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         UniProtKB/Swiss-Prot protein knowledgebase release 2019_10 statistics





1.  INTRODUCTION



Release 2019_10 of 13-Nov-19 of UniProtKB/Swiss-Prot contains 561356 sequence entries,

comprising 201858328 amino acids abstracted from 269319 references. 



181 sequences have been added since release 2019_09, the sequence data of

30 existing entries has been updated and the annotations of

89827 entries have been revised.



Number of fragments: 9203

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40210





Protein existence (PE):           entries     %



1: Evidence at protein level       101928   18.2%

2: Evidence at transcript level     57282   10.2%

3: Inferred from homology          386905   68.9%

4: Predicted                        13404    2.4%

5: Uncertain                         1837    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13846



   The first twenty species represent 121083 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5699

                            2x: 1996

                            3x: 1076

                            4x:  702

                            5x:  518

                            6x:  410

                            7x:  305

                            8x:  253

                            9x:  229

                           10x:  145

                       11- 20x:  773

                       21- 50x:  465

                       51-100x:  222

                         >100x: 1053





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20379  Homo sapiens (Human)

       2      17025  Mus musculus (Mouse)

       3      15911  Arabidopsis thaliana (Mouse-ear cress)

       4       8080  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6008  Bos taurus (Bovine)

       7       5140  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4518  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4148  Dictyostelium discoideum (Slime mold)

      11       4102  Caenorhabditis elegans

      12       4067  Oryza sativa subsp. japonica (Rice)

      13       3589  Drosophila melanogaster (Fruit fly)

      14       3447  Xenopus laevis (African clawed frog)

      15       3126  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2291  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2187  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2040  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1797  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1706  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1685  Shigella flexneri

      27       1432  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1339  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1175  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1066  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1035  Archaeoglobus fulgidus 

      34       1025  Yersinia pestis

      35       1011  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        977  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        941  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      38        940  Emericella nidulans  

      39        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      40        929  Staphylococcus aureus (strain N315)

      41        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      42        919  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        903  Staphylococcus aureus (strain COL)

      45        896  Staphylococcus aureus (strain MW2)

      46        894  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      47        894  Oryctolagus cuniculus (Rabbit)

      48        889  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        883  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      51        882  Salmonella choleraesuis (strain SC-B67)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        856  Neurospora crassa 

      56        844  Oryza sativa subsp. indica (Rice)

      57        841  Escherichia coli O9:H4 (strain HS)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        831  Zea mays (Maize)

      60        829  Shigella boydii serotype 4 (strain Sb227)

      61        827  Canis lupus familiaris (Dog) (Canis familiaris)

      62        825  Escherichia coli (strain UTI89 / UPEC)

      63        822  Shigella dysenteriae serotype 1 (strain Sd197)

      64        821  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      65        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      66        803  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      67        801  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      68        794  Staphylococcus aureus (strain NCTC 8325)

      69        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      70        791  Escherichia coli (strain SMS-3-5 / SECEC)

      71        786  Aquifex aeolicus (strain VF5)

      72        771  Escherichia coli (strain K12 / DH10B)

      73        770  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        770  Pasteurella multocida (strain Pm70)

      75        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      76        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        760  Shigella flexneri serotype 5b (strain 8401)

      81        759  Staphylococcus epidermidis (strain ATCC 12228)

      82        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        751  Bacillus anthracis

      86        748  Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      87        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      88        742  Bacillus halodurans 

      89        739  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        724  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      93        722  Salmonella enteritidis PT4 (strain P125109)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      97        715  Enterobacter sp. (strain 638)

      98        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      99        714  Salmonella paratyphi A (strain AKU_12601)

     100        714  Escherichia coli O1:K1 / APEC

     101        713  Salmonella newport (strain SL254)

     102        713  Salmonella agona (strain SL483)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     109        698  Klebsiella pneumoniae (strain 342)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        686  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        677  Staphylococcus aureus (strain USA300)

