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         UniProtKB/Swiss-Prot protein knowledgebase release 2021_02 statistics





1.  INTRODUCTION



Release 2021_02 of 07-Apr-21 of UniProtKB/Swiss-Prot contains 564638 sequence entries,

comprising 203519613 amino acids abstracted from 278054 references. 



373 sequences have been added since release 2021_01, the sequence data of

43 existing entries has been updated and the annotations of

245770 entries have been revised.



Number of fragments: 9236

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40503





Protein existence (PE):           entries     %



1: Evidence at protein level       106358   18.8%

2: Evidence at transcript level     56264     10%

3: Inferred from homology          386874   68.5%

4: Predicted                        13298    2.4%

5: Uncertain                         1844    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 14051



   The first twenty species represent 121714 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5752

                            2x: 2030

                            3x: 1090

                            4x:  724

                            5x:  513

                            6x:  425

                            7x:  320

                            8x:  257

                            9x:  231

                           10x:  139

                       11- 20x:  820

                       21- 50x:  471

                       51-100x:  224

                         >100x: 1055





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20395  Homo sapiens (Human)

       2      17073  Mus musculus (Mouse)

       3      16043  Arabidopsis thaliana (Mouse-ear cress)

       4       8125  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6014  Bos taurus (Bovine)

       7       5137  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4518  Escherichia coli (strain K12)

       9       4226  Caenorhabditis elegans

      10       4191  Bacillus subtilis (strain 168)

      11       4150  Dictyostelium discoideum (Slime mold)

      12       4112  Oryza sativa subsp. japonica (Rice)

      13       3632  Drosophila melanogaster (Fruit fly)

      14       3471  Xenopus laevis (African clawed frog)

      15       3196  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2297  Gallus gallus (Chicken)

      17       2255  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      18       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      19       2042  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1804  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1705  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      25       1701  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1685  Shigella flexneri

      27       1438  Sus scrofa (Pig)

      28       1399  Pseudomonas aeruginosa 

      29       1347  Salmonella typhi

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1174  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1079  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1030  Archaeoglobus fulgidus 

      34       1026  Yersinia pestis

      35       1014  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        988  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        978  Emericella nidulans  

      38        941  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      40        929  Staphylococcus aureus (strain N315)

      41        928  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      42        919  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        903  Staphylococcus aureus (strain COL)

      45        896  Staphylococcus aureus (strain MW2)

      46        894  Oryctolagus cuniculus (Rabbit)

      47        894  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      48        890  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        885  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      51        882  Salmonella choleraesuis (strain SC-B67)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        875  Neurospora crassa 

      55        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      56        848  Oryza sativa subsp. indica (Rice)

      57        841  Escherichia coli O9:H4 (strain HS)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        833  Canis lupus familiaris (Dog) (Canis familiaris)

      60        833  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      61        833  Zea mays (Maize)

      62        829  Shigella boydii serotype 4 (strain Sb227)

      63        825  Escherichia coli (strain UTI89 / UPEC)

      64        822  Shigella dysenteriae serotype 1 (strain Sd197)

      65        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      66        808  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      67        803  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      68        800  Staphylococcus aureus (strain NCTC 8325 / PS 47)

      69        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      70        791  Escherichia coli (strain SMS-3-5 / SECEC)

      71        787  Aquifex aeolicus (strain VF5)

      72        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      73        771  Escherichia coli (strain K12 / DH10B)

      74        770  Pasteurella multocida (strain Pm70)

      75        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      76        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)

      80        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      81        760  Shigella flexneri serotype 5b (strain 8401)

      82        758  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        756  Bacillus anthracis

      85        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      86        748  Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      87        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      88        742  Bacillus halodurans 

      89        739  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        725  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      93        722  Salmonella enteritidis PT4 (strain P125109)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      97        715  Enterobacter sp. (strain 638)

      98        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      99        714  Escherichia coli O1:K1 / APEC

     100        714  Salmonella paratyphi A (strain AKU_12601)

     101        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     102        713  Salmonella newport (strain SL254)

     103        713  Salmonella agona (strain SL483)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        699  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        697  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     111        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     112        692  Pan troglodytes (Chimpanzee)

     113        686  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        686  Escherichia coli

