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         UniProtKB/Swiss-Prot protein knowledgebase release 2018_10 statistics





1.  INTRODUCTION



Release 2018_10 of 07-Nov-18 of UniProtKB/Swiss-Prot contains 558681 sequence entries,

comprising 200603466 amino acids abstracted from 262816 references. 



101 sequences have been added since release 2018_09, the sequence data of

15 existing entries has been updated and the annotations of

259269 entries have been revised.



Number of fragments: 9158

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 39980





Protein existence (PE):           entries     %



1: Evidence at protein level        99594   17.8%

2: Evidence at transcript level     57178   10.2%

3: Inferred from homology          386617   69.2%

4: Predicted                        13456    2.4%

5: Uncertain                         1836    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13682



   The first twenty species represent 120677 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5662

                            2x: 1954

                            3x: 1067

                            4x:  694

                            5x:  511

                            6x:  408

                            7x:  297

                            8x:  249

                            9x:  229

                           10x:  139

                       11- 20x:  747

                       21- 50x:  457

                       51-100x:  218

                         >100x: 1050





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20408  Homo sapiens (Human)

       2      17000  Mus musculus (Mouse)

       3      15818  Arabidopsis thaliana (Mouse-ear cress)

       4       8053  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6003  Bos taurus (Bovine)

       7       5141  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4477  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4139  Dictyostelium discoideum (Slime mold)

      11       4036  Caenorhabditis elegans

      12       4008  Oryza sativa subsp. japonica (Rice)

      13       3541  Drosophila melanogaster (Fruit fly)

      14       3444  Xenopus laevis (African clawed frog)

      15       3083  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2291  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2173  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2037  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1796  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      24       1706  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1683  Shigella flexneri

      27       1427  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1326  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1173  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1064  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1034  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35       1009  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        975  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        930  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      38        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      39        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      40        926  Staphylococcus aureus (strain N315)

      41        914  Kluyveromyces lactis   

      42        914  Emericella nidulans  

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        899  Staphylococcus aureus (strain COL)

      45        895  Staphylococcus aureus (strain MW2)

      46        893  Oryctolagus cuniculus (Rabbit)

      47        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      48        889  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        882  Salmonella choleraesuis (strain SC-B67)

      51        882  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        855  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      58        829  Shigella boydii serotype 4 (strain Sb227)

      59        825  Oryza sativa subsp. indica (Rice)

      60        825  Escherichia coli (strain UTI89 / UPEC)

      61        822  Shigella dysenteriae serotype 1 (strain Sd197)

      62        821  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      63        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      64        819  Canis lupus familiaris (Dog) (Canis familiaris)

      65        808  Zea mays (Maize)

      66        796  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      67        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      68        792  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      69        791  Escherichia coli (strain SMS-3-5 / SECEC)

      70        784  Aquifex aeolicus (strain VF5)

      71        776  Pasteurella multocida (strain Pm70)

      72        771  Escherichia coli (strain K12 / DH10B)

      73        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        766  Staphylococcus aureus (strain NCTC 8325)

      75        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      76        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        760  Shigella flexneri serotype 5b (strain 8401)

      81        759  Staphylococcus epidermidis (strain ATCC 12228)

      82        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        751  Bacillus anthracis

      86        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      87        746  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      88        741  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Vibrio vulnificus (strain YJ016)

      94        718  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      97        715  Enterobacter sp. (strain 638)

      98        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      99        714  Escherichia coli O1:K1 / APEC

     100        714  Salmonella paratyphi A (strain AKU_12601)

     101        713  Salmonella newport (strain SL254)

     102        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     103        713  Salmonella agona (strain SL483)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     109        698  Klebsiella pneumoniae (strain 342)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        673  Escherichia coli

     118        673  Staphylococcus aureus (strain USA300)

     119        670  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        664  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     124        664  Bradyrhizobium diazoefficiens 

     125        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        646  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        645  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Treponema pallidum (strain Nichols)

     134        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     135        620  Methanothermobacter thermautotrophicus  

     136        614  Staphylococcus haemolyticus (strain JCSC1435)

     137        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     138        610  Xanthomonas campestris pv. campestris 

     139        608  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     140        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     141        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     142        602  Staphylococcus saprophyticus subsp. saprophyticus 

     143        602  Photobacterium profundum (strain SS9)

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     147        594  Pseudomonas aeruginosa (strain UCBPP-PA14)

