UniProtKB/Swiss-Prot protein knowledgebase release 2018_06 statistics





1.  INTRODUCTION



Release 2018_06 of 20-Jun-18 of UniProtKB/Swiss-Prot contains 557713 sequence entries,

comprising 200130199 amino acids abstracted from 260117 references. 



225 sequences have been added since release 2018_05, the sequence data of

25 existing entries has been updated and the annotations of

103253 entries have been revised.



Number of fragments: 9151

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 39896





Protein existence (PE):           entries     %



1: Evidence at protein level        98669   17.7%

2: Evidence at transcript level     57241   10.3%

3: Inferred from homology          386324   69.3%

4: Predicted                        13613    2.4%

5: Uncertain                         1866    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13634



   The first twenty species represent 120347 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5652

                            2x: 1943

                            3x: 1058

                            4x:  690

                            5x:  509

                            6x:  408

                            7x:  296

                            8x:  247

                            9x:  229

                           10x:  134

                       11- 20x:  750

                       21- 50x:  451

                       51-100x:  218

                         >100x: 1049





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20360  Homo sapiens (Human)

       2      16976  Mus musculus (Mouse)

       3      15759  Arabidopsis thaliana (Mouse-ear cress)

       4       8027  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6002  Bos taurus (Bovine)

       7       5141  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4443  Escherichia coli (strain K12)

       9       4188  Bacillus subtilis (strain 168)

      10       4136  Dictyostelium discoideum (Slime mold)

      11       4022  Caenorhabditis elegans

      12       3956  Oryza sativa subsp. japonica (Rice)

      13       3518  Drosophila melanogaster (Fruit fly)

      14       3428  Xenopus laevis (African clawed frog)

      15       3057  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2290  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2171  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      19       2036  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1795  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      24       1705  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      25       1694  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1683  Shigella flexneri

      27       1423  Sus scrofa (Pig)

      28       1347  Salmonella typhi

      29       1324  Pseudomonas aeruginosa 

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1173  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1064  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1031  Archaeoglobus fulgidus 

      34       1022  Yersinia pestis

      35       1006  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        975  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        930  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      38        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      39        927  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      40        926  Staphylococcus aureus (strain N315)

      41        914  Emericella nidulans  

      42        914  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        899  Staphylococcus aureus (strain COL)

      45        895  Staphylococcus aureus (strain MW2)

      46        893  Oryctolagus cuniculus (Rabbit)

      47        892  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      48        889  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        882  Salmonella choleraesuis (strain SC-B67)

      51        881  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      52        879  Shigella sonnei (strain Ss046)

      53        871  Candida glabrata   

      54        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      55        855  Neurospora crassa 

      56        841  Escherichia coli O9:H4 (strain HS)

      57        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      58        829  Shigella boydii serotype 4 (strain Sb227)

      59        825  Escherichia coli (strain UTI89 / UPEC)

      60        822  Shigella dysenteriae serotype 1 (strain Sd197)

      61        819  Canis lupus familiaris (Dog) (Canis familiaris)

      62        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      63        818  Oryza sativa subsp. indica (Rice)

      64        804  Zea mays (Maize)

      65        796  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      66        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      67        793  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      68        791  Escherichia coli (strain SMS-3-5 / SECEC)

      69        784  Aquifex aeolicus (strain VF5)

      70        776  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      71        776  Pasteurella multocida (strain Pm70)

      72        771  Escherichia coli (strain K12 / DH10B)

      73        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      75        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      76        762  Escherichia coli (strain 55989 / EAEC)

      77        761  Escherichia coli O8 (strain IAI1)

      78        760  Shigella flexneri serotype 5b (strain 8401)

      79        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      80        759  Staphylococcus epidermidis (strain ATCC 12228)

      81        758  Staphylococcus aureus (strain NCTC 8325)

      82        756  Escherichia coli (strain SE11)

      83        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      84        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      85        749  Bacillus anthracis

      86        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      87        746  Photorhabdus luminescens subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      88        741  Bacillus halodurans 

      89        737  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        722  Salmonella enteritidis PT4 (strain P125109)

      93        718  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      97        715  Enterobacter sp. (strain 638)

      98        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      99        714  Escherichia coli O1:K1 / APEC

