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UniProtKB/Swiss-Prot P69905: Variant p.Lys8Glu

Hemoglobin subunit alpha
Gene: HBA2
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Variant information Variant position: help 8 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Lysine (K) to Glutamate (E) at position 8 (K8E, p.Lys8Glu). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (K) to medium size and acidic (E) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In Kurosaki. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 8 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 142 The length of the canonical sequence.
Location on the sequence: help MVLSPAD K TNVKAAWGKVGAHAGEYGAE The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         MVLSPADKTNVKAAWGKVGAHAGEYGAE

Gorilla                       -VLSPADKTNVKAAWGKVGAHAGDYGAE

Rhesus macaque                MVLSPADKSNVKAAWGKVGGHAGEYGAE

Chimpanzee                    MVLSPADKTNVKAAWGKVGAHAGEYGAE

Mouse                         MVLSGEDKSNIKAAWGKIGGHGAEYGAE

Rat                           MVLSADDKTNIKNCWGKIGGHGGEYGEE

Pig                           -VLSAADKANVKAAWGKVGGQAGAHGAE

Bovine                        MVLSAADKGNVKAAWGKVGGHAAEYGAE

Rabbit                        MVLSPADKTNIKTAWEKIGSHGGEYGAE

Sheep                         MVLSAADKSNVKAAWGKVGGNAGAYGAE

Cat                           -VLSAADKSNVKACWGKIGSHAGEYGAE

Horse                         MVLSAADKTNVKAAWSKVGGHAGEYGAE

Chicken                       MVLSAADKNNVKGIFTKIAGHAEEYGAE

Xenopus tropicalis            MHLTADDKKHIKAIWPSVAAHGDKYGGE

Zebrafish                     MSLSDTDKAVVKAIWAKISPKADEIGAE
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Initiator methionine 1 – 1 Removed
Chain 2 – 142 Hemoglobin subunit alpha
Site 12 – 12 Not glycated
Modified residue 4 – 4 Phosphoserine
Modified residue 8 – 8 N6-succinyllysine; alternate
Modified residue 9 – 9 Phosphothreonine
Modified residue 12 – 12 N6-succinyllysine
Modified residue 17 – 17 N6-acetyllysine; alternate
Modified residue 17 – 17 N6-succinyllysine; alternate
Modified residue 25 – 25 Phosphotyrosine
Glycosylation 8 – 8 N-linked (Glc) (glycation) lysine; alternate
Glycosylation 17 – 17 N-linked (Glc) (glycation) lysine; alternate
Helix 5 – 18



Literature citations
Hb Kurosaki [alpha 7(A5)Lys-->Glu]: a new alpha chain variant found in a Japanese woman.
Harano T.; Harano K.; Imai K.; Murakami T.; Matsubara H.;
Hemoglobin 19:197-201(1995)
Cited for: VARIANT KUROSAKI GLU-8;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.