specific databases
MIM 21963 15455 0.04 67 Organism-specific databases
MINT 22798 22798 0.04 65 Protein-protein interaction databases
MoonDB 348 348 <0.01 152 Protein family/group databases
MoonProt 281 281 <0.01 155 Protein family/group databases
neXtProt 20365 20365 0.04 69 Organism-specific databases
NIAGADS 68 68 <0.01 162 Organism-specific databases
OGP 373 373 <0.01 150 2D gel databases
OMA 422699 422699 0.75 12 Phylogenomic databases
OpenTargets 18321 18171 0.03 79 Organism-specific databases
Orphanet 7724 4116 0.01 98 Organism-specific databases
OrthoDB 246139 246139 0.44 21 Phylogenomic databases
PANTHER 287431 274964 0.51 20 Family and domain databases
PathwayCommons 19484 19484 0.03 74 Enzyme and pathway databases
PATRIC 92547 92547 0.16 38 Genome annotation databases
PaxDb 125666 125666 0.22 32 Proteomic databases
PCDDB 125 125 <0.01 160 3D structure databases
PDB 216759 30515 0.38 22 3D structure databases
PDBsum 216759 30515 0.38 23 3D structure databases
PeptideAtlas 33723 33723 0.06 56 Proteomic databases
PeroxiBase 783 761 <0.01 142 Protein family/group databases
Pfam 786427 524357 1.39 4 Family and domain databases
PharmGKB 18309 18290 0.03 80 Organism-specific databases
Pharos 20084 20084 0.04 73 Miscellaneous databases
PHI-base 1485 1230 <0.01 130 Miscellaneous databases
PhosphoSitePlus 39081 39081 0.07 54 PTM databases
PhylomeDB 97067 97067 0.17 37 Phylogenomic databases
PIR 124568 114293 0.22 33 Sequence databases
PIRSF 107824 106729 0.19 34 Family and domain databases
PlantReactome 1080 741 <0.01 137 Enzyme and pathway databases
PomBase 5129 5125 0.01 105 Organism-specific databases
PRIDE 140850 140850 0.25 27 Proteomic databases
PRINTS 131250 116377 0.23 30 Family and domain databases
PRO 97286 97286 0.17 36 Miscellaneous databases
ProMEX 467 467 <0.01 149 Proteomic databases
PROSITE 482652 306199 0.85 9 Family and domain databases
Proteomes 505460 471285 0.89 7 Miscellaneous databases
ProteomicsDB 82334 52892 0.15 39 Proteomic databases
PseudoCAP 1410 1401 <0.01 132 Organism-specific databases
Reactome 125786 35877 0.22 31 Enzyme and pathway databases
REBASE 786 395 <0.01 141 Protein family/group databases
RefSeq 617487 471725 1.09 5 Sequence databases
REPRODUCTION-2DPAGE 1259 1038 <0.01 133 2D gel databases
RGD 8056 8053 0.01 96 Organism-specific databases
RNAct 43016 43016 0.08 52 Miscellaneous databases
SABIO-RK 4896 4896 0.01 108 Enzyme and pathway databases
SASBDB 476 476 <0.01 148 3D structure databases
SFLD 9480 7361 0.02 93 Family and domain databases
SGD 6740 6735 0.01 100 Organism-specific databases
SignaLink 3093 3093 0.01 117 Enzyme and pathway databases
SIGNOR 5380 5380 0.01 104 Enzyme and pathway databases
SMART 194397 143332 0.34 26 Family and domain databases
SMR 457260 457260 0.81 10 3D structure databases
STRING 329947 329947 0.58 16 Protein-protein interaction databases
SUPFAM 515367 389645 0.91 6 Family and domain databases
SWISS-2DPAGE 1177 1177 <0.01 134 2D gel databases
SwissLipids 1471 1387 <0.01 131 Chemistry databases
SwissPalm 8647 8647 0.02 94 PTM databases
TAIR 14906 14850 0.03 87 Organism-specific databases
TCDB 7804 7741 0.01 97 Protein family/group databases
TIGRFAMs 293074 273011 0.52 19 Family and domain databases
TopDownProteomics 3237 2960 0.01 114 Proteomic databases
TreeFam 45790 45783 0.08 51 Phylogenomic databases
TubercuList 2277 2241 <0.01 123 Organism-specific databases
UCD-2DPAGE 496 496 <0.01 147 2D gel databases
UCSC 50468 46065 0.09 47 Genome annotation databases
UniLectin 288 288 <0.01 154 Protein family/group databases
UniPathway 138437 125200 0.24 29 Enzyme and pathway databases
VEuPathDB 41468 40094 0.07 53 Organism-specific databases
VGNC 4404 4391 0.01 111 Organism-specific databases
WBParaSite 48 43 <0.01 164 Genome annotation databases
World-2DPAGE 933 922 <0.01 140 2D gel databases
WormBase 6594 4866 0.01 101 Organism-specific databases
Xenbase 4540 4539 0.01 110 Organism-specific databases
ZFIN 3178 3173 0.01 115 Organism-specific databases
Total number of cross-referenced databases: 164
6. AMINO ACID COMPOSITION
6.1 Composition in percent for the complete database
Ala (A) 8.25 Gln (Q) 3.93 Leu (L) 9.65 Ser (S) 6.64
Arg (R) 5.53 Glu (E) 6.72 Lys (K) 5.80 Thr (T) 5.35
Asn (N) 4.06 Gly (G) 7.07 Met (M) 2.41 Trp (W) 1.10
Asp (D) 5.46 His (H) 2.27 Phe (F) 3.86 Tyr (Y) 2.92
Cys (C) 1.38 Ile (I) 5.91 Pro (P) 4.73 Val (V) 6.86
Asx (B) 0.000 Glx (Z) 0.000 Xaa (X) 0.00
Legend: gray = aliphatic, red = acidic, green = small hydroxy,
blue = basic, black = aromatic, white = amide, yellow = sulfur
6.2 Classification of the amino acids by their frequency
Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
Phe, Tyr, Met, His, Cys, Trp
7. MISCELLANEOUS STATISTICS
4463 entries are encoded on a mitochondrion, and 3949 are encoded on a plasmid.
12189 entries are encoded on a plastid,
of which 21 are encoded on apicoplasts,
11624 on chloroplasts,
51 on organellar chromatophores,
145 on cyanelles,
149 on non-photosynthetic plastids and
199 on unspecified types of plastid.
Number of entries with at least one sequence correction: 80278