UniProtKB/Swiss-Prot protein knowledgebase release 2025_03 statistics
1. INTRODUCTION
Release 2025_03 of 18-Jun-2025 of UniProtKB/Swiss-Prot contains 573661 sequence
entries, curated from 306849 unique references and comprising 207922125 amino acids.
434 sequences have been added since release 2025_02, the sequence data of
72 existing entries has been updated and the annotations of
354873 entries have been revised.
Number of fragments: 9280
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 41243
Protein existence (PE): entries %
1: Evidence at protein level 118866 20.7%
2: Evidence at transcript level 54383 9.5%
3: Inferred from homology 385903 67.3%
4: Predicted 12771 2.2%
5: Uncertain 1738 0.3%
The growth of the database is summarized below.
2. TAXONOMIC ORIGIN
Total number of species represented in this release of UniProtKB/Swiss-Prot: 14803
The first twenty species represent 123272 sequences: 21.5 % of the total
number of entries.
2.1 Table of the frequency of occurrence of species
Species represented 1x: 6026
2x: 2136
3x: 1168
4x: 786
5x: 549
6x: 451
7x: 331
8x: 294
9x: 237
10x: 163
11- 20x: 851
21- 50x: 518
51-100x: 233
>100x: 1060
2.2 Table of the most represented species
------ --------- --------------------------------------------
Number Frequency Species
------ --------- --------------------------------------------
1 20420 Homo sapiens (Human)
2 17240 Mus musculus (Mouse)
3 16397 Arabidopsis thaliana (Mouse-ear cress)
4 8219 Rattus norvegicus (Rat)
5 6733 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
6 6052 Bos taurus (Bovine)
7 5123 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
8 4531 Escherichia coli (strain K12)
9 4493 Caenorhabditis elegans
10 4195 Oryza sativa subsp. japonica (Rice)
11 4191 Bacillus subtilis (strain 168)
12 4160 Dictyostelium discoideum (Social amoeba)
13 3846 Drosophila melanogaster (Fruit fly)
14 3510 Xenopus laevis (African clawed frog)
15 3355 Danio rerio (Zebrafish) (Brachydanio rerio)
16 2331 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
17 2312 Gallus gallus (Chicken)
18 2218 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
19 2047 Escherichia coli O157:H7
20 1899 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
21 1830 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
22 1787 Methanocaldococcus jannaschii
23 1713 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
24 1703 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
25 1702 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
26 1696 Shigella flexneri
27 1479 Pseudomonas aeruginosa
28 1459 Sus scrofa (Pig)
29 1349 Salmonella typhi
30 1244 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
31 1176 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
32 1147 Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
33 1103 Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)
34 1038 Archaeoglobus fulgidus
35 1030 Yersinia pestis
36 1026 Emericella nidulans
37 1000 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
38 979 Oryctolagus cuniculus (Rabbit)
39 970 Neurospora crassa
40 949 Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293)
41 942 Staphylococcus aureus (strain Mu50 / ATCC 700699)
42 930 Salmonella paratyphi A (strain ATCC 9150 / SARB42)
43 929 Staphylococcus aureus (strain N315)
44 928 Eremothecium gossypii
45 919 Kluyveromyces lactis
46 909 Acanthamoeba polyphaga mimivirus (APMV)
47 905 Staphylococcus aureus (strain COL)
48 896 Staphylococcus aureus (strain MW2)
49 894 Escherichia coli O6:K15:H31 (strain 536 / UPEC)
50 891 Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
51 890 Staphylococcus aureus (strain MSSA476)
52 888 Candida glabrata
53 888 Staphylococcus aureus (strain MRSA252)
54 882 Salmonella choleraesuis (strain SC-B67)
55 879 Shigella sonnei (strain Ss046)
56 873 Oryza sativa subsp. indica (Rice)
57 863 Yersinia pseudotuberculosis serotype I (strain IP32953)
58 854 Canis lupus familiaris (Dog) (Canis familiaris)
59 850 Zea mays (Maize)
60 847 Escherichia coli O9:H4 (strain HS)
61 838 Escherichia coli O139:H28 (strain E24377A / ETEC)
62 829 Shigella boydii serotype 4 (strain Sb227)
63 825 Escherichia coli (strain UTI89 / UPEC)
64 822 Escherichia coli
65 822 Shigella dysenteriae serotype 1 (strain Sd197)
66 819 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
67 812 Staphylococcus aureus (strain NCTC 8325 / PS 47)
68 804 Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
69 796 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
70 791 Escherichia coli (strain SMS-3-5 / SECEC)
71 788 Aquifex aeolicus (strain VF5)
72 779 Escherichia coli O127:H6 (strain E2348/69 / EPEC)
73 771 Escherichia coli (strain K12 / DH10B)
74 770 Pasteurella multocida (strain Pm70)
75 767 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
76 765 Escherichia coli (strain K12 / MC4100 / BW2952)
77 762 Escherichia coli (strain 55989 / EAEC)
78 761 Escherichia coli O8 (strain IAI1)
79 760 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)
