Variant position: 456 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1480 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LGTPVLKDINFKIERGQLLA VAGSTGAGKTSLLMVIMGELE
Gorilla LGTPVLKDINFKIERGQLLA VAGSTGAGKTSLLMMIMGELE
Rhesus macaque LGTPVLKDINFKIERGQLLA VAGSTGAGKTSLLMMIMGELE
Chimpanzee LGTPVLKDINFKIERGQLLA VAGSTGAGKTSLLMMIMGELE
Mouse VGNPVLKNINLNIEKGEMLA ITGSTGSGKTSLLMLILGELE
Rat VGNPVLKNINLNIKKGEMLA ITGSTGAGKTSLLMLILGELE
Pig LGTPVLKDISFKIERGQLLA VAGSTGAGKTSLLMMIMGELE
Bovine LGTPVLKDISFKIERGQLLA VAGSTGAGKTSLLMMIMGELE
Rabbit LGAPVLKDISFKIERGQLLA VAGSTGAGKTSLLMMIMGELE
Sheep LGTPVLKDISFKIERGQLLA VAGSTGAGKTSLLMMIMGELE
Horse LGTPVLKDISFKIERGQLLA VAGSTGAGKTSLLMMIMGELE
Xenopus laevis HVAPVLRNINFKIEKGQLLA IAGSTGAGKTSLLMMIMGELE
Zebrafish YVAPVLKDISLKLKKGEMLA VTGSMGSGKSSLLMTILGELV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1480 Cystic fibrosis transmembrane conductance regulator
359 – 858 Cytoplasmic
423 – 646 ABC transporter 1
404 – 464 Missing. In isoform 2.
464 – 464 K -> M. Impaired maturation of glycan chains indicating impaired trafficking from the endoplasmic reticulum to the cell membrane.
453 – 457
No reference for the current variant in UniProtKB/Swiss-Prot.
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