Variant position: 1022 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1464 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PPGLAGPPGESGREGAPGAE GSPGRDGSPGAKGDRGETGPA
Mouse PPGLAGPPGESGREGSPGAE GSPGRDGAPGAKGDRGETGPA
Rat PPGLAGPPGESGREGSPGAE GSPGRDGAPGAKGDRGETGPA
Bovine PPGLAGPPGESGREGAPGAE GSPGRDGSPGAKGDRGETGPA
Chicken PPGLAGPPGEAGREGAPGAE GAPGRDGAAGPKGDRGETGPA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Substitution of serine for alpha 1(I)-glycine 844 in a severe variant of osteogenesis imperfecta minimally destabilizes the triple helix of type I procollagen. The effects of glycine substitutions on thermal stability are either position of amino acid specific.
Pack M.; Constantinou C.D.; Kalia K.; Nielsen K.B.; Prockop D.J.;
J. Biol. Chem. 264:19694-19699(1989)
Cited for: VARIANT OI3 SER-1022;
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