Variant position: 1061 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1464 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PAGPPGAPGAPGAPGPVGPA GKSGDRGETGPAGPTGPVGPV
Mouse PAGPPGAPGAPGAPGPVGPA GKNGDRGETGPAGPAGPIGPA
Rat PAGPPGAPGAPGAPGPVGPA GKNGDRGETGPAGPAGPIGPA
Bovine PAGPPGAPGAPGAPGPVGPA GKSGDRGETGPAGPAGPIGPV
Chicken PAGPPGAPGAPGAPGPVGPA GKNGDRGETGPAGPAGPPGPA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Substitution of serine for glycine 883 in the triple helix of the pro alpha 1 (I) chain of type I procollagen produces osteogenesis imperfecta type IV and introduces a structural change in the triple helix that does not alter cleavage of the molecule by procollagen N-proteinase.
Lightfoot S.J.; Atkinson M.S.; Murphy G.; Byers P.H.; Kadler K.E.;
J. Biol. Chem. 269:30352-30357(1994)
Cited for: VARIANT OI4 SER-1061;
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