Sequence information
Variant position: 307 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1480 The length of the canonical sequence.
Location on the sequence:
NLRQTELKLTRKAAYVRYFN
S SAFFFSGFFVVFLSVLPYAL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NLRQTELKLTRKAAYVRYFNS SAFFFSGFFVVFLSVLPYAL
Gorilla NLRQTELKLTRKAAYVRYFNS SAFFFSGFFVVFLSVLPYAL
Rhesus macaque NLRQTELKLTRKAAYVRYFNS SAFFFSGFFVVFLSVLPYAL
Chimpanzee NLRQTELKLTRKAAYVRYFNS SAFFFSGFFVVFLSVLPYAL
Mouse NLREVELKMTRKAAYMRFFTS SAFFFSGFFVVFLSVLPYTV
Rat SLREEELKMTRRSAYMRFFTS SAFFFSGFFVVFLSVLPYTV
Pig NLRQTELKLTRKAAYVRYFNS SAFFFSGLFVVFLSVLPYAL
Bovine NLRQTELKLTRKAAYVRYLNS SAFFFSGFFVVFLSVLPYAL
Rabbit NLRQTELKLTRKAAYVRYFNS SAFFFSGFFVVFLSVLPYAL
Sheep NLRQTELKLTRKAAYVRYLNS SAFFFSGFFVVFLSVLPYAL
Horse NLRQTELKLTRKAAYVRYFNS SAFFFSGFFVVFLSVLPYAL
Xenopus laevis TIRETELKLTRKAAYVRYFNS SAFFFSGFFVVFLSIVPHLL
Zebrafish NIRQDEVKLTRKIGSLRYFYS SAYFFSAIFVIVAAVVPHAL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1480
Cystic fibrosis transmembrane conductance regulator
Transmembrane
299 – 319
Helical; Name=5
Domain
81 – 365
ABC transmembrane type-1 1
Helix
278 – 312
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.