Sequence information
Variant position: 94 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 99 The length of the canonical sequence.
Location on the sequence:
WSTVKDKFSEFWDLDPEVRP
T SAVAA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WSTVKDKFSEFWDLDPEVR-PT SAVAA-
CSTFKGKFTGFWDSASEAK-PT PASD
Mouse WSKFTDKFTGFWDSNPEDQ-PT PAIE
Rat WSKFTDKFTGLWESGPEDQLTT PTLE
Pig WSTFKGKFTDFWDYTPK---PE PSSS
Bovine WSSFKGKFTDFWESA-----TS PTQS
Horse WGKLKGKFSSFWDSTFEDTTPS PAVA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
21 – 99
Apolipoprotein C-III
Region
68 – 99
Lipid-binding
Glycosylation
94 – 94
O-linked (GalNAc...) threonine
Helix
93 – 98
Literature citations
Molecular cloning of a human apoC-III variant: Thr 74-->Ala 74 mutation prevents O-glycosylation.
Maeda H.; Hashimoto R.K.; Oguro T.; Hiraga S.; Uzawa H.;
J. Lipid Res. 28:1405-1409(1987)
Cited for: VARIANT C-III-0 ALA-94; GLYCOSYLATION AT THR-94;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.