     148        594  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        580  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Bacillus cereus (strain ZK / E33L)

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        559  Clostridium acetobutylicum 

     165        557  Xanthomonas axonopodis pv. citri (strain 306)

     166        555  Pseudomonas fluorescens (strain Pf0-1)

     167        555  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     168        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     169        553  Oceanobacillus iheyensis 

     170        551  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     171        550  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        537  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Listeria monocytogenes serotype 4b (strain F2365)

     176        529  Corynebacterium glutamicum 

     177        529  Sodalis glossinidius (strain morsitans)

     178        527  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        522  Xylella fastidiosa (strain 9a5c)

     180        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     181        517  Chromobacterium violaceum 

     182        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        514  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     185        513  Deinococcus radiodurans 

     186        513  Staphylococcus aureus (strain Newman)

     187        512  Pseudomonas aeruginosa (strain PA7)

     188        511  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     189        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     190        510  Geobacillus kaustophilus (strain HTA426)

     191        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     192        508  Streptomyces avermitilis 

     193        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     194        502  Pseudomonas entomophila (strain L48)

     195        501  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     196        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     199        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     200        497  Haemophilus influenzae (strain 86-028NP)

     201        496  Burkholderia pseudomallei (strain K96243)

     202        496  Bacillus clausii (strain KSM-K16)

     203        494  Proteus mirabilis (strain HI4320)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        488  Methanosarcina mazei  

     209        487  Pyrococcus horikoshii 

     210        487  Shewanella sp. (strain MR-7)

     211        486  Mannheimia succiniciproducens (strain MBEL55E)

     212        485  Thermosynechococcus elongatus (strain BP-1)

     213        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     214        484  Shewanella sp. (strain MR-4)

     215        484  Pseudomonas aeruginosa (strain LESB58)

     216        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     217        483  Brucella abortus (strain 2308)

     218        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     219        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     221        478  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     222        477  Pyrococcus abyssi (strain GE5 / Orsay)

     223        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     224        475  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     225        475  Nicotiana tabacum (Common tobacco)

     226        474  Burkholderia lata 

     227        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     228        468  Clostridium perfringens (strain 13 / Type A)

     229        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     230        467  Shewanella frigidimarina (strain NCIMB 400)

     231        466  Shewanella sp. (strain ANA-3)

     232        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     233        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     234        466  Pseudomonas putida (strain GB-1)

     235        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     236        464  Aeromonas hydrophila subsp. hydrophila 

     237        463  Enterococcus faecalis (strain ATCC 700802 / V583)

     238        462  Burkholderia mallei (strain ATCC 23344)

     239        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     241        457  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     242        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     243        457  Ovis aries (Sheep)

     244        455  Staphylococcus aureus (strain JH1)

     245        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     246        453  Pseudomonas putida (strain W619)

     247        452  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     248        452  Shewanella baltica (strain OS185)

     249        452  Aeromonas salmonicida (strain A449)

     250        450  Caldanaerobacter subterraneus subsp. tengcongensis  





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19544 (  3%)

    Bacteria         333711 ( 60%)

    Eukaryota        188590 ( 34%)

    Viruses           16836 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20409 ( 11%)           (  4%)

     Other Mammalia         46685 ( 25%)           (  8%)

     Other Vertebrata       18342 ( 10%)           (  3%)

     Viridiplantae          39701 ( 21%)           (  7%)

     Fungi                  33721 ( 18%)           (  6%)

     Insecta                 9213 (  5%)           (  2%)

     Nematoda                4938 (  3%)           (  1%)

     Other                  15581 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9576             1001-1100     3985

                 51- 100   42547             1101-1200     2799

                101- 150   59000             1201-1300     2143

                151- 200   58872             1301-1400     2001

                201- 250   57719             1401-1500     1621

                251- 300   51441             1501-1600      792

                301- 350   51811             1601-1700      616

                351- 400   44961             1701-1800      552

                401- 450   36946             1801-1900      470

                451- 500   29785             1901-2000      375

                501- 550   21495             2001-2100      248

                551- 600   15338             2101-2200      325

                601- 650   12801             2201-2300      313

                651- 700    9217             2301-2400      212

                701- 750    7649             2401-2500      160

                751- 800    5526             >2500         1281

                801- 850    4770

                851- 900    5206

                901- 950    4049

                951-1000    2921



   





   The average sequence length in UniProtKB/Swiss-Prot is 359 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2753