     100        714  Salmonella paratyphi A (strain AKU_12601)

     101        713  Salmonella newport (strain SL254)

     102        713  Salmonella agona (strain SL483)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     111        693  Pan troglodytes (Chimpanzee)

     112        692  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     113        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     114        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     115        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     116        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     117        673  Staphylococcus aureus (strain USA300)

     118        673  Escherichia coli

     119        670  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        667  Yersinia pestis (strain Pestoides F)

     122        665  Bacillus cereus 

     123        664  Bradyrhizobium diazoefficiens 

     124        658  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     125        653  Debaryomyces hansenii   

     126        650  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     127        646  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        645  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Treponema pallidum (strain Nichols)

     134        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     135        620  Methanothermobacter thermautotrophicus  

     136        613  Staphylococcus haemolyticus (strain JCSC1435)

     137        611  Mesorhizobium japonicum  (Mesorhizobium loti 

     138        610  Xanthomonas campestris pv. campestris 

     139        607  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     140        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     141        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     142        602  Photobacterium profundum (strain SS9)

     143        602  Staphylococcus saprophyticus subsp. saprophyticus 

     144        601  Salmonella paratyphi C (strain RKS4594)

     145        600  Yersinia pestis bv. Antiqua (strain Angola)

     146        594  Bacillus cereus (strain ATCC 10987 / NRS 248)

     147        594  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     148        593  Pseudomonas aeruginosa (strain UCBPP-PA14)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        586  Rickettsia prowazekii (strain Madrid E)

     151        582  Neisseria meningitidis serogroup B (strain MC58)

     152        579  Brucella suis biovar 1 (strain 1330)

     153        578  Caenorhabditis briggsae

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Vibrio fischeri (strain ATCC 700601 / ES114)

     156        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     157        571  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     158        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     159        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     160        567  Pseudomonas syringae pv. syringae (strain B728a)

     161        564  Bacillus licheniformis 

     162        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     163        562  Bacillus cereus (strain ZK / E33L)

     164        559  Clostridium acetobutylicum 

     165        557  Xanthomonas axonopodis pv. citri (strain 306)

     166        555  Pseudomonas fluorescens (strain Pf0-1)

     167        555  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     168        554  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     169        553  Oceanobacillus iheyensis 

     170        550  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     171        550  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     172        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     173        537  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     174        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     175        529  Listeria monocytogenes serotype 4b (strain F2365)

     176        529  Sodalis glossinidius (strain morsitans)

     177        528  Corynebacterium glutamicum 

     178        527  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     179        522  Xylella fastidiosa (strain 9a5c)

     180        520  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     181        517  Chromobacterium violaceum 

     182        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     183        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     184        514  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     185        513  Deinococcus radiodurans 

     186        512  Pseudomonas aeruginosa (strain PA7)

     187        511  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     188        511  Staphylococcus aureus (strain Newman)

     189        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     190        510  Geobacillus kaustophilus (strain HTA426)

     191        508  Streptomyces avermitilis 

     192        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     193        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     194        502  Pseudomonas entomophila (strain L48)

     195        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     196        499  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     199        497  Haemophilus influenzae (strain 86-028NP)

     200        496  Bacillus clausii (strain KSM-K16)

     201        496  Burkholderia pseudomallei (strain K96243)

     202        494  Proteus mirabilis (strain HI4320)

     203        493  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     204        493  Xanthomonas campestris pv. campestris (strain 8004)

     205        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     206        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     207        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     208        488  Methanosarcina mazei  

     209        487  Shewanella sp. (strain MR-7)

     210        486  Mannheimia succiniciproducens (strain MBEL55E)

     211        485  Pyrococcus horikoshii 

     212        485  Thermosynechococcus elongatus (strain BP-1)

     213        484  Shewanella sp. (strain MR-4)

     214        484  Pseudomonas aeruginosa (strain LESB58)

     215        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     216        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     217        483  Brucella abortus (strain 2308)

     218        480  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     219        479  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     220        478  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     221        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     222        477  Pyrococcus abyssi (strain GE5 / Orsay)

     223        475  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     224        475  Nicotiana tabacum (Common tobacco)

