Variant position: 301 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1480 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MEKMIENLRQTELKLTRKAA YVRYFNSSAFFFSGFFVVFLS
Gorilla MEKMIENLRQTELKLTRKAA YVRYFNSSAFFFSGFFVVFLS
Rhesus macaque MEKMIENLRQTELKLTRKAA YVRYFNSSAFFFSGFFVVFLS
Chimpanzee MEKMIENLRQTELKLTRKAA YVRYFNSSAFFFSGFFVVFLS
Mouse MEKMIENLREVELKMTRKAA YMRFFTSSAFFFSGFFVVFLS
Rat MEKIIESLREEELKMTRRSA YMRFFTSSAFFFSGFFVVFLS
Pig MEKMIENLRQTELKLTRKAA YVRYFNSSAFFFSGLFVVFLS
Bovine MEKIIENLRQTELKLTRKAA YVRYLNSSAFFFSGFFVVFLS
Rabbit MEKMIENLRQTELKLTRKAA YVRYFNSSAFFFSGFFVVFLS
Sheep MEKIIENLRQTELKLTRKAA YVRYLNSSAFFFSGFFVVFLS
Horse MEKMIENLRQTELKLTRKAA YVRYFNSSAFFFSGFFVVFLS
Xenopus laevis MEKIIETIRETELKLTRKAA YVRYFNSSAFFFSGFFVVFLS
Zebrafish METLIKNIRQDEVKLTRKIG SLRYFYSSAYFFSAIFVIVAA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1480 Cystic fibrosis transmembrane conductance regulator
299 – 319 Helical; Name=5
81 – 365 ABC transmembrane type-1 1
279 – 307
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.