80 760 Staphylococcus epidermidis
81 760 Shigella flexneri serotype 5b (strain 8401)
82 759 Escherichia coli O45:K1 (strain S88 / ExPEC)
83 758 Bacillus anthracis
84 756 Escherichia coli (strain SE11)
85 753 Escherichia coli O7:K1 (strain IAI39 / ExPEC)
86 749 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)
87 748 Escherichia coli O157:H7 (strain EC4115 / EHEC)
88 744 Halalkalibacterium halodurans
89 739 Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
90 738 Pseudomonas putida
91 733 Vibrio vulnificus (strain CMCP6)
92 731 Escherichia coli O81 (strain ED1a)
93 726 Escherichia coli
94 722 Salmonella enteritidis PT4 (strain P125109)
95 719 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
96 718 Vibrio vulnificus (strain YJ016)
97 716 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
98 715 Escherichia coli O1:K1 / APEC
99 715 Enterobacter sp. (strain 638)
100 715 Yersinia pestis bv. Antiqua (strain Nepal516)
101 714 Salmonella paratyphi A (strain AKU_12601)
102 713 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
103 713 Salmonella newport (strain SL254)
104 713 Salmonella agona (strain SL483)
105 712 Salmonella schwarzengrund (strain CVM19633)
106 711 Yersinia pestis bv. Antiqua (strain Antiqua)
107 710 Salmonella heidelberg (strain SL476)
108 708 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
109 702 Salmonella dublin (strain CT_02021853)
110 699 Klebsiella pneumoniae (strain 342)
111 698 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
112 695 Escherichia fergusonii
113 692 Pan troglodytes (Chimpanzee)
114 686 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)
115 684 Salmonella gallinarum (strain 287/91 / NCTC 13346)
116 683 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)
117 679 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
118 679 Staphylococcus aureus (strain USA300)
119 672 Serratia proteamaculans (strain 568)
120 670 Bacillus cereus
121 669 Mycobacterium leprae (strain TN)
122 669 Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
123 667 Bradyrhizobium diazoefficiens
124 667 Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
125 667 Yersinia pestis (strain Pestoides F)
126 663 Shewanella oneidensis
127 658 Sinorhizobium fredii (strain NBRC 101917 / NGR234)
128 653 Debaryomyces hansenii
129 643 Staphylococcus aureus (strain bovine RF122 / ET3-1)
130 642 Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
131 642 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
132 634 Yersinia pseudotuberculosis serotype IB (strain PB1/+)
133 623 Methanothermobacter thermautotrophicus
134 623 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
135 622 Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
136 622 Treponema pallidum (strain Nichols)
137 620 Pseudomonas aeruginosa (strain UCBPP-PA14)
138 615 Xanthomonas campestris pv. campestris
139 614 Staphylococcus haemolyticus (strain JCSC1435)
140 613 Mesorhizobium japonicum (Mesorhizobium loti
141 613 Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
142 605 Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
143 604 Ralstonia nicotianae (strain ATCC BAA-1114 / GMI1000) (Ralstonia solanacearum)
144 602 Staphylococcus saprophyticus subsp. saprophyticus
145 602 Photobacterium profundum (strain SS9)
146 601 Salmonella paratyphi C (strain RKS4594)
147 600 Yersinia pestis bv. Antiqua (strain Angola)
148 598 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)
149 595 Bacillus cereus (strain ATCC 10987 / NRS 248)
150 592 Neisseria meningitidis serogroup B (strain ATCC BAA-335 / MC58)
151 591 Pectobacterium carotovorum subsp. carotovorum (strain PC1)
152 586 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
153 584 Rickettsia prowazekii (strain Madrid E)
154 582 Caenorhabditis briggsae
155 579 Brucella suis biovar 1 (strain 1330)
156 576 Brucella melitensis biotype 1
157 575 Caulobacter vibrioides (strain ATCC 19089 / CIP 103742 / CB 15)
158 573 Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri)
159 572 Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)
160 569 Bacillus thuringiensis subsp. konkukian (strain 97-27)
161 568 Pseudomonas syringae pv. syringae (strain B728a)
162 568 Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)
163 566 Bacillus licheniformis
164 566 Thermotoga maritima
165 562 Bacillus cereus (strain ZK / E33L)
166 562 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
167 559 Clostridium acetobutylicum
168 557 Xanthomonas axonopodis pv. citri (strain 306)
169 555 Pseudomonas fluorescens (strain Pf0-1)
170 554 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
171 554 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
172 553 Oceanobacillus iheyensis
173 547 Pseudomonas savastanoi pv. phaseolicola (Pseudomonas syringae pv. phaseolicola
174 543 Corynebacterium glutamicum
175 541 Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
176 531 Erwinia tasmaniensis
177 530 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