     225        474  Burkholderia lata 

     226        474  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     227        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     228        468  Clostridium perfringens (strain 13 / Type A)

     229        466  Shewanella frigidimarina (strain NCIMB 400)

     230        466  Shewanella sp. (strain ANA-3)

     231        466  Pseudomonas putida (strain GB-1)

     232        466  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     233        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     234        465  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     235        464  Aeromonas hydrophila subsp. hydrophila 

     236        463  Campylobacter jejuni subsp. jejuni serotype O:2 

     237        463  Enterococcus faecalis (strain ATCC 700802 / V583)

     238        462  Burkholderia mallei (strain ATCC 23344)

     239        459  Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     240        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     241        457  Ovis aries (Sheep)

     242        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     243        455  Staphylococcus aureus (strain JH1)

     244        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     245        453  Pseudomonas putida (strain W619)

     246        452  Shewanella baltica (strain OS185)

     247        452  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     248        452  Aeromonas salmonicida (strain A449)

     249        450  Dechloromonas aromatica (strain RCB)

     250        450  Caldanaerobacter subterraneus subsp. tengcongensis  





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19521 (  4%)

    Bacteria         333552 ( 60%)

    Eukaryota        187848 ( 34%)

    Viruses           16792 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20361 ( 11%)           (  4%)

     Other Mammalia         46629 ( 25%)           (  8%)

     Other Vertebrata       18259 ( 10%)           (  3%)

     Viridiplantae          39539 ( 21%)           (  7%)

     Fungi                  33465 ( 18%)           (  6%)

     Insecta                 9180 (  5%)           (  2%)

     Nematoda                4922 (  3%)           (  1%)

     Other                  15493 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9495             1001-1100     3977

                 51- 100   42459             1101-1200     2788

                101- 150   58937             1201-1300     2135

                151- 200   58821             1301-1400     1986

                201- 250   57660             1401-1500     1609

                251- 300   51357             1501-1600      786

                301- 350   51750             1601-1700      613

                351- 400   44908             1701-1800      549

                401- 450   36882             1801-1900      468

                451- 500   29738             1901-2000      376

                501- 550   21425             2001-2100      245

                551- 600   15299             2101-2200      323

                601- 650   12765             2201-2300      311

                651- 700    9209             2301-2400      208

                701- 750    7639             2401-2500      157

                751- 800    5507             >2500         1264

                801- 850    4760

                851- 900    5202

                901- 950    4044

                951-1000    2910



   





   The average sequence length in UniProtKB/Swiss-Prot is 358 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2730





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  860

                       2x:  387

                       3x:  167

                       4x:  134

                       5x:  110

                       6x:   97

                       7x:   63

                       8x:   52

                       9x:   42

                      10x:   36

                  11- 20x:  213

                  21- 50x:  222

                  51-100x:  119

                    >100x:  228





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        24268   Journal of Biological Chemistry

    2        11208   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6559   Journal of Bacteriology

