Variant position: 168 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 557 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human P-GTKDSVMWALDGLSFTYSL VIWKNSSGVEERIENIYSRHK
Mouse PPG-QDGNMWALEKPSFSYTI RIWQKSSSDKKTINSTYYVE
Pig PPGTKNSVMWAMDSSSFVYSL VIWKNSSSLEERTKTVYARD
Bovine PPGTKDSIMWAMDRSSFRYSV VIWKNSSSLEERTETVYPED
Sheep PPGTEDSIMWALDRSSFRYSV VIWKNSSSLEERTETVYPED
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
28 – 557 Interferon alpha/beta receptor 1
28 – 436 Extracellular
127 – 227 Fibronectin type-III 2
172 – 172 N-linked (GlcNAc...) asparagine
164 – 171
Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA.
Uze G.; Lutfalla G.; Gresser I.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT LEU-168; FUNCTION; SUBCELLULAR LOCATION;
The structure of the human interferon alpha/beta receptor gene.
Lutfalla G.; Gardiner K.; Proudhon D.; Vielh E.; Uze G.;
J. Biol. Chem. 267:2802-2809(1992)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LEU-168;
Suzuki Y.; Sugano S.; Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT LEU-168;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.