178 530 Listeria monocytogenes serotype 4b (strain F2365)
179 529 Sodalis glossinidius (strain morsitans)
180 525 Staphylococcus aureus (strain Newman)
181 523 Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)
182 523 Deinococcus radiodurans
183 522 Xylella fastidiosa (strain 9a5c)
184 519 Chromobacterium violaceum
185 519 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
186 519 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
187 516 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
188 515 Xylella fastidiosa (strain Temecula1 / ATCC 700964)
189 512 Geobacillus kaustophilus (strain HTA426)
190 512 Haemophilus ducreyi (strain 35000HP / ATCC 700724)
191 512 Pseudomonas paraeruginosa (strain DSM 24068 / PA7) (Pseudomonas aeruginosa
192 511 Streptomyces avermitilis
193 511 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
194 509 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
195 509 Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
196 508 Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
197 508 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
198 507 Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
199 506 Nicotiana tabacum (Common tobacco)
200 504 Pseudomonas entomophila (strain L48)
201 501 Methanosarcina mazei
202 499 Brucella abortus biovar 1 (strain 9-941)
203 499 Haemophilus influenzae (strain 86-028NP)
204 498 Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)
205 497 Burkholderia pseudomallei (strain K96243)
206 497 Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805)
207 497 Pyrococcus horikoshii
208 497 Xanthomonas campestris pv. campestris (strain 8004)
209 497 Proteus mirabilis (strain HI4320)
210 496 Shouchella clausii (strain KSM-K16) (Alkalihalobacillus clausii)
211 496 Rickettsia conorii (strain ATCC VR-613 / Malish 7)
212 495 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
213 495 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
214 492 Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42)
215 492 Brucella abortus (strain 2308)
216 491 Vibrio campbellii (strain ATCC BAA-1116)
217 488 Shewanella sp. (strain MR-7)
218 486 Mannheimia succiniciproducens (strain KCTC 0769BP / MBEL55E)
219 485 Pseudomonas aeruginosa (strain LESB58)
220 485 Shewanella sp. (strain MR-4)
221 484 Staphylococcus aureus (strain Mu3 / ATCC 700698)
222 483 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
223 483 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
224 480 Pseudomonas putida
225 478 Pyrococcus abyssi (strain GE5 / Orsay)
226 478 Cupriavidus necator
227 475 Campylobacter jejuni subsp. jejuni serotype O:2
228 475 Burkholderia lata
229 472 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
230 472 Enterococcus faecalis (strain ATCC 700802 / V583)
231 471 Cereibacter sphaeroides
232 470 Clostridium perfringens (strain 13 / Type A)
233 468 Pseudomonas putida (strain GB-1)
234 468 Shewanella frigidimarina (strain NCIMB 400)
235 468 Shewanella sp. (strain ANA-3)
236 467 Aeromonas hydrophila subsp. hydrophila
237 466 Xanthomonas euvesicatoria pv. vesicatoria (strain 85-10)
238 465 Trichormus variabilis (strain ATCC 29413 / PCC 7937) (Anabaena variabilis)
239 463 Burkholderia mallei (strain ATCC 23344)
240 462 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
241 461 Ovis aries (Sheep)
242 460 Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
243 457 Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
244 455 Shewanella baltica (strain OS185)
245 455 Staphylococcus aureus (strain JH1)
246 455 Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
247 453 Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
248 453 Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
249 453 Pseudomonas putida (strain W619)
250 452 Caldanaerobacter subterraneus subsp. tengcongensis
2.3 Taxonomic distribution of the sequences
Kingdom sequences (% of the database)
Archaea 19814 ( 3%)
Bacteria 336823 ( 59%)
Eukaryota 199540 ( 35%)
Viruses 17484 ( 3%)
Within Eukaryota:
Category sequences (% of Eukaryota) (% of the complete database)
Human 20421 ( 10%) ( 4%)
Other Mammalia 47503 ( 24%) ( 8%)
Other Vertebrata 19025 ( 10%) ( 3%)
Viridiplantae 41948 ( 21%) ( 7%)
Fungi 37669 ( 19%) ( 7%)
Insecta 10058 ( 5%) ( 2%)
Nematoda 5411 ( 3%) ( 1%)
Other 17505 ( 9%) ( 3%)
3. SEQUENCE SIZE
Repartition of the sequences by size (excluding fragments)
From To Number From To Number
1- 50 10030 1001-1100 4159
51- 100 43788 1101-1200 2926
101- 150 60069 1201-1300 2234
151- 200 59783 1301-1400 2095
201- 250 58692 1401-1500 1700
251- 300 52685 1501-1600 844
301- 350 53125 1601-1700 651
351- 400 46201 1701-1800 604
401- 450 37883 1801-1900 536
451- 500 30772 1901-2000 405
501- 550 22518 2001-2100 278
551- 600 15939 2101-2200 396
601- 650 13233 2201-2300 345
651- 700 9461 2301-2400 240
701- 750 7925 2401-2500 200
751- 800 5739 >2500 1504
801- 850 4918
851- 900 5337
901- 950 4143
951-1000 3023
The average sequence length in UniProtKB/Swiss-Prot is 362 amino acids.