     118        676  Escherichia coli

     119        672  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        668  Bacillus cereus 

     122        667  Yersinia pestis (strain Pestoides F)

     123        664  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     124        664  Bradyrhizobium diazoefficiens 

     125        657  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        650  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        650  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        640  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        622  Treponema pallidum (strain Nichols)

     135        620  Methanothermobacter thermautotrophicus  

     136        615  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     137        615  Xanthomonas campestris pv. campestris 

     138        614  Staphylococcus haemolyticus (strain JCSC1435)

     139        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     140        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     141        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     142        602  Photobacterium profundum (strain SS9)

     143        602  Staphylococcus saprophyticus subsp. saprophyticus 

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        598  Pseudomonas aeruginosa (strain UCBPP-PA14)

     147        595  Bacillus cereus (strain ATCC 10987 / NRS 248)

     148        595  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        584  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        580  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        560  Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 

     165        559  Clostridium acetobutylicum 

     166        557  Xanthomonas axonopodis pv. citri (strain 306)

     167        555  Pseudomonas fluorescens (strain Pf0-1)

     168        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     169        553  Oceanobacillus iheyensis 

     170        553  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     171        550  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        540  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        530  Corynebacterium glutamicum 

     176        529  Listeria monocytogenes serotype 4b (strain F2365)

     177        529  Sodalis glossinidius (strain morsitans)

     178        528  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        524  Staphylococcus aureus (strain Newman)

     180        522  Xylella fastidiosa (strain 9a5c)

     181        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     182        517  Chromobacterium violaceum 

     183        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     184        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     185        515  Deinococcus radiodurans 

     186        514  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     187        513  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     188        512  Pseudomonas aeruginosa (strain PA7)

     189        511  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     190        511  Streptomyces avermitilis 

     191        510  Geobacillus kaustophilus (strain HTA426)

     192        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     193        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     194        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     195        502  Pseudomonas entomophila (strain L48)

     196        501  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     199        497  Haemophilus influenzae (strain 86-028NP)

     200        496  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     201        496  Burkholderia pseudomallei (strain K96243)

     202        496  Bacillus clausii (strain KSM-K16)

     203        494  Proteus mirabilis (strain HI4320)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     207        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     208        489  Pyrococcus horikoshii 

     209        488  Methanosarcina mazei  

     210        487  Shewanella sp. (strain MR-7)

     211        486  Brucella abortus (strain 2308)

     212        486  Mannheimia succiniciproducens (strain MBEL55E)

     213        485  Thermosynechococcus elongatus (strain BP-1)

     214        484  Shewanella sp. (strain MR-4)

     215        484  Pseudomonas aeruginosa (strain LESB58)

     216        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     217        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     218        482  Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 

     219        482  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     221        480  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     222        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     223        477  Pyrococcus abyssi (strain GE5 / Orsay)

     224        477  Nicotiana tabacum (Common tobacco)

     225        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     226        474  Burkholderia lata 

     227        474  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     228        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     229        469  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        468  Clostridium perfringens (strain 13 / Type A)

     231        468  Pseudomonas putida (strain GB-1)

     232        467  Shewanella frigidimarina (strain NCIMB 400)

     233        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     234        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     235        466  Shewanella sp. (strain ANA-3)

     236        466  Aeromonas hydrophila subsp. hydrophila 

     237        466  Enterococcus faecalis (strain ATCC 700802 / V583)

     238        465  Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)

     239        463  Burkholderia mallei (strain ATCC 23344)

     240        459  Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator 

     241        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     242        458  Ovis aries (Sheep)

     243        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     244        455  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        455  Staphylococcus aureus (strain JH1)

     246        455  Shewanella baltica (strain OS185)

     247        453  Pseudomonas putida (strain W619)

     248        453  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     249        452  Aeromonas salmonicida (strain A449)

     250        450  Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) 





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19577 (  3%)

    Bacteria         334328 ( 60%)