     115        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     116        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     117        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     118        677  Staphylococcus aureus (strain USA300)

     119        672  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        668  Bacillus cereus 

     122        667  Yersinia pestis (strain Pestoides F)

     123        665  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     124        664  Bradyrhizobium diazoefficiens 

     125        657  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        652  Shewanella oneidensis (strain MR-1)

     128        651  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        641  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     134        622  Treponema pallidum (strain Nichols)

     135        622  Methanothermobacter thermautotrophicus  

     136        621  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     137        615  Xanthomonas campestris pv. campestris 

     138        614  Staphylococcus haemolyticus (strain JCSC1435)

     139        613  Mesorhizobium japonicum  (Mesorhizobium loti 

     140        612  Pseudomonas aeruginosa (strain UCBPP-PA14)

     141        608  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     142        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     143        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     144        602  Staphylococcus saprophyticus subsp. saprophyticus 

     145        602  Photobacterium profundum (strain SS9)

     146        601  Salmonella paratyphi C (strain RKS4594)

     147        600  Yersinia pestis bv. Antiqua (strain Angola)

     148        595  Bacillus cereus (strain ATCC 10987 / NRS 248)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        584  Rickettsia prowazekii (strain Madrid E)

     151        583  Neisseria meningitidis serogroup B (strain MC58)

     152        579  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        575  Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 

     155        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     156        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     157        573  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     159        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     160        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     161        567  Pseudomonas syringae pv. syringae (strain B728a)

     162        564  Bacillus licheniformis 

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        562  Bacillus cereus (strain ZK / E33L)

     165        561  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     166        559  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     167        559  Clostridium acetobutylicum 

     168        557  Xanthomonas axonopodis pv. citri (strain 306)

     169        555  Pseudomonas fluorescens (strain Pf0-1)

     170        554  Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)

     171        554  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        553  Oceanobacillus iheyensis 

     173        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     174        540  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     175        534  Corynebacterium glutamicum 

     176        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     177        529  Sodalis glossinidius (strain morsitans)

     178        529  Listeria monocytogenes serotype 4b (strain F2365)

     179        528  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     180        524  Staphylococcus aureus (strain Newman)

     181        522  Xylella fastidiosa (strain 9a5c)

     182        521  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     183        519  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     184        517  Chromobacterium violaceum 

     185        516  Deinococcus radiodurans 

     186        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     187        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     188        514  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     189        512  Pseudomonas aeruginosa (strain PA7)

     190        511  Streptomyces avermitilis 

     191        510  Geobacillus kaustophilus (strain HTA426)

     192        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     193        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     194        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     195        502  Pseudomonas entomophila (strain L48)

     196        502  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Haemophilus influenzae (strain 86-028NP)

     198        499  Brucella abortus biovar 1 (strain 9-941)

     199        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     200        496  Burkholderia pseudomallei (strain K96243)

     201        496  Bacillus clausii (strain KSM-K16)

     202        496  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     203        494  Proteus mirabilis (strain HI4320)

     204        494  Xanthomonas campestris pv. campestris (strain 8004)

     205        494  Pyrococcus horikoshii 

     206        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     207        492  Thermosynechococcus elongatus (strain BP-1)

     208        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     209        491  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     210        489  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     211        488  Methanosarcina mazei  

     212        488  Brucella abortus (strain 2308)

     213        487  Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans R2)

     214        487  Shewanella sp. (strain MR-7)

     215        486  Mannheimia succiniciproducens (strain MBEL55E)

     216        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     217        484  Pseudomonas aeruginosa (strain LESB58)

     218        484  Shewanella sp. (strain MR-4)

     219        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     220        483  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     221        482  Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 

     222        480  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     223        478  Nicotiana tabacum (Common tobacco)

     224        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     225        477  Pyrococcus abyssi (strain GE5 / Orsay)

     226        475  Cupriavidus necator  

     227        475  Burkholderia lata 

     228        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     229        469  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        468  Clostridium perfringens (strain 13 / Type A)

     231        468  Pseudomonas putida (strain GB-1)

     232        467  Shewanella frigidimarina (strain NCIMB 400)

     233        467  Aeromonas hydrophila subsp. hydrophila 

     234        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     235        467  Enterococcus faecalis (strain ATCC 700802 / V583)