The shortest sequence is GWA_SEPOF (P83570): 2 amino acids.
The longest sequence is TITIN_MOUSE (A2ASS6): 35213 amino acids.
4. JOURNAL CITATIONS
Note: the following citation statistics reflect the number of distinct
journal citations.
Total number of journals cited in this release of UniProtKB/Swiss-Prot: 3220
4.1 Table of the frequency of journal citations
Journals cited 1x: 1007
2x: 429
3x: 232
4x: 150
5x: 134
6x: 92
7x: 60
8x: 79
9x: 56
10x: 40
11- 20x: 252
21- 50x: 279
51-100x: 141
>100x: 269
4.2 List of the most cited journals in UniProtKB/Swiss-Prot
Nb Citations Journal name
-- --------- -------------------------------------------------------------
1 27747 Journal of Biological Chemistry
2 13051 Proceedings of the National Academy of Sciences of the U.S.A.
3 7311 Journal of Bacteriology
4 6158 Biochemical and Biophysical Research Communications
5 5978 Biochemistry
6 5450 Nucleic Acids Research
7 5350 Nature
8 5144 FEBS Letters
9 5077 The EMBO Journal
10 4904 Gene
11 4682 Journal of Molecular Biology
12 4637 Molecular and Cellular Biology
13 4093 Biochimica et Biophysica Acta
14 3954 Cell
15 3688 Journal of Virology
16 3525 European Journal of Biochemistry
17 3475 Science
18 3231 Biochemical Journal
19 2947 Molecular Microbiology
20 2842 Plant Physiology
21 2766 PLoS ONE
22 2547 Genomics
23 2479 The American Journal of Human Genetics
24 2406 Journal of Cell Biology
25 2212 The Plant Cell
26 2063 Human Molecular Genetics
27 2048 The Plant Journal
28 1982 Genes and Development
29 1940 Molecular Cell
30 1933 Virology
31 1928 Plant Molecular Biology
32 1870 Nature Genetics
33 1861 Molecular Biology of the Cell
34 1840 Development
35 1747 Journal of Immunology
36 1687 Human Mutation
37 1586 Nature Communications
38 1578 Oncogene
39 1510 Structure
40 1443 Journal of Biochemistry
41 1442 Molecular and General Genetics
42 1440 Genetics
43 1425 Journal of Cell Science
44 1315 Blood
45 1293 Infection and Immunity
46 1210 Microbiology
47 1203 Developmental Biology
48 1197 Journal of General Virology
49 1176 Current Biology
50 1168 Archives of Biochemistry and Biophysics
51 1067 Journal of Neuroscience
52 1059 Applied and Environmental Microbiology
53 1054 Scientific Reports
54 1006 Acta Crystallographica, Section D
55 953 PLoS Genetics
56 947 FEMS Microbiology Letters
57 939 Cancer Research
58 906 American Journal of Physiology
59 900 Toxicon
60 895 Protein Science
61 880 Journal of Clinical Investigation
62 858 Yeast
63 848 Neuron
64 795 The Journal of Experimental Medicine
65 776 Plant and Cell Physiology
66 771 Human Genetics
67 749 Nature Structural and Molecular Biology
68 748 PLoS Pathogens
69 735 Journal of Medical Genetics
70 722 The FEBS Journal
71 713 Proteins
72 681 Mechanisms of Development
73 678 Nature Cell Biology
74 655 Nature Structural Biology
75 647 Bioscience, Biotechnology, and Biochemistry
76 643 Antimicrobial Agents and Chemotherapy
77 614 Developmental Cell
78 606 Current Genetics
79 586 Cell Reports
80 582 Journal of Neurochemistry
81 560 Molecular Endocrinology
82 556 The Journal of Clinical Endocrinology and Metabolism
83 555 Journal of the American Chemical Society
84 553 Endocrinology
85 538 Molecular and Biochemical Parasitology
86 512 Eukaryotic Cell
87 500 Experimental Cell Research
88 499
89 495 Mammalian Genome
90 492 RNA
91 492 EMBO Reports
92 481 Peptides
93 481 The FASEB Journal
94 475 Journal of Experimental Botany
95 473 American Journal of Medical Genetics. Part A
96 462 Planta
97 448 Molecular Pharmacology
98 443 Acta Crystallographica, Section F
99 440 European Journal of Human Genetics
100 435 Immunogenetics
101 431 Clinical Genetics
102 425 Molecular Plant-Microbe Interactions
103 424 Molecular Biology and Evolution
104 423 Immunity