    Eukaryota        190466 ( 34%)

    Viruses           16985 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20380 ( 11%)           (  4%)

     Other Mammalia         46817 ( 25%)           (  8%)

     Other Vertebrata       18419 ( 10%)           (  3%)

     Viridiplantae          40171 ( 21%)           (  7%)

     Fungi                  34181 ( 18%)           (  6%)

     Insecta                 9343 (  5%)           (  2%)

     Nematoda                5012 (  3%)           (  1%)

     Other                  16143 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9674             1001-1100     4021

                 51- 100   42746             1101-1200     2815

                101- 150   59293             1201-1300     2151

                151- 200   59057             1301-1400     2016

                201- 250   57916             1401-1500     1629

                251- 300   51663             1501-1600      801

                301- 350   52017             1601-1700      619

                351- 400   45105             1701-1800      565

                401- 450   37127             1801-1900      481

                451- 500   29962             1901-2000      379

                501- 550   21673             2001-2100      251

                551- 600   15441             2101-2200      345

                601- 650   12879             2201-2300      321

                651- 700    9251             2301-2400      215

                701- 750    7683             2401-2500      167

                751- 800    5559             >2500         1322

                801- 850    4796

                851- 900    5216

                901- 950    4056

                951-1000    2941



   





   The average sequence length in UniProtKB/Swiss-Prot is 359 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2837





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  904

                       2x:  403

                       3x:  170

                       4x:  133

                       5x:  109

                       6x:   92

                       7x:   78

                       8x:   64

                       9x:   36

                      10x:   31

                  11- 20x:  226

                  21- 50x:  233

                  51-100x:  123

                    >100x:  235





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24982   Journal of Biological Chemistry

    2        11643   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6687   Journal of Bacteriology

