Variant position: 571 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1480 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCV
Gorilla GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCV
Rhesus macaque GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCV
Chimpanzee GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCV
Mouse GQRARISLARAVYKDADLYL LDSPFGYLDVFTEEQVFESCV
Rat GQRARISLARAVYKDADLYL LDSPFGYLDVLTEEQIFESCV
Pig GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCV
Bovine GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCI
Rabbit GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCV
Sheep GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCV
Horse GQRARISLARAVYKDADLYL LDSPFGYLDVLTEKEIFESCV
Xenopus laevis GQRARISLARAVYKDADLYL LDSPFSYLDLFTEKEIFESCV
Zebrafish GQKARVALARAVYRDADLYL LDAPFTHLDIATEKEIFDKCL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1480 Cystic fibrosis transmembrane conductance regulator
359 – 858 Cytoplasmic
423 – 646 ABC transporter 1
567 – 573
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.