105 420 Journal of Investigative Dermatology
106 407 Journal of Molecular Evolution
107 398 DNA and Cell Biology
108 398 Neurology
109 396 Biochimie
110 384 Biology of Reproduction
111 381 DNA Sequence
112 380 Comparative Biochemistry and Physiology
113 366 Virus Research
114 365 Genes to Cells
115 363 Nature Immunology
116 361 Applied Microbiology and Biotechnology
117 359 PLoS Biology
118 355 Journal of Lipid Research
119 350 Journal of Medicinal Chemistry
120 348 Developmental Dynamics
121 345 The New England Journal of Medicine
122 343 BMC Genomics
123 342 Brain Research. Molecular Brain Research
124 341 Annals of Neurology
125 325 European Journal of Immunology
126 320 Genome Research
127 316 Journal of Human Genetics
128 313 Investigative Ophthalmology and Visual Science
129 302 Nature Chemical Biology
130 299 Biological Chemistry Hoppe-Seyler
131 296 Glycobiology
132 293 Brain
133 285 Archives of Microbiology
134 284 Journal of General Microbiology
135 281 Cytogenetics and Cell Genetics
136 276 Fungal Genetics and Biology
137 268 Traffic
138 267 Protein Expression and Purification
139 264 Nature Medicine
140 262 Molecular Genetics and Metabolism
141 262 Phytochemistry
142 261 Molecular Immunology
143 257 Cell Research
144 252 Journal of Cellular Biochemistry
145 251 Cell Cycle
146 243 Circulation Research
147 237 Diabetes
148 236 New Phytologist
149 236 Insect Biochemistry and Molecular Biology
150 235 Chemistry and Biology
5. STATISTICS FOR SOME LINE TYPES
The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.
Total Number of Average
Line type / subtype number entries per entry
------------------------------------ -------- --------- ---------
References (RL) 1330300 2.32
Journal 1158290 478555 2.02 1
Submitted to EMBL/GenBank/DDBJ 160378 144415 0.28 2
Submitted to other databases 7909 7213 0.01 3
Book citation 1876 1853 <0.01 4
Plant Gene Register 613 600 <0.01 5
Unpublished observations 536 532 <0.01 6
Thesis 478 475 <0.01 7
Patent 214 207 <0.01 8
Worm Breeder's Gazette 6 6 <0.01 9
Total number of distinct authors cited in UniProtKB/Swiss-Prot: 483818
Total Number of Average
Line type / subtype number entries per entry Rank
------------------------------------ -------- --------- --------- ----
Comments (CC) 2784889 4.85
ACTIVITY REGULATION 19289 19155 0.03 17
ALLERGEN 960 960 <0.01 26
ALTERNATIVE PRODUCTS 25982 25982 0.05 14
BIOPHYSICOCHEMICAL PROPERTIES 12171 12116 0.02 20
BIOTECHNOLOGY 2256 2195 <0.01 24
CATALYTIC ACTIVITY 351957 259184 0.61 4
CAUTION 14523 14221 0.03 19
COFACTOR 134922 122515 0.24 7
DEVELOPMENTAL STAGE 14745 14621 0.03 18
DISEASE 8617 5784 0.02 21
DISRUPTION PHENOTYPE 22636 22573 0.04 16
DOMAIN 62071 52671 0.11 9
FUNCTION 497995 471942 0.87 2
INDUCTION 26609 26498 0.05 13
INTERACTION 25016 25016 0.04 15
MASS SPECTROMETRY 7666 5935 0.01 22
MISCELLANEOUS 46550 40900 0.08 11
PATHWAY 144670 130645 0.25 6
PHARMACEUTICAL 170 163 <0.01 29
POLYMORPHISM 1515 1388 <0.01 25
PTM 66835 47178 0.12 8
RNA EDITING 646 646 <0.01 28
SEQUENCE CAUTION 45344 45274 0.08 12
SIMILARITY 522063 517698 0.91 1
SUBCELLULAR LOCATION 368885 360038 0.64 3
SUBUNIT 302541 296777 0.53 5
TISSUE SPECIFICITY 52048 51344 0.09 10
TOXIC DOSE 890 711 <0.01 27
WEB RESOURCE 5317 4790 0.01 23
Total number of comment topics: 29
Total Number of Average
Line type / subtype number entries per entry Rank
------------------------------------ -------- --------- --------- ----
Features (FT) 5612961 9.78
ACT_SITE 178829 106828 0.31 10
BINDING 1274333 221442 2.22 1
CARBOHYD 125886 32052 0.22 14
CHAIN 582136 565890 1.01 2
COILED 22814 15786 0.04 25
COMPBIAS 267385 93018 0.47 7
CONFLICT 139840 48708 0.24 12
CROSSLNK 25622 9183 0.04 24
DISULFID 139736 37053 0.24 13
DNA_BIND 12252 10971 0.02 31
DOMAIN 218879 133903 0.38 9