    4         5695   Biochemical and Biophysical Research Communications

    5         5406   Biochemistry

    6         5032   Nucleic Acids Research

    7         4862   FEBS Letters

    8         4823   Gene

    9         4719   The EMBO Journal

   10         4634   Nature

   11         4384   Molecular and Cellular Biology

   12         4309   Journal of Molecular Biology

   13         3700   Biochimica et Biophysica Acta

   14         3610   Cell

   15         3412   European Journal of Biochemistry

   16         3298   Journal of Virology

   17         3062   Science

   18         2892   Biochemical Journal

   19         2604   Plant Physiology

   20         2582   Molecular Microbiology

   21         2537   Genomics

   22         2217   Journal of Cell Biology

   23         2204   The American Journal of Human Genetics

   24         2037   The Plant Cell

   25         2018   PLoS ONE

   26         1885   The Plant Journal

   27         1874   Plant Molecular Biology

   28         1853   Human Molecular Genetics

   29         1848   Genes and Development

   30         1813   Virology

   31         1773   Nature Genetics

   32         1692   Molecular Biology of the Cell

   33         1685   Development

   34         1581   Human Mutation

   35         1573   Molecular Cell

   36         1543   Oncogene

   37         1503   Journal of Immunology

   38         1395   Molecular and General Genetics

   39         1370   Structure

   40         1350   Journal of Biochemistry

   41         1326   Genetics

   42         1284   Journal of Cell Science

   43         1175   Blood

   44         1149   Journal of General Virology

   45         1144   Infection and Immunity

   46         1078   Microbiology

   47         1067   Current Biology

   48         1062   Archives of Biochemistry and Biophysics

   49         1059   Developmental Biology

   50          928   Applied and Environmental Microbiology

   51          927   Journal of Neuroscience

   52          899   Acta Crystallographica, Section D

   53          888   Cancer Research

   54          845   FEMS Microbiology Letters

   55          839   Yeast

   56          791   Toxicon

   57          788   Protein Science

   58          768   Neuron

   59          751   Journal of Clinical Investigation

   60          702   Plant and Cell Physiology

   61          702   Human Genetics

   62          697   American Journal of Physiology

   63          686   PLoS Genetics

   64          662   The Journal of Experimental Medicine

   65          649   Mechanisms of Development

   66          646   Nature Structural Biology

   67          635   Proteins

   68          626   Journal of Medical Genetics

   69          584   Nature Cell Biology

   70          574   Current Genetics

   71          556   Bioscience, Biotechnology, and Biochemistry

   72          552   Nature Structural and Molecular Biology

   73          542   Journal of Neurochemistry

   74          539   Molecular Endocrinology

   75          534   The FEBS Journal

   76          526   Nature Communications

   77          523   Developmental Cell

   78          521   The Journal of Clinical Endocrinology and Metabolism

   79          506   Endocrinology

   80          488   Mammalian Genome

   81          482   Antimicrobial Agents and Chemotherapy

   82          464   Experimental Cell Research

   83          450   Molecular and Biochemical Parasitology

   84          440   Immunogenetics

   85          440   Scientific Reports

   86          433   Eukaryotic Cell

   87          433   Planta

   88          421   RNA

   89          417   Peptides

   90          411   PLoS Pathogens

   91          407   Journal of Molecular Evolution

   92          399   Molecular Biology and Evolution

   93          394   Journal of Experimental Botany

   94          394   Journal of the American Chemical Society

   95          388   DNA and Cell Biology

   96          382   Molecular Pharmacology

   97          375   DNA Sequence

   98          373   EMBO Reports

   99          372   The FASEB Journal

  100          370   Neurology

  101          369   Acta Crystallographica, Section F

  102          369   American Journal of Medical Genetics. Part A

  103          369   Journal of Investigative Dermatology

  104          362   Molecular Plant-Microbe Interactions

  105          356   European Journal of Human Genetics

  106          351   Comparative Biochemistry and Physiology

  107          351   Biology of Reproduction

  108          343   Immunity

  109          340   Brain Research. Molecular Brain Research

  110          328   Virus Research

  111          327   Genes to Cells

  112          323   Biochimie

  113          321   The New England Journal of Medicine

  114          318   Developmental Dynamics

  115          314   Clinical Genetics

  116          301   Annals of Neurology

  117          299   Genome Research

  118          297   Biological Chemistry Hoppe-Seyler

  119          287   European Journal of Immunology

  120          283   BMC Genomics

  121          282   Cytogenetics and Cell Genetics

  122          281   Nature Immunology

  123          274   Investigative Ophthalmology and Visual Science

  124          271   Journal of General Microbiology

  125          267   Applied Microbiology and Biotechnology

  126          266   Journal of Lipid Research

  127          266   Journal of Human Genetics

  128          261   Journal of Medicinal Chemistry

  129          261   PLoS Biology

  130          248   Archives of Microbiology

  131          245   Cell Reports

  132          241   Tissue Antigens

  133          240   Glycobiology

  134          235   Journal of Cellular Biochemistry

  135          234   Molecular Immunology

  136          233   Traffic

  137          232   DNA Research

  138          227   Molecular Genetics and Metabolism

  139          222   Cell Cycle

  140          219   Diabetes

  141          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  142          217   Circulation Research

  143          213   Archives of Virology

  144          212   Phytochemistry

  145          210   Protein Expression and Purification

  146          210   Nature Medicine

  147          208   Molecular and Cellular Endocrinology

  148          206   Fungal Genetics and Biology

  149          197   Molecular Genetics and Genomics

  150          190   Molecular and Cellular Neuroscience





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1234361                 2.20                                         

   Journal                           1057943     458548      1.88       1                                 

   Submitted to EMBL/GenBank/DDBJ     165441     149802      0.29       2                                 

   Submitted to other databases         7454       6876      0.01       3                                 

   Book citation                        1830       1807     <0.01       4                                 

   Plant Gene Register                   612        599     <0.01       5                                 

   Thesis                                434        431     <0.01       6                                 

   Unpublished observations              431        427     <0.01       7                                 

   Patent                                210        204     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 418439



