Sequence information
Variant position: 8 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
MVLSPAD
K TNVKAAWGKVGAHAGEYGAE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVLSPADK TNVKAAWGKVGAHAGEYGAE
Gorilla -VLSPADK TNVKAAWGKVGAHAGDYGAE
-VLSPADK TNIKSTWDKIGGHAGDYGGE
Rhesus macaque MVLSPADK SNVKAAWGKVGGHAGEYGAE
Chimpanzee MVLSPADK TNVKAAWGKVGAHAGEYGAE
Mouse MVLSGEDK SNIKAAWGKIGGHGAEYGAE
Rat MVLSADDK TNIKNCWGKIGGHGGEYGEE
Pig -VLSAADK ANVKAAWGKVGGQAGAHGAE
Bovine MVLSAADK GNVKAAWGKVGGHAAEYGAE
Rabbit MVLSPADK TNIKTAWEKIGSHGGEYGAE
Sheep MVLSAADK SNVKAAWGKVGGNAGAYGAE
Cat -VLSAADK SNVKACWGKIGSHAGEYGAE
Horse MVLSAADK TNVKAAWSKVGGHAGEYGAE
Chicken MVLSAADK NNVKGIFTKIAGHAEEYGAE
Xenopus tropicalis MHLTADDK KHIKAIWPSVAAHGDKYGGE
Zebrafish MSLSDTDK AVVKAIWAKISPKADEIGAE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Initiator methionine
1 – 1
Removed
Chain
2 – 142
Hemoglobin subunit alpha
Site
12 – 12
Not glycated
Modified residue
4 – 4
Phosphoserine
Modified residue
8 – 8
N6-succinyllysine; alternate
Modified residue
9 – 9
Phosphothreonine
Modified residue
12 – 12
N6-succinyllysine
Modified residue
17 – 17
N6-acetyllysine; alternate
Modified residue
17 – 17
N6-succinyllysine; alternate
Modified residue
25 – 25
Phosphotyrosine
Glycosylation
8 – 8
N-linked (Glc) (glycation) lysine; alternate
Glycosylation
17 – 17
N-linked (Glc) (glycation) lysine; alternate
Helix
5 – 18
Literature citations
Hb Kurosaki [alpha 7(A5)Lys-->Glu]: a new alpha chain variant found in a Japanese woman.
Harano T.; Harano K.; Imai K.; Murakami T.; Matsubara H.;
Hemoglobin 19:197-201(1995)
Cited for: VARIANT KUROSAKI GLU-8;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.