Variant position: 462 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VLSEKVIIFGMGKRKCIGET IARWEVFLFLAILLQRVEFSV
Rhesus macaque VLSEKVILFGLGKRKCIGET IARWEVFLFLAILLQRVEFSV
Mouse RLSEKVTLFGLGKRKCIGET IGRSEVFLFLAILLQQIEFKV
Rat HLSEKVILFGLGKRKCIGET IGRLEVFLFLAILLQQMEFNV
Rabbit ALTEKVLLFGLGKRKCIGET IGRLEVFLFLATLLQQVEFSV
Sheep VLSEKVIIFGLGKRQCIGEI IARLEVFLFLAILLHQVEFHV
Cat ALSEKVILFGLGKRKCIGET IARLEVFLFLAILLQQVEFSV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 512 Cytochrome P450 1A1
457 – 457 Iron (heme axial ligand)
190 – 512 Missing. In isoform 2.
419 – 512 Missing. In isoform 3.
460 – 477
Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.
Kisselev P.; Schunck W.H.; Roots I.; Schwarz D.;
Cancer Res. 65:2972-2978(2005)
Cited for: FUNCTION; CATALYTIC ACTIVITY; CHARACTERIZATION OF VARIANT ASN-461 AND VARIANT VAL-462; BIOPHYSICOCHEMICAL PROPERTIES; PATHWAY;
Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene.
Hayashi S.; Watanabe J.; Nakachi K.; Kawajiri K.;
J. Biochem. 110:407-411(1991)
Cited for: VARIANT VAL-462;
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Jiang Z.; Dalton T.P.; Jin L.; Wang B.; Tsuneoka Y.; Shertzer H.G.; Deka R.; Nebert D.W.;
Hum. Mutat. 25:196-206(2005)
Cited for: VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.