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2569060                 4.58                                         

   ACTIVITY REGULATION                 15367      15365      0.03      16                                 

   ALLERGEN                              872        872     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25352      25352      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8756       8756      0.02      20                                 

   BIOTECHNOLOGY                        1069       1053     <0.01      25                                 

   CATALYTIC ACTIVITY                 294640     240368      0.52       4                                 

   CAUTION                             13239      12973      0.02      18                                 

   COFACTOR                           126426     115058      0.23       7                                 

   DEVELOPMENTAL STAGE                 12461      12460      0.02      19                                 

   DISEASE                              7267       4886      0.01      21                                 

   DISRUPTION PHENOTYPE                15321      15318      0.03      17                                 

   DOMAIN                              50415      43225      0.09       9                                 

   FUNCTION                           470187     449073      0.84       2                                 

   INDUCTION                           21874      21861      0.04      14                                 

   INTERACTION                         19601      19601      0.03      15                                 

   MASS SPECTROMETRY                    6869       5280      0.01      23                                 

   MISCELLANEOUS                       39081      35892      0.07      12                                 

   PATHWAY                            139388     126304      0.25       6                                 

   PHARMACEUTICAL                        119        115     <0.01      29                                 

   POLYMORPHISM                         1285       1229     <0.01      24                                 

   PTM                                 58154      42557      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44243      44243      0.08      11                                 

   SIMILARITY                         510172     505996      0.91       1                                 

   SUBCELLULAR LOCATION               351415     343835      0.63       3                                 

   SUBUNIT                            280468     279537      0.50       5                                 

   TISSUE SPECIFICITY                  46792      46791      0.08      10                                 

   TOXIC DOSE                            675        616     <0.01      27                                 

   WEB RESOURCE                         6925       5756      0.01      22                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4574938                 8.15                                         

   ACT_SITE                           165432     100150      0.29      10                                 

   BINDING                            409431     108541      0.73       2                                 

   CA_BIND                              4206       1743      0.01      36                                 

   CARBOHYD                           117275      30143      0.21      15                                 

   CHAIN                              569447     554212      1.01       1                                 

   COILED                              22093      15292      0.04      27                                 

   COMPBIAS                            59171      31833      0.11      21                                 

   CONFLICT                           135943      47543      0.24      13                                 

   CROSSLNK                            23713       8518      0.04      26                                 

   DISULFID                           126796      34025      0.23      14                                 

   DNA_BIND                            11879      10621      0.02      32                                 

   DOMAIN                             200265     123008      0.36       9                                 

   HELIX                              267767      24479      0.48       6                                 

   INIT_MET                            17208      17208      0.03      28                                 

   INTRAMEM                             2791       1275     <0.01      37                                 

   LIPID                               13166       8493      0.02      30                                 

   METAL                              396185      96791      0.71       3                                 

   MOD_RES                            252910      72253      0.45       7                                 

   MOTIF                               44245      28924      0.08      23                                 

   MUTAGEN                             74507      16176      0.13      18                                 

   NON_CONS                             2523        820     <0.01      38                                 

   NON_STD                               357        282     <0.01      39                                 

   NON_TER                             12517       9592      0.02      31                                 

   NP_BIND                            158539      86087      0.28      11                                 

   PEPTIDE                             11685       8053      0.02      33                                 

   PROPEP                              14366      12257      0.03      29                                 

   REGION                             201923      94920      0.36       8                                 

   REPEAT                             106010      14829      0.19      16                                 

   SIGNAL                              42482      42481      0.08      24                                 

   SITE                                59599      32387      0.11      20                                 

   STRAND                             277818      23070      0.49       5                                 

   TOPO_DOM                           141254      28904      0.25      12                                 

   TRANSIT                              9176       9060      0.02      34                                 

   TRANSMEM                           372540      77773      0.66       4                                 

   TURN                                64538      19900      0.11      19                                 

   UNSURE                               5577        839      0.01      35                                 

   VAR_SEQ                             52202      22126      0.09      22                                 

   VARIANT                             97398      17112      0.17      17                                 

   ZN_FING                             30004      12788      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18585938                33.11                                                           