     236        466  Shewanella sp. (strain ANA-3)

     237        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     238        465  Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)

     239        463  Burkholderia mallei (strain ATCC 23344)

     240        459  Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator 

     241        459  Ovis aries (Sheep)

     242        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     243        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     244        455  Staphylococcus aureus (strain JH1)

     245        455  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     246        455  Shewanella baltica (strain OS185)

     247        453  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     248        453  Pseudomonas putida (strain W619)

     249        452  Aeromonas salmonicida (strain A449)

     250        451  Caldanaerobacter subterraneus subsp. tengcongensis  





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19638 (  3%)

    Bacteria         334967 ( 59%)

    Eukaryota        193019 ( 34%)

    Viruses           17014 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20396 ( 11%)           (  4%)

     Other Mammalia         47002 ( 24%)           (  8%)

     Other Vertebrata       18634 ( 10%)           (  3%)

     Viridiplantae          40799 ( 21%)           (  7%)

     Fungi                  35153 ( 18%)           (  6%)

     Insecta                 9425 (  5%)           (  2%)

     Nematoda                5135 (  3%)           (  1%)

     Other                  16475 (  9%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9770             1001-1100     4041

                 51- 100   43035             1101-1200     2845

                101- 150   59463             1201-1300     2172

                151- 200   59205             1301-1400     2041

                201- 250   58084             1401-1500     1646

                251- 300   51925             1501-1600      811

                301- 350   52346             1601-1700      624

                351- 400   45416             1701-1800      573

                401- 450   37336             1801-1900      489

                451- 500   30192             1901-2000      386

                501- 550   21935             2001-2100      259

                551- 600   15561             2101-2200      364

                601- 650   12967             2201-2300      331

                651- 700    9308             2301-2400      225

                701- 750    7742             2401-2500      180

                751- 800    5619             >2500         1373

                801- 850    4843

                851- 900    5247

                901- 950    4076

                951-1000    2972



   





   The average sequence length in UniProtKB/Swiss-Prot is 360 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2929





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  946

                       2x:  401

                       3x:  180

                       4x:  140

                       5x:  120

                       6x:   84

                       7x:   71

                       8x:   68

                       9x:   39

                      10x:   35

                  11- 20x:  235

                  21- 50x:  243

                  51-100x:  126

                    >100x:  241





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        25745   Journal of Biological Chemistry

    2        11975   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6876   Journal of Bacteriology

