Variant position: 261 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2419 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EVNAAWERLRGLALQRQKAL SNAANLQRFKRDVTEAIQWIK
Mouse EVNAAWDRLWSLALKRRESL SNAADLQRFKRDVNEAIQWME
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 2419 Spectrin alpha chain, erythrocytic 1
159 – 261 Spectrin 2
Sequence and exon-intron organization of the DNA encoding the alpha I domain of human spectrin. Application to the study of mutations causing hereditary elliptocytosis.
Sahr K.E.; Tobe T.; Scarpa A.; Laughinghouse K.; Marchesi S.L.; Agre P.; Linnenbach A.J.; Marchesi V.T.; Forget B.G.;
J. Clin. Invest. 84:1243-1252(1989)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-533; VARIANTS EL2 PRO-260; PRO-261 AND PRO-471;
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