   ABCD                                 1612       1612     <0.01     121      Protocols and materials databases            

   Allergome                            1930       1255     <0.01     119      Protein family/group databases               

   ArachnoServer                        1163       1154     <0.01     129      Organism-specific databases                  

   Araport                             15931      15835      0.03      81      Organism-specific databases                  

   Bgee                                56745      56744      0.10      41      Gene expression databases                    

   BindingDB                            5194       5194      0.01      98      Chemistry                                    

   BioCyc                             270128     244541      0.48      22      Enzyme and pathway databases                 

   BioGrid                             54527      52838      0.10      45      Protein-protein interaction databases        

   BioMuta                             20329      20314      0.04      67      Polymorphism and mutation databases          

   BRENDA                              12957      12174      0.02      84      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     130      PTM databases                                

   CAZy                                 9506       8569      0.02      87      Protein family/group databases               

   CCDS                                48318      34258      0.09      49      Sequence databases                           

   CDD                                184351     167287      0.33      28      Family and domain databases                  

   CGD                                  1999       1982     <0.01     118      Organism-specific databases                  

   ChEMBL                               7279       7158      0.01      93      Chemistry                                    

   ChiTaRS                             29624      29587      0.05      54      Other                                        

   CollecTF                              135        135     <0.01     152      Gene expression databases                    

   ComplexPortal                        9223       4894      0.02      88      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     153      2D gel databases                             

   ConoServer                            952        869     <0.01     131      Organism-specific databases                  

   CORUM                                5805       5805      0.01      97      Protein-protein interaction databases        

   CPTAC                                2221       1423     <0.01     114      Proteomic databases                          

   CTD                                 75261      74363      0.13      40      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     150      PTM databases                                

   dictyBase                            4213       4099      0.01     106      Organism-specific databases                  

   DIP                                 17403      17371      0.03      77      Protein-protein interaction databases        

   DisGeNET                            15661      15430      0.03      82      Organism-specific databases                  

   DisProt                              1505       1492     <0.01     122      Family and domain databases                  

   DMDM                                16210      16208      0.03      80      Polymorphism and mutation databases          

   DNASU                               19022      18956      0.03      72      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     151      2D gel databases                             

   DrugBank                            27239       4519      0.05      60      Chemistry                                    

   DrugCentral                          2531       2531     <0.01     113      Chemistry                                    

   EchoBASE                             4159       4159      0.01     107      Organism-specific databases                  

   eggNOG                             666358     332449      1.19       5      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     120      Protein-protein interaction databases        

   EMBL                               985772     549297      1.76       3      Sequence databases                           

   Ensembl                             91933      50583      0.16      39      Genome annotation databases                  

   EnsemblBacteria                    355967     336789      0.63      16      Genome annotation databases                  

   EnsemblFungi                        29544      27988      0.05      56      Genome annotation databases                  

   EnsemblMetazoa                      17709      10349      0.03      75      Genome annotation databases                  

   EnsemblPlants                       28058      21007      0.05      57      Genome annotation databases                  

   EnsemblProtists                      4921       4742      0.01     101      Genome annotation databases                  

   EPD                                 22046      22046      0.04      64      Proteomic databases                          

   ESTHER                               2539       2538     <0.01     112      Protein family/group databases               

   euHCVdb                                55         44     <0.01     155      Organism-specific databases                  

   EuPathDB                            19697      19685      0.04      71      Organism-specific databases                  

   EvolutionaryTrace                   16635      16635      0.03      79      Other                                        

   ExpressionAtlas                     49481      49481      0.09      48      Gene expression databases                    

