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UniProtKB/Swiss-Prot Q14203: Variant p.Ala163Pro

Dynactin subunit 1
Gene: DCTN1
Variant information

Variant position:  163
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Alanine (A) to Proline (P) at position 163 (A163P, p.Ala163Pro).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from small size and hydrophobic (A) to medium size and hydrophobic (P)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page



Sequence information

Variant position:  163
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  1278
The length of the canonical sequence.

Location on the sequence:   RKTTTRRPKPTRPASTGVAG  A SSSLGPSGSASAGELSSSEP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         RKTTTRRPKPTR-------------PASTGVAGASSSLGPSGSAS-----------AGELSSSEP

Mouse                         RKTTTRRPKPTR-------------PASTGVAGPSSSLGPS

Rat                           RKTTTRRPKPTR-------------PASTGVAGPSSSLGPS

Chicken                       KKTTARRPKPTR------------TPTSAPSSG---TAGPS

Xenopus laevis                ---------PTR-------------PSSS------AASSGT

Drosophila                    ERTASSSSIGPRKSLAPQNSKDKESPSTSLAEGAPAASGGN

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 1278 Dynactin subunit 1
Region 100 – 223 Disordered
Compositional bias 158 – 188 Polar residues
Modified residue 145 – 145 Phosphothreonine; by SLK
Modified residue 146 – 146 Phosphothreonine; by SLK
Modified residue 147 – 147 Phosphothreonine; by SLK
Modified residue 179 – 179 Phosphoserine; by PLK1
Mutagenesis 145 – 145 T -> A. Affects centrosomal localization; when associated with A-146 and A-147.
Mutagenesis 146 – 146 T -> A. Affects centrosomal localization; when associated with A-145 and A-147.
Mutagenesis 147 – 147 T -> A. Affects centrosomal localization; when associated with A-145 and A-146.
Mutagenesis 179 – 179 S -> A. Non-phosphorylatable by PLK1. Decreased nuclear envelope localization. No loss of microtubule-binding. No effect on its interaction with CLIP1.
Mutagenesis 179 – 179 S -> D. No loss of localization to nuclear envelope. Decrease in microtubule-binding. No effect on its interaction with CLIP1.


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.