    4         5799   Biochemical and Biophysical Research Communications

    5         5556   Biochemistry

    6         5123   Nucleic Acids Research

    7         4943   FEBS Letters

    8         4850   Gene

    9         4783   The EMBO Journal

   10         4765   Nature

   11         4450   Molecular and Cellular Biology

   12         4388   Journal of Molecular Biology

   13         3820   Biochimica et Biophysica Acta

   14         3678   Cell

   15         3446   European Journal of Biochemistry

   16         3387   Journal of Virology

   17         3153   Science

   18         2995   Biochemical Journal

   19         2693   Plant Physiology

   20         2679   Molecular Microbiology

   21         2539   Genomics

   22         2296   The American Journal of Human Genetics

   23         2258   Journal of Cell Biology

   24         2246   PLoS ONE

   25         2095   The Plant Cell

   26         1958   The Plant Journal

   27         1901   Human Molecular Genetics

   28         1894   Plant Molecular Biology

   29         1885   Genes and Development

   30         1836   Virology

   31         1802   Nature Genetics

   32         1734   Molecular Biology of the Cell

   33         1724   Development

   34         1633   Molecular Cell

   35         1594   Human Mutation

   36         1561   Journal of Immunology

   37         1549   Oncogene

   38         1411   Structure

   39         1406   Molecular and General Genetics

   40         1374   Journal of Biochemistry

   41         1348   Genetics

   42         1307   Journal of Cell Science

   43         1199   Blood

   44         1181   Infection and Immunity

   45         1159   Journal of General Virology

   46         1112   Microbiology

   47         1098   Current Biology

   48         1095   Developmental Biology

   49         1092   Archives of Biochemistry and Biophysics

   50          956   Journal of Neuroscience

   51          955   Applied and Environmental Microbiology

   52          941   Acta Crystallographica, Section D

   53          908   Cancer Research

   54          861   FEMS Microbiology Letters

   55          841   Yeast

   56          823   Toxicon

   57          807   Protein Science

   58          787   Journal of Clinical Investigation

   59          783   Neuron

   60          776   PLoS Genetics

   61          735   American Journal of Physiology

   62          731   Plant and Cell Physiology

   63          715   Human Genetics

   64          702   Nature Communications

   65          700   The Journal of Experimental Medicine

   66          658   Proteins

   67          655   Mechanisms of Development

   68          649   Journal of Medical Genetics

   69          647   Nature Structural Biology

   70          603   Nature Cell Biology

   71          593   Scientific Reports

   72          588   Nature Structural and Molecular Biology

   73          584   The FEBS Journal

   74          579   Current Genetics

   75          572   Bioscience, Biotechnology, and Biochemistry

   76          552   Journal of Neurochemistry

   77          545   Developmental Cell

   78          544   Molecular Endocrinology

   79          533   The Journal of Clinical Endocrinology and Metabolism

   80          515   Endocrinology

   81          511   Antimicrobial Agents and Chemotherapy

   82          490   Mammalian Genome

   83          473   Experimental Cell Research

   84          471   PLoS Pathogens

   85          469   Molecular and Biochemical Parasitology

   86          450   Eukaryotic Cell

   87          441   Peptides

   88          440   Planta

   89          438   Journal of the American Chemical Society

   90          437   RNA

   91          430   Immunogenetics

   92          422   Journal of Experimental Botany

   93          406   Journal of Molecular Evolution

   94          406   Molecular Biology and Evolution

   95          400   Molecular Pharmacology

   96          394   EMBO Reports

   97          394   The FASEB Journal

   98          391   Acta Crystallographica, Section F

   99          390   DNA and Cell Biology

  100          388   American Journal of Medical Genetics. Part A

  101          380   European Journal of Human Genetics

  102          378   Journal of Investigative Dermatology

  103          377   Molecular Plant-Microbe Interactions

  104          376   DNA Sequence

  105          375   Neurology

  106          373   Immunity

  107          360   Comparative Biochemistry and Physiology

  108          358   Biology of Reproduction

  109          348   Biochimie

  110          341   Brain Research. Molecular Brain Research

  111          338   Virus Research

  112          337   Genes to Cells

  113          332   Clinical Genetics

  114          324   Developmental Dynamics

  115          323   The New England Journal of Medicine

  116          320   Journal of Lipid Research

  117          307   Annals of Neurology

  118          301   Genome Research

  119          299   Nature Immunology

  120          299   Biological Chemistry Hoppe-Seyler

  121          299   BMC Genomics

  122          298   European Journal of Immunology

  123          297   Cell Reports

  124          287   Investigative Ophthalmology and Visual Science

  125          285   Applied Microbiology and Biotechnology

  126          282   Journal of Medicinal Chemistry

  127          281   Cytogenetics and Cell Genetics

  128          280   PLoS Biology

  129          273   Journal of General Microbiology

  130          271   Journal of Human Genetics

  131          262   Glycobiology

  132          256   Archives of Microbiology

  133          247   

  134          247   Traffic

  135          244   Molecular Immunology

  136          239   Journal of Cellular Biochemistry

  137          239   Molecular Genetics and Metabolism

  138          233   DNA Research

  139          231   Phytochemistry

  140          229   Protein Expression and Purification

  141          229   Cell Cycle

  142          226   Nature Medicine

  143          225   Diabetes

  144          223   Circulation Research

  145          221   Archives of Virology

  146          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  147          216   Fungal Genetics and Biology

  148          211   Nature Chemical Biology

  149          209   Molecular and Cellular Endocrinology

  150          207   Brain





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1257251                 2.23                                         

   Journal                           1080697     462405      1.91       1                                 

   Submitted to EMBL/GenBank/DDBJ     165356     149694      0.29       2                                 

   Submitted to other databases         7595       6987      0.01       3                                 

   Book citation                        1855       1832     <0.01       4                                 

   Plant Gene Register                   612        599     <0.01       5                                 

   Unpublished observations              479        475     <0.01       6                                 

   Thesis                                439        436     <0.01       7                                 

   Patent                                212        205     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 433747