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  866

                       2x:  391

                       3x:  163

                       4x:  136

                       5x:  110

                       6x:  100

                       7x:   66

                       8x:   56

                       9x:   37

                      10x:   33

                  11- 20x:  219

                  21- 50x:  227

                  51-100x:  118

                    >100x:  231





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24439   Journal of Biological Chemistry

    2        11326   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6606   Journal of Bacteriology

    4         5619   Biochemical and Biophysical Research Communications

    5         5312   Biochemistry

    6         4984   Nucleic Acids Research

    7         4816   FEBS Letters

    8         4805   Gene

    9         4679   The EMBO Journal

   10         4501   Nature

   11         4333   Molecular and Cellular Biology

   12         4248   Journal of Molecular Biology

   13         3616   Biochimica et Biophysica Acta

   14         3549   Cell

   15         3391   European Journal of Biochemistry

   16         3218   Journal of Virology

   17         2996   Science

   18         2842   Biochemical Journal

   19         2546   Plant Physiology

   20         2534   Genomics

   21         2516   Molecular Microbiology

   22         2188   Journal of Cell Biology

   23         2133   The American Journal of Human Genetics

   24         1981   The Plant Cell

   25         1876   PLoS ONE

   26         1852   Plant Molecular Biology

   27         1833   Genes and Development

   28         1823   The Plant Journal

   29         1795   Human Molecular Genetics

   30         1780   Virology

   31         1744   Nature Genetics

   32         1664   Development

   33         1656   Molecular Biology of the Cell

   34         1567   Human Mutation

   35         1540   Oncogene

   36         1528   Molecular Cell

   37         1417   Journal of Immunology

   38         1394   Molecular and General Genetics

   39         1334   Journal of Biochemistry

   40         1329   Structure

   41         1310   Genetics

   42         1242   Journal of Cell Science

   43         1146   Blood

   44         1135   Journal of General Virology

   45         1106   Infection and Immunity

   46         1051   Microbiology

   47         1044   Developmental Biology

   48         1043   Current Biology

   49         1042   Archives of Biochemistry and Biophysics

   50          900   Applied and Environmental Microbiology

   51          885   Journal of Neuroscience

   52          882   Cancer Research

   53          873   Acta Crystallographica, Section D

   54          838   Yeast

   55          836   FEMS Microbiology Letters

   56          769   Protein Science

   57          767   Toxicon

   58          739   Neuron

   59          720   Journal of Clinical Investigation

   60          688   Human Genetics

   61          672   American Journal of Physiology

   62          670   Plant and Cell Physiology

   63          648   Mechanisms of Development

   64          645   Nature Structural Biology

   65          629   PLoS Genetics

   66          627   The Journal of Experimental Medicine

   67          615   Proteins

   68          599   Journal of Medical Genetics

   69          574   Current Genetics

   70          568   Nature Cell Biology

   71          550   Bioscience, Biotechnology, and Biochemistry

   72          532   Molecular Endocrinology

   73          530   Journal of Neurochemistry

   74          529   Nature Structural and Molecular Biology

   75          517   The Journal of Clinical Endocrinology and Metabolism

   76          507   Developmental Cell

   77          502   Endocrinology

   78          501   The FEBS Journal

   79          488   Mammalian Genome

   80          472   Immunogenetics

   81          464   Antimicrobial Agents and Chemotherapy

   82          457   Experimental Cell Research

   83          448   Molecular and Biochemical Parasitology

   84          431   Eukaryotic Cell

   85          423   Planta

   86          416   RNA

   87          410   Peptides

   88          407   Journal of Molecular Evolution

   89          397   Molecular Biology and Evolution

   90          392   Nature Communications

   91          386   DNA and Cell Biology

   92          381   Journal of Experimental Botany

   93          374   DNA Sequence

   94          374   Journal of the American Chemical Society

   95          373   Molecular Pharmacology

   96          359   EMBO Reports

   97          358   Neurology

   98          358   Journal of Investigative Dermatology

   99          357   PLoS Pathogens

  100          351   The FASEB Journal

  101          349   Comparative Biochemistry and Physiology

  102          347   Biology of Reproduction

  103          345   Acta Crystallographica, Section F

  104          339   Brain Research. Molecular Brain Research

  105          339   Molecular Plant-Microbe Interactions

  106          336   American Journal of Medical Genetics. Part A

  107          333   European Journal of Human Genetics

  108          327   Scientific Reports

  109          326   Tissue Antigens

  110          323   Immunity

  111          317   Biochimie

  112          317   Virus Research

  113          316   Genes to Cells

  114          315   The New England Journal of Medicine

  115          312   Developmental Dynamics

  116          296   Biological Chemistry Hoppe-Seyler

  117          296   Genome Research

