Variant position: 17 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVLSPADKTNVKAAWG KVGAHAGEYGAEALERMFLSF
Gorilla -VLSPADKTNVKAAWG KVGAHAGDYGAEALERMFLSF
Rhesus macaque MVLSPADKSNVKAAWG KVGGHAGEYGAEALERMFLSF
Chimpanzee MVLSPADKTNVKAAWG KVGAHAGEYGAEALERMFLSF
Mouse MVLSGEDKSNIKAAWG KIGGHGAEYGAEALERMFASF
Rat MVLSADDKTNIKNCWG KIGGHGGEYGEEALQRMFAAF
Pig -VLSAADKANVKAAWG KVGGQAGAHGAEALERMFLGF
Bovine MVLSAADKGNVKAAWG KVGGHAAEYGAEALERMFLSF
Rabbit MVLSPADKTNIKTAWE KIGSHGGEYGAEAVERMFLGF
Sheep MVLSAADKSNVKAAWG KVGGNAGAYGAEALERMFLSF
Cat -VLSAADKSNVKACWG KIGSHAGEYGAEALERTFCSF
Horse MVLSAADKTNVKAAWS KVGGHAGEYGAEALERMFLGF
Chicken MVLSAADKNNVKGIFT KIAGHAEEYGAETLERMFTTY
Xenopus tropicalis MHLTADDKKHIKAIWP SVAAHGDKYGGEALHRMFMCA
Zebrafish MSLSDTDKAVVKAIWA KISPKADEIGAEALARMLTVY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
4 – 4 Phosphoserine
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
5 – 18
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.