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         UniProtKB/Swiss-Prot protein knowledgebase release 2021_01 statistics





1.  INTRODUCTION



Release 2021_01 of 10-Feb-21 of UniProtKB/Swiss-Prot contains 564277 sequence entries,

comprising 203340877 amino acids abstracted from 276972 references. 



312 sequences have been added since release 2020_06, the sequence data of

57 existing entries has been updated and the annotations of

211834 entries have been revised.



Number of fragments: 9231

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 40440





Protein existence (PE):           entries     %



1: Evidence at protein level       105964   18.8%

2: Evidence at transcript level     56294     10%

3: Inferred from homology          386864   68.6%

4: Predicted                        13309    2.4%

5: Uncertain                         1846    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 14014



   The first twenty species represent 121612 sequences:  21.6 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5734

                            2x: 2026

                            3x: 1091

                            4x:  723

                            5x:  511

                            6x:  419

                            7x:  319

                            8x:  257

                            9x:  230

                           10x:  143

                       11- 20x:  812

                       21- 50x:  470

                       51-100x:  224

                         >100x: 1055





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20396  Homo sapiens (Human)

       2      17063  Mus musculus (Mouse)

       3      16036  Arabidopsis thaliana (Mouse-ear cress)

       4       8118  Rattus norvegicus (Rat)

       5       6721  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       6014  Bos taurus (Bovine)

       7       5140  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4518  Escherichia coli (strain K12)

       9       4191  Bacillus subtilis (strain 168)

      10       4190  Caenorhabditis elegans

      11       4150  Dictyostelium discoideum (Slime mold)

      12       4104  Oryza sativa subsp. japonica (Rice)

      13       3623  Drosophila melanogaster (Fruit fly)

      14       3459  Xenopus laevis (African clawed frog)

      15       3195  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2297  Gallus gallus (Chicken)

      17       2239  Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

      18       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      19       2042  Escherichia coli O157:H7

      20       1898  Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)

      21       1802  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1787  Methanocaldococcus jannaschii  

      23       1707  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1705  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      25       1697  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      26       1685  Shigella flexneri

      27       1438  Sus scrofa (Pig)

      28       1394  Pseudomonas aeruginosa 

      29       1347  Salmonella typhi

      30       1244  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      31       1174  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      32       1079  Synechocystis sp. (strain PCC 6803 / Kazusa)

      33       1035  Archaeoglobus fulgidus 

      34       1026  Yersinia pestis

      35       1014  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      36        988  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      37        978  Emericella nidulans  

      38        941  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      40        929  Staphylococcus aureus (strain N315)

      41        928  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      42        919  Kluyveromyces lactis   

      43        909  Acanthamoeba polyphaga mimivirus (APMV)

      44        903  Staphylococcus aureus (strain COL)

      45        896  Staphylococcus aureus (strain MW2)

      46        894  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      47        894  Oryctolagus cuniculus (Rabbit)

      48        890  Staphylococcus aureus (strain MSSA476)

      49        888  Staphylococcus aureus (strain MRSA252)

      50        883  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      51        882  Salmonella choleraesuis (strain SC-B67)

      52        879  Shigella sonnei (strain Ss046)

      53        878  Candida glabrata   

      54        875  Neurospora crassa 

      55        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      56        848  Oryza sativa subsp. indica (Rice)

      57        841  Escherichia coli O9:H4 (strain HS)

      58        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      59        833  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

      60        833  Zea mays (Maize)

      61        832  Canis lupus familiaris (Dog) (Canis familiaris)

      62        829  Shigella boydii serotype 4 (strain Sb227)

      63        825  Escherichia coli (strain UTI89 / UPEC)

      64        822  Shigella dysenteriae serotype 1 (strain Sd197)

      65        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      66        804  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      67        803  Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) 

      68        800  Staphylococcus aureus (strain NCTC 8325 / PS 47)

      69        793  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      70        791  Escherichia coli (strain SMS-3-5 / SECEC)

      71        787  Aquifex aeolicus (strain VF5)

      72        772  Pasteurella multocida (strain Pm70)

      73        771  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      74        771  Escherichia coli (strain K12 / DH10B)

      75        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      76        765  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      77        762  Escherichia coli (strain 55989 / EAEC)

      78        761  Escherichia coli O8 (strain IAI1)

      79        760  Shigella flexneri serotype 5b (strain 8401)

      80        760  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      81        760  Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)

      82        758  Escherichia coli O45:K1 (strain S88 / ExPEC)

      83        756  Escherichia coli (strain SE11)

      84        756  Bacillus anthracis

      85        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      86        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      87        748  Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)