    4         5573   Biochemical and Biophysical Research Communications

    5         5253   Biochemistry

    6         4966   Nucleic Acids Research

    7         4801   Gene

    8         4797   FEBS Letters

    9         4656   The EMBO Journal

   10         4448   Nature

   11         4315   Molecular and Cellular Biology

   12         4223   Journal of Molecular Biology

   13         3596   Biochimica et Biophysica Acta

   14         3530   Cell

   15         3386   European Journal of Biochemistry

   16         3138   Journal of Virology

   17         2966   Science

   18         2828   Biochemical Journal

   19         2533   Genomics

   20         2504   Plant Physiology

   21         2476   Molecular Microbiology

   22         2164   Journal of Cell Biology

   23         2098   The American Journal of Human Genetics

   24         1946   The Plant Cell

   25         1843   Plant Molecular Biology

   26         1815   Genes and Development

   27         1810   PLoS ONE

   28         1788   The Plant Journal

   29         1781   Human Molecular Genetics

   30         1745   Virology

   31         1730   Nature Genetics

   32         1648   Development

   33         1641   Molecular Biology of the Cell

   34         1561   Human Mutation

   35         1534   Oncogene

   36         1506   Molecular Cell

   37         1407   Journal of Immunology

   38         1393   Molecular and General Genetics

   39         1332   Journal of Biochemistry

   40         1309   Structure

   41         1305   Genetics

   42         1226   Journal of Cell Science

   43         1138   Blood

   44         1117   Journal of General Virology

   45         1100   Infection and Immunity

   46         1045   Microbiology

   47         1038   Archives of Biochemistry and Biophysics

   48         1038   Current Biology

   49         1028   Developmental Biology

   50          885   Applied and Environmental Microbiology

   51          879   Cancer Research

   52          878   Journal of Neuroscience

   53          864   Acta Crystallographica, Section D

   54          837   Yeast

   55          830   FEMS Microbiology Letters

   56          766   Protein Science

   57          762   Toxicon

   58          734   Neuron

   59          712   Journal of Clinical Investigation

   60          682   Human Genetics

   61          666   American Journal of Physiology

   62          661   Plant and Cell Physiology

   63          644   Nature Structural Biology

   64          643   Mechanisms of Development

   65          621   The Journal of Experimental Medicine

   66          612   Proteins

   67          600   PLoS Genetics

   68          587   Journal of Medical Genetics

   69          570   Current Genetics

   70          564   Nature Cell Biology

   71          543   Bioscience, Biotechnology, and Biochemistry

   72          532   Molecular Endocrinology

   73          527   Journal of Neurochemistry

   74          518   Nature Structural and Molecular Biology

   75          514   The Journal of Clinical Endocrinology and Metabolism

   76          498   Developmental Cell

   77          497   Endocrinology

   78          490   The FEBS Journal

   79          488   Mammalian Genome

   80          472   Immunogenetics

   81          452   Experimental Cell Research

   82          448   Molecular and Biochemical Parasitology

   83          434   Antimicrobial Agents and Chemotherapy

   84          424   Eukaryotic Cell

   85          419   Planta

   86          413   RNA

   87          409   Peptides

   88          408   Journal of Molecular Evolution

   89          396   Molecular Biology and Evolution

   90          386   DNA and Cell Biology

   91          374   DNA Sequence

   92          370   Molecular Pharmacology

   93          366   Nature Communications

   94          365   Journal of the American Chemical Society

   95          364   Journal of Experimental Botany

   96          357   Journal of Investigative Dermatology

   97          356   Neurology

   98          353   EMBO Reports

   99          347   Comparative Biochemistry and Physiology

  100          347   The FASEB Journal

  101          342   Biology of Reproduction

  102          341   Acta Crystallographica, Section F

  103          340   Brain Research. Molecular Brain Research

  104          326   Tissue Antigens

  105          325   European Journal of Human Genetics

  106          323   American Journal of Medical Genetics. Part A

  107          322   PLoS Pathogens

  108          321   Molecular Plant-Microbe Interactions

  109          320   Immunity

  110          314   Biochimie

  111          313   Genes to Cells

  112          311   The New England Journal of Medicine

  113          308   Developmental Dynamics

  114          303   Virus Research

  115          296   Biological Chemistry Hoppe-Seyler

  116          296   Genome Research

  117          287   Clinical Genetics

  118          282   Cytogenetics and Cell Genetics

  119          278   Annals of Neurology

  120          271   Journal of General Microbiology

  121          266   BMC Genomics

  122          266   European Journal of Immunology

  123          265   Scientific Reports

  124          263   Investigative Ophthalmology and Visual Science

  125          263   Nature Immunology

  126          255   Applied Microbiology and Biotechnology

  127          250   Journal of Human Genetics

  128          246   Journal of Medicinal Chemistry

  129          239   Archives of Microbiology

  130          237   PLoS Biology

  131          231   Glycobiology

  132          229   DNA Research

  133          228   Journal of Cellular Biochemistry

  134          223   Traffic

  135          218   Molecular Genetics and Metabolism

  136          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  137          216   Cell Cycle

  138          213   Circulation Research

  139          213   Journal of Lipid Research

  140          208   Molecular Immunology

  141          208   Archives of Virology

  142          208   Diabetes

  143          206   Molecular and Cellular Endocrinology

  144          204   Protein Expression and Purification

  145          202   Phytochemistry

  146          194   Nature Medicine

  147          193   Fungal Genetics and Biology

  148          191   Molecular Genetics and Genomics

  149          183   Molecular and Cellular Neuroscience

  150          182   Insect Biochemistry and Molecular Biology





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1209101                 2.17                                         