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2632374                 4.66                                         

   ACTIVITY REGULATION                 16255      16202      0.03      17                                 

   ALLERGEN                              924        924     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25552      25552      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        9603       9592      0.02      20                                 

   BIOTECHNOLOGY                        1411       1387     <0.01      24                                 

   CATALYTIC ACTIVITY                 312021     244255      0.55       4                                 

   CAUTION                             13558      13275      0.02      18                                 

   COFACTOR                           128848     117186      0.23       7                                 

   DEVELOPMENTAL STAGE                 13104      13067      0.02      19                                 

   DISEASE                              7539       5069      0.01      21                                 

   DISRUPTION PHENOTYPE                17109      17098      0.03      16                                 

   DOMAIN                              52661      44994      0.09       9                                 

   FUNCTION                           476515     454075      0.84       2                                 

   INDUCTION                           22848      22796      0.04      15                                 

   INTERACTION                         23546      23546      0.04      14                                 

   MASS SPECTROMETRY                    7095       5455      0.01      22                                 

   MISCELLANEOUS                       44490      39087      0.08      12                                 

   PATHWAY                            141304     127896      0.25       6                                 

   PHARMACEUTICAL                        159        151     <0.01      29                                 

   POLYMORPHISM                         1309       1254     <0.01      25                                 

   PTM                                 60250      43594      0.11       8                                 

   RNA EDITING                           628        628     <0.01      28                                 

   SEQUENCE CAUTION                    44656      44585      0.08      11                                 

   SIMILARITY                         513288     509082      0.91       1                                 

   SUBCELLULAR LOCATION               354657     346747      0.63       3                                 

   SUBUNIT                            287244     283161      0.51       5                                 

   TISSUE SPECIFICITY                  48281      48088      0.09      10                                 

   TOXIC DOSE                            798        644     <0.01      27                                 

   WEB RESOURCE                         6721       5560      0.01      23                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4694983                 8.32                                         

   ACT_SITE                           168383     101744      0.30      10                                 

   BINDING                            419719     111423      0.74       2                                 

   CA_BIND                              4215       1750      0.01      36                                 

   CARBOHYD                           119931      30701      0.21      15                                 

   CHAIN                              572872     557310      1.01       1                                 

   COILED                              22180      15353      0.04      27                                 

   COMPBIAS                            59257      31888      0.10      21                                 

   CONFLICT                           137337      47948      0.24      13                                 

   CROSSLNK                            24247       8710      0.04      26                                 

   DISULFID                           129519      34643      0.23      14                                 

   DNA_BIND                            11953      10705      0.02      33                                 

   DOMAIN                             207502     127398      0.37       9                                 

   HELIX                              285606      25773      0.51       6                                 

   INIT_MET                            17440      17392      0.03      28                                 

   INTRAMEM                             2871       1316      0.01      37                                 

   LIPID                               13409       8648      0.02      30                                 

   METAL                              407121      98108      0.72       3                                 

   MOD_RES                            257112      72991      0.46       7                                 

   MOTIF                               45276      29567      0.08      23                                 

   MUTAGEN                             81088      17379      0.14      18                                 

   NON_CONS                             2511        815     <0.01      38                                 

   NON_STD                               358        283     <0.01      39                                 

   NON_TER                             12566       9642      0.02      31                                 

   NP_BIND                            161012      86977      0.29      11                                 

   PEPTIDE                             12039       8257      0.02      32                                 

   PROPEP                              14727      12563      0.03      29                                 

   REGION                             209578      97702      0.37       8                                 

   REPEAT                             107350      14959      0.19      16                                 

   SIGNAL                              43142      43141      0.08      24                                 

   SITE                                61967      33371      0.11      20                                 

   STRAND                             295369      24313      0.52       5                                 

   TOPO_DOM                           145661      29645      0.26      12                                 

   TRANSIT                              9290       9171      0.02      34                                 

   TRANSMEM                           376101      78707      0.67       4                                 

   TURN                                68964      20999      0.12      19                                 

   UNSURE                               5580        843      0.01      35                                 

   VAR_SEQ                             52509      22319      0.09      22                                 

   VARIANT                             99019      17217      0.18      17                                 

   ZN_FING                             30202      12910      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18229120                32.28                                                           