      88        742  Bacillus halodurans 

      89        739  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      90        733  Vibrio vulnificus (strain CMCP6)

      91        731  Escherichia coli O81 (strain ED1a)

      92        725  Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

      93        722  Salmonella enteritidis PT4 (strain P125109)

      94        718  Vibrio vulnificus (strain YJ016)

      95        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      96        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      97        715  Enterobacter sp. (strain 638)

      98        715  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      99        714  Salmonella paratyphi A (strain AKU_12601)

     100        714  Escherichia coli O1:K1 / APEC

     101        713  Salmonella newport (strain SL254)

     102        713  Salmonella agona (strain SL483)

     103        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     104        712  Salmonella schwarzengrund (strain CVM19633)

     105        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     106        710  Salmonella heidelberg (strain SL476)

     107        702  Salmonella dublin (strain CT_02021853)

     108        698  Klebsiella pneumoniae (strain 342)

     109        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     110        697  Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)

     111        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     112        692  Pan troglodytes (Chimpanzee)

     113        686  Escherichia coli

     114        686  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     115        684  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     116        680  Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

     117        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     118        677  Staphylococcus aureus (strain USA300)

     119        672  Serratia proteamaculans (strain 568)

     120        669  Mycobacterium leprae (strain TN)

     121        668  Bacillus cereus 

     122        667  Yersinia pestis (strain Pestoides F)

     123        665  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     124        664  Bradyrhizobium diazoefficiens 

     125        657  Sinorhizobium fredii (strain NBRC 101917 / NGR234)

     126        653  Debaryomyces hansenii   

     127        650  Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens 

     128        650  Shewanella oneidensis (strain MR-1)

     129        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     130        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     131        641  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     132        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     133        622  Treponema pallidum (strain Nichols)

     134        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     135        622  Methanothermobacter thermautotrophicus  

     136        619  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     137        615  Xanthomonas campestris pv. campestris 

     138        614  Staphylococcus haemolyticus (strain JCSC1435)

     139        613  Mesorhizobium japonicum  (Mesorhizobium loti 

     140        608  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     141        603  Pseudomonas aeruginosa (strain UCBPP-PA14)

     142        603  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     143        603  Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)

     144        602  Staphylococcus saprophyticus subsp. saprophyticus 

     145        602  Photobacterium profundum (strain SS9)

     146        601  Salmonella paratyphi C (strain RKS4594)

     147        600  Yersinia pestis bv. Antiqua (strain Angola)

     148        595  Bacillus cereus (strain ATCC 10987 / NRS 248)

     149        591  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     150        584  Rickettsia prowazekii (strain Madrid E)

     151        583  Neisseria meningitidis serogroup B (strain MC58)

     152        579  Caenorhabditis briggsae

     153        579  Brucella suis biovar 1 (strain 1330)

     154        574  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     155        573  Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus)

     156        573  Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)

     157        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     158        572  Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) 

     159        569  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     160        568  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     161        567  Pseudomonas syringae pv. syringae (strain B728a)

     162        564  Bacillus licheniformis 

     163        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     164        562  Bacillus cereus (strain ZK / E33L)

     165        561  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     166        559  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     167        559  Clostridium acetobutylicum 

     168        557  Xanthomonas axonopodis pv. citri (strain 306)

     169        555  Pseudomonas fluorescens (strain Pf0-1)

     170        554  Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)

     171        553  Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)

     172        553  Oceanobacillus iheyensis 

     173        547  Pseudomonas savastanoi pv. phaseolicola  (Pseudomonas syringae pv. phaseolicola 

     174        540  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     175        534  Corynebacterium glutamicum 

     176        531  Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

     177        529  Listeria monocytogenes serotype 4b (strain F2365)

     178        529  Sodalis glossinidius (strain morsitans)

     179        528  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     180        524  Staphylococcus aureus (strain Newman)

     181        522  Xylella fastidiosa (strain 9a5c)

     182        521  Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

     183        519  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     184        517  Chromobacterium violaceum 

     185        516  Deinococcus radiodurans 

     186        516  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     187        515  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     188        514  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     189        512  Pseudomonas aeruginosa (strain PA7)

     190        511  Streptomyces avermitilis 

     191        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     192        510  Geobacillus kaustophilus (strain HTA426)

     193        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     194        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     195        502  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     196        502  Pseudomonas entomophila (strain L48)

     197        499  Brucella abortus biovar 1 (strain 9-941)

     198        499  Haemophilus influenzae (strain 86-028NP)

     199        498  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     200        496  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     201        496  Bacillus clausii (strain KSM-K16)

     202        496  Burkholderia pseudomallei (strain K96243)

