One cell. One organism. One fate: male, or female. The way Nature designs things, you would expect traits as fundamental as those that make a boy a boy or a girl a girl, for instance, to be inscribed in their respective DNA from the very start. In a way they are, of course, but there is a subtlety: if what defines gender is for some reason missing, then the other sex may emerge almost by default. So the process is far more than a simple case of gender that is genetically predetermined. The same goes for Musca domestica, or the common housefly, as it does for many other animals. There seems to be a sort of switch which, when on or off, will produce one sex or the other. This particular part of the sex decision system is preserved in many organisms, and scientists are beginning to realise that the upstream mechanisms leading to the definitive sex switch are surprisingly diverse and, in the case of Musca domestica, can even change from fly to fly. But one thing is preserved: to become male or female, you need a factor that will ultimately push the on/off sex switch. In the housefly, that factor is Mdmd, or Musca domestica male determiner.
More from Protein Spotlight
Tales From A Small World
Tales From A Small World is a collection of the first hundred articles which originally appeared on this site. Published in September 2009, the book is enriched by poems from the Dublin poet, Pat Ingoldsby. Learn more and order your copy online.
Journey Into A Tiny World
« Globin and Poietin set out to save Lily's life. But time is running short and they can't find the marrow... Here is the tale of their courage, fun and laughter on a journey that takes them deep into the tiniest of worlds.» For children. Learn more and order your copy online.
Snapshot : Sodium channel protein type 9 subunit alpha
Pain is not pointless. Deprived of the capacity to sense the red hot of metal, the cut of a sharp blade, or even the breaking of a bone, our bodies would be in very poor shape indeed. A child has to learn very fast what is too hot, and what can bruise. Without the perception of pain, there is little chance of survival. We need to learn to shun what could hurt us and rest when part of us needs to repair.
A little bit of praise!
“I recently stumbled upon your columns. Let me congratulate you on achieving the near impossible, for your articles have enabled me to successfully marry IT with the Life Sciences and better explain the concepts of bioinformatics to those who are not in the know of the field.
Your articles are very well written, lucid, and contain just enough information to excite the reader to want to learn more about the topic being discussed. They fall in a very rare category where they are accessible to everyone, from the undergraduate students to research students who want to have a basic idea of the topics being discussed. Some of your articles, like "Our hollow architecture" and "Throb" are outstanding pieces.
I would highly recommend your articles as a necessary reading in undergrad classes to get students inspired about the various avenues of research.”