Sequence information
Variant position: 168 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 557 The length of the canonical sequence.
Location on the sequence:
PGTKDSVMWALDGLSFTYSL
V IWKNSSGVEERIENIYSRHK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human P-GTKDSVMWALDGLSFTYSLV IWKNSSGVEERIENIYSRHK
Mouse PPG-QDGNMWALEKPSFSYTIR IWQKSSSDKKTINSTYYVE
Pig PPGTKNSVMWAMDSSSFVYSLV IWKNSSSLEERTKTVYARD
Bovine PPGTKDSIMWAMDRSSFRYSVV IWKNSSSLEERTETVYPED
Sheep PPGTEDSIMWALDRSSFRYSVV IWKNSSSLEERTETVYPED
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
28 – 557
Interferon alpha/beta receptor 1
Topological domain
28 – 436
Extracellular
Domain
127 – 227
Fibronectin type-III 2
Glycosylation
172 – 172
N-linked (GlcNAc...) asparagine
Beta strand
164 – 171
Literature citations
Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA.
Uze G.; Lutfalla G.; Gresser I.;
Cell 60:225-234(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT LEU-168; FUNCTION; SUBCELLULAR LOCATION;
The structure of the human interferon alpha/beta receptor gene.
Lutfalla G.; Gardiner K.; Proudhon D.; Vielh E.; Uze G.;
J. Biol. Chem. 267:2802-2809(1992)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LEU-168;
Submission
Suzuki Y.; Sugano S.; Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT LEU-168;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.