Variant position: 22 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VLSPADKTNVKAAWGKVGAH AGEYGAEALERMFLSFPTTKT
Gorilla VLSPADKTNVKAAWGKVGAH AGDYGAEALERMFLSFPTTKT
Rhesus macaque VLSPADKSNVKAAWGKVGGH AGEYGAEALERMFLSFPTTKT
Chimpanzee VLSPADKTNVKAAWGKVGAH AGEYGAEALERMFLSFPTTKT
Mouse VLSGEDKSNIKAAWGKIGGH GAEYGAEALERMFASFPTTKT
Rat VLSADDKTNIKNCWGKIGGH GGEYGEEALQRMFAAFPTTKT
Pig VLSAADKANVKAAWGKVGGQ AGAHGAEALERMFLGFPTTKT
Bovine VLSAADKGNVKAAWGKVGGH AAEYGAEALERMFLSFPTTKT
Rabbit VLSPADKTNIKTAWEKIGSH GGEYGAEAVERMFLGFPTTKT
Sheep VLSAADKSNVKAAWGKVGGN AGAYGAEALERMFLSFPTTKT
Cat VLSAADKSNVKACWGKIGSH AGEYGAEALERTFCSFPTTKT
Horse VLSAADKTNVKAAWSKVGGH AGEYGAEALERMFLGFPTTKT
Chicken VLSAADKNNVKGIFTKIAGH AEEYGAETLERMFTTYPPTKT
Xenopus tropicalis HLTADDKKHIKAIWPSVAAH GDKYGGEALHRMFMCAPKTKT
Zebrafish SLSDTDKAVVKAIWAKISPK ADEIGAEALARMLTVYPQTKT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
12 – 12 Not glycated
4 – 4 Phosphoserine
8 – 8 N6-succinyllysine; alternate
9 – 9 Phosphothreonine
12 – 12 N6-succinyllysine
17 – 17 N6-acetyllysine; alternate
17 – 17 N6-succinyllysine; alternate
25 – 25 Phosphotyrosine
36 – 36 Phosphoserine
41 – 41 N6-succinyllysine; alternate
8 – 8 N-linked (Glc) (glycation) lysine; alternate
17 – 17 N-linked (Glc) (glycation) lysine; alternate
41 – 41 N-linked (Glc) (glycation) lysine; alternate
22 – 36
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.