Variant position: 99 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 317 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RALMDETMKELKAYKSELEE QLTPVAEETRARLSKELQAAQ
Gorilla TALMDETMKELKAYKSELEE QLTPVAEETRARLSKELQAAQ
Rhesus macaque TTLMDETMKELKAYKSELEE QLSPVAEETRARLSKELQAAQ
Chimpanzee TALMDETMKELKAYKSELEE QLTPVAEETRARLSKELQAAQ
Mouse TALMEDTMTEVKAYKKELEE QLGPVAEETRARLGKEVQAAQ
Rat TVLMEDTMTEVKAYKKELEE QLGPVAEETRARLAKEVQAAQ
Pig TELIEESMKEVKAYREELEA QLGPVTQETQARLSKELQAAQ
Bovine TALMEETMKEVKAYKEELEG QLGPMAQETQARVSKELQAAQ
Rabbit TMLMEETMKEVKAYKSELEE QLSPMAQEHRARLSKELQVAG
Sheep TVLMEETMKEVKAYREELEG QLAPMAQETQARVSKELQAAQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
19 – 317 Apolipoprotein E
80 – 101 1
80 – 255 8 X 22 AA approximate tandem repeats
93 – 93 N-linked (Glc) (glycation) lysine
79 – 79 R -> T. Changes the plasma lipoprotein distribution of ApoE4 to the HDL.
97 – 99
Characterization of the gene for apolipoprotein E5-Frankfurt (Gln81->Lys, Cys112->Arg) by polymerase chain reaction, restriction isotyping, and temperature gradient gel electrophoresis.
Ruzicka V.; Maerz W.; Russ A.; Fisher E.; Mondorf W.; Gross W.;
Cited for: VARIANTS LYS-99 AND ARG-130;
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