Left only to the passage of time, everything gravitates towards chaos. Gardens become overgrown. Roads gather potholes and cracks. Relationships wither, and teeth rot. We have ways of dealing with this however. Gardeners look after the lawns, engineers inspect the roads, therapists have a go at unravelling relationships, and dentists tend to our mouths. Life, too, has its keepers. Left unattended, the very essence of life - our DNA - will collect unfortunate mutations that have the power to wreak havoc inside us. Over time, our cells have found ways of coping with this by promoting, for example, self-destruction so as not to propagate what has become unhealthy, or by repairing damaged DNA. As a result, cells are kept on the right track. Who, though, is the keeper? Different keepers are summoned at different stages and depending on the cell's fate. One protein, however, seems to be the orchestrator. Its name is p53, and it has been studied extensively since the 1970s because when it goes wrong, life is at stake.
More from Protein Spotlight
Tales From A Small World
Tales From A Small World is a collection of the first hundred articles which originally appeared on this site. Published in September 2009, the book is enriched by poems from the Dublin poet, Pat Ingoldsby. Learn more and order your copy online.
Journey Into A Tiny World
« Globin and Poietin set out to save Lily's life. But time is running short and they can't find the marrow... Here is the tale of their courage, fun and laughter on a journey that takes them deep into the tiniest of worlds.» For children. Learn more and order your copy online.
Snapshot : Dofusin
Have you ever felt the uncontrollable urge to stare at your computer screen? As though some invisible force were pushing you to switch on your pc and sit in front of it for hours on end, gloating over virtual images that pinball, dialogue, fight and rest. It is a need from which many an adolescent suffers and even more so in the past few years. Believe it or not, it is all because of a protein known as Dofusin. And Theo – eleven years old – tells us about his experience.
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