Variant position: 3 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MV LSPADKTNVKAAWGKVGAHAG
Gorilla -V LSPADKTNVKAAWGKVGAHAG
Rhesus macaque MV LSPADKSNVKAAWGKVGGHAG
Chimpanzee MV LSPADKTNVKAAWGKVGAHAG
Mouse MV LSGEDKSNIKAAWGKIGGHGA
Rat MV LSADDKTNIKNCWGKIGGHGG
Pig -V LSAADKANVKAAWGKVGGQAG
Bovine MV LSAADKGNVKAAWGKVGGHAA
Rabbit MV LSPADKTNIKTAWEKIGSHGG
Sheep MV LSAADKSNVKAAWGKVGGNAG
Cat -V LSAADKSNVKACWGKIGSHAG
Horse MV LSAADKTNVKAAWSKVGGHAG
Chicken MV LSAADKNNVKGIFTKIAGHAE
Xenopus tropicalis MH LTADDKKHIKAIWPSVAAHGD
Zebrafish MS LSDTDKAVVKAIWAKISPKAD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
4 – 4 Phosphoserine
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
Hemoglobin Chongqing [alpha 2(NA2)Leu-->Arg] and hemoglobin Harbin [alpha 16(A14)Lys-->Met] found in China.
Zeng Y.-T.; Huang S.-Z.; Qiu X.-K.; Cheng G.-C.; Ren Z.-R.; Jin Q.-C.; Chen C.-Y.; Jiao C.-T.; Tang Z.-G.; Liu R.-H.; Bao X.-H.; Zeng L.-Z.; Duan Y.-Q.; Zhang G.-Y.;
Cited for: VARIANTS CHONGQING ARG-3 AND HARBIN MET-17;
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