Variant position: 267 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1220 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SDHVKKSLDKDPLLLSGTHV MEGSGRMVVTAVGVNSQTGII
Mouse SDHVKKSLDKDPLLLSGTHV MEGSGRMVVTAVGVNSQTGII
Rat SDHVKKSLDKDPLLLSGTHV MEGSGRMVVTAVGVNSQTGII
Pig SDHVKKSLDKDPLLLSGTHV MEGSGRMVVTAVGINSQTGII
Rabbit SDHVKKSLDKDPLLLSGTHV MEGSGRMVVTAVGVNSQTGII
Chicken SDHVKKSLDRDPMLLSGTHV MEGSGRMVVTAVGVNSQTGII
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 1220 Plasma membrane calcium-transporting ATPase 1
176 – 366 Cytoplasmic
Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique.
Benkwitz C.; Kubsisch C.; Kraft K.; Neyses L.;
J. Mol. Med. 75:62-66(1997)
Cited for: VARIANT ARG-267;
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