Variant position: 771 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 919 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DGVGDTLDLVVIGAYLGRGK RAGRYGGFLLASYDEDSEELQ
Mouse DGVGDTLDLVVIGAYLGRGK RAGRYGGFLLAAYDEESEELQ
Rat EGVGDTLDLVVIGAYLGRGK RPGRYGGFLLAAYDEESEELA
Xenopus laevis EGVGDTLDLVVIGAYLGKGK RTGIYGGFLLASYDEESEEYQ
Caenorhabditis elegans DGVGDTLDLVVMGAYSGVGK RTGVYGGYLLGCYNPTTEEYE
Drosophila SNVGDSLDLVVIGGYKGKGR RTGTYGGFLLACYDTENEEYQ
Slime mold QGMTDSLDLVPIGAWYGKGK RTGTYGAYLLACYDENNEEFQ
Baker's yeast EGVGDSLDLCVLGAYYGRGK RTGTYGGFLLGCYNQDTGEFE
Fission yeast SGVGDSLDLIVIGAYYGKGK RTSVYGAFLLGCYDPDTETVQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents.
Barnes D.E.; Tomkinson A.E.; Lehmann A.R.; Webster A.D.B.; Lindahl T.;
Cited for: VARIANTS LYS-566 AND TRP-771;
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