   ABCD                                 2717       2717     <0.01     118      Protocols and materials databases            

   Allergome                            2011       1296     <0.01     125      Protein family/group databases               

   Antibodypedia                       32118      32007      0.06      56      Protocols and materials databases            

   ArachnoServer                        1163       1154     <0.01     135      Organism-specific databases                  

   Araport                             16063      15967      0.03      85      Organism-specific databases                  

   Bgee                                57361      57359      0.10      43      Gene expression databases                    

   BindingDB                            5793       5793      0.01     103      Chemistry databases                          

   BioCyc                             202392     198340      0.36      24      Enzyme and pathway databases                 

   BioGRID                             59165      57335      0.10      42      Protein-protein interaction databases        

   BioGRID-ORCS                        39034      38499      0.07      54      Miscellaneous databases                      

   BioMuta                             20318      20300      0.04      71      Genetic variation databases                  

   BMRB                                 6908       6908      0.01      99      3D structure databases                       

   BRENDA                              13029      12244      0.02      88      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     136      PTM databases                                

   CAZy                                 9554       8610      0.02      92      Protein family/group databases               

   CCDS                                48746      34298      0.09      48      Sequence databases                           

   CDD                                195592     175197      0.35      25      Family and domain databases                  

   CGD                                  2001       1984     <0.01     126      Organism-specific databases                  

   ChEMBL                               7831       7667      0.01      96      Chemistry databases                          

   ChiTaRS                             29659      29622      0.05      60      Miscellaneous databases                      

   CLAE                                  357        354     <0.01     151      Protein family/group databases               

   CollecTF                              135        135     <0.01     159      Gene expression databases                    

   ComplexPortal                       11502       6454      0.02      89      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     161      2D gel databases                             

   ConoServer                            968        880     <0.01     139      Organism-specific databases                  

   CORUM                                5809       5809      0.01     102      Protein-protein interaction databases        

   CPTAC                                2525       1632     <0.01     121      Proteomic databases                          

   CPTC                                  302        302     <0.01     153      Protocols and materials databases            

   CTD                                 75416      74515      0.13      40      Organism-specific databases                  

   DEPOD                                 254        254     <0.01     157      PTM databases                                

   dictyBase                            4215       4101      0.01     112      Organism-specific databases                  

   DIP                                 17459      17419      0.03      80      Protein-protein interaction databases        

   DisGeNET                            17034      16809      0.03      81      Organism-specific databases                  

   DisProt                              1538       1526     <0.01     128      Family and domain databases                  

   DMDM                                16193      16191      0.03      84      Genetic variation databases                  

   DNASU                               19075      19008      0.03      74      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     158      2D gel databases                             

   DrugBank                            29408       4704      0.05      62      Chemistry databases                          

   DrugCentral                          2564       2564     <0.01     120      Chemistry databases                          

   EchoBASE                             4158       4158      0.01     113      Organism-specific databases                  

   eggNOG                             336976     331113      0.60      14      Phylogenomic databases                       

   ELM                                  1812       1812     <0.01     127      Protein-protein interaction databases        

   EMBL                               991285     552391      1.76       3      Sequence databases                           

   Ensembl                             99193      51736      0.18      35      Genome annotation databases                  

   EnsemblBacteria                    309126     297707      0.55      17      Genome annotation databases                  

   EnsemblFungi                        30110      28492      0.05      59      Genome annotation databases                  

   EnsemblMetazoa                      18185      10517      0.03      78      Genome annotation databases                  

   EnsemblPlants                       30383      21519      0.05      57      Genome annotation databases                  

   EnsemblProtists                      5047       4868      0.01     106      Genome annotation databases                  

   EPD                                 21199      21199      0.04      67      Proteomic databases                          

   ESTHER                               2586       2585     <0.01     119      Protein family/group databases               

   euHCVdb                                55         44     <0.01     163      Organism-specific databases                  

   EvolutionaryTrace                   16674      16674      0.03      83      Miscellaneous databases                      

   ExpressionAtlas                     48488      48488      0.09      49      Gene expression databases                    

   FlyBase                              4930       4805      0.01     107      Organism-specific databases                  