   Journal                           1031991     453420      1.85       1                                 

   Submitted to EMBL/GenBank/DDBJ     166331     150732      0.30       2                                 

   Submitted to other databases         7381       6818      0.01       3                                 

   Book citation                        1736       1713     <0.01       4                                 

   Plant Gene Register                   611        598     <0.01       5                                 

   Thesis                                436        433     <0.01       6                                 

   Unpublished observations              408        404     <0.01       7                                 

   Patent                                201        196     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 401589



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2501980                 4.49                                         

   ALLERGEN                              719        719     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25176      25176      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        8013       8013      0.01      20                                 

   BIOTECHNOLOGY                         912        901     <0.01      25                                 

   CATALYTIC ACTIVITY                 266122     235548      0.48       5                                 

   CAUTION                             12726      12480      0.02      18                                 

   COFACTOR                           122745     112388      0.22       7                                 

   DEVELOPMENTAL STAGE                 11896      11895      0.02      19                                 

   DISEASE                              6837       4578      0.01      22                                 

   DISRUPTION PHENOTYPE                13619      13619      0.02      17                                 

   DOMAIN                              47924      41328      0.09       9                                 

   ENZYME REGULATION                   14587      14585      0.03      16                                 

   FUNCTION                           463638     443444      0.83       2                                 

   INDUCTION                           20382      20370      0.04      14                                 

   INTERACTION                         19187      19187      0.03      15                                 

   MASS SPECTROMETRY                    6779       5099      0.01      23                                 

   MISCELLANEOUS                       38182      35200      0.07      12                                 

   PATHWAY                            137723     124925      0.25       6                                 

   PHARMACEUTICAL                        114        111     <0.01      29                                 

   POLYMORPHISM                         1289       1233     <0.01      24                                 

   PTM                                 55375      41108      0.10       8                                 

   RNA EDITING                           627        627     <0.01      28                                 

   SEQUENCE CAUTION                    44123      44123      0.08      11                                 

   SIMILARITY                         506181     502036      0.91       1                                 

   SUBCELLULAR LOCATION               347477     340300      0.62       3                                 

   SUBUNIT                            276848     276336      0.50       4                                 

   TISSUE SPECIFICITY                  45179      45178      0.08      10                                 

   TOXIC DOSE                            668        611     <0.01      27                                 

   WEB RESOURCE                         6932       5775      0.01      21                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4450935                 7.98                                         