HELIX 368758 31362 0.64 5
INIT_MET 17636 17582 0.03 26
INTRAMEM 3155 1497 0.01 34
LIPID 14009 8933 0.02 28
MOD_RES 264825 75087 0.46 8
MOTIF 48836 31683 0.09 21
MUTAGEN 105434 21169 0.18 17
NON_CONS 2661 831 <0.01 35
NON_STD 360 285 <0.01 36
NON_TER 12598 9682 0.02 30
PEPTIDE 12800 8865 0.02 29
PROPEP 15623 13346 0.03 27
REGION 328306 151443 0.57 6
REPEAT 110054 15277 0.19 15
SIGNAL 45101 45100 0.08 22
SITE 68835 36986 0.12 19
STRAND 373003 29524 0.65 4
TOPO_DOM 153782 30888 0.27 11
TRANSIT 9643 9520 0.02 32
TRANSMEM 384650 80533 0.67 3
TURN 89294 25641 0.16 18
UNSURE 5766 903 0.01 33
VAR_SEQ 53373 22729 0.09 20
VARIANT 105900 17613 0.18 16
ZN_FING 30847 13190 0.05 23
Total number of feature keys: 36
Total Number of Average
Line type / subtype number entries per entry Rank Category
------------------------------------ -------- --------- --------- ---- -------------------------------------------
Cross-references (DR) 21704331 37.83
ABCD 3195 3195 0.01 125 Protocols and materials databases
AGR 69213 68532 0.12 43 Organism-specific databases
Allergome 2046 1315 <0.01 134 Protein family/group databases
AlphaFoldDB 548729 548729 0.96 10 3D structure databases
Antibodypedia 32329 32219 0.06 64 Protocols and materials databases
AntiFam 22 22 <0.01 169 Family and domain databases
ArachnoServer 1148 1138 <0.01 142 Organism-specific databases
Araport 16417 16321 0.03 94 Organism-specific databases
Bgee 61882 61882 0.11 45 Gene expression databases
BindingDB 6928 6928 0.01 110 Chemistry databases
BioCyc 48238 44187 0.08 54 Enzyme and pathway databases
BioGRID 62300 60262 0.11 44 Protein-protein interaction databases
BioGRID-ORCS 45105 44519 0.08 56 Miscellaneous databases
BioMuta 20287 20260 0.04 79 Genetic variation databases
BMRB 6915 6915 0.01 111 3D structure databases
BRENDA 20480 18662 0.04 74 Enzyme and pathway databases
CarbonylDB 1159 1159 <0.01 141 PTM databases
CARD 321 319 <0.01 158 Protein family/group databases
CAZy 9712 8744 0.02 101 Protein family/group databases
CCDS 49744 34822 0.09 52 Sequence databases
CD-CODE 10734 8219 0.02 99 Miscellaneous databases
CDD 393291 309337 0.69 17 Family and domain databases
CGD 2108 2091 <0.01 132 Organism-specific databases
ChEMBL 9289 9109 0.02 102 Chemistry databases
ChiTaRS 29803 29758 0.05 65 Miscellaneous databases
CollecTF 138 138 <0.01 161 Gene expression databases
ComplexPortal 17788 9243 0.03 90 Protein-protein interaction databases
ConoServer 967 879 <0.01 145 Organism-specific databases
CORUM 8089 8089 0.01 105 Protein-protein interaction databases
CPTAC 3472 1929 0.01 120 Proteomic databases
CPTC 406 406 <0.01 153 Protocols and materials databases
CTD 76343 75470 0.13 41 Organism-specific databases
DEPOD 254 254 <0.01 160 PTM databases
dictyBase 4225 4111 0.01 117 Organism-specific databases
DIP 17569 17528 0.03 92 Protein-protein interaction databases
DisGeNET 17610 17412 0.03 91 Organism-specific databases
DisProt 1769 1763 <0.01 136 Family and domain databases
DMDM 16166 16165 0.03 96 Genetic variation databases
DNASU 48512 48433 0.08 53 Protocols and materials databases
DrugBank 35599 4937 0.06 63 Chemistry databases
DrugCentral 2982 2982 0.01 127 Chemistry databases
EchoBASE 4158 4158 0.01 118 Organism-specific databases
eggNOG 340142 334263 0.59 20 Phylogenomic databases
ELM 1814 1814 <0.01 135 Protein-protein interaction databases
EMBL 1009628 560693 1.76 3 Sequence databases
EMDB 113633 10736 0.20 35 3D structure databases
Ensembl 103554 49662 0.18 37 Genome annotation databases
EnsemblBacteria 55535 55357 0.10 49 Genome annotation databases
EnsemblFungi 23418 22968 0.04 70 Genome annotation databases
EnsemblMetazoa 21315 11932 0.04 73 Genome annotation databases
EnsemblPlants 44651 21984 0.08 57 Genome annotation databases