   FlyBase                              4894       4768      0.01     102      Organism-specific databases                  

   Gene3D                             402246     314325      0.72      14      Family and domain databases                  

   GeneCards                           20358      20185      0.04      66      Organism-specific databases                  

   GeneDB                                581        525     <0.01     139      Genome annotation databases                  

   GeneID                             290455     280801      0.52      20      Genome annotation databases                  

   GeneReviews                          1479       1475     <0.01     123      Organism-specific databases                  

   GeneTree                            56064      56014      0.10      42      Phylogenomic databases                       

   Genevisible                         55234      55234      0.10      43      Gene expression databases                    

   GeneWiki                            10351      10268      0.02      86      Other                                        

   GenomeRNAi                          22145      22145      0.04      63      Other                                        

   GlyConnect                           2201       2113     <0.01     116      PTM databases                                

   GO                                2986874     536002      5.32       1      Ontologies                                   

   Gramene                             28058      21007      0.05      58      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2013       2013     <0.01     117      Chemistry                                    

   HAMAP                              330174     327254      0.59      17      Family and domain databases                  

   HGNC                                20324      20185      0.04      68      Organism-specific databases                  

   HOGENOM                            392279     392279      0.70      15      Phylogenomic databases                       

   HPA                                 27372      16807      0.05      59      Organism-specific databases                  

   IMGT_GENE-DB                          266        266     <0.01     149      Protein family/group databases               

   InParanoid                         139870     139870      0.25      29      Phylogenomic databases                       

   IntAct                              54778      54778      0.10      44      Protein-protein interaction databases        

   InterPro                          2291870     542555      4.08       2      Family and domain databases                  

   iPTMnet                             52601      52601      0.09      46      PTM databases                                

   jPOST                               26786      26786      0.05      61      Proteomic databases                          

   KEGG                               504761     475824      0.90       7      Genome annotation databases                  

   KO                                 408044     407596      0.73      13      Phylogenomic databases                       

   LegioList                             765        763     <0.01     135      Organism-specific databases                  

   Leproma                               672        669     <0.01     136      Organism-specific databases                  

   MaizeGDB                              520        516     <0.01     141      Organism-specific databases                  

   MalaCards                            4604       4600      0.01     103      Organism-specific databases                  

   MassIVE                             17457      17457      0.03      76      Proteomic databases                          

   MaxQB                               29592      29592      0.05      55      Proteomic databases                          

   MEROPS                              11454      11452      0.02      85      Protein family/group databases               

   MGI                                 16935      16895      0.03      78      Organism-specific databases                  

   MIM                                 21397      15186      0.04      65      Organism-specific databases                  

   MINT                                22777      22777      0.04      62      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     146      Protein family/group databases               

   MoonProt                              280        280     <0.01     147      Protein family/group databases               

   mycoCLAP                              355        352     <0.01     145      Protein family/group databases               

   neXtProt                            20277      20277      0.04      69      Organism-specific databases                  

   NIAGADS                                72         72     <0.01     154      Organism-specific databases                  

   OGP                                   373        373     <0.01     144      2D gel databases                             

   OMA                                411708     411708      0.73      12      Phylogenomic databases                       

   OpenTargets                         18438      18284      0.03      73      Organism-specific databases                  

   Orphanet                             7605       4035      0.01      92      Organism-specific databases                  

   OrthoDB                            257236     257236      0.46      23      Phylogenomic databases                       

   PANTHER                            281890     270286      0.50      21      Family and domain databases                  

   PATRIC                              92167      92167      0.16      38      Genome annotation databases                  

   PaxDb                              124882     124882      0.22      33      Proteomic databases                          

   PDB                                185445      28235      0.33      27      3D structure databases                       

   PDBsum                             185445      28235      0.33      26      3D structure databases                       

   PeptideAtlas                        32505      32505      0.06      53      Proteomic databases                          

   PeroxiBase                            782        760     <0.01     134      Protein family/group databases               