     203        494  Pyrococcus horikoshii 

     204        494  Proteus mirabilis (strain HI4320)

     205        494  Xanthomonas campestris pv. campestris (strain 8004)

     206        492  Thermosynechococcus elongatus (strain BP-1)

     207        492  Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / FZB42) 

     208        491  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     209        491  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     210        489  Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

     211        488  Methanosarcina mazei  

     212        487  Shewanella sp. (strain MR-7)

     213        487  Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans R2)

     214        486  Mannheimia succiniciproducens (strain MBEL55E)

     215        486  Brucella abortus (strain 2308)

     216        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     217        484  Pseudomonas aeruginosa (strain LESB58)

     218        484  Shewanella sp. (strain MR-4)

     219        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     220        482  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     221        482  Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 

     222        480  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     223        478  Nicotiana tabacum (Common tobacco)

     224        478  Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1)

     225        477  Pyrococcus abyssi (strain GE5 / Orsay)

     226        475  Burkholderia lata 

     227        475  Cupriavidus necator  

     228        472  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     229        469  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     230        468  Clostridium perfringens (strain 13 / Type A)

     231        468  Pseudomonas putida (strain GB-1)

     232        467  Enterococcus faecalis (strain ATCC 700802 / V583)

     233        467  Aeromonas hydrophila subsp. hydrophila 

     234        467  Shewanella frigidimarina (strain NCIMB 400)

     235        467  Campylobacter jejuni subsp. jejuni serotype O:2 

     236        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     237        466  Shewanella sp. (strain ANA-3)

     238        465  Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)

     239        463  Burkholderia mallei (strain ATCC 23344)

     240        459  Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator 

     241        459  Ovis aries (Sheep)

     242        458  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     243        457  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     244        455  Shewanella baltica (strain OS185)

     245        455  Staphylococcus aureus (strain JH1)

     246        455  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     247        453  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)

     248        453  Pseudomonas putida (strain W619)

     249        452  Aeromonas salmonicida (strain A449)

     250        450  Dechloromonas aromatica (strain RCB)





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19641 (  3%)

    Bacteria         334868 ( 59%)

    Eukaryota        192754 ( 34%)

    Viruses           17014 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20397 ( 11%)           (  4%)

     Other Mammalia         46960 ( 24%)           (  8%)

     Other Vertebrata       18616 ( 10%)           (  3%)

     Viridiplantae          40718 ( 21%)           (  7%)

     Fungi                  35121 ( 18%)           (  6%)

     Insecta                 9401 (  5%)           (  2%)

     Nematoda                5099 (  3%)           (  1%)

     Other                  16442 (  9%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9757             1001-1100     4038

                 51- 100   43014             1101-1200     2837

                101- 150   59443             1201-1300     2167

                151- 200   59201             1301-1400     2038

                201- 250   58074             1401-1500     1643

                251- 300   51899             1501-1600      809

                301- 350   52301             1601-1700      624

                351- 400   45375             1701-1800      572

                401- 450   37316             1801-1900      489

                451- 500   30167             1901-2000      386

                501- 550   21909             2001-2100      259

                551- 600   15548             2101-2200      361

                601- 650   12957             2201-2300      331

                651- 700    9299             2301-2400      225

                701- 750    7730             2401-2500      180

                751- 800    5603             >2500         1372

                801- 850    4836

                851- 900    5245

                901- 950    4074

                951-1000    2967



   





   The average sequence length in UniProtKB/Swiss-Prot is 360 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2917





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  938

                       2x:  402

                       3x:  181

                       4x:  139

                       5x:  119

                       6x:   82

                       7x:   73

                       8x:   68

                       9x:   39

                      10x:   33

                  11- 20x:  237

                  21- 50x:  241

                  51-100x:  125

                    >100x:  240





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        25629   Journal of Biological Chemistry

    2        11930   Proceedings of the National Academy of Sciences of the U.S.A.