   Gene3D                             415567     322568      0.74      13      Family and domain databases                  

   GeneCards                           20359      20194      0.04      68      Organism-specific databases                  

   GeneDB                                618        562     <0.01     145      Genome annotation databases                  

   GeneID                             308959     285760      0.55      18      Genome annotation databases                  

   GeneReviews                          1492       1489     <0.01     129      Organism-specific databases                  

   GeneTree                            60020      59974      0.11      41      Phylogenomic databases                       

   Genevisible                         55256      55256      0.10      45      Gene expression databases                    

   GeneWiki                            10350      10267      0.02      91      Miscellaneous databases                      

   GenomeRNAi                          22182      22181      0.04      65      Miscellaneous databases                      

   GlyConnect                           2328       2199     <0.01     122      PTM databases                                

   GlyGen                              11178      11178      0.02      90      PTM databases                                

   GO                                3089906     540272      5.47       1      Ontologies                                   

   Gramene                             30383      21519      0.05      58      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2052       2052     <0.01     124      Chemistry databases                          

   HAMAP                              330566     327646      0.59      15      Family and domain databases                  

   HGNC                                20338      20205      0.04      69      Organism-specific databases                  

   HOGENOM                            424185     424185      0.75      11      Phylogenomic databases                       

   HPA                                 18983      18847      0.03      75      Organism-specific databases                  

   IDEAL                                 986        986     <0.01     138      Family and domain databases                  

   IMGT_GENE-DB                          267        267     <0.01     156      Protein family/group databases               

   InParanoid                         140328     140328      0.25      27      Phylogenomic databases                       

   IntAct                              56159      56159      0.10      44      Protein-protein interaction databases        

   InterPro                          2330805     545716      4.13       2      Family and domain databases                  

   iPTMnet                             52683      52683      0.09      46      PTM databases                                

   jPOST                               26400      26400      0.05      63      Proteomic databases                          

   KEGG                               502527     476937      0.89       8      Genome annotation databases                  

   LegioList                             765        763     <0.01     142      Organism-specific databases                  

   Leproma                               672        669     <0.01     143      Organism-specific databases                  

   MaizeGDB                              521        517     <0.01     146      Organism-specific databases                  

   MalaCards                            4823       4819      0.01     109      Organism-specific databases                  

   MassIVE                             17468      17468      0.03      79      Proteomic databases                          

   MaxQB                               29618      29618      0.05      61      Proteomic databases                          

   MEROPS                              13678      13678      0.02      87      Protein family/group databases               

   MetOSite                             3106       3106      0.01     117      PTM databases                                

   MGI                                 16984      16944      0.03      82      Organism-specific databases                  

   MIM                                 21882      15418      0.04      66      Organism-specific databases                  

   MINT                                22800      22800      0.04      64      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     152      Protein family/group databases               

   MoonProt                              281        281     <0.01     155      Protein family/group databases               

   neXtProt                            20336      20336      0.04      70      Organism-specific databases                  

   NIAGADS                                68         68     <0.01     162      Organism-specific databases                  

   OGP                                   373        373     <0.01     150      2D gel databases                             

   OMA                                422434     422434      0.75      12      Phylogenomic databases                       

   OpenTargets                         18359      18209      0.03      76      Organism-specific databases                  

   Orphanet                             7730       4117      0.01      98      Organism-specific databases                  

   OrthoDB                            245908     245908      0.44      21      Phylogenomic databases                       

   PANTHER                            284237     271783      0.50      20      Family and domain databases                  

   PathwayCommons                      19491      19491      0.03      73      Enzyme and pathway databases                 

   PATRIC                              92502      92502      0.16      38      Genome annotation databases                  

   PaxDb                              125615     125615      0.22      32      Proteomic databases                          

   PCDDB                                 129        129     <0.01     160      3D structure databases                       

   PDB                                214448      30336      0.38      22      3D structure databases                       

   PDBsum                             214448      30336      0.38      23      3D structure databases                       

   PeptideAtlas                        33449      33449      0.06      55      Proteomic databases                          

   PeroxiBase                            783        761     <0.01     141      Protein family/group databases               

   Pfam                               785569     523880      1.39       4      Family and domain databases                  

