Variant position: 157 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 333 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AIKSPDTFVRTIYAGNALCT VKCDEKVKVFSVRGTSFDAAA
Mouse EIKSPDTFVRTIYAGNALCT VKCDEKVKVFSVRGTSFEAAA
Rat EIKSPDTFVRTIYAGNALCT VKCDEKVKVFSVRGTSFEAAA
Bovine AIKSPDTFVRTIYAGNAICT VKCDEKVKVFSVRGTSFEAAA
Caenorhabditis elegans EVHSADSFTRTLYAGNAVKK VKSTAPIKLLTFRGTSFE-PA
Slime mold KVKDAETFQRPIYAGNAIAT VKSTDKCKVGTVRTTAFDKAP
Baker's yeast VIKDPKTFIRPIYAGNIIST IECQAEKKLLIIRASAFP-PI
Fission yeast GVVSADTFVRPTYAGNVNVT VSTKDPIKIVTVRASAFDAAP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 333 Electron transfer flavoprotein subunit alpha, mitochondrial
20 – 204 Domain I
139 – 139 N6-acetyllysine
140 – 140 Phosphoserine
158 – 158 N6-acetyllysine; alternate
158 – 158 N6-succinyllysine; alternate
164 – 164 N6-acetyllysine
153 – 159
Molecular characterization of variant alpha-subunit of electron transfer flavoprotein in three patients with glutaric acidemia type II -- and identification of glycine substitution for valine-157 in the sequence of the precursor, producing an unstable mature protein in a patient.
Indo Y.; Glassberg R.; Yokota I.; Tanaka K.;
Am. J. Hum. Genet. 49:575-580(1991)
Cited for: VARIANT GA2A GLY-157; FUNCTION;
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