Variant position: 1181 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1464 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PIGPPGPRGRTGDAGPVGPP GPPGPPGPPGPPSAGFDFSFL
Mouse PIGPPGPRGRTGDSGPAGPP GPPGPPGPPGPPSGGYDFSFL
Rat PIGPPGPRGRTGDSGPAGPP GPPGPPGPPGPPSGGYDFSFL
Bovine PIGPPGPRGRTGDAGPAGPP GPPGPPGPPGPPSGGYDLSFL
Chicken PIGPPGPRGRTGEVGPVGPP GPPGPPGPPGPPSGGFDLSFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Serine for glycine substitutions in the alpha1(I) chain of type I collagen: biological plasticity in the Gly-Pro-Hyp clamp at the carboxyl-terminal end of triple helicalH domain.
Cohn D.H.; Wallis G.A.; Zhang X.; Byers P.H.;
Cited for: VARIANTS OI2 SER-1091; SER-1181; SER-1187 AND VAL-1187;
Osteogenesis imperfecta due to recurrent point mutations at CpG dinucleotides in the COL1A1 gene of type I collagen.
Pruchno C.J.; Cohn D.H.; Wallis G.A.; Willing M.C.; Starman B.J.; Zhang X.; Byers P.H.;
Hum. Genet. 87:33-40(1991)
Cited for: VARIANT OI3 ARG-332; VARIANT OI2 SER-1181;
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