Sequence information
Variant position: 462 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 512 The length of the canonical sequence.
Location on the sequence:
VLSEKVIIFGMGKRKCIGET
I ARWEVFLFLAILLQRVEFSV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VLSEKVIIFGMGKRKCIGETI ARWEVFLFLAILLQRVEFSV
ALSEKVILFGLGKRKCIGETI ARLEVFLFLAILLQQVEFSV
Rhesus macaque VLSEKVILFGLGKRKCIGETI ARWEVFLFLAILLQRVEFSV
Mouse RLSEKVTLFGLGKRKCIGETI GRSEVFLFLAILLQQIEFKV
Rat HLSEKVILFGLGKRKCIGETI GRLEVFLFLAILLQQMEFNV
Rabbit ALTEKVLLFGLGKRKCIGETI GRLEVFLFLATLLQQVEFSV
Sheep VLSEKVIIFGLGKRQCIGEII ARLEVFLFLAILLHQVEFHV
Cat ALSEKVILFGLGKRKCIGETI ARLEVFLFLAILLQQVEFSV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 512
Cytochrome P450 1A1
Metal binding
457 – 457
Iron (heme axial ligand)
Alternative sequence
190 – 512
Missing. In isoform 2.
Alternative sequence
419 – 512
Missing. In isoform 3.
Helix
460 – 477
Literature citations
Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone.
Kisselev P.; Schunck W.H.; Roots I.; Schwarz D.;
Cancer Res. 65:2972-2978(2005)
Cited for: FUNCTION; CATALYTIC ACTIVITY; CHARACTERIZATION OF VARIANT ASN-461 AND VARIANT VAL-462; BIOPHYSICOCHEMICAL PROPERTIES; PATHWAY;
Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene.
Hayashi S.; Watanabe J.; Nakachi K.; Kawajiri K.;
J. Biochem. 110:407-411(1991)
Cited for: VARIANT VAL-462;
Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
Jiang Z.; Dalton T.P.; Jin L.; Wang B.; Tsuneoka Y.; Shertzer H.G.; Deka R.; Nebert D.W.;
Hum. Mutat. 25:196-206(2005)
Cited for: VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.