Sequence information
Variant position: 336 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1480 The length of the canonical sequence.
Location on the sequence:
FVVFLSVLPYALIKGIILRK
I FTTISFCIVLRMAVTRQFPW
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FVVFLSVLPYALIKGIILRKI FTTISFCIVLRMAVTRQFPW
Gorilla FVVFLSVLPYALIKGIILRKI FTTISFCIVLRMAVTRQFPW
Rhesus macaque FVVFLSVLPYALIKGIVLRKI FTTISFCIVLRMAVTRQFPW
Chimpanzee FVVFLSVLPYALIKGIILRKI FTTISFCIVLRMAVTRQFPW
Mouse FVVFLSVLPYTVINGIVLRKI FTTISFCIVLRMSVTRQFPT
Rat FVVFLSVLPYTVINGIVLRKI FTTISFCIVLRMSVTRQFPT
Pig FVVFLSVLPYALLKGIMLRKI FTTISFCIVLRMAVTRQFPW
Bovine FVVFLSVLPYALLKGIILRKI FTTISFCIVLRMAVTRQFPW
Rabbit FVVFLSVLPYALTKGIILRKI FTTISFCIVLRMAVTRQFPW
Sheep FVVFLSVLPYALLKGIILRKI FTTISFCIVLRMAVTRQFPW
Horse FVVFLSVLPYALIKGIVLRRI FTTISFCIVLRMAVTRQFPW
Xenopus laevis FVVFLSIVPHLLLDGISLRKI FTTISFSIVLRMAVTRQFPW
Zebrafish FVIVAAVVPHALSRGINLRRI FTTLSYCMVLRMTVTRQLPG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1480
Cystic fibrosis transmembrane conductance regulator
Topological domain
320 – 339
Extracellular
Domain
81 – 365
ABC transmembrane type-1 1
Helix
333 – 351
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.