Variant position: 18 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 260 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MSHHWG-----YGKHNGPEHW---H KDFPIAK-GERQSPVDIDTHTA
Mouse MSHHWG-----YSKHNGPENW---H KDFPIAN-GDRQS
Rat MSHHWG-----YSKSNGPENW---H KEFPIAN-GDRQS
Bovine MSHHWG-----YGKHNGPEHW---H KDFPIAN-GERQS
Rabbit MSHHWG-----YGKHNGPEHW---H KDFPIAN-GERQS
Sheep MSHHWG-----YGEHNGPEHW---H KDFPIAD-GERQS
Chicken MSHHWG-----YDSHNGPAHW---H EHFPIAN-GERQS
Caenorhabditis elegans -MIPWLLTACIYPCVIGPDFWGLLH GDWRMCTAGQMQS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 260 Carbonic anhydrase 2
3 – 259 Alpha-carbonic anhydrase
2 – 2 N-acetylserine
2 – 2 Phosphoserine
5 – 5 W -> A. Impaired activity, not rescued by 4-methylimidazole (4-MI); when associated with W-64.
7 – 7 Y -> F. Enhanced activity.
7 – 7 Y -> H. Reduced proton transfer rate.
16 – 18
Chemical and enzymological characterization of an Indonesian variant of human erythrocyte carbonic anhydrase II, CAII Jogjakarta (17 Lys leads to Glu).
Jones G.L.; Sofro A.S.M.; Shaw D.C.;
Biochem. Genet. 20:979-1000(1982)
Cited for: VARIANT JOGJAKARTA GLU-18;
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