EnsemblProtists 5461 5204 0.01 114 Genome annotation databases
ESTHER 3025 3022 0.01 126 Protein family/group databases
euHCVdb 55 44 <0.01 166 Organism-specific databases
EvolutionaryTrace 22685 22685 0.04 71 Miscellaneous databases
ExpressionAtlas 51247 51247 0.09 50 Gene expression databases
FlyBase 3976 3867 0.01 119 Organism-specific databases
FunCoup 143393 143393 0.25 30 Protein-protein interaction databases
FunFam 558097 327323 0.97 9 Family and domain databases
Gene3D 799040 477613 1.39 6 Family and domain databases
GeneCards 20372 20242 0.04 77 Organism-specific databases
GeneID 267850 260629 0.47 24 Genome annotation databases
GeneReviews 1632 1628 <0.01 137 Organism-specific databases
GeneTree 56458 56448 0.10 48 Phylogenomic databases
GeneWiki 10351 10269 0.02 100 Miscellaneous databases
GenomeRNAi 22330 22329 0.04 72 Miscellaneous databases
GlyConnect 2372 2215 <0.01 129 PTM databases
GlyCosmos 28908 28908 0.05 67 PTM databases
GlyGen 37350 37350 0.07 62 PTM databases
GO 3259326 552917 5.68 1 Ontologies
Gramene 44651 21984 0.08 58 Genome annotation databases
GuidetoPHARMACOLOGY 2278 2278 <0.01 131 Chemistry databases
HAMAP 331007 328070 0.58 22 Family and domain databases
HGNC 20373 20245 0.04 76 Organism-specific databases
HOGENOM 428247 428247 0.75 16 Phylogenomic databases
HPA 19354 19215 0.03 84 Organism-specific databases
IDEAL 1101 1101 <0.01 143 Family and domain databases
IMGT_GENE-DB 267 267 <0.01 159 Protein family/group databases
InParanoid 164400 164400 0.29 26 Phylogenomic databases
IntAct 58598 58598 0.10 46 Protein-protein interaction databases
InterPro 2573327 555533 4.49 2 Family and domain databases
iPTMnet 56779 56779 0.10 47 PTM databases
JaponicusDB 43 43 <0.01 167 Organism-specific databases
jPOST 29048 29048 0.05 66 Proteomic databases
KEGG 517392 481691 0.90 13 Genome annotation databases
LegioList 765 763 <0.01 148 Organism-specific databases
Leproma 672 669 <0.01 149 Organism-specific databases
MaizeGDB 529 525 <0.01 151 Organism-specific databases
MalaCards 7272 7260 0.01 108 Organism-specific databases
MANE-Select 18565 18453 0.03 87 Genome annotation databases
MassIVE 19137 19137 0.03 85 Proteomic databases
MEROPS 14255 13836 0.02 97 Protein family/group databases
MetOSite 3456 3456 0.01 121 PTM databases
MGI 17154 17112 0.03 93 Organism-specific databases
MIM 23911 16424 0.04 69 Organism-specific databases
MINT 24141 24141 0.04 68 Protein-protein interaction databases
MoonDB 348 348 <0.01 157 Protein family/group databases
MoonProt 368 368 <0.01 155 Protein family/group databases
NCBIfam 547249 347089 0.95 11 Family and domain databases
neXtProt 20299 20298 0.04 78 Organism-specific databases
NIAGADS 76 76 <0.01 163 Organism-specific databases
OGP 373 373 <0.01 154 2D gel databases
OMA 120581 120581 0.21 33 Phylogenomic databases
OpenTargets 18569 18424 0.03 86 Organism-specific databases
Orphanet 8039 4405 0.01 106 Organism-specific databases
OrthoDB 270086 270086 0.47 23 Phylogenomic databases
PAN-GO 20212 20212 0.04 80 Phylogenomic databases
PANTHER 963200 505013 1.68 4 Family and domain databases
PathwayCommons 19437 19437 0.03 83 Enzyme and pathway databases
PATRIC 93239 93239 0.16 39 Genome annotation databases
PaxDb 154035 154035 0.27 27 Proteomic databases
PCDDB 134 134 <0.01 162 3D structure databases
PDB 342066 37442 0.60 18 3D structure databases
PDBsum 342066 37442 0.60 19 3D structure databases
PeptideAtlas 38903 38903 0.07 61 Proteomic databases
PeroxiBase 793 772 <0.01 147 Protein family/group databases
Pfam 866585 545517 1.51 5 Family and domain databases
PharmGKB 18032 18013 0.03 89 Organism-specific databases
Pharos 20196 20196 0.04 81 Miscellaneous databases
PHI-base 2436 1918 <0.01 128 Miscellaneous databases