   ACT_SITE                           163116      98959      0.29      10                                 

   BINDING                            402997     106068      0.72       2                                 

   CA_BIND                              4168       1727      0.01      36                                 

   CARBOHYD                           115549      29635      0.21      15                                 

   CHAIN                              565568     550735      1.01       1                                 

   COILED                              21978      15190      0.04      27                                 

   COMPBIAS                            58888      31685      0.11      20                                 

   CONFLICT                           134850      47203      0.24      13                                 

   CROSSLNK                            23474       8414      0.04      26                                 

   DISULFID                           123551      33387      0.22      14                                 

   DNA_BIND                            11600      10492      0.02      32                                 

   DOMAIN                             192904     118869      0.35       9                                 

   HELIX                              248459      23027      0.45       6                                 

   INIT_MET                            17131      17131      0.03      28                                 

   INTRAMEM                             2641       1197     <0.01      37                                 

   LIPID                               12959       8367      0.02      30                                 

   METAL                              377199      93669      0.68       3                                 

   MOD_RES                            247594      71448      0.44       7                                 

   MOTIF                               42395      27798      0.08      23                                 

   MUTAGEN                             67238      14864      0.12      18                                 

   NON_CONS                             2257        787     <0.01      38                                 

   NON_STD                               358        283     <0.01      39                                 

   NON_TER                             12374       9492      0.02      31                                 

   NP_BIND                            156491      85054      0.28      11                                 

   PEPTIDE                             11456       7871      0.02      33                                 

   PROPEP                              14128      12040      0.03      29                                 

   REGION                             195884      92949      0.35       8                                 

   REPEAT                             105048      14694      0.19      16                                 

   SIGNAL                              41469      41467      0.07      24                                 

   SITE                                56853      31530      0.10      21                                 

   STRAND                             259186      21680      0.46       5                                 

   TOPO_DOM                           139744      28698      0.25      12                                 

   TRANSIT                              9048       8932      0.02      34                                 

   TRANSMEM                           369689      77133      0.66       4                                 

   TURN                                59826      18669      0.11      19                                 

   UNSURE                               4429        788      0.01      35                                 

   VAR_SEQ                             51862      21948      0.09      22                                 

   VARIANT                             96196      17040      0.17      17                                 

   ZN_FING                             30378      13323      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18709557                33.55                                                           

   Allergome                            1751       1146     <0.01     121      Protein family/group databases               

   ArachnoServer                        1149       1140     <0.01     129      Organism-specific databases                  

   Araport                             15780      15684      0.03      83      Organism-specific databases                  

   Bgee                                56304      56302      0.10      45      Gene expression databases                    

   BindingDB                            5013       5013      0.01     103      Chemistry                                    

   BioCyc                             158042     153981      0.28      29      Enzyme and pathway databases                 

   BioGrid                             50660      50165      0.09      50      Protein-protein interaction databases        

   BioMuta                             17245      17240      0.03      78      Polymorphism and mutation databases          

   BRENDA                              12873      12101      0.02      87      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     127      PTM databases                                

   CAZy                                 9454       8528      0.02      90      Protein family/group databases               

   CCDS                                47710      33947      0.09      52      Sequence databases                           

   CDD                                181089     166066      0.32      26      Family and domain databases                  

   CGD                                  1987       1970     <0.01     119      Organism-specific databases                  

   ChEMBL                               6527       6527      0.01      96      Chemistry                                    

   ChiTaRS                             20458      20448      0.04      68      Other                                        

   CleanEx                             30019      29387      0.05      59      Gene expression databases                    

   CollecTF                              133        133     <0.01     151      Gene expression databases                    

   ComplexPortal                        6849       4286      0.01      93      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     152      2D gel databases                             

   ConoServer                            949        866     <0.01     130      Organism-specific databases                  

   CORUM                                5168       5168      0.01     101      Protein-protein interaction databases        

   CTD                                 74777      73893      0.13      43      Organism-specific databases                  

   DEPOD                                 239        239     <0.01     148      PTM databases                                

   dictyBase                            4212       4097      0.01     108      Organism-specific databases                  

   DIP                                 17346      17314      0.03      77      Protein-protein interaction databases        

   DisGeNET                            14852      14615      0.03      84      Organism-specific databases                  

   DisProt                               708        703     <0.01     134      3D structure databases                       

   DMDM                                16360      16296      0.03      81      Polymorphism and mutation databases          

   DNASU                               18971      18900      0.03      73      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     149      2D gel databases                             

   DrugBank                            18751       3639      0.03      74      Chemistry                                    

   EchoBASE                             4159       4159      0.01     109      Organism-specific databases                  

   EcoGene                              4293       4293      0.01     107      Organism-specific databases                  

   eggNOG                             664003     331301      1.19       5      Phylogenomic databases                       

   ELM                                  1809       1809     <0.01     120      Protein-protein interaction databases        

   EMBL                               984795     546066      1.77       3      Sequence databases                           

   Ensembl                             89971      50160      0.16      41      Genome annotation databases                  

   EnsemblBacteria                    354498     335383      0.64      17      Genome annotation databases                  

   EnsemblFungi                        30744      28900      0.06      58      Genome annotation databases                  

   EnsemblMetazoa                      15936      10365      0.03      82      Genome annotation databases                  

   EnsemblPlants                       28805      21275      0.05      63      Genome annotation databases                  

   EnsemblProtists                      4975       4796      0.01     104      Genome annotation databases                  

   EPD                                 20233      20233      0.04      71      Proteomic databases                          

   ESTHER                               2493       2493     <0.01     116      Protein family/group databases               

   euHCVdb                                55         44     <0.01     153      Organism-specific databases                  

   EuPathDB                            37902      37707      0.07      55      Organism-specific databases                  

   EvolutionaryTrace                   16620      16620      0.03      80      Other                                        