    3         6854   Journal of Bacteriology

    4         5785   Biochemical and Biophysical Research Communications

    5         5546   Biochemistry

    6         5115   Nucleic Acids Research

    7         4923   FEBS Letters

    8         4845   Gene

    9         4774   The EMBO Journal

   10         4744   Nature

   11         4441   Molecular and Cellular Biology

   12         4384   Journal of Molecular Biology

   13         3801   Biochimica et Biophysica Acta

   14         3669   Cell

   15         3445   European Journal of Biochemistry

   16         3385   Journal of Virology

   17         3141   Science

   18         2981   Biochemical Journal

   19         2688   Plant Physiology

   20         2666   Molecular Microbiology

   21         2537   Genomics

   22         2288   The American Journal of Human Genetics

   23         2255   Journal of Cell Biology

   24         2213   PLoS ONE

   25         2093   The Plant Cell

   26         1948   The Plant Journal

   27         1895   Human Molecular Genetics

   28         1890   Plant Molecular Biology

   29         1881   Genes and Development

   30         1833   Virology

   31         1797   Nature Genetics

   32         1726   Molecular Biology of the Cell

   33         1713   Development

   34         1625   Molecular Cell

   35         1591   Human Mutation

   36         1556   Journal of Immunology

   37         1547   Oncogene

   38         1407   Structure

   39         1405   Molecular and General Genetics

   40         1373   Journal of Biochemistry

   41         1348   Genetics

   42         1306   Journal of Cell Science

   43         1198   Blood

   44         1181   Infection and Immunity

   45         1158   Journal of General Virology

   46         1109   Microbiology

   47         1093   Current Biology

   48         1090   Archives of Biochemistry and Biophysics

   49         1088   Developmental Biology

   50          954   Journal of Neuroscience

   51          948   Applied and Environmental Microbiology

   52          937   Acta Crystallographica, Section D

   53          903   Cancer Research

   54          858   FEMS Microbiology Letters

   55          841   Yeast

   56          817   Toxicon

   57          805   Protein Science

   58          783   Journal of Clinical Investigation

   59          780   Neuron

   60          759   PLoS Genetics

   61          730   Plant and Cell Physiology

   62          729   American Journal of Physiology

   63          713   Human Genetics

   64          700   The Journal of Experimental Medicine

   65          684   Nature Communications

   66          655   Mechanisms of Development

   67          654   Proteins

   68          648   Journal of Medical Genetics

   69          647   Nature Structural Biology

   70          602   Nature Cell Biology

   71          585   Nature Structural and Molecular Biology

   72          581   Scientific Reports

   73          579   Current Genetics

   74          574   The FEBS Journal

   75          572   Bioscience, Biotechnology, and Biochemistry

   76          552   Journal of Neurochemistry

   77          544   Developmental Cell

   78          544   Molecular Endocrinology

   79          533   The Journal of Clinical Endocrinology and Metabolism

   80          514   Endocrinology

   81          508   Antimicrobial Agents and Chemotherapy

   82          488   Mammalian Genome

   83          472   Experimental Cell Research

   84          469   Molecular and Biochemical Parasitology

   85          468   PLoS Pathogens

   86          448   Eukaryotic Cell

   87          441   Peptides

   88          438   Planta

   89          434   Journal of the American Chemical Society

   90          432   RNA

   91          430   Immunogenetics

   92          420   Journal of Experimental Botany

   93          406   Journal of Molecular Evolution

   94          403   Molecular Biology and Evolution

   95          398   Molecular Pharmacology

   96          392   EMBO Reports

   97          390   The FASEB Journal

   98          390   DNA and Cell Biology

   99          386   American Journal of Medical Genetics. Part A

  100          385   Acta Crystallographica, Section F

  101          377   Journal of Investigative Dermatology

  102          376   Molecular Plant-Microbe Interactions

  103          376   DNA Sequence

  104          375   Neurology

  105          374   European Journal of Human Genetics

  106          371   Immunity

  107          360   Comparative Biochemistry and Physiology

  108          356   Biology of Reproduction

  109          345   Biochimie

  110          341   Brain Research. Molecular Brain Research

  111          337   Virus Research

  112          336   Genes to Cells

  113          330   Clinical Genetics

  114          323   The New England Journal of Medicine

  115          322   Developmental Dynamics

  116          319   Journal of Lipid Research

  117          306   Annals of Neurology

  118          301   Genome Research

  119          299   Biological Chemistry Hoppe-Seyler

  120          298   BMC Genomics

  121          297   European Journal of Immunology

  122          297   Nature Immunology

  123          292   Cell Reports

  124          285   Applied Microbiology and Biotechnology

  125          284   Investigative Ophthalmology and Visual Science

  126          282   Cytogenetics and Cell Genetics

  127          279   Journal of Medicinal Chemistry

  128          277   PLoS Biology

  129          273   Journal of General Microbiology

  130          270   Journal of Human Genetics

  131          262   Glycobiology

  132          255   Archives of Microbiology

  133          245   Traffic

  134          244   Molecular Immunology

  135          239   Journal of Cellular Biochemistry

  136          238   Molecular Genetics and Metabolism

  137          237   

  138          232   DNA Research

  139          229   Protein Expression and Purification

  140          228   Phytochemistry

  141          227   Cell Cycle

  142          225   Diabetes

  143          223   Nature Medicine

  144          219   Archives of Virology

  145          219   Circulation Research

  146          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  147          216   Fungal Genetics and Biology

