Variant position: 15 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVLSPADKTNVKAA WGKVGAHAGEYGAEALERMFL
Gorilla -VLSPADKTNVKAA WGKVGAHAGDYGAEALERMFL
Rhesus macaque MVLSPADKSNVKAA WGKVGGHAGEYGAEALERMFL
Chimpanzee MVLSPADKTNVKAA WGKVGAHAGEYGAEALERMFL
Mouse MVLSGEDKSNIKAA WGKIGGHGAEYGAEALERMFA
Rat MVLSADDKTNIKNC WGKIGGHGGEYGEEALQRMFA
Pig -VLSAADKANVKAA WGKVGGQAGAHGAEALERMFL
Bovine MVLSAADKGNVKAA WGKVGGHAAEYGAEALERMFL
Rabbit MVLSPADKTNIKTA WEKIGSHGGEYGAEAVERMFL
Sheep MVLSAADKSNVKAA WGKVGGNAGAYGAEALERMFL
Cat -VLSAADKSNVKAC WGKIGSHAGEYGAEALERTFC
Horse MVLSAADKTNVKAA WSKVGGHAGEYGAEALERMFL
Chicken MVLSAADKNNVKGI FTKIAGHAEEYGAETLERMFT
Xenopus tropicalis MHLTADDKKHIKAI WPSVAAHGDKYGGEALHRMFM
Zebrafish MSLSDTDKAVVKAI WAKISPKADEIGAEALARMLT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
14 – 15 (Microbial infection) Cleavage; by N.americanus apr-2
4 – 4 Phosphoserine
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
5 – 18
Hemoglobin Evanston: alpha 14(A12) Trp leads to Arg. A variant hemoglobin associated with alpha-thalassemia-2.
Moo-Penn W.F.; Baine R.M.; Jue D.L.; Johnson M.H.; McGuffey J.E.; Benson J.M.;
Biochim. Biophys. Acta 747:65-70(1983)
Cited for: VARIANT EVANSTON ARG-15;
Hemoglobin Evanston (alpha 14 Trp----Arg). An unstable alpha-chain variant expressed as alpha-thalassemia.
Honig G.R.; Shamsuddin M.; Vida L.N.; Mompoint M.; Valcourt E.; Bowie L.J.; Jones E.C.; Powers P.A.; Spritz R.A.; Guis M.;
J. Clin. Invest. 73:1740-1749(1984)
Cited for: CHARACTERIZATION OF VARIANT EVANSTON ARG-15;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.