A touch of warmth

by Vivienne Baillie Gerritsen

We need heat. All warm-blooded animals know this instinctively because when life leaves us, the cold creeps in fast. Heat is produced in different ways inside us, and not only to keep our body temperature at a healthy level but also to keep it stable. After the fashion of small mobile furnaces, we carry adipose tissues that are full of stored fat waiting to be burnt down to release heat - a process termed thermogenesis. Researchers are becoming more and more interested in thermogenesis, especially adaptive thermogenesis which is the capacity an organism has to adjust its energy needs according to the environment, i.e. the amount of food that is available and the surrounding climate. Because where there is talk of food, there is talk of obesity and its direct cousin diabetes, two afflictions from which millions of people currently suffer worldwide. For some time already, scientists have known that molecules known as N-acyl amino acids, are important in biological processes such as thermogenesis, but they knew little more. Until they discovered an enzyme that is secreted by fat cells in adipose tissues, which knows how to make them: peptidase M20 domain containing 1, or PM20D1.

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A little bit of praise!

“I recently stumbled upon your columns. Let me congratulate you on achieving the near impossible, for your articles have enabled me to successfully marry IT with the Life Sciences and better explain the concepts of bioinformatics to those who are not in the know of the field.

Your articles are very well written, lucid, and contain just enough information to excite the reader to want to learn more about the topic being discussed. They fall in a very rare category where they are accessible to everyone, from the undergraduate students to research students who want to have a basic idea of the topics being discussed. Some of your articles, like "Our hollow architecture" and "Throb" are outstanding pieces.

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