Variant position: 207 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2419 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GEDWERTEVLHKKFEDFQVE LVAKEGRVVEVNQYANECAEE
Mouse GDDWERTEVLHKKFEEFQEE LTARKGKVDRVNQYANECAQE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 2419 Spectrin alpha chain, erythrocytic 1
159 – 261 Spectrin 2
A common type of the spectrin alpha I 46-50a-kD peptide abnormality in hereditary elliptocytosis and pyropoikilocytosis is associated with a mutation distant from the proteolytic cleavage site. Evidence for the functional importance of the triple helical model of spectrin.
Gallagher P.G.; Tse W.T.; Coetzer T.; Lecomte M.-C.; Garbarz M.; Zarkowsky H.S.; Baruchel A.; Ballas S.K.; Dhermy D.; Palek J.; Forget B.G.;
J. Clin. Invest. 89:892-898(1992)
Cited for: VARIANT EL2/HPP PRO-207;
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