   Pfam                               780662     522278      1.39       4      Family and domain databases                  

   PharmGKB                            18318      18300      0.03      74      Organism-specific databases                  

   Pharos                              20124      20124      0.04      70      Other                                        

   PhosphoSitePlus                     39014      39014      0.07      52      PTM databases                                

   PhylomeDB                           96447      96447      0.17      36      Phylogenomic databases                       

   PIR                                124219     113931      0.22      34      Sequence databases                           

   PIRSF                              109021     107992      0.19      35      Family and domain databases                  

   PlantReactome                         941        671     <0.01     132      Enzyme and pathway databases                 

   PMAP-CutDB                           1400       1400     <0.01     124      Other                                        

   PomBase                              5132       5128      0.01      99      Organism-specific databases                  

   PRIDE                              234543     234543      0.42      24      Proteomic databases                          

   PRINTS                             130442     115737      0.23      31      Family and domain databases                  

   PRO                                 95974      95974      0.17      37      Other                                        

   ProMEX                                463        463     <0.01     143      Proteomic databases                          

   PROSITE                            473896     301525      0.84      10      Family and domain databases                  

   Proteomes                          484606     460306      0.86       9      Other                                        

   ProteomicsDB                        40948      19836      0.07      51      Proteomic databases                          

   PseudoCAP                            1347       1338     <0.01     126      Organism-specific databases                  

   Reactome                           128917      36597      0.23      32      Enzyme and pathway databases                 

   REBASE                                618        378     <0.01     137      Protein family/group databases               

   RefSeq                             611906     466051      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     127      2D gel databases                             

   RGD                                  8004       8002      0.01      91      Organism-specific databases                  

   SABIO-RK                             4376       4376      0.01     104      Enzyme and pathway databases                 

   SFLD                                 8106       6016      0.01      90      Family and domain databases                  

   SGD                                  6740       6735      0.01      95      Organism-specific databases                  

   SignaLink                            3069       3069      0.01     111      Enzyme and pathway databases                 

   SIGNOR                               4278       4278      0.01     105      Enzyme and pathway databases                 

   SMART                              193114     142388      0.34      25      Family and domain databases                  

   SMR                                445691     445691      0.79      11      3D structure databases                       

   STRING                             328694     328694      0.59      18      Protein-protein interaction databases        

   SUPFAM                             503162     381137      0.90       8      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     128      2D gel databases                             

   SwissLipids                          1392       1305     <0.01     125      Chemistry                                    

   SwissPalm                            8601       8601      0.02      89      PTM databases                                

   TAIR                                14715      14659      0.03      83      Organism-specific databases                  

   TCDB                                 7229       7179      0.01      94      Protein family/group databases               

   TIGRFAMs                           292602     272596      0.52      19      Family and domain databases                  

   TopDownProteomics                    3239       2962      0.01     109      Proteomic databases                          

   TreeFam                             45605      45595      0.08      50      Phylogenomic databases                       

   TubercuList                          2205       2169     <0.01     115      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     142      2D gel databases                             

   UCSC                                50117      45768      0.09      47      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     138      PTM databases                                

   UniLectin                             275        275     <0.01     148      Protein family/group databases               

   UniPathway                         137062     124116      0.24      30      Enzyme and pathway databases                 

   VectorBase                            581        502     <0.01     140      Genome annotation databases                  

   VGNC                                 3971       3971      0.01     108      Organism-specific databases                  

   WBParaSite                             31         31     <0.01     156      Genome annotation databases                  

   World-2DPAGE                          931        920     <0.01     133      2D gel databases                             

   WormBase                             6224       4701      0.01      96      Organism-specific databases                  

   Xenbase                              5010       4979      0.01     100      Organism-specific databases                  

   ZFIN                                 3104       3099      0.01     110      Organism-specific databases                  



Total number of cross-referenced databases: 156



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.63

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3920 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79608