  118          293   Clinical Genetics

  119          286   Annals of Neurology

  120          282   Cytogenetics and Cell Genetics

  121          271   Journal of General Microbiology

  122          270   European Journal of Immunology

  123          269   BMC Genomics

  124          266   Investigative Ophthalmology and Visual Science

  125          266   Nature Immunology

  126          260   Applied Microbiology and Biotechnology

  127          253   Journal of Human Genetics

  128          249   Journal of Medicinal Chemistry

  129          244   PLoS Biology

  130          240   Archives of Microbiology

  131          233   Glycobiology

  132          231   DNA Research

  133          229   Journal of Cellular Biochemistry

  134          224   Traffic

  135          220   Cell Cycle

  136          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  137          218   Molecular Genetics and Metabolism

  138          216   Journal of Lipid Research

  139          215   Circulation Research

  140          213   Molecular Immunology

  141          209   Archives of Virology

  142          208   Diabetes

  143          207   Molecular and Cellular Endocrinology

  144          204   Protein Expression and Purification

  145          203   Phytochemistry

  146          199   Fungal Genetics and Biology

  147          198   Nature Medicine

  148          196   Molecular Genetics and Genomics

  149          194   Cell Reports

  150          183   Insect Biochemistry and Molecular Biology





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1217150                 2.18                                         

   Journal                           1039800     454453      1.86       1                                 

   Submitted to EMBL/GenBank/DDBJ     166562     150930      0.30       2                                 

   Submitted to other databases         7364       6799      0.01       3                                 

   Book citation                        1757       1734     <0.01       4                                 

   Plant Gene Register                   611        598     <0.01       5                                 

   Thesis                                433        430     <0.01       6                                 

   Unpublished observations              408        404     <0.01       7                                 

   Patent                                209        203     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 406039



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2513974                 4.50                                         

   ACTIVITY REGULATION                 14722      14722      0.03      16                                 

   ALLERGEN                              722        722     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25239      25239      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8165       8165      0.01      20                                 

   BIOTECHNOLOGY                         945        931     <0.01      25                                 

   CATALYTIC ACTIVITY                 268440     236499      0.48       5                                 

   CAUTION                             12791      12554      0.02      18                                 

   COFACTOR                           123055     112672      0.22       7                                 

   DEVELOPMENTAL STAGE                 12082      12081      0.02      19                                 

   DISEASE                              6976       4682      0.01      21                                 

   DISRUPTION PHENOTYPE                14125      14124      0.03      17                                 

   DOMAIN                              48593      41855      0.09       9                                 

   FUNCTION                           465198     444787      0.83       2                                 

   INDUCTION                           20819      20807      0.04      14                                 

   INTERACTION                         19120      19120      0.03      15                                 

   MASS SPECTROMETRY                    6918       5213      0.01      22                                 

   MISCELLANEOUS                       38515      35456      0.07      12                                 

   PATHWAY                            137976     125168      0.25       6                                 

   PHARMACEUTICAL                        115        111     <0.01      29                                 

   POLYMORPHISM                         1309       1253     <0.01      24                                 

   PTM                                 56181      41634      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44009      44009      0.08      11                                 

   SIMILARITY                         507626     503478      0.91       1                                 

   SUBCELLULAR LOCATION               348563     341274      0.62       3                                 

   SUBUNIT                            278053     277261      0.50       4                                 

   TISSUE SPECIFICITY                  45672      45671      0.08      10                                 

   TOXIC DOSE                            666        609     <0.01      27                                 

   WEB RESOURCE                         6752       5591      0.01      23                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4479559                 8.02                                         