  148          209   Nature Chemical Biology

  149          209   Molecular and Cellular Endocrinology

  150          204   Molecular Genetics and Genomics





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1254796                 2.22                                         

   Journal                           1078330     462042      1.91       1                                 

   Submitted to EMBL/GenBank/DDBJ     165304     149648      0.29       2                                 

   Submitted to other databases         7576       6975      0.01       3                                 

   Book citation                        1855       1832     <0.01       4                                 

   Plant Gene Register                   612        599     <0.01       5                                 

   Unpublished observations              464        460     <0.01       6                                 

   Thesis                                437        434     <0.01       7                                 

   Patent                                212        205     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 431899



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2626922                 4.66                                         

   ACTIVITY REGULATION                 16137      16088      0.03      17                                 

   ALLERGEN                              924        924     <0.01      26                                 

   ALTERNATIVE PRODUCTS                25508      25508      0.05      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        9499       9488      0.02      20                                 

   BIOTECHNOLOGY                        1405       1381     <0.01      24                                 

   CATALYTIC ACTIVITY                 311270     243910      0.55       4                                 

   CAUTION                             13518      13240      0.02      18                                 

   COFACTOR                           128001     116345      0.23       7                                 

   DEVELOPMENTAL STAGE                 13020      12989      0.02      19                                 

   DISEASE                              7513       5048      0.01      21                                 

   DISRUPTION PHENOTYPE                16915      16905      0.03      16                                 

   DOMAIN                              52441      44831      0.09       9                                 

   FUNCTION                           475857     453509      0.84       2                                 

   INDUCTION                           22752      22700      0.04      15                                 

   INTERACTION                         23573      23573      0.04      14                                 

   MASS SPECTROMETRY                    7061       5429      0.01      22                                 

   MISCELLANEOUS                       44226      38870      0.08      12                                 

   PATHWAY                            141162     127770      0.25       6                                 

   PHARMACEUTICAL                        157        149     <0.01      29                                 

   POLYMORPHISM                         1295       1241     <0.01      25                                 

   PTM                                 59800      43454      0.11       8                                 

   RNA EDITING                           628        628     <0.01      28                                 

   SEQUENCE CAUTION                    44626      44555      0.08      11                                 

   SIMILARITY                         512923     508717      0.91       1                                 

   SUBCELLULAR LOCATION               354294     346420      0.63       3                                 

   SUBUNIT                            286814     282788      0.51       5                                 

   TISSUE SPECIFICITY                  48100      47918      0.09      10                                 

   TOXIC DOSE                            783        638     <0.01      27                                 

   WEB RESOURCE                         6720       5559      0.01      23                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        4681627                 8.30                                         

   ACT_SITE                           167671     101625      0.30      10                                 

   BINDING                            416498     110706      0.74       2                                 

   CA_BIND                              4214       1749      0.01      36                                 

   CARBOHYD                           119765      30676      0.21      15                                 

   CHAIN                              572513     556964      1.01       1                                 

   COILED                              22167      15342      0.04      27                                 

   COMPBIAS                            59233      31875      0.10      21                                 

   CONFLICT                           137197      47896      0.24      13                                 

   CROSSLNK                            24116       8683      0.04      26                                 

   DISULFID                           129289      34570      0.23      14                                 

   DNA_BIND                            11978      10715      0.02      33                                 

   DOMAIN                             206884     127208      0.37       9                                 

   HELIX                              285055      25728      0.51       6                                 

   INIT_MET                            17435      17387      0.03      28                                 

   INTRAMEM                             2862       1313      0.01      37                                 

   LIPID                               13406       8644      0.02      30                                 

   METAL                              405777      97939      0.72       3                                 

   MOD_RES                            255988      72908      0.45       7                                 

   MOTIF                               45094      29444      0.08      23                                 

   MUTAGEN                             80289      17226      0.14      18                                 

   NON_CONS                             2513        817     <0.01      38                                 

   NON_STD                               358        283     <0.01      39                                 

   NON_TER                             12558       9634      0.02      31                                 

   NP_BIND                            160805      86892      0.28      11                                 

   PEPTIDE                             12021       8242      0.02      32                                 

   PROPEP                              14692      12531      0.03      29                                 

   REGION                             208334      96917      0.37       8                                 

   REPEAT                             107173      14932      0.19      16                                 

   SIGNAL                              43055      43054      0.08      24                                 

   SITE                                61475      33205      0.11      20                                 

   STRAND                             294914      24270      0.52       5                                 

   TOPO_DOM                           145404      29593      0.26      12                                 

   TRANSIT                              9260       9144      0.02      34                                 

   TRANSMEM                           375789      78632      0.67       4                                 

   TURN                                68863      20959      0.12      19                                 

   UNSURE                               5578        842      0.01      35                                 

   VAR_SEQ                             52428      22275      0.09      22                                 

   VARIANT                             98787      17195      0.18      17                                 

   ZN_FING                             30189      12902      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               18146830                32.16                                                           

