Variant position: 155 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 210 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KLGGDLGTYVINKQTPNKQI WLSSPSSGPKRYDW----TGKNWVY
Mouse KLGGDLGTYVINKQTPNKQI WLSSPSSGPKRYDW----TGK
Rat KLGGDLGTYVINKQTPLLYL WFSGPCSGPKRYDW----TGK
Bovine KLGGDLGTYVINKQTPNKQI WLSSPSSGPKRYDW----TGR
Caenorhabditis elegans NVSKSVGTYVINKQSPNKQI WLSSPMSGPKRYDLE---EEG
Drosophila NLGGQHGTYVINRQTPNKQI WLSSPTSGPKRYDFVGTVAAG
Slime mold IVGNK-GTYVINKQTPNRQI WWSSPLSGPKRFDYD--SVEK
Baker's yeast EIPAF-GTYVINKQPPNKQI WLASPLSGPNRFDL----LNG
Fission yeast MLGEK-GTYVINKQPPAHQI WLSSPVSGPKHYEYS--LKSK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones.
Shan Y.; Napoli E.; Cortopassi G.;
Hum. Mol. Genet. 16:929-941(2007)
Cited for: INTERACTION WITH LYRM4 AND HSPA9; CHARACTERIZATION OF VARIANTS PHE-154 AND ARG-155;
A missense mutation (W155R) in an American patient with Friedreich's ataxia.
Labuda M.; Poirier J.; Pandolfo M.;
Cited for: VARIANT FRDA ARG-155;
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