   ACT_SITE                           163560      99292      0.29      10                                 

   BINDING                            404320     106475      0.72       2                                 

   CA_BIND                              4176       1729      0.01      36                                 

   CARBOHYD                           115703      29756      0.21      15                                 

   CHAIN                              566504     551610      1.01       1                                 

   COILED                              22012      15221      0.04      27                                 

   COMPBIAS                            58979      31736      0.11      20                                 

   CONFLICT                           135109      47314      0.24      13                                 

   CROSSLNK                            23591       8458      0.04      26                                 

   DISULFID                           124686      33650      0.22      14                                 

   DNA_BIND                            11632      10524      0.02      32                                 

   DOMAIN                             194239     119725      0.35       9                                 

   HELIX                              253182      23419      0.45       6                                 

   INIT_MET                            17154      17154      0.03      28                                 

   INTRAMEM                             2656       1199     <0.01      37                                 

   LIPID                               13019       8404      0.02      30                                 

   METAL                              380572      94104      0.68       3                                 

   MOD_RES                            248510      71803      0.44       7                                 

   MOTIF                               42934      28040      0.08      23                                 

   MUTAGEN                             69387      15242      0.12      18                                 

   NON_CONS                             2257        787     <0.01      38                                 

   NON_STD                               357        282     <0.01      39                                 

   NON_TER                             12391       9506      0.02      31                                 

   NP_BIND                            156735      85175      0.28      11                                 

   PEPTIDE                             11567       7966      0.02      33                                 

   PROPEP                              14211      12118      0.03      29                                 

   REGION                             197546      93578      0.35       8                                 

   REPEAT                             105422      14737      0.19      16                                 

   SIGNAL                              41628      41626      0.07      24                                 

   SITE                                57210      31722      0.10      21                                 

   STRAND                             263773      22046      0.47       5                                 

   TOPO_DOM                           140313      28758      0.25      12                                 

   TRANSIT                              9088       8972      0.02      34                                 

   TRANSMEM                           370471      77297      0.66       4                                 

   TURN                                60979      18981      0.11      19                                 

   UNSURE                               4454        796      0.01      35                                 

   VAR_SEQ                             51963      22005      0.09      22                                 

   VARIANT                             96747      17075      0.17      17                                 

   ZN_FING                             30522      13402      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18904424                33.84                                                           

   Allergome                            1758       1148     <0.01     121      Protein family/group databases               

   ArachnoServer                        1145       1136     <0.01     130      Organism-specific databases                  

   Araport                             15839      15743      0.03      83      Organism-specific databases                  

   Bgee                                56453      56453      0.10      45      Gene expression databases                    

   BindingDB                            5000       5000      0.01     104      Chemistry                                    

   BioCyc                             158125     154060      0.28      29      Enzyme and pathway databases                 

   BioGrid                             50997      50497      0.09      50      Protein-protein interaction databases        

   BioMuta                             17236      17227      0.03      79      Polymorphism and mutation databases          

   BRENDA                              12910      12136      0.02      87      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     128      PTM databases                                

   CAZy                                 9483       8548      0.02      90      Protein family/group databases               

   CCDS                                48139      34128      0.09      52      Sequence databases                           

   CDD                                184998     169025      0.33      26      Family and domain databases                  

   CGD                                  1997       1980     <0.01     118      Organism-specific databases                  

   ChEMBL                               6868       6868      0.01      96      Chemistry                                    

   ChiTaRS                             20475      20464      0.04      69      Other                                        

   CleanEx                             30013      29382      0.05      59      Gene expression databases                    

   CollecTF                              133        133     <0.01     152      Gene expression databases                    

   ComplexPortal                        8537       4488      0.02      91      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     153      2D gel databases                             

   ConoServer                            951        868     <0.01     131      Organism-specific databases                  

   CORUM                                5168       5168      0.01     101      Protein-protein interaction databases        

   CTD                                 74929      74051      0.13      43      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     148      PTM databases                                

   dictyBase                            4215       4100      0.01     108      Organism-specific databases                  

   DIP                                 17350      17318      0.03      77      Protein-protein interaction databases        

   DisGeNET                            14840      14606      0.03      85      Organism-specific databases                  

   DisProt                               708        703     <0.01     135      3D structure databases                       

   DMDM                                16277      16277      0.03      82      Polymorphism and mutation databases          

   DNASU                               18994      18927      0.03      73      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     150      2D gel databases                             

   DrugBank                            18747       3637      0.03      74      Chemistry                                    

   EchoBASE                             4159       4159      0.01     109      Organism-specific databases                  

   EcoGene                              4293       4293      0.01     107      Organism-specific databases                  

   eggNOG                             664769     331670      1.19       5      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     120      Protein-protein interaction databases        

   EMBL                               984094     546966      1.76       3      Sequence databases                           