   ExpressionAtlas                     51578      51578      0.09      47      Gene expression databases                    

   FlyBase                              6146       5849      0.01      97      Organism-specific databases                  

   Gene3D                             364625     291845      0.65      16      Family and domain databases                  

   GeneCards                           20311      20146      0.04      69      Organism-specific databases                  

   GeneDB                                572        516     <0.01     138      Genome annotation databases                  

   GeneID                             290256     279920      0.52      22      Genome annotation databases                  

   GeneReviews                          1155       1152     <0.01     128      Organism-specific databases                  

   GeneTree                            59200      59176      0.11      44      Phylogenomic databases                       

   Genevisible                         55226      55226      0.10      46      Gene expression databases                    

   GeneWiki                            10366      10282      0.02      89      Other                                        

   GenomeRNAi                          22017      22014      0.04      65      Other                                        

   GlyConnect                            568        495     <0.01     139      PTM databases                                

   GO                                2825442     531170      5.07       1      Ontologies                                   

   Gramene                             28805      21275      0.05      62      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2028       2028     <0.01     118      Chemistry                                    

   H-InvDB                              5589       4769      0.01     100      Organism-specific databases                  

   HAMAP                              329799     326928      0.59      19      Family and domain databases                  

   HGNC                                20299      20158      0.04      70      Organism-specific databases                  

   HOGENOM                            391084     391084      0.70      15      Phylogenomic databases                       

   HOVERGEN                            75943      75943      0.14      42      Phylogenomic databases                       

   HPA                                 27411      16833      0.05      64      Organism-specific databases                  

   IMGT_GENE-DB                          142        142     <0.01     150      Protein family/group databases               

   InParanoid                         136872     136872      0.25      30      Phylogenomic databases                       

   IntAct                              51294      51294      0.09      48      Protein-protein interaction databases        

   InterPro                          2223831     538691      3.99       2      Family and domain databases                  

   iPTMnet                             51233      51233      0.09      49      PTM databases                                

   KEGG                               503370     475102      0.90       7      Genome annotation databases                  

   KO                                 403646     403205      0.72      14      Phylogenomic databases                       

   LegioList                             765        763     <0.01     133      Organism-specific databases                  

   Leproma                               672        669     <0.01     135      Organism-specific databases                  

   MaizeGDB                              509        505     <0.01     140      Organism-specific databases                  

   MalaCards                            4438       4435      0.01     106      Organism-specific databases                  

   MaxQB                               29689      29689      0.05      60      Proteomic databases                          

   MEROPS                              11388      11388      0.02      88      Protein family/group databases               

   MGI                                 16880      16840      0.03      79      Organism-specific databases                  

   MIM                                 20817      15005      0.04      67      Organism-specific databases                  

   MINT                                21788      21788      0.04      66      Protein-protein interaction databases        

   MoonDB                                349        349     <0.01     146      Protein family/group databases               

   MoonProt                              279        279     <0.01     147      Protein family/group databases               

   mycoCLAP                              359        354     <0.01     145      Protein family/group databases               

   neXtProt                            20186      20183      0.04      72      Organism-specific databases                  

   OGP                                   374        374     <0.01     144      2D gel databases                             

   OMA                                416366     416366      0.75      13      Phylogenomic databases                       

   OpenTargets                         18305      18149      0.03      76      Organism-specific databases                  

   Orphanet                             6144       3286      0.01      98      Organism-specific databases                  

   OrthoDB                            293165     293165      0.53      20      Phylogenomic databases                       

   PANTHER                            270341     258049      0.48      23      Family and domain databases                  

   PATRIC                              91781      91781      0.16      40      Genome annotation databases                  

   PaxDb                              124356     124356      0.22      33      Proteomic databases                          

   PDB                                161944      26436      0.29      28      3D structure databases                       

   PDBsum                             161944      26436      0.29      27      3D structure databases                       

   PeptideAtlas                        32094      32094      0.06      57      Proteomic databases                          

   PeroxiBase                            773        755     <0.01     132      Protein family/group databases               

   Pfam                               756015     514288      1.36       4      Family and domain databases                  

   PharmGKB                            18363      18321      0.03      75      Organism-specific databases                  