   ABCD                                 2716       2716     <0.01     118      Protocols and materials databases            

   Allergome                            2011       1296     <0.01     125      Protein family/group databases               

   Antibodypedia                       32100      31989      0.06      56      Protocols and materials databases            

   ArachnoServer                        1163       1154     <0.01     136      Organism-specific databases                  

   Araport                             16056      15960      0.03      85      Organism-specific databases                  

   Bgee                                57296      57294      0.10      42      Gene expression databases                    

   BindingDB                            5782       5782      0.01     103      Chemistry databases                          

   BioCyc                             202323     198273      0.36      24      Enzyme and pathway databases                 

   BioGRID                             58210      56424      0.10      41      Protein-protein interaction databases        

   BioGRID-ORCS                        38973      38460      0.07      54      Miscellaneous databases                      

   BioMuta                             20318      20301      0.04      71      Genetic variation databases                  

   BMRB                                 6905       6905      0.01      99      3D structure databases                       

   BRENDA                              13021      12236      0.02      87      Enzyme and pathway databases                 

   CarbonylDB                           1157       1157     <0.01     137      PTM databases                                

   CAZy                                 9550       8606      0.02      92      Protein family/group databases               

   CCDS                                48745      34302      0.09      48      Sequence databases                           

   CDD                                190486     171209      0.34      26      Family and domain databases                  

   CGD                                  2001       1984     <0.01     126      Organism-specific databases                  

   ChEMBL                               7827       7663      0.01      96      Chemistry databases                          

   ChiTaRS                             29650      29613      0.05      60      Miscellaneous databases                      

   CLAE                                  357        354     <0.01     151      Protein family/group databases               

   CollecTF                              135        135     <0.01     159      Gene expression databases                    

   ComplexPortal                       11392       6366      0.02      89      Protein-protein interaction databases        

   COMPLUYEAST-2DPAGE                     97         97     <0.01     161      2D gel databases                             

   ConoServer                            969        881     <0.01     139      Organism-specific databases                  

   CORUM                                5808       5808      0.01     102      Protein-protein interaction databases        

   CPTAC                                2525       1632     <0.01     121      Proteomic databases                          

   CPTC                                  296        296     <0.01     153      Protocols and materials databases            

   CTD                                 75330      74422      0.13      39      Organism-specific databases                  

   DEPOD                                 254        254     <0.01     157      PTM databases                                

   dictyBase                            4215       4101      0.01     112      Organism-specific databases                  

   DIP                                 17452      17412      0.03      80      Protein-protein interaction databases        

   DisGeNET                            17034      16809      0.03      81      Organism-specific databases                  

   DisProt                              1425       1413     <0.01     131      Family and domain databases                  

   DMDM                                16195      16193      0.03      84      Genetic variation databases                  

   DNASU                               19072      19005      0.03      74      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     145        145     <0.01     158      2D gel databases                             

   DrugBank                            29149       4692      0.05      62      Chemistry databases                          

   DrugCentral                          2533       2533     <0.01     120      Chemistry databases                          

   EchoBASE                             4158       4158      0.01     113      Organism-specific databases                  

   eggNOG                             336826     330968      0.60      15      Phylogenomic databases                       

   ELM                                  1811       1811     <0.01     127      Protein-protein interaction databases        

   EMBL                               990643     552048      1.76       3      Sequence databases                           

   Ensembl                             98873      51726      0.18      35      Genome annotation databases                  

   EnsemblBacteria                    356516     337260      0.63      14      Genome annotation databases                  

   EnsemblFungi                        30055      28462      0.05      59      Genome annotation databases                  

   EnsemblMetazoa                      18076      10461      0.03      78      Genome annotation databases                  

   EnsemblPlants                       30220      21450      0.05      58      Genome annotation databases                  

   EnsemblProtists                      5046       4867      0.01     105      Genome annotation databases                  

   EPD                                 21175      21175      0.04      67      Proteomic databases                          

   ESTHER                               2584       2583     <0.01     119      Protein family/group databases               

   euHCVdb                                55         44     <0.01     163      Organism-specific databases                  