   Ensembl                             90229      50323      0.16      41      Genome annotation databases                  

   EnsemblBacteria                    354635     335506      0.63      17      Genome annotation databases                  

   EnsemblFungi                        30822      28977      0.06      58      Genome annotation databases                  

   EnsemblMetazoa                      17336      10146      0.03      78      Genome annotation databases                  

   EnsemblPlants                       27447      20482      0.05      63      Genome annotation databases                  

   EnsemblProtists                      5016       4830      0.01     103      Genome annotation databases                  

   EPD                                 21826      21826      0.04      66      Proteomic databases                          

   ESTHER                               2503       2503     <0.01     116      Protein family/group databases               

   euHCVdb                                55         44     <0.01     154      Organism-specific databases                  

   EuPathDB                            31153      30961      0.06      57      Organism-specific databases                  

   EvolutionaryTrace                   16625      16625      0.03      81      Other                                        

   ExpressionAtlas                     51735      51735      0.09      48      Gene expression databases                    

   FlyBase                              6169       5873      0.01      98      Organism-specific databases                  

   Gene3D                             366738     292693      0.66      16      Family and domain databases                  

   GeneCards                           20360      20189      0.04      71      Organism-specific databases                  

   GeneDB                                575        519     <0.01     139      Genome annotation databases                  

   GeneID                             290242     279963      0.52      23      Genome annotation databases                  

   GeneReviews                          1154       1151     <0.01     129      Organism-specific databases                  

   GeneTree                            59463      59441      0.11      44      Phylogenomic databases                       

   Genevisible                         55238      55238      0.10      46      Gene expression databases                    

   GeneWiki                            10356      10273      0.02      89      Other                                        

   GenomeRNAi                          22044      22044      0.04      65      Other                                        

   GlyConnect                           1439       1353     <0.01     122      PTM databases                                

   GO                                2931260     532502      5.25       1      Ontologies                                   

   Gramene                             27447      20482      0.05      62      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  1957       1957     <0.01     119      Chemistry                                    

   H-InvDB                              5628       4802      0.01     100      Organism-specific databases                  

   HAMAP                              329828     326952      0.59      19      Family and domain databases                  

   HGNC                                20347      20207      0.04      72      Organism-specific databases                  

   HOGENOM                            391700     391700      0.70      15      Phylogenomic databases                       

   HOVERGEN                            76120      76120      0.14      42      Phylogenomic databases                       

   HPA                                 27402      16829      0.05      64      Organism-specific databases                  

   IMGT_GENE-DB                          142        142     <0.01     151      Protein family/group databases               

   InParanoid                         139563     139563      0.25      30      Phylogenomic databases                       

   IntAct                              52728      52728      0.09      47      Protein-protein interaction databases        

   InterPro                          2246772     540217      4.02       2      Family and domain databases                  

   iPTMnet                             51306      51306      0.09      49      PTM databases                                

   KEGG                               502782     475415      0.90       7      Genome annotation databases                  

   KO                                 405196     404752      0.73      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     134      Organism-specific databases                  

   Leproma                               672        669     <0.01     136      Organism-specific databases                  

   MaizeGDB                              509        505     <0.01     140      Organism-specific databases                  

   MalaCards                            4499       4496      0.01     106      Organism-specific databases                  

   MaxQB                               29709      29709      0.05      60      Proteomic databases                          

   MEROPS                              11396      11396      0.02      88      Protein family/group databases               

   MGI                                 16906      16866      0.03      80      Organism-specific databases                  

   MIM                                 21020      15072      0.04      68      Organism-specific databases                  

   MINT                                21793      21793      0.04      67      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     146      Protein family/group databases               

   MoonProt                              279        279     <0.01     147      Protein family/group databases               

   mycoCLAP                              355        352     <0.01     145      Protein family/group databases               

   neXtProt                            20371      20371      0.04      70      Organism-specific databases                  

   OGP                                   373        373     <0.01     144      2D gel databases                             

   OMA                                408602     408602      0.73      13      Phylogenomic databases                       

   OpenTargets                         18379      18218      0.03      75      Organism-specific databases                  

   Orphanet                             7425       3912      0.01      93      Organism-specific databases                  

   OrthoDB                            293558     293558      0.53      20      Phylogenomic databases                       

   PANTHER                            293205     279576      0.52      21      Family and domain databases                  

   PATRIC                              91862      91862      0.16      40      Genome annotation databases                  