   PharmGKB                            18313      18294      0.03      77      Organism-specific databases                  

   Pharos                              20095      20095      0.04      72      Miscellaneous databases                      

   PHI-base                             1460       1213     <0.01     130      Miscellaneous databases                      

   PhosphoSitePlus                     39082      39082      0.07      53      PTM databases                                

   PhylomeDB                           97034      97034      0.17      37      Phylogenomic databases                       

   PIR                                124491     114218      0.22      33      Sequence databases                           

   PIRSF                              107782     106687      0.19      34      Family and domain databases                  

   PlantReactome                        1080        741     <0.01     137      Enzyme and pathway databases                 

   PomBase                              5129       5125      0.01     105      Organism-specific databases                  

   PRIDE                              136407     136407      0.24      29      Proteomic databases                          

   PRINTS                             131145     116289      0.23      30      Family and domain databases                  

   PRO                                 97291      97291      0.17      36      Miscellaneous databases                      

   ProMEX                                467        467     <0.01     148      Proteomic databases                          

   PROSITE                            481844     305842      0.85       9      Family and domain databases                  

   Proteomes                          502975     468839      0.89       7      Miscellaneous databases                      

   ProteomicsDB                        82272      52828      0.15      39      Proteomic databases                          

   PseudoCAP                            1406       1397     <0.01     132      Organism-specific databases                  

   Reactome                           125725      35849      0.22      31      Enzyme and pathway databases                 

   REBASE                                623        385     <0.01     144      Protein family/group databases               

   RefSeq                             616365     470850      1.09       5      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     133      2D gel databases                             

   RGD                                  8050       8047      0.01      95      Organism-specific databases                  

   RNAct                               43023      43023      0.08      51      Miscellaneous databases                      

   SABIO-RK                             4863       4863      0.01     108      Enzyme and pathway databases                 

   SASBDB                                461        461     <0.01     149      3D structure databases                       

   SFLD                                 9469       7350      0.02      93      Family and domain databases                  

   SGD                                  6740       6735      0.01     100      Organism-specific databases                  

   SignaLink                            3110       3110      0.01     116      Enzyme and pathway databases                 

   SIGNOR                               5197       5197      0.01     104      Enzyme and pathway databases                 

   SMART                              194146     143157      0.34      26      Family and domain databases                  

   SMR                                457015     457015      0.81      10      3D structure databases                       

   STRING                             329734     329734      0.58      16      Protein-protein interaction databases        

   SUPFAM                             514895     389306      0.91       6      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     134      2D gel databases                             

   SwissLipids                          1456       1371     <0.01     131      Chemistry databases                          

   SwissPalm                            8646       8646      0.02      94      PTM databases                                

   TAIR                                14840      14784      0.03      86      Organism-specific databases                  

   TCDB                                 7757       7693      0.01      97      Protein family/group databases               

   TIGRFAMs                           293003     272951      0.52      19      Family and domain databases                  

   TopDownProteomics                    3237       2960      0.01     114      Proteomic databases                          

   TreeFam                             45773      45766      0.08      50      Phylogenomic databases                       

   TubercuList                          2274       2238     <0.01     123      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     147      2D gel databases                             

   UCSC                                50410      46011      0.09      47      Genome annotation databases                  

   UniLectin                             286        286     <0.01     154      Protein family/group databases               

   UniPathway                         138333     125113      0.24      28      Enzyme and pathway databases                 

   VEuPathDB                           41409      40035      0.07      52      Organism-specific databases                  

   VGNC                                 4362       4349      0.01     111      Organism-specific databases                  

   WBParaSite                             48         43     <0.01     164      Genome annotation databases                  

   World-2DPAGE                          932        921     <0.01     140      2D gel databases                             

   WormBase                             6506       4827      0.01     101      Organism-specific databases                  

   Xenbase                              4541       4540      0.01     110      Organism-specific databases                  

   ZFIN                                 3169       3164      0.01     115      Organism-specific databases                  



Total number of cross-referenced databases: 164



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.63

   Arg (R) 5.53   Glu (E) 6.72   Lys (K) 5.80   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.07   Met (M) 2.41   Trp (W) 1.10

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.91   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3946 are encoded on a plasmid.



12189 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11624 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 80210