Venom has a language of its own. The recurring message is not a nice one, and usually expresses one thing: back off. Certain animals use venom - a cocktail of molecules - to ward off predators or, at the very least, to divert oncoming danger. We all know what a wasp's sting is like and many of us may have felt the sting of a jellyfish, or perhaps even the bite of a snake. It is a painful experience. To what end? The reason is twofold: one, we at once recoil from the animal that has just caused pain and two, our body is instantly told where it hurts. Concomitantly, the animal takes flight while our body attends to our wound. The feeling of pain itself is caused by the opening and closing of minute channels that riddle the membranes of our nerve cells just under our skin. This gives rise to pain signals that originate at the location of the sting, or bite, and are relayed to our brain. Understanding how pain occurs on the molecular plane helps scientists find ways of designing pain relievers. However, more often than not, pain is usually accompanied by swelling which has a protective role. So we face a conundrum: how do you relieve pain while preserving inflammation? One particular scorpion toxin, the Black Rock scorpion toxin known as the wasabi receptor toxin or WaTx, may well provide an answer.
More from Protein Spotlight
Tales From A Small World
Tales From A Small World is a collection of the first hundred articles which originally appeared on this site. Published in September 2009, the book is enriched by poems from the Dublin poet, Pat Ingoldsby. Learn more and order your copy online.
Journey Into A Tiny World
« Globin and Poietin set out to save Lily's life. But time is running short and they can't find the marrow... Here is the tale of their courage, fun and laughter on a journey that takes them deep into the tiniest of worlds.» For children. Learn more and order your copy online.
Snapshot : cytochrome C
There is no life without energy. Much in the way a car needs petrol to run, we also need something essential to keep us going. And it is called adenosine tri-phosphate or ATP. ATP runs through every nook and cranny of our body to keep our heart pumping, our fingers moving and our thoughts alive. But - like petrol - we do not get it for free. We have to make it. So, in the great majority of our cells, we have powerhouses - known as mitochondria - that spend their time synthesizing ATP and distributing it where need be. Not surprisingly, hordes of proteins are involved in this process, one of which has been known for decades: cytochrome C.
A little bit of praise!
“I recently stumbled upon your columns. Let me congratulate you on achieving the near impossible, for your articles have enabled me to successfully marry IT with the Life Sciences and better explain the concepts of bioinformatics to those who are not in the know of the field.
Your articles are very well written, lucid, and contain just enough information to excite the reader to want to learn more about the topic being discussed. They fall in a very rare category where they are accessible to everyone, from the undergraduate students to research students who want to have a basic idea of the topics being discussed. Some of your articles, like "Our hollow architecture" and "Throb" are outstanding pieces.
I would highly recommend your articles as a necessary reading in undergrad classes to get students inspired about the various avenues of research.”