Variant position: 13 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVLSPADKTNVK AAWGKVGAHAGEYGAEALERM
Gorilla -VLSPADKTNVK AAWGKVGAHAGDYGAEALERM
Rhesus macaque MVLSPADKSNVK AAWGKVGGHAGEYGAEALERM
Chimpanzee MVLSPADKTNVK AAWGKVGAHAGEYGAEALERM
Mouse MVLSGEDKSNIK AAWGKIGGHGAEYGAEALERM
Rat MVLSADDKTNIK NCWGKIGGHGGEYGEEALQRM
Pig -VLSAADKANVK AAWGKVGGQAGAHGAEALERM
Bovine MVLSAADKGNVK AAWGKVGGHAAEYGAEALERM
Rabbit MVLSPADKTNIK TAWEKIGSHGGEYGAEAVERM
Sheep MVLSAADKSNVK AAWGKVGGNAGAYGAEALERM
Cat -VLSAADKSNVK ACWGKIGSHAGEYGAEALERT
Horse MVLSAADKTNVK AAWSKVGGHAGEYGAEALERM
Chicken MVLSAADKNNVK GIFTKIAGHAEEYGAETLERM
Xenopus tropicalis MHLTADDKKHIK AIWPSVAAHGDKYGGEALHRM
Zebrafish MSLSDTDKAVVK AIWAKISPKADEIGAEALARM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
4 – 4 Phosphoserine
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
5 – 18
Hb Yuda or alpha 130(H13)Ala-->Asp; a new alpha chain variant with low oxygen affinity.
Fujisawa K.; Hattori Y.; Ohba Y.; Ando S.;
Cited for: VARIANT YUDA ASP-131;
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