Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P02768: Variant p.Asp574Ala

Albumin
Gene: ALB
Feedback?
Variant information Variant position: help 574
Type of variant: help LB/B
Residue change: help From Aspartate (D) to Alanine (A) at position 574 (D574A, p.Asp574Ala).
Physico-chemical properties: help Change from medium size and acidic (D) to small size and hydrophobic (A)
BLOSUM score: help -2
Polymorphism: help A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A.
Variant description: help In Malmo-61.
Other resources: help


Sequence information Variant position: help 574
Protein sequence length: help 609
Location on the sequence: help VELVKHKPKATKEQLKAVMD D FAAFVEKCCKADDKETCFAE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 25 – 609 Albumin
Domain 404 – 601 Albumin 3
Site 562 – 562 Not glycated
Site 565 – 565 Not glycated
Site 581 – 581 Not glycated
Site 584 – 584 Not glycated
Site 588 – 588 Not glycated
Modified residue 558 – 558 N6-methyllysine; alternate
Modified residue 588 – 588 N6-succinyllysine
Glycosylation 558 – 558 N-linked (Glc) (glycation) lysine; alternate
Glycosylation 560 – 560 N-linked (Glc) (glycation) lysine; in vitro
Glycosylation 569 – 569 N-linked (Glc) (glycation) lysine; in vitro
Disulfide bond 538 – 583
Helix 565 – 583



Literature citations
Alloalbuminemia in Sweden: structural study and phenotypic distribution of nine albumin variants.
Carlson J.; Sakamoto Y.; Laurell C.-B.; Madison J.; Watkins S.; Putnam F.W.;
Proc. Natl. Acad. Sci. U.S.A. 89:8225-8229(1992)
Cited for: VARIANT MALMO-I CYS-23; VARIANT MALMO-95 ASN-87; VARIANT MALMO-10 ARG-292; VARIANT MALMO-47 LYS-342; VARIANT MALMO-5 GLN-400; VARIANT MALMO-61 ALA-574;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.