PhosphoSitePlus 42211 42211 0.07 60 PTM databases
PhylomeDB 115758 115758 0.20 34 Phylogenomic databases
PIR 125234 114896 0.22 32 Sequence databases
PIRSF 111161 109989 0.19 36 Family and domain databases
PlantReactome 1320 771 <0.01 139 Enzyme and pathway databases
PomBase 5131 5127 0.01 115 Organism-specific databases
PRIDE 637 637 <0.01 150 Proteomic databases
PRINTS 151412 129976 0.26 28 Family and domain databases
PRO 98646 98646 0.17 38 Miscellaneous databases
ProMEX 489 489 <0.01 152 Proteomic databases
PROSITE 494627 312414 0.86 15 Family and domain databases
Proteomes 500362 459984 0.87 14 Miscellaneous databases
ProteomicsDB 72780 45416 0.13 42 Proteomic databases
PseudoCAP 2054 2054 <0.01 133 Organism-specific databases
Pumba 18204 18204 0.03 88 Proteomic databases
Reactome 145389 39088 0.25 29 Enzyme and pathway databases
REBASE 799 397 <0.01 146 Protein family/group databases
RefSeq 635703 447823 1.11 8 Sequence databases
REPRODUCTION-2DPAGE 1260 1039 <0.01 140 2D gel databases
RGD 8152 8151 0.01 104 Organism-specific databases
RNAct 43121 43121 0.08 59 Miscellaneous databases
SABIO-RK 5951 5951 0.01 113 Enzyme and pathway databases
SASBDB 985 985 <0.01 144 3D structure databases
SFLD 20396 9117 0.04 75 Family and domain databases
SGD 6753 6748 0.01 112 Organism-specific databases
SignaLink 19952 19952 0.03 82 Enzyme and pathway databases
SIGNOR 7673 7673 0.01 107 Enzyme and pathway databases
SMART 206683 149082 0.36 25 Family and domain databases
SMR 524392 524392 0.91 12 3D structure databases
STRENDA-DB 59 45 <0.01 164 Enzyme and pathway databases
STRING 336721 336721 0.59 21 Protein-protein interaction databases
SUPFAM 651134 461267 1.14 7 Family and domain databases
SwissLipids 1478 1394 <0.01 138 Chemistry databases
SwissPalm 13972 13972 0.02 98 PTM databases
TAIR 16407 16321 0.03 95 Organism-specific databases
TCDB 8749 8652 0.02 103 Protein family/group databases
TopDownProteomics 3235 2956 0.01 124 Proteomic databases
TreeFam 46354 46331 0.08 55 Phylogenomic databases
TubercuList 2352 2316 <0.01 130 Organism-specific databases
UCSC 51042 46564 0.09 51 Genome annotation databases
UniLectin 367 367 <0.01 156 Protein family/group databases
UniPathway 140340 126687 0.24 31 Enzyme and pathway databases
VEuPathDB 87283 79958 0.15 40 Organism-specific databases
VGNC 3456 3453 0.01 122 Organism-specific databases
WBParaSite 56 54 <0.01 165 Genome annotation databases
WormBase 6951 5102 0.01 109 Organism-specific databases
Xenbase 4754 4754 0.01 116 Organism-specific databases
YCharOS 36 36 <0.01 168 Protocols and materials databases
ZFIN 3246 3245 0.01 123 Organism-specific databases
Total number of cross-referenced databases: 169
6. AMINO ACID COMPOSITION
6.1 Composition in percent for the complete database
Ala (A) 8.25 Gln (Q) 3.93 Leu (L) 9.64 Ser (S) 6.65
Arg (R) 5.52 Glu (E) 6.71 Lys (K) 5.79 Thr (T) 5.36
Asn (N) 4.06 Gly (G) 7.07 Met (M) 2.41 Trp (W) 1.10
Asp (D) 5.46 His (H) 2.27 Phe (F) 3.86 Tyr (Y) 2.92
Cys (C) 1.38 Ile (I) 5.90 Pro (P) 4.74 Val (V) 6.85
Asx (B) 0.000 Glx (Z) 0.000 Xaa (X) 0.00
Legend: gray = aliphatic, red = acidic, green = small hydroxy,
blue = basic, black = aromatic, white = amide, yellow = sulfur
6.2 Classification of the amino acids by their frequency
Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
Phe, Tyr, Met, His, Cys, Trp
7. MISCELLANEOUS STATISTICS
4467 entries are encoded on a mitochondrion, and 4049 are encoded on a plasmid.
12200 entries are encoded on a plastid,
of which 22 are encoded on apicoplasts,
11634 on chloroplasts,
51 on organellar chromatophores,
145 on cyanelles,
149 on non-photosynthetic plastids and
199 on unspecified types of plastid.
Number of entries with at least one sequence correction: 81457
