Variant position: 144 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 156 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RDVARYLR-------------AAAGGTRG--------SNHA RIDAAEGPSDIPD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 156 Cyclin-dependent kinase inhibitor 2A
140 – 140 Phosphoserine
152 – 152 Phosphoserine
117 – 156 Missing. In isoform 3.
The MTS1 gene is frequently mutated in primary human esophageal tumors.
Zhou X.; Tarmin L.; Yin J.; Jiang H.-Y.; Suzuki H.; Rhyu M.-G.; Abraham J.M.; Meltzer S.J.;
Cited for: VARIANTS SQUAMOUS CELL CARCINOMA SER-127 AND CYS-144;
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