Variant position: 658 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 911 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FKVSNSSARGWVIHPLGLRS EFPIWMMFASALPALLVFILI
Mouse LKVSNSSARGWVIHPLGLYR LFPTWMMFASVLPALLVFILI
Rat LKVSNSSARGWVIHPLGLYN HFPKWMMFASVLPALLVFILI
Chicken LEVTNGTARGWFIHPMGSAT PFPIWMMFASPVPALLVFILI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 911 Band 3 anion transport protein
624 – 663 Extracellular
642 – 642 N-linked (GlcNAc...) (complex) asparagine
642 – 642 N -> D. Loss of N-glycosylation site.
Changes in the blood group Wright antigens are associated with a mutation at amino acid 658 in human erythrocyte band 3: a site of interaction between band 3 and glycophorin A under certain conditions.
Bruce L.J.; Ring S.M.; Anstee D.J.; Reid M.E.; Wilkinson S.; Tanner M.J.;
Cited for: VARIANT BLOOD GROUP WR(A) LYS-658;
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