Variant position: 78 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 99 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QA-RGWVTDGFSSLKDYWSTV KDKFSEFWDLDPEVR-PTSAVA
Mouse VA-RGWMDNHFRFLKGYWSKF TDKFTGFWDSNPEDQ-PTPA
Rat VASRGWMDNRFKSLKGYWSKF TDKFTGLWESGPEDQLTTPT
Pig QA-RGWVTDSISSLKDYWSTF KGKFTDFWDYTPK---PEPS
Bovine QA-RDWMTESFSSLKDYWSSF KGKFTDFWESA-----TSPT
Horse QA-RDWVNDGLSSLKDYWGKL KGKFSSFWDSTFEDTTPSPA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
21 – 99 Apolipoprotein C-III
68 – 99 Lipid-binding
94 – 94 O-linked (GalNAc...) threonine
69 – 80
Apolipoprotein C-III(Lys-58-->Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia.
von Eckardstein A.; Holz H.; Sandkamp M.; Weng W.; Funke H.; Assmann G.;
J. Clin. Invest. 87:1724-1731(1991)
Cited for: VARIANT HALP2 GLU-78;
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