   EvolutionaryTrace                   16668      16668      0.03      83      Miscellaneous databases                      

   ExpressionAtlas                     48456      48456      0.09      49      Gene expression databases                    

   FlyBase                              4921       4796      0.01     106      Organism-specific databases                  

   Gene3D                             415333     322407      0.74      12      Family and domain databases                  

   GeneCards                           20359      20194      0.04      68      Organism-specific databases                  

   GeneDB                                618        562     <0.01     145      Genome annotation databases                  

   GeneID                             264993     249251      0.47      20      Genome annotation databases                  

   GeneReviews                          1479       1475     <0.01     128      Organism-specific databases                  

   GeneTree                            59985      59946      0.11      40      Phylogenomic databases                       

   Genevisible                         55252      55252      0.10      45      Gene expression databases                    

   GeneWiki                            10350      10267      0.02      91      Miscellaneous databases                      

   GenomeRNAi                          22173      22172      0.04      65      Miscellaneous databases                      

   GlyConnect                           2320       2178     <0.01     122      PTM databases                                

   GlyGen                              11178      11178      0.02      90      PTM databases                                

   GO                                3082830     539890      5.46       1      Ontologies                                   

   Gramene                             30220      21450      0.05      57      Genome annotation databases                  

   GuidetoPHARMACOLOGY                  2041       2041     <0.01     124      Chemistry databases                          

   HAMAP                              330401     327481      0.59      16      Family and domain databases                  

   HGNC                                20339      20206      0.04      69      Organism-specific databases                  

   HOGENOM                            424046     424046      0.75      11      Phylogenomic databases                       

   HPA                                 18983      18847      0.03      75      Organism-specific databases                  

   IDEAL                                 985        985     <0.01     138      Family and domain databases                  

   IMGT_GENE-DB                          267        267     <0.01     156      Protein family/group databases               

   InParanoid                         140274     140274      0.25      27      Phylogenomic databases                       

   IntAct                              55876      55876      0.10      44      Protein-protein interaction databases        

   InterPro                          2326050     545361      4.12       2      Family and domain databases                  

   iPTMnet                             52679      52679      0.09      46      PTM databases                                

   jPOST                               26396      26396      0.05      63      Proteomic databases                          

   KEGG                               499149     476657      0.88       8      Genome annotation databases                  

   LegioList                             765        763     <0.01     142      Organism-specific databases                  

   Leproma                               672        669     <0.01     143      Organism-specific databases                  

   MaizeGDB                              520        516     <0.01     146      Organism-specific databases                  

   MalaCards                            4823       4819      0.01     108      Organism-specific databases                  

   MassIVE                             17470      17470      0.03      79      Proteomic databases                          

   MaxQB                               29613      29613      0.05      61      Proteomic databases                          

   MEROPS                              11512      11510      0.02      88      Protein family/group databases               

   MetOSite                             3106       3106      0.01     117      PTM databases                                

   MGI                                 16974      16934      0.03      82      Organism-specific databases                  

   MIM                                 21832      15396      0.04      66      Organism-specific databases                  

   MINT                                22798      22798      0.04      64      Protein-protein interaction databases        

   MoonDB                                348        348     <0.01     152      Protein family/group databases               

   MoonProt                              281        281     <0.01     155      Protein family/group databases               

   neXtProt                            20338      20338      0.04      70      Organism-specific databases                  

   NIAGADS                                68         68     <0.01     162      Organism-specific databases                  

   OGP                                   373        373     <0.01     150      2D gel databases                             

   OMA                                414480     414480      0.73      13      Phylogenomic databases                       

   OpenTargets                         18361      18210      0.03      76      Organism-specific databases                  

   Orphanet                             7731       4117      0.01      97      Organism-specific databases                  

   OrthoDB                            245788     245788      0.44      21      Phylogenomic databases                       

   PANTHER                            280917     268488      0.50      19      Family and domain databases                  

   PathwayCommons                      19492      19492      0.03      73      Enzyme and pathway databases                 

   PATRIC                              92453      92453      0.16      38      Genome annotation databases                  

   PaxDb                              125552     125552      0.22      31      Proteomic databases                          

   PCDDB                                 129        129     <0.01     160      3D structure databases                       

   PDB                                209826      30003      0.37      22      3D structure databases                       

   PDBsum                             209826      30003      0.37      23      3D structure databases                       

   PeptideAtlas                        33424      33424      0.06      55      Proteomic databases                          

   PeroxiBase                            783        761     <0.01     141      Protein family/group databases               

   Pfam                               785366     523734      1.39       4      Family and domain databases                  

