Variant position: 140 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 300 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NKILLWSRIKDLAHQFTQVQ RDMFTLEDTLLGYLADDLTWC
Mouse NKTLFWSKSKHLAHQYTWIQ GKMFTLEDTLLGYIADDLRWC
Rat NKTLFWSKSKHLAHQYTWIQ GKMFTLEDTLLGYIADDLRWC
Rabbit NKTLFWSRSKELAHQYSGIQ KEMFTLEDTLLGYIADNLVWC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 300 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
43 – 300 Extracellular
99 – 180
122 – 122 I -> K. In isoform 2.
123 – 300 Missing. In isoform 2.
160 – 160 C -> A. Loss of cADPr hydrolase and ADP-ribosyl cyclase activity.
136 – 141
A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.
Yagui K.; Shimada F.; Mimura M.; Hashimoto N.; Suzuki Y.; Tokuyama Y.; Nata K.; Tohgo A.; Ikehata F.; Takasawa S.; Okamoto H.; Makino H.; Saito Y.; Kanatsuka A.;
Cited for: VARIANT TRP-140;
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