Variant position: 20 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVLSPADKTNVKAAWGKVG AHAGEYGAEALERMFLSFPTT
Gorilla -VLSPADKTNVKAAWGKVG AHAGDYGAEALERMFLSFPTT
Rhesus macaque MVLSPADKSNVKAAWGKVG GHAGEYGAEALERMFLSFPTT
Chimpanzee MVLSPADKTNVKAAWGKVG AHAGEYGAEALERMFLSFPTT
Mouse MVLSGEDKSNIKAAWGKIG GHGAEYGAEALERMFASFPTT
Rat MVLSADDKTNIKNCWGKIG GHGGEYGEEALQRMFAAFPTT
Pig -VLSAADKANVKAAWGKVG GQAGAHGAEALERMFLGFPTT
Bovine MVLSAADKGNVKAAWGKVG GHAAEYGAEALERMFLSFPTT
Rabbit MVLSPADKTNIKTAWEKIG SHGGEYGAEAVERMFLGFPTT
Sheep MVLSAADKSNVKAAWGKVG GNAGAYGAEALERMFLSFPTT
Cat -VLSAADKSNVKACWGKIG SHAGEYGAEALERTFCSFPTT
Horse MVLSAADKTNVKAAWSKVG GHAGEYGAEALERMFLGFPTT
Chicken MVLSAADKNNVKGIFTKIA GHAEEYGAETLERMFTTYPPT
Xenopus tropicalis MHLTADDKKHIKAIWPSVA AHGDKYGGEALHRMFMCAPKT
Zebrafish MSLSDTDKAVVKAIWAKIS PKADEIGAEALARMLTVYPQT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1 Removed
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
4 – 4 Phosphoserine
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
19 – 21
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.