   PharmGKB                            18313      18294      0.03      77      Organism-specific databases                  

   Pharos                              20097      20097      0.04      72      Miscellaneous databases                      

   PHI-base                             1459       1212     <0.01     129      Miscellaneous databases                      

   PhosphoSitePlus                     39080      39080      0.07      53      PTM databases                                

   PhylomeDB                           97002      97002      0.17      37      Phylogenomic databases                       

   PIR                                124444     114176      0.22      33      Sequence databases                           

   PIRSF                              107786     106691      0.19      34      Family and domain databases                  

   PlantReactome                        1163        715     <0.01     135      Enzyme and pathway databases                 

   PomBase                              5132       5128      0.01     104      Organism-specific databases                  

   PRIDE                              134830     134830      0.24      29      Proteomic databases                          

   PRINTS                             131178     116284      0.23      30      Family and domain databases                  

   PRO                                 97294      97294      0.17      36      Miscellaneous databases                      

   ProMEX                                467        467     <0.01     148      Proteomic databases                          

   PROSITE                            481266     305701      0.85       9      Family and domain databases                  

   Proteomes                          501655     467531      0.89       7      Miscellaneous databases                      

   ProteomicsDB                        56871      35743      0.10      43      Proteomic databases                          

   PseudoCAP                            1401       1392     <0.01     132      Organism-specific databases                  

   Reactome                           125359      35805      0.22      32      Enzyme and pathway databases                 

   REBASE                                622        384     <0.01     144      Protein family/group databases               

   RefSeq                             615194     470036      1.09       5      Sequence databases                           

   REPRODUCTION-2DPAGE                  1259       1038     <0.01     133      2D gel databases                             

   RGD                                  8043       8040      0.01      95      Organism-specific databases                  

   RNAct                               43019      43019      0.08      51      Miscellaneous databases                      

   SABIO-RK                             4580       4580      0.01     109      Enzyme and pathway databases                 

   SASBDB                                422        422     <0.01     149      3D structure databases                       

   SFLD                                 8213       6102      0.01      94      Family and domain databases                  

   SGD                                  6740       6735      0.01     100      Organism-specific databases                  

   SignaLink                            3106       3106      0.01     116      Enzyme and pathway databases                 

   SIGNOR                               4843       4843      0.01     107      Enzyme and pathway databases                 

   SMART                              194131     143077      0.34      25      Family and domain databases                  

   SMR                                453874     453874      0.80      10      3D structure databases                       

   STRING                             329595     329595      0.58      17      Protein-protein interaction databases        

   SUPFAM                             514592     389098      0.91       6      Family and domain databases                  

   SWISS-2DPAGE                         1177       1177     <0.01     134      2D gel databases                             

   SwissLipids                          1451       1367     <0.01     130      Chemistry databases                          

   SwissPalm                            8637       8637      0.02      93      PTM databases                                

   TAIR                                14833      14777      0.03      86      Organism-specific databases                  

   TCDB                                 7709       7650      0.01      98      Protein family/group databases               

   TIGRFAMs                           292939     272891      0.52      18      Family and domain databases                  

   TopDownProteomics                    3237       2960      0.01     114      Proteomic databases                          

   TreeFam                             45758      45751      0.08      50      Phylogenomic databases                       

   TubercuList                          2258       2222     <0.01     123      Organism-specific databases                  

   UCD-2DPAGE                            496        496     <0.01     147      2D gel databases                             

   UCSC                                50324      45928      0.09      47      Genome annotation databases                  

   UniLectin                             282        282     <0.01     154      Protein family/group databases               

   UniPathway                         138219     125014      0.24      28      Enzyme and pathway databases                 

   VEuPathDB                           40076      39822      0.07      52      Organism-specific databases                  

   VGNC                                 4330       4317      0.01     111      Organism-specific databases                  

   WBParaSite                             48         43     <0.01     164      Genome annotation databases                  

   World-2DPAGE                          932        921     <0.01     140      2D gel databases                             

   WormBase                             6441       4791      0.01     101      Organism-specific databases                  

   Xenbase                              4531       4530      0.01     110      Organism-specific databases                  

   ZFIN                                 3169       3164      0.01     115      Organism-specific databases                  



Total number of cross-referenced databases: 164



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.65   Ser (S) 6.63

   Arg (R) 5.53   Glu (E) 6.72   Lys (K) 5.80   Thr (T) 5.35

   Asn (N) 4.06   Gly (G) 7.07   Met (M) 2.41   Trp (W) 1.10

   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.38   Ile (I) 5.91   Pro (P) 4.73   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3945 are encoded on a plasmid.



12189 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11624 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 80138