   PhosphoSitePlus                     39008      39008      0.07      54      PTM databases                                

   PhylomeDB                           95565      95565      0.17      38      Phylogenomic databases                       

   PIR                                124093     113651      0.22      34      Sequence databases                           

   PIRSF                              108698     107669      0.19      37      Family and domain databases                  

   PMAP-CutDB                           1462       1462     <0.01     122      Other                                        

   PomBase                              5133       5129      0.01     102      Organism-specific databases                  

   PRIDE                              224932     224932      0.40      24      Proteomic databases                          

   PRINTS                             132752     117274      0.24      32      Family and domain databases                  

   PRO                                 95561      95561      0.17      39      Other                                        

   ProDom                              29134      28951      0.05      61      Family and domain databases                  

   ProMEX                                454        454     <0.01     142      Proteomic databases                          

   PROSITE                            465961     298037      0.84      10      Family and domain databases                  

   ProteinModelPortal                 448010     448010      0.80      11      3D structure databases                       

   Proteomes                          478427     454370      0.86       9      Other                                        

   ProteomicsDB                        36419      19847      0.07      56      Proteomic databases                          

   PseudoCAP                            1332       1323     <0.01     124      Organism-specific databases                  

   Reactome                           123216      36734      0.22      35      Enzyme and pathway databases                 

   REBASE                                397        397     <0.01     143      Protein family/group databases               

   RefSeq                             607330     462667      1.09       6      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     125      2D gel databases                             

   RGD                                  7951       7950      0.01      91      Organism-specific databases                  

   SABIO-RK                             3925       3925      0.01     111      Enzyme and pathway databases                 

   SFLD                                14127       6502      0.03      86      Family and domain databases                  

   SGD                                  6739       6734      0.01      94      Organism-specific databases                  

   SignaLink                            3026       3026      0.01     115      Enzyme and pathway databases                 

   SIGNOR                               4067       4067      0.01     110      Enzyme and pathway databases                 

   SMART                              191808     141597      0.34      25      Family and domain databases                  

   SMR                                443752     443752      0.80      12      3D structure databases                       

   STRING                             332307     332307      0.60      18      Protein-protein interaction databases        

   SUPFAM                             495713     376409      0.89       8      Family and domain databases                  

   SWISS-2DPAGE                         1178       1178     <0.01     126      2D gel databases                             

   SwissLipids                          1345       1258     <0.01     123      Chemistry                                    

   SwissPalm                            7256       7256      0.01      92      PTM databases                                

   TAIR                                14575      14519      0.03      85      Organism-specific databases                  

   TCDB                                 6731       6690      0.01      95      Protein family/group databases               

   TIGRFAMs                           292621     272599      0.52      21      Family and domain databases                  

   TopDownProteomics                    3247       2967      0.01     113      Proteomic databases                          

   TreeFam                             45275      45267      0.08      53      Phylogenomic databases                       

   TubercuList                          2189       2153     <0.01     117      Organism-specific databases                  

   UCD-2DPAGE                            497        497     <0.01     141      2D gel databases                             

   UCSC                                49830      45531      0.09      51      Genome annotation databases                  

   UniCarbKB                             584        584     <0.01     136      PTM databases                                

   UniGene                            109623      96247      0.20      36      Sequence databases                           

   UniPathway                         136240     123455      0.24      31      Enzyme and pathway databases                 

   VectorBase                            577        497     <0.01     137      Genome annotation databases                  

   VGNC                                 3731       3731      0.01     112      Organism-specific databases                  

   WBParaSite                             34         34     <0.01     154      Genome annotation databases                  

   World-2DPAGE                          929        918     <0.01     131      2D gel databases                             

   WormBase                             5996       4579      0.01      99      Organism-specific databases                  

   Xenbase                              4546       4540      0.01     105      Organism-specific databases                  

   ZFIN                                 3037       3032      0.01     114      Organism-specific databases                  



Total number of cross-referenced databases: 154



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.62

   Arg (R) 5.53   Glu (E) 6.73   Lys (K) 5.81   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.07   Met (M) 2.41   Trp (W) 1.09

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.91

   Cys (C) 1.38   Ile (I) 5.92   Pro (P) 4.72   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3871 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 79172