   PaxDb                              124674     124674      0.22      33      Proteomic databases                          

   PDB                                168573      26924      0.30      28      3D structure databases                       

   PDBsum                             168573      26924      0.30      27      3D structure databases                       

   PeptideAtlas                        32139      32139      0.06      56      Proteomic databases                          

   PeroxiBase                            780        758     <0.01     133      Protein family/group databases               

   Pfam                               761600     518559      1.36       4      Family and domain databases                  

   PharmGKB                            18359      18317      0.03      76      Organism-specific databases                  

   PhosphoSitePlus                     39021      39021      0.07      54      PTM databases                                

   PhylomeDB                           96330      96330      0.17      38      Phylogenomic databases                       

   PIR                                124187     113737      0.22      34      Sequence databases                           

   PIRSF                              108915     107886      0.19      37      Family and domain databases                  

   PMAP-CutDB                           1401       1401     <0.01     123      Other                                        

   PomBase                              5133       5129      0.01     102      Organism-specific databases                  

   PRIDE                              230699     230699      0.41      24      Proteomic databases                          

   PRINTS                             132710     117158      0.24      32      Family and domain databases                  

   PRO                                 95984      95984      0.17      39      Other                                        

   ProDom                              29163      28980      0.05      61      Family and domain databases                  

   ProMEX                                457        457     <0.01     142      Proteomic databases                          

   PROSITE                            467429     298895      0.84      10      Family and domain databases                  

   ProteinModelPortal                 449116     449116      0.80      11      3D structure databases                       

   Proteomes                          479445     455315      0.86       9      Other                                        

   ProteomicsDB                        36382      19831      0.07      55      Proteomic databases                          

   PseudoCAP                            1334       1325     <0.01     125      Organism-specific databases                  

   Reactome                           123647      36729      0.22      35      Enzyme and pathway databases                 

   REBASE                                395        395     <0.01     143      Protein family/group databases               

   RefSeq                             608447     463427      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     126      2D gel databases                             

   RGD                                  7977       7976      0.01      92      Organism-specific databases                  

   SABIO-RK                             3963       3963      0.01     111      Enzyme and pathway databases                 

   SFLD                                15543       7107      0.03      84      Family and domain databases                  

   SGD                                  6739       6734      0.01      97      Organism-specific databases                  

   SignaLink                            3066       3066      0.01     114      Enzyme and pathway databases                 

   SIGNOR                               4081       4081      0.01     110      Enzyme and pathway databases                 

   SMART                              192268     141835      0.34      25      Family and domain databases                  

   SMR                                444421     444421      0.80      12      3D structure databases                       

   STRING                             332705     332705      0.60      18      Protein-protein interaction databases        

   SUPFAM                             498029     377697      0.89       8      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     127      2D gel databases                             

   SwissLipids                          1360       1273     <0.01     124      Chemistry                                    

   SwissPalm                            7298       7298      0.01      94      PTM databases                                

   TAIR                                14626      14570      0.03      86      Organism-specific databases                  

   TCDB                                 6877       6831      0.01      95      Protein family/group databases               

   TIGRFAMs                           292361     272375      0.52      22      Family and domain databases                  

   TopDownProteomics                    3241       2964      0.01     113      Proteomic databases                          

   TreeFam                             45483      45473      0.08      53      Phylogenomic databases                       

   TubercuList                          2191       2155     <0.01     117      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     141      2D gel databases                             

   UCSC                                49914      45604      0.09      51      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     138      PTM databases                                

   UniGene                            109788      96226      0.20      36      Sequence databases                           

   UniLectin                             238        238     <0.01     149      Protein family/group databases               

   UniPathway                         136333     123547      0.24      31      Enzyme and pathway databases                 

   VectorBase                            597        517     <0.01     137      Genome annotation databases                  

   VGNC                                 3893       3893      0.01     112      Organism-specific databases                  

   WBParaSite                             34         34     <0.01     155      Genome annotation databases                  

   World-2DPAGE                          930        919     <0.01     132      2D gel databases                             

   WormBase                             6025       4595      0.01      99      Organism-specific databases                  

   Xenbase                              4558       4552      0.01     105      Organism-specific databases                  

   ZFIN                                 3063       3058      0.01     115      Organism-specific databases                  



Total number of cross-referenced databases: 155



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.62

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.05   Gly (G